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( Ga Won Song ),( Sun Young Shin ),( Kyu Hyun Han ),( Suk Pyo Shin ),( Seong Gyu Hwang ),( Kyu Sung Rim ),( Hana Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background/Aim: Transarterial chemoembolization (TACE) is one of the locolesional treatment modalities for hepatocellular carcinoma (HCC). However, disease progression after TACE is often developed. The aim of our study was to determine the predictors of progression after TACE in patients with HCC. Method: We retrospectively reviewed a total of 374 patients who had diagnosed as HCC and performed the fi rst TACE in our institution, Bundang CHA hospital, from 2004 January to 2013 September. Tumor response was estimated as CR (complete response), PR (partial response), SD (stable disease) and PD (progressive disease) based on the results of computed tomography 4 weeks after TACE with modifi ed RECIST criteria.Results: Among a total 374 patients, 13 patients(3.5%) had experienced previous TACE, and 361 patients(96.5%) were TACE naive. Most patients(n=370, 98.9%) had liver cirrhosis, 289 patients(77.3%) were classifi ed as Child-Pugh class A and 85 patients( 22.2%) as Child-Pugh class B. After 4 weeks after TACE, tumor response was as follows: CR 146(39.0%), PR 124(3.2%), SD 16(4.3%) and PD 88(23.5%). In patients with PD, there was a signifi cantly greater portion of TACE experienced patients compared to those with CR, PR, and SD(8.0 vs. 2.1%, p=0.016). The mean size of largest tumor and total sum of tumor sizes were signifi cantly greater in patients with PD(6.4 vs. 3.6 cm of largest tumor size, p<0.001; 7.0 vs 4.1 cm of total sum of tumor sizes, p=0.001, respectively). In multivariate analysis, previous TACE experience[Odds ratio (OR) 8.746, p=0.002] and a total sum of tumor sizes( = 3cm; OR 4.022, p=0.016, = 10cm; OR 9.153, p=0.008) were predictors of progression after TACE.Conclusion: Progression of HCC after TACE is associated with history of previous TACE experience and the total sum of tumor sizes. * Ga Won Song and Sun Young Shin contributed equally.
( Ga Won Yim ),( Hoon Kim ),( Young Min Choi ),( Seok Hyun Kim ),( Yong Sang Song ),( Noh Hyun Park ),( Chang Suk Suh ),( Jae Won Kim ),( Joong Shin Park ),( Seung Yup Koo ),( Hyun Hoon Chung ),( Myun 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: To identify the impact of care given by gynecologic hospitalist on waiting time prior to final disposition in the emergency department. Methods: Since September 2016, the government adopted a pilot program to introduce hospitalist system in Korea. Gynecologic hospitalist system was implemented at a high-volume hospital since May 2018 for the first time in Korea. The hospitalist provided acute and/or palliative medical care in the emergency department (ED), intensive care unit (ICU), and at the general ward. Three-month data before and after the implementation of hospitalist system on the waiting time at the ED was analyzed. Waiting time was defined as the time of referral for gynecologic consultation by the ED staff to the time of final plan (disposition) given by the hospitalist formally through the consultation reply. Patients that were given care during the daytime (9AM - 6PM) were included for analysis. Results: The number of monthly gynecologic consultation during daytime at the ED were 11, 4, and 18 on February, March, and April (group 1), respectively. The number increased gradually after the implementation of the hospitalist system; 13, 21, and 22 patients in May, June, and July (group 2), respectively. The proportion of patients with conditions related to oncologic treatment (neutropenic fever, septic shock, bowel obstruction, etc.) was 60.7%. The number of patients with extended length of stay (> 12 hours) at the ED were 5 vs. 1 in group 1 and 2, respectively. The median waiting time prior to final deposition was 142 min (range 45 - 492 min) in group 1 (before hospitalist system) and 81 min (range 17 - 212 min) in group 2 (after hospitalist system). Conclusion: The waiting time of gynecologic patients upon ED admission was significantly decreased after the establishment of the hospitalist system. Further related to patient mortality and patient / staff satisfaction are needed.
S-454 : Does timing of adjuvant chemotherapy for gastric cancer influence outcome?
( Ga Won Song ),( Mi Sun Ahn ),( Jin Hyuk Choi ),( Seok Yun Kang ),( Hyun Woo Lee ),( Yong Kwan Cho ),( Sang Uk Han ),( Hoon Hur ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background: According to recent large phase III trials, adjuvant chemotherapy is currently established as standard treatment in patients with stage II, III gastric cancer. However, to the authors` knowledge, the effect of the interval between surgery and the start of chemotherapy on outcome has not been investigated. Methods: A retrospective review was conducted of 716 patients who underwent adjuvant chemotherapy for stage IB-IIIC (AJCC 7th edition) gastric cancer after radical surgery with D2 dissection between 1994 and 2004 at the Ajou University Hospital. Overall survival (OS) was compared among patients grouped by time from surgery to start of adjuvant chemotherapy. Results: In terms of chemotherapy regimens, 5-FU/mitomycin-C-based (61.3%) was the most commonly used regimen, followed by 5-FU/doxorubicin-based one (16.9%), oral fluoropyrimidines (10.3%) and others (11.4%). The median time from surgery to chemotherapy was 20 days (range: 4-105 days), while 114 patients (15.9%) began adjuvant chemotherapy >4 weeks after surgery. The median follow-up duration was 152 months (range: 97-222 months) for the survivors. There was no significant difference in 10 year-OS between patients starting chemotherapy ≤ 20 days after surgery and those initiating later (51.2% vs. 48.5%, p=0.896). Commencing chemotherapy 4 weeks, 6 weeks and 8 weeks after surgery was not associated with inferior OS, compared with earlier initiation at each time interval (p=0.183, 0.739, 0.434, respectively). Even very early initiation of chemotherapy (≤ 2 weeks after surgery) did not correlate with better outcome (p=0.579). Conclusion: This study did not demonstrate any significant survival benefit from early initiation of adjuvant chemotherapy after surgery.
Song, Hyeong-Sub,Kwon, Sung-Kyu,Jeon, So-Ra,Oh, Dong-Jun,Lee, Ga-Won,Lee, Hi-Deok Institute of Pure and Applied Physics 2016 Japanese Journal of Applied Physics Vol. No.
<P>To realize high-resolution pixels in the CMOS image sensor, it is necessary to reduce low-frequency noise, particularly random telegraph signal (RTS) noise of the source-follower transistor (SFT). To achieve less relative variation of drain noise current, Delta I-D/Delta I-D, a metal-oxide-semiconductor field-effect transistor structure without the lightly doped drain (LDD) for the SFT transistor is proposed. Then, a comparison of RTS noise characteristics between the proposed SFT structure without LDD and the conventional SFT structure with LDD was conducted. Although the RTS noise occurrence probability of the proposed SFT structure without LDD is somewhat greater than that of the conventional SFTstructure with LDD, the amplitude of relative variation of drain noise current of the proposed SFTstructure is significantly less than that of the conventional SFT. Despite changes in several factors in the proposed SFT, such as effective channel length, trap depth profile in gate oxide, and random dopant fluctuation (RDF), it is believed that the change of trap depth profile is a primary factor for the improved RTS characteristic. Therefore, the proposed SFT is highly desirable for the high-resolution CMOS image sensor. (C) 2016 The Japan Society of Applied Physics</P>
Glycosylation study of phenolic complunds by amylosucrase
Ga Yeon Noh,Jihye Baek,Jin Woo Lee,Jong Won Song,Hun Sang Lee,Jae Kyung SohngH 한국당과학회 2018 한국당과학회 학술대회 Vol.2018 No.01
The purpose of this experiment is to investigate the glycosylation using enzymes. E. coli BL21 (DE3) was used as a host for protein overexpression. Phloroglucinol (PG) is used as an antiseptic and the treatment of gallstones, cramps and gastrointestinal disorders. According to HPLC results, the glycosylation of PG quickly generated in a few hours. Pyrogallol is a medicinal product that is used in psoriasis and antimicrobial agents. We progressed this reaction with ascorbic acid which is antioxidant for reaction stability of phloroglucinol and pyrogallol. 2,4-dihydroxybenzoic acid are belong to flavor modulators. The pharmacological action of 2,5-dihydroxybenzoic acid has a wide range of biological activities such as anti-inflammatory, antirheumatic and antioxidant properties. When salicylic acid is glycosylated, we anticipate both antivirus and antipyretic effects against influenza. In the case of p-aminosalicylic acid, when glycosylated, we anticipate alleviation of various side effects mentioned above as a result of enhanced water solubility of drug. The glycosylation of salicylic acid by amylosucrase was not detected, but we observed through HPLC that the level of glycosylation of p-aminosalicylic acid, 2,4-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid, although slow in reaction rate, increased over a time period.
Jae-Won Song,Na-Rae Yoon,Soo-Min Jang,Ga-Young Lee,Bung-Nyun Kim 대한소아청소년정신의학회 2020 소아청소년정신의학 Vol.31 No.3
Deep learning (DL) is a kind of machine learning technique that uses artificial intelligence to identify the characteristics of given data and efficiently analyze large amounts of information to perform tasks such as classification and prediction. In the field of neuroimaging of neurodevelopmental disorders, various biomarkers for diagnosis, classification, prognosis prediction, and treatment response prediction have been examined; however, they have not been efficiently combined to produce meaningful results. DL can be applied to overcome these limitations and produce clinically helpful results. Here, we review studies that combine neurodevelopmental disorder neuroimaging and DL techniques to explore the strengths, limitations, and future directions of this research area.