노인운동의 변화단계에 따른 의사결정 균형에 대한 연구

김소인,전영자,박은숙,김순용,장성옥,이평숙,이숙자 성인간호학회 2000 성인간호학회지 Vol.12 No.1

Purpose : This study was carried out to identify the factor of decisional balance for exercise. This was composed of a set of variables at the level of decision making when the elderly decide to do exercise. It was used to classify and identify the characteristics of the stages of change for exercise to which the elderly belong, and was used to identify the variables of decisional balance which influence the stage of change for exercise in the elderly. Methods : Convenient samples of 198 subjects over age 60 in Seoul(mean age=70) were selected from community living, mentally competent older adults and the data was collected from April 1, 1999 to May 31, 1999. The research instrument was the Decisional Balance Measure for Exercise(Marcus & Owen., 1992), Stage of Change Measure(Marcus et al, 1992). The data was analyzed by SAS Program. Results: 1. According to stage of change measure, without missing data, 191 subjects were distributed in each stage of change for exercise : 50 subjects(26.1%), 7 subjects(3.6%), 52 subjects(27.2%), 4 subjects(2%), and 78 subjects(40.8%) belonged to the pre-contemplation stage, contemplation stage, preparation stage, action stage and maintenance stage. 2. Factor analysis identified 3 factors of decisional balance as appropriate factors for excise of the elderly and named by researchers; 1)'Perceived Physical-psychological benefit', 2)'Perceived Physical-psychological burden', and 3)'Perceived time burden'. 3. The analysis of variance showed that the two components Perceived Physical - psychological benefit(F=45.95, p=.0001), and Perceived Physical-psychological burden(F=26.52, P=.001) were significantly associated with stage of change. 4. Through the discriminant analysis, it was found that both 'Self Perceived Physical-Psychological benefit' and 'Perceived Physical-Psychological burden' were the influential variables in discriminating the three stages of change(pre-contemplation, preparation, and maintenance). Conclusion: Results are consistent with the application of the Transtheoretical model, which has been used to understand how people change health behaviors. Even though this study is a cross-sectional, not a longitudinal study, the findings of this study give useful information for exercise intervention about especially the factors relating to decision making for exercise of the elderly in the different stages of change of exercise.

Which Environmental Factors Caused Lammas Shoot Growth of Korean Red Pine?

Lee, Chang-Seok,Song, Hye-Gyung,Kim, Hye-Soo,Lee, Bit-Na-Ra,Pi, Jeong-Hoon,Cho, Yong-Chan,Seol, Eun-Sil,Oh, Woo-Seok,Park, Sung-Ae,Lee, Seon-Mi The Ecological Society of Korea 2007 Journal of Ecology and Environment Vol.30 No.1

Lammas growth, a rare phenomenon for Korean red pine (Pinus densiflora), occurred in 2006. Lammas shoots showed higher frequency and longer length in Seoul's hotter urban center than in urban boundary or suburban forest sites. Frequency and length showed a close correlation with urbanization density and vegetation cover expressed in NDVI. Air temperature in the late summer of 2006 was more than $1^{\circ}C$ higher than an average year. Of the predominant environmental signals that modulate bud flush, only temperature changed significantly during the year. Differences in temperature between the urban centers, urban boundaries and suburban forests correlated with varying land-use density. The rise in temperature likely spurred lammas growth of the Korean red pine. Symptoms of climate change are being detected throughout the world, and its consequences will be clearer in the future. Considerate interest in the responses of ecological systems to the variable changes is required to prepare for unforeseeable crises. Monitoring of diverse ecological phenomena at Long Term Ecological Research sites could offer harbingers of change.

보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구

이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7

Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)

월경전 불쾌기분장애가 식이패턴에 미치는 영향

이은정,홍인선,김선희,정은영,장은재 동덕여자대학교 생활과학연구소 2008 생활과학연구 Vol.13 No.-

The purpose of this study was to identify the change of the dietary pattern, food craving in accordance with menstrual cycle among women with the premenstrual dysphoric disorder(PMDD) and women with no premenstrual symptoms(Non-PMS). The 24 subjects were divided by two groups, PMDD group and Non-PMS group. And the change of dietary pattern and food craving were measured for 4 weeks according to the menstrual cycle. The frequency of meal, the amount of meal and the change of palatability of meat intake, fatty food, carbonate drinks, fruit, confectionery and caffeine containing beverage were more significantly increased in luteal and menstrual phase than follicular phase without regard to PMDD group and Non-PMS group, but there were no statistically difference between groups. The change of palatability of vegetable & alcohol were no difference among the phase without regard to PMDD group and Non-PMS group, and there were no statistically difference between groups. Above the findings showed that the change of women's dietary pattern has connection with the change of menstrual cycle. It is considered that unconsidered variables in this study could be applied for the therapy of premenstrual symptom or management method in connection with variable related to menstrual cycle the systematic study is requested.

Altered Regulation of Renal Acid Base Transporters in Response to Ammonium Chloride Loading in Rats

Kim, Eun-Young,Choi, Joon-Seok,Lee, Ko-Eun,Kim, Chang-Seong,Bae, Eun-Hui,Ma, Seong-Kwon,Kim, Suhn-Hee,Lee, Jong-Un,Kim, Soo-Wan The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.2

The role of the kidney in combating metabolic acidosis has been a subject of considerable interest for many years. The present study was aimed to determine whether there is an altered regulation of renal acid base transporters in acute and chronic acid loading. Male Sprague-Dawley rats were used. Metabolic acidosis was induced by administration of $NH_4Cl$ for 2 days (acute) and for 7days (chronic). The serum and urinary pH and bicarbonate were measured. The protein expression of renal acid base transporters [type 3 $Na^+/H^+$ exchanger (NHE3), type 1 $Na^+/{HCO_3}^-$ cotransporter (NBC1), Na-$K^+$ ATPase, $H^+$-ATPase, anion exchanger-1 (AE-1)] was measured by semiquantitative immunoblotting. Serum bicarbonate and pH were decreased in acute acid loading rats compared with controls. Accordingly, urinary pH decreased. The protein expression of NHE3, $H^+$-ATPase, AE-1 and NBC1 was not changed. In chronic acid loading rats, serum bicarbonate and pH were not changed, while urinary pH was decreased compared with controls. The protein expression of NHE3, $H^+$-ATPase was increased in the renal cortex of chronic acid loading rats. These results suggest that unaltered expression of acid transporters combined with acute acid loading may contribute to the development of acidosis. The subsequent increased expression of NHE3, $H^+$-ATPase in the kidney may play a role in promoting acid excretion in the later stage of acid loading, which counteract the development of metabolic acidosis.

MODIS 16-Day Albedo 자료를 이용한 동북아시아 지역의 토지피복 별 알베도 변화 분석

박은빈 ( Eun Bin Park ),한경수 ( Kyung Soo Han ),이창석 ( Chang Suk Lee ),피경진 ( Kyung Jin Pi ) 대한원격탐사학회 2012 大韓遠隔探査學會誌 Vol.28 No.5

알베도는 지구 복사균형을 이루는 요소 중에서 지표의 에너지 균형에 직접적으로 영향을 주는 인자로 알려져 있다. 이러한 알베도 변화는 토양 수분량, 식생, 태양광의 입사 각도, 적설 등의 변화를 포함하여 지구 복사균형과 그것이 기후와 식생 변화에 미치는 영향력을 이해할 수 있는 결정적인 변수로 작용한다. 따라서 알베도 변화 모니터링은 기후 변화 예측에서 필요한 과정 중 하나이다. 본 연구에서는 동북아시아의 알베도 변화를 관측하기 위하여 2001년부터 2011년의 MODIS Albedo 16-Day 자료를 이용하였다. 연간알베도 변화에서 식생이 활발한 토지피복의 알베도 값이 NIR 밴드에서 높은 알베도 값을 VIS 밴드에서 낮은 알베도 값을 가짐을 확인하였고, 2002년을 기준으로 고비사막 부근과 만주지역의 알베도 값이 변화를 보여 식생 변화 지역으로 사료되어 세부 연구영역으로 선정하였다. 또한 최솟값의 변화로 두 지역 모두 2010년 이후 식생이 악화됨을 감지할 수 있었다. Albedo is known as a factor that directly impacts on the surface energy balance one of the elements of earth radiation balance. The change of albedo includes the change of soil moisture, vegetation, solar zenith angle, snow, and so on. In addition, it operates as a crucial path to understanding feedback mechanisms between radiation balance and its influence on climate and vegetation dynamics and therefore, observing the variation of albedo is a one of the essential procedures for anticipating climate change. In this study, we used MODIS 16-Day composited Albedo data from 2001 to 2011 years with the purpose of observing the change of albedo over Northeast Asia. According to the tendency of albedo for 11 years, albedo in the area of an active vegetation has increased in near-infrared (NIR) domain and decreased in visible (VIS) domain. On the basis of local changes in vegetation in 2002, the both area of the Gobi Desert and the Manchuria was enormously changed and chosen the research area and furthermore, the vegetation of both regions had deteriorated due to the change of the minimum value since 2010.

Analysis of Research Trends in Nitrous Oxide Emissions from Upland in Korea

Sun-Il Lee,Chang-Kyu Lee,Gun-Yeob Kim,Hyo-Suk Gwon,Jong-Sik Lee,Eun-Jung Choi,Joung-Du Shin 한국토양비료학회 2019 한국토양비료학회지 Vol.52 No.4

Global climate change, especially global warming is considered as threat to our future and posterity. Increasing concentrations of greenhouse gas such as carbon dioxide (CO₂), methane (CH₄) and nitrous oxide (N₂O) are the main causes of global warming. The Korean government has set a goal to cut the carbon emissions by 37% based on business-as-usual levels by 2030. According to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC), agricultural sector is an important source of greenhouse gas emissions. In this regard, it is common belief that reducing of such emission is of great significance to global climate change. In Korea, upland is one of the main sources of agricultural N₂O emission. In order to analyze domestic research trends related to N₂O emissions in the upland, 53 academic publications from 2009 to September 2019 were critically reviewed. The results were classified according to the research purposes. Reduction technologies of N₂O emission account for approximately 28.3%. N₂O characteristics and assessment for 24.5%, development of N₂O emission factors for 22.6%, and N₂O inventory assessment for 20.8% etc. Biochar, green manure, no tillage, and inhibitor were studied as a means of reducing N₂O release. The optimum technologies to reduce N₂O emission in Korea were discussed and proposed through the previous researches.

Modulation of Gene Expressions and Enzyme Activities of Methionine Sulfoxide Reductases by Cold, Aba or High Salt Treatments in Arabidopsis

Oh, Jee-Eun,Hong, Suk-Whan,Lee, Yunsook,Koh, Eun-Ji,Kim, Kideok,Seo, Youngwon,Chung, Namhyun,Jeong, Moonsoo,Chang,Chang, Cheolseong,Lee, Byoungcheon,Kim, Kyoung Heon,Lee, Kwangwon,Lee, Hojoung 생명자원연구 2005 생명자원연구 Vol.13 No.-

암세포 증식에 대한 YB-1 안티센스 올리고핵산염의 영향

김명성 ( Myung Sung Kim ),이완식 ( Wan Sik Lee ),박창환 ( Chang Hwan Park ),주영은 ( Young Eun Joo ),김현수 ( Hyun Soo Kim ),최성규 ( Sung Kyu Choi ),유종선 ( Jong Sun Rew ),정영도 ( Young Do Jung ),김세종 ( Sei Jong Kim ),안봉환 대한내과학회 2006 대한내과학회지 Vol.71 No.3

목적: YB-1은 PCNA, DNA 중합효소 및 MDR 유전자 등의 전사인자로 작용한다. YB-1 유전자는 정상 어른의 간에서는 발현되지 않지만 태아의 간이나 재생 중인 간에서는 발현이 현저히 증가되어서 세포의 증식과 밀접한 관련이 있음이 보고되었다. 본 연구에서는 YB-1 유전자의 안티센스 올리고핵산염을 이용하여 YB-1의 발현을 억제함으로써 암세포 증식을 차단 할 수 있는지를 실험하고 암치료를 위한 유전자 요법으로서의 가능성을 알아보았다. 방법: 세포주로는 Chang liver, HepG2, CT-26 세포를 사용하였고, 사람의 정상세포로는 섬유아세포와 내피세포가 혼재된 조직을 사용하였다. YB-1 유전자의 안티센스 올리고핵산염으로는 YB-1 cDNA의 변역 시작 부위에 상보적인 21mer 올리고핵산염을 제작하여 사용하였다. 세포의 성장은 MTT assay를 이용하였고, 유전자 발현은 Northern blot으로 분석하였으며, 세포주기 변화는 propidium iodide로 염색하여 유식세포분석기로 분석하였다. 동물실험에서는 CT-26 세포를 1.0×10(5)개씩 Balb/c 생쥐의 피하에 접종하여 종양을 유도하였다. 종양이 유도된 Balb/c 생쥐에 YB-1 안티센스 올리고핵산염을 꼬리정맥이나 종양조직에 주사한 후 종양의 크기를 측정하여 종양억제 효과를 관찰하였다. 결과: YB-1 안티센스 올리고핵산염은 CT-26 세포에서는 50 nM 이상 농도에서 Chang liver와 HepG2 세포에서는 10 nM 이상 농도에서 세포주의 성장을 강하게 억제하였지만 정상 조직세포의 성장에는 아무런 영향을 미치지 않았다. 안티센스 올리고핵산염을 DOTAP에 담지한 경우 세포성장 억제에 미치는 효과가 안티센스 올리고핵산염 단독 처치 보다 강하였다. 이때 YB-1의 발현은 증식이 억제된 세포주(Chang liver 및 CT-26)에서는 감소하였으나 정상조직세포에서는 변화가 없었다. 증식이 억제된 세포주에서 세포주기를 살펴보면 초기에 S phase가 감소함을 관찰 할 수 있었다. 꼬리정맥이나 종양조직에 YB-1 안티센스 올리고핵산염을 주입 시 종양의 크기가 유의하게 감소하였다. 결론: 이상의 실험 결과 YB-1 안티센스 올리고핵산염은 암세포의 성장을 저해하며 종양 동물모델에서 종양의 성장을 억제할 수 있음을 시사하였다. Background: Human YB-1 is a transcription factor that binds to the inverted CCAAT box in the promoter region of a variety of genes such as PCNA, DNA polymerase and MDR. In this study we evaluated the effect of YB-1 antisense oligonucleotides on tumor cell growth. Methods: Chang liver, HepG2 and CT-26 cells were cultured as immortalized cell lines. The MTT (3-[4,5-dimethylthiazol-2-yl] 2,5-diphenyltetrazolium bromide) assay, Northern blot and flow cytometric analyses were used to determine cell growth, gene expression and cell cycle changes. In an animal model, CT-26 cells were injected into Balb/c mice to induce tumor; YB-1 antisense oligonucleotides were injected into the tail vein or tumor tissue of the mice; change of tumor size was then measured. Results: Phosphorothioated YB-1 antisense oligonucleotides suppressed the proliferation of the immortalized liver cells (Chang liver cells) and a variety of cancer cells (HepG2 and CT-26 cells); however, it did not inhibit normal cell growth. The DOTAP/antisense oligonucleotide mixture showed stronger effects on cell proliferation than did the antisense oligonucleotide alone. The YB-1 antisense oligonucleotide decreased specific expression of the YB-1 mRNA in the immortalized cancer cell lines. Flow cytometric analysis revealed that the inhibition of cell proliferation might have been due to a decrease in the S phase of the cell cycle. We found that in an animal tumor model, the administration of the YB-1 antisense oligonucleotide, in the vein or tumor tissues, decreased the tumor size significantly. Conclusions: These results suggest that the YB-1 antisense oligonucleotide may inhibit growth of a variety of cancer cells.(Korean J Med 71:293-301, 2006)

건강신념모델에 근거한 노인 대상 식품안전·영양교육 프로그램 효과 평가

최정화(Jung-Hwa Choi),이은실(Eun-Sil Lee),이윤진(Yoon-Jin Lee),이혜상(Hye-Sang Lee),장혜자(Hye-Ja Chang),이경은(Kyung-Eun Lee),이나영(Na-Young Yi),안윤(Yoon Ahn),곽동경(Tong-Kyung Kwak) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.9

노인은 면역취약집단으로 다른 인구 집단보다 만성질환과 식품매개 질병에 걸릴 위험이 크며 식행동은 오랜 세월 굳어져 왔기 때문에 변화하기가 쉽지 않다. 노인을 대상으로 건강신념모델을 적용하여 식품안전・영양교육 프로그램을 시범 적용하고 그 효과를 평가하였다. 식품안전·영양 시범 교육은 서울 마포, 충북 청주, 경북 의성, 충북 진천의 노인복지관을 이용하는 65세 이상 노인을 대상으로 2011년 7월 28일부터 9월 9일까지 총 5주간 매주 1회, 35~40분씩 교육을 시행하였다. 교육 전후 조사가 완료된 최종 연구대상은 교육군이 5회 교육 중 3회 이상 교육에 참여하고 교육 전후 평가를 마친 대상자로 137명, 대조군은 사후 설문조사를 하지 않거나 불성실한 응답자를 제외한 83명으로 총 220명이었다. 교육은 건강신념모델을 적용하여 노인들이 식습관을 변화하지 않을 경우 질병 가능성을 알려 심각성을 인지하도록 하였으며 노인들이 식행동 수정 시 얻게 되는 이들을 알려주고 행동을 실행할 수 있도록 자아효능감을 제공해주고자 하였다. 교육 후 식품안전·영양지식은 모든 항목에서 향상을 보였으며, 식품안전 영역 5문항 중 4문항, 영양 영역 3문항 중 2문항에서는 유의적인 향상을 보였다. 식행동은 교육군에서 ‘고기, 생선류는 조리 시 속까지 완전히 익힌다’를 제외한 모든 항목에서 유의적인 향상을 보였다. 건강신념은 식품안전의 영역에서는 인지된 심각성과 자아효능감, 영양 영역에서는 인지된 민감성, 인지된 장애, 자아효능감에서 유의적인 향상을 보였다. 지식, 식행동, 건강신념 변화량의 상관관계를 분석한 결과 건강신념의 변화량과 식행동의 변화 가능성 간의 유의적인 상관관계를 보였다(P<0.001). 본 연구의 참여 대상자들이 일반 재가 노인보다 복지관에서 봉사하거나 활동하는 노인이었기 때문에 표본의 대표성이 떨어져 결과를 일반화하기에 어려움이 있다. 또한, 교육기간이 5주로 비교적 짧았기 때문에 오랜 기간에 걸쳐 형성된 식행동이 쉽게 변화하거나 개선되기 어려우므로 장기간에 걸친 반복교육이 필요할 것으로 생각한다. 본 연구에서 개발된 교육 프로그램을 향후 보건소나 복지관 등을 통해 지속해서 시행된다면 노인의 식품안전・영양에 대한 인식을 높이고 바람직한 식행동 변화에 긍정적인 기여를 할 수 있을 것으로 생각된다. Most elderly have difficulties in managing food safety and nutrition by themselves. Various nutrition educations for the elderly have been developed, but food safety and nutrition education program and educational tools for the elderly are very limited. The aim of the study was to evaluate a food safety and nutrition education program based on the Health Belief Model (HBM) for the elderly. Education program was implemented for 220 seniors (137 educated group and 83 control group) aged over 65 years at senior welfare community centers. The intervention study was carried out on a weekly basis during each of 5 weeks, and each session lasted about 35 or 40 minutes. The effectiveness of the program was assessed with a questionnaire before and after education. Education program consisted of a 5 week program, and topics were ‘Dietary changes for the elderly"s healthy life’, ‘Prevention of food poisoning in everyday life’, ‘Safe food handling for my health’, ‘Healthy dietary life to prevent chronic disease’, and ‘Safety! nutrition! healthy dietary life’. Education program materials such as slides, handouts, videos, leaflet, and booklets were developed. As a result, there were score improvements in knowledge, dietary behaviors, and health belief after intervention in the intervention group, which were higher than those of the control group. In particular, there was a meaningful interrelation between dietary behavior and health belief (r=0.520, P<0.001). This finding suggests that changing beliefs is very important to make desirable dietary behavioral changes. For this reason, we can conclude HBM theory is an effective model to educate nutrition and food safety for the elderly. Furthermore, food safety and nutrition education programs are implemented and delivered continuously at various settings such as a health center or community welfare center, and those will contribute significantly to enhance perception and change their desirable dietary behaviors for the elderly.