Psychopathological Profile of Women with Breast Cancer Based on the Symptom Checklist-90-R

Pan, Xiong-Fei,Fei, Man-Dong,Zhang, Kenneth Y.,Fan, Zhen-Lie,Fu, Feng-Huan,Fan, Jin-Hu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: With effective early treatments, many breast cancer patients suffer from psychological distress due to adverse effects and lifelong physical disfigurement. Our study aimed to evaluate the psychopathological profile of breast cancer patients in comparison with healthy women and explored demographic correlates. Method: We consecutively enrolled breast cancer patients who came to the hospital for follow-up or rehabilitation care after primary treatment, and healthy female relatives or friends of inpatients in the Cancer Institute of Chinese Academy of Medical Sciences between August 30, 2010 and January 1, 2012. Psychopathological profile was assessed based on the Symptom Checklist-90-R (SCL-90-R) for patients and controls. We compared demographics such as age, ethnicity, education, marriage, and occupation, and incorporated these data plus cancer status for the association with the general SCL-90-R index and scores for 9 major symptom dimensions in multiple regression analysis. Results: We surveyed a total of 291 female breast cancer patients and 531 healthy women. The average age was $55.1{\pm}6.40$ years for breast cancer patients and $43.1{\pm}12.8$ for healthy controls (P<0.01). The mean survival was 5.20 years for cancer patients (range, 0.60-9.90 years). There were statistically significant differences in education, marriage, and occupation between the two groups (P<0.01). General index ($1.45{\pm}0.45$ versus $1.32{\pm}0.37$) and 8 dimension scores (excluding anxiety) on SCL-90-R were significantly higher in patients (P<0.05). Multiple regression analysis showed that the breast cancer status was positively correlated with general SCL-90-R index and 6 dimension scores (excluding the anxiety, phobic anxiety and paranoid ideation dimensions) (P<0.05). Regression coefficients ranged from 0.10 (depression) to 0.19 (somatization). Higher interpersonal sensitivity was noticed in single women compared to married women. Conclusions: Chinese patients with breast cancer demonstrate greater psychopathology compared to healthy controls. The breast cancer status is an independent contributing factor to the general psychopathological profile. Breast cancer patients should be given particular counseling and care to alleviate their psychological distress.

Icefex: Protocol Format Extraction from IL-based Concolic Execution

( Fan Pan ),( Li-fa Wu ),( Zheng Hong ),( Hua-bo Li ),( Hai-guang Lai ),( Chen-hui Zheng ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.3

Protocol reverse engineering is useful for many security applications, including intelligent fuzzing, intrusion detection and fingerprint generation. Since manual reverse engineering is a time-consuming and tedious process, a number of automatic techniques have been proposed. However, the accuracy of these techniques is limited due to the complexity of binary instructions, and the derived formats have missed constraints that are critical for security applications. In this paper, we propose a new approach for protocol format extraction. Our approach reasons about only the evaluation behavior of a program on the input message from concolic execution, and enables field identification and constraint inference with high accuracy. Moreover, it performs binary analysis with low complexity by reducing modern instruction sets to BIL, a small, well-specified and architecture-independent language. We have implemented our approach into a system called Icefex and evaluated it over real-world implementations of DNS, eDonkey, FTP, HTTP and McAfee ePO protocols. Experimental results show that our approach is more accurate and effective at extracting protocol formats than other approaches.

Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study

Pan Xiaoming,Gu Yinger,Zhang Xian,Shi Biwei,Cui Long,Wang Fangfang,Qu Fan 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.1

Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Chinese herbal medicine (CHM) has many advantages in treating PCOS. We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF in Chinese patients with PCOS and the potential underlying mechanism. Methods: A total of 111 patients with PCOS who undergone IVF between November 2009 and July 2018 were included. Fifty-four patients received a three-month BSTJF therapy before controlled ovarian hyperstimulation, while the other 57 patients didn't. The data of the PCOS patients was collected. Anti-Müllerian hormone (AMH), growth differentiation factor-8 (GDF-8) levels in the follicular fluid were evaluated. Results: BSTJF helped patients with PCOS to get more retrieved oocytes (P<0.05) and fertilized oocytes (P<0.05). The clinical cumulative pregnancy rate, live birth rate, and term delivery rate were significantly higher in the same stimulated cycle of the PCOS patients with BSTJF treatment (P<0.05). No significant differences existed between the two groups in the rate of fertilization, hospitalization rate of ovarian hyper stimulation syndrome and obstetrical or neonatal complications. BSTJF significantly decreased the AMH levels in the follicular fluids (P<0.05). Conclusion: BSTJF significantly may improve the outcomes of IVF in Chinese patients with PCOS through decreasing AMH levels in follicular fluids. However, the evidence is limited due to the small sample size and the several potential bias. Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Chinese herbal medicine (CHM) has many advantages in treating PCOS. We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF in Chinese patients with PCOS and the potential underlying mechanism. Methods: A total of 111 patients with PCOS who undergone IVF between November 2009 and July 2018 were included. Fifty-four patients received a three-month BSTJF therapy before controlled ovarian hyperstimulation, while the other 57 patients didn't. The data of the PCOS patients was collected. Anti-Müllerian hormone (AMH), growth differentiation factor-8 (GDF-8) levels in the follicular fluid were evaluated. Results: BSTJF helped patients with PCOS to get more retrieved oocytes (P<0.05) and fertilized oocytes (P<0.05). The clinical cumulative pregnancy rate, live birth rate, and term delivery rate were significantly higher in the same stimulated cycle of the PCOS patients with BSTJF treatment (P<0.05). No significant differences existed between the two groups in the rate of fertilization, hospitalization rate of ovarian hyper stimulation syndrome and obstetrical or neonatal complications. BSTJF significantly decreased the AMH levels in the follicular fluids (P<0.05). Conclusion: BSTJF significantly may improve the outcomes of IVF in Chinese patients with PCOS through decreasing AMH levels in follicular fluids. However, the evidence is limited due to the small sample size and the several potential bias.

Orthogonal-Gradient Measurement Matrix Construction Algorithm

Pan, Tian,Choi, Youngjune,Tian, Shujuan,Fan, Xiaoping,Li, Zhetao,Sekiya, Hiroo Institution of Electrical Engineers 2016 Chinese journal of electronics Vol.25 No.1

<P>An orthogonal-gradient measurement matrix construction algorithm is proposed for reducing the maximum and average mutual-coherence of sensing matrix. It shrinks Gram matrix based on equiangular tight frame theory. An orthogonal-gradient factor matrix is deduced. It obtains an optimized measurement matrix with the orthogonal-gradient factor matrix. The results of experiments show that the proposed algorithm effectively reduces the maximum and average mutual-coherence of sensing matrix. This leads to a better reconstruction performance for signals with different sparsities compared with Gaussian matrix, Elad's, Xu's, Vahid's and Li's methods.</P>

Intracerebral Microdialysis Technique and its Application on Brain Pharmacokinetic-Pharmacodynamic Study

Pan, Yue-Fang,Feng, Jian,Cheng, Qiao-Yuan,Li, Fan-Zhu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12

Intracerebral microdialysis (IC-MD) has been developed as a well-validated and powerful technique for decades. As a practical sampling tool, it can gain the continuous dialysates of endogenous and exogenous substances in extracellular fluid (ECF) of awake freely moving animals. Also, variform IC-MD probes (IC-MDPs) have grown more exquisite. The implantation of the IC-MDP in certain tissue of brain allows monitor drug distribution and measure drug and corresponding neurotransmitters levels in brain ECF a after administration for brain pharmacokinetic-pharmacodynamic (B-PK-PD) study. So it is suitable for IC-MD to B-PK-PD study (IC-MD/B-PK-PD). The performance of IC-MD/B-PK-PD can not only elevate the degree of precision and accuracy of experimental data, minimize the individual difference by reduced number of animals, but also give important information for the prediction and optimization of drug effective dose in preclinical study. In this review, we have discussed various IC-MD/B-PK-PD studies of analgesic, antiepileptic and antidepressant drug. The role of IC-MD/B-PK-PD in confirming and assessing the drug effect before clinic trials is highlighted.

UKF Estimation Method of Centroid Slip Angle for Vehicle Stability Control

Pan Wang,Xiaobin Fan,Xinbo Chen,Juean Yi,Shuwen He 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.7

Vehicle center of sideslip angle is an essential parameter in vehicle stability control system. In view of the current problems is taken as the research object including low estimation accuracy and poor real-time performance of the current centroid sideslip angle, the four-wheel motor driven electric vehicle. The estimation problem of the sideslip angle is studied in-depth when the vehicle is in a nonlinear state. In addition, an Unscented Kalman Filter (UKF) estimation method is proposed to reduce observation error and improve the practicability of the estimation system. First of all, the research starts with building a 7-degree-of-freedom vehicle model which is based on the Dugoff tire model. Then, after measuring the state parameters, the UKF algorithm is used to estimate the sideslip angle. By comparing with the Extended Kalman Filter (EKF) algorithm, it is confirmed that the estimation method can not only better estimate the center of sideslip angle in real time, but also greater improve the handling stability of the vehicle in the driving state. Besides, the effectiveness of the algorithm is further verified by the real vehicle road test.

Determination of Amatoxins in Lepiota brunneoincarnata and Lepiota venenata by High-Performance Liquid Chromatography Coupled with Mass Spectrometry

( Pan Long ),( Fengxia Fan ),( Bin Xu ),( Zhengmi He ),( Yuting Su ),( Ping Zhang ),( Jianwei Xie ),( Zuohong Chen ) 한국균학회 2020 Mycobiology Vol.48 No.3

Three hepatic failure poisoning incidents caused by Lepiota brunneoincarnata and Lepiota venenata mushrooms have been occurred in China in 2017, L. venenata has been described as a new species. However, the cyclopeptide toxins of these lethal mushrooms remain poorly understood. In this study, the composition and content of amatoxins in L. brunneoincarnata and L. venenata are analyzed and compared, the analysis of composition and content of amatoxins in L. venenata are reported for the first time. The results showed that b-amanitin (b-AMA), a-amanitin (a-AMA), amanin, and amaninamide were identified in L. brunneoincarnata, and a-AMA, amanin II (an analog of amanin), and an unknown compound were identified in L. venenata. The differences between L. brunneoincarnata and L. venenata in the identified compounds provide chemical evidence for L. venenata as a new species. Quantitative analysis shows that a-AMA concentrations in L. brunneoincarnata and L. venenata were 0.72-1.97mg/g dry weight, b-AMA concentrations in L. brunneoincarnata were 0.57-0.94mg/g dry weight, and b-AMA was absent in L. venenata.

Design of Concentrating System for Solar Side-pumped Slab Laser

Fan, Wentong,Liu, Yan,Guo, Pan,Deng, Rui,Li, Nan,Ding, Fukang,Li, Yasha,Zhou, Jun,Xie, Shiwei Optical Society of Korea 2020 Current Optics and Photonics Vol.4 No.1

The design of a concentration system for a solar side-pumped slab laser was investigated. The side size of the slab laser medium is 2 mm × 20 mm. Based on the principle of the edge ray, a secondary concentrating system consisting of a rectangular parabolic mirror (RPM) and a rectangular dielectric-filled compound parabolic concentrator (RDCPC) was demonstrated. The focal length of RPM is 1200 mm and the size is 734 mm × 2000 mm. The outlet size of the RDCPC is 2 mm × 20 mm. The concentration effect was analyzed by using Tracepro optical software. The results showed that the concentration efficiency reached 81.3% and the uniformity of the spot was 91.4% after optimization. This design of concentration system is of great reference value for a solar side-pumped slab laser.

In Vitro and In Vivo Studies on the Complexes of Vinpocetine with $Hydroxypropyl-{\beta}-cyclodextrin$

Fan, Xiaowen,Peng, Ying,Yang, Xingang,Wang, Chao,Pan, Weisan,Nie, Shufang 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8

The purpose of this study was to evaluate complexes of vinpocetine (VIN), a poorly water-soluble base type drug, with $Hydroxypropyl-{\beta}-cyclodextrin$ ($HP-{\beta}-CD$) in aqueous environment and in solid state, with or without citric acid (CA) as an acidifier of the complexation medium. The apparent stability constant ($K_c$) calculated by phase solubility was 282 $M^{-1}$ and the complexation in solution was structurally characterized by $^1H-NMR$ which showed VIN was likely to fit into the cyclodextrin cavity with its phenyl ring and ethyl ester bond. Solid complexes of VIN and $HP-{\beta}-CD$ were prepared by kneading (KE), co-evaporating (CE) and freeze-drying (FD) methods. Physical mixtures were prepared for comparison. The study in the solid state included the differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and infrared absorption spectroscopy (IR). From these analyses, CE and FD products were found in amorphous state, allowing to the conclusion of strong evidences of inclusion complex formation However, the dissolution test showed that only $VIN/HP-{\beta}-CD+CA$ complexes by CE and FD method could provide satisfying dissolution behavior (rapid, complete and lasting) when compared to that of $VIN/HP-{\beta}-CD$ complexes. Interestingly, the addition of CA in inclusion complexes could significantly decrease the amount of $HP-{\beta}-CD$ needed to solubilize the same amount of VIN and thereby reducing the formulation bulk. Furthermore, in-vivo study revealed that the bioavailability of VIN after oral administration to rabbits (n=6) was significantly improved by $VIN/HP-{\beta}-CD+CA$ inclusion complex.

Performance Analysis of Amplify-and-Forward Two-Way Relaying with Antenna Correlation

( Zhangjun Fan ),( Kun Xu ),( Bangning Zhang ),( Xiaofei Pan ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.6

This paper investigates the performance of an amplify-and-forward (AF) two-way relaying system with antenna correlation. The system consists of two multiple-antenna sources, which exchange information via the aid of a single-antenna relay. In particular, we derive the exact outage probability expression. Furthermore, we provide a simple, tight closed-form lower bound for the outage probability. Based on the lower bound, we obtain the closed-form asymptotic outage probability and the average symbol error rate expressions at high signal-to-noise ratio (SNR), which reveal the system`s diversity order and coding gain with antenna correlation. To investigate the system`s throughput performance with antenna correlation, we also derive a closed-form lower bound for the average sum-rate, which is quite tight from medium to high SNR regime. The analytical results readily enable us to obtain insight into the effect of antenna correlation on the system`s performance. Extensive Monte Carlo simulations are conducted to verify the analytical results.