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분만시 지속적 또는 간헐적 투여에 의한 경막외 제통의 비교
박욱,이은찬,배상철,강규식,곽수달 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2
Background : Continuous epidural infusion of the mixed solution of local anesthetic (bupivacaine) and lipid-soluble opioid (fentanyl) has known as a more useful method than intermittent epidural injection for relief of pain during labor. The purpose of this study was to compare a clinical usefulness between continuous infusion and intermittent injection with epidural analgesia during labor. Methods: One hundred healthy parturients were divided into two groups as follows: Continuous epidural group (C-group); 50 parturients received epidural analgesia continuously with 0.167% bupivacaine and 0.000167% fentanyl in the speed of 10 ml h-1 at cervical dilatation (3-5 cm) and then injected 0.25% bupivacaine 5 ml additionally at complaints of severe labor pain. Intermittent epidural group (I-group); 50 parturients received inermittently 0.167% bupivacaine and 0.00083% fentanyl in the initial dose of 12 ml at cervical dilatation (3-5 cm) and then additionally used the same dose at severe labor pain. Result: There were no statistically significant differences in the clinical states of maternoneonate, pain free score, degree of motor block, mode of delivery, cause of Cesarean section, neonatal Apgar score and incidence of side effects between groups(Table 1.2.3.7.8). The total dose of bupivacaine and fentanyl, the duration of lst and 2nd delivery stages and the frequency of top up injection for incomplete relief of pain during labor appeared significant differences in statistics between groups (Table 4.5.6). Conclusion: It was similar to the effectiveness of maternal epidural analgesia during labor between groups by means of continuous or intermittent injection.
Involvement of βPIX in angiotensin II-induced migration of vascular smooth muscle cells
Eun-Young Shin,Chan-Soo Lee,Mee-Hee Park,Duk-Joong Kim,Sahng-June Kwak,김응국 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.6
Angiotensin II (Ang II) stimulates migration of vascular smooth muscle cell (VSMC) in addition to its contribution to contraction and hypertrophy. It is well established that Rho GTPases regulate cellular contractility and migration by reorganizing the actin cytoskeleton. Ang II activates Rac1 GTPase, but its upstream guanine nucleotide exchange factor (GEF) remains elusive. Here, we show that Ang II-induced VSMC migration occurs in a βPIX GEF-dependent manner. βPIX-specific siRNA treatment significantly inhibited Ang II-induced VSMC migration. Ang II activated the catalytic activity of βPIX towards Rac1 in dose- and time-dependent manners. Activity reached a peak at 10 min and declined close to a basal level by 30 min following stimulation. Pharmacological inhibition with specific kinase inhibitors revealed the participation of protein kinase C, Src family kinase, and phosphatidylinositol 3-kinase (PI3-K) upstream of βPIX. Both p21-activated kinase and reactive oxygen species played key roles in cytoskeletal reorganization downstream of βPIX-Rac1. Taken together, our results suggest that βPIX is involved in Ang II-induced VSMC migration.
Provisioning QoS for WiFi-enabled Portable Devices in Home Networks
( Eun-chan Park ),( Nojun Kwak ),( Suk Kyu Lee ),( Jong-kook Kim ),( Hwangnam Kim ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.4
Wi-Fi-enabled portable devices have recently been introduced into the consumer electronics market. These devices download or upload content, from or to a host machine, such as a personal computer, a laptop, a home gateway, or a media server. This paper investigates the fairness among multiple Wi-Fi-enabled portable devices in a home network when they are simultaneously communicated with the host machine. First, we present that, a simple IEEE 802.11-based home network suffers from unfairness, and the fairness is exaggerated by the wireless link errors. This unfairness is due to the asymmetric response of the TCP to data-packet loss and to acknowledgment-packet loss, and the wireless link errors that occur in the proximity of any node; the errors affect other wireless devices through the interaction at the interface queue of the home gateway. We propose a QoS-provisioning framework in order to achieve per-device fairness and service differentiation. For this purpose, we introduce the medium access price, which denotes an aggregate value of network-wide traffic load, per-device link usage, and per-device link error rate. We implemented the proposed framework in the ns-2 simulator, and carried out a simulation study to evaluate its performance with respect to fairness, service differentiation, loss and delay. The simulation results indicate that the proposed method enforces the per-device fairness, regardless of the number of devices present and regardless of the level of wireless link errors; furthermore it achieves high link utilization with only a small amount of frame losses.
고추 탄저병 저항성 중간모본 ‘원예 100005호 ’,‘원예 100006호’ 육성
양은영,김수,채영,채수영,조명철,문지혜,박태성,이우문,곽정호 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2
Owing to frequent heavy rain due to abnormal weather, the occurrence of pepper anthracnose has recently increased, which affects the supply and demand of pepper. As a result, the price of red pepper powder in 2011, for example, increased three times compared to the average year. Although anthracnose of pepper plants has been controlled by fungicides until now, it is important to develop new resistant cultivars because of the reduction of the labor force in rural area and occurrence of new anthracnose strains resistant to fungicides. National Institute of Horticultural and Herbal Science developed two pepper lines, ‘Wonye 100005’ and ‘Wonye 100006’ that are resistant to pepper anthracnose. These lines were developed by continuous selection of progenies from a cross between ‘Wonye AR1’, which were developed from interspecific hybridization and ‘TF68’. The anthracnose resistance level of the two lines was higher than that of commercial cultivars and similar to check varieties showing highest level of anthracnose resistance.
A Synthetic Chenodeoxycholic Acid Derivative, HS-1200-induced Apoptosis of RBL-2H3 Cells
Byung-Chan Koo,Jeong-Soo Kim,Hyun-Ho Kwak,In-Ryoung Kim,Seung-Eun Lee,Gyoo-Cheon Kim,Hongsuk Suh1,Bong-Soo Park 대한해부학회 2009 Anatomy & Cell Biology Vol.42 No.1
Bile acids and synthetic bile acid derivatives induced apoptosis in various kinds of cancer cells and anticancer effects. Although synthetic chenodeoxycholic acid (CDCA) derivatives have been demonstrated to induce apoptosis of various cancer cells, there is no report on their effect on RBL-2H3 basophilic leukemia cell line to date. Therefore, this study was undertaken to examine in vitro effects of cytotoxicity and growth inhibition, and the molecular mechanism underlying induction of apoptosis in RBL-2H3 cells treated with a synthetic CDCA derivative, HS-1200. The viability and the growth inhibition of RBL-2H3 cells were assessed by MTT assay and clonogenic assay respectively. The Hoechst staining and DNA electrophoresis were conducted to observe RBL-2H3 cells undergoing apoptosis. RBL-2H3 cells were treated with HS-1200, and Western blotting, immunocytochemistry, confocal microscopy, DNA hypoploidy assay, MMP activity and proteasome activity were performed. HS-1200 treatment of RBL-2H3 cells resulted in a time- and does-dependent decrease of cell viability and a does-dependent inhibition of cell growth, and induced apoptotic cell death. Furthermore, HS-1200 treatment result in the alteration of G1 cell cycle-related proteins. And tested RBL-2H3 cells showed several lines of apoptotic manifestation.We presented data indicating that HS-1200 induces apoptois via the proteasome, mitochondria and caspase pathway, and induces the alteration of the G1 cell cycle-related proteins in RBL-2H3 cells. Therefore our data provide the possibility that HS-1200 could be as a novel therapeutic strategy in the allergy treatment.
이정찬,박수진,박상은,곽승근,신현영,김성은,이정호,윤환중,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1
Although the Working Formulation is commonly used to classify NHL in Korea, it has been recognized as imperfect for primary extranodal lymphoma, expecially for patients with nasal, paranasal disease because of their histological characteristics. Angiocentric T/NK cell lymphoma remains rare clinical presentation in North America and Europe but is more common in Asia and Latin America. The optimal mode of treatment has also not been decided on, probably because of their rarity and limited understanding of its natural course. The aim of this study was to analyze our experience with 14 patients with angiocentric lymphoma seen at the Chungnam Natioanl University Hospital over the last 5 years. We reviewed the records of 14 patients who were treated at the Chungnam National University Hospital between January, 1996 and December, 2000. The angiocentric T/NK cell lymphoma accounted for about 8.2% of NHL. The median age was 52.5 (range 36-71) years. Sex ratio was equal. According to the Ann Arbor staging system, disease was classified as stage Ⅰin 3 patients, stage Ⅱ in 8 patients and stage Ⅳ in 3 patients. Systemic B symptoms were present in only four patients in only four patients. All patients has extranodal involvement. The most frequently involved extranodal sites were nasal cavity followed by paranasal sinuses and orpharynx. The most common presenting symptoms were nasal obstruction with purupent rhinorrhea followed by dysphagia. According to the International prognostic index (IPI), most patients was in low-risk group (11 patients). Nine patients responded completely. Seven patients were received combination chemotherapy and 2 patients had radiation therapy as a initial treatment. Five patients were relapsed. After a median follow-up of 660.5 days, the overall survival and disease-free survival rates at 3 years was 56.8% and 42.9% respectively. The median survival time was not yet reached. The median overall survival time was 1338.5 (range 1212-1564) days for non-relapsed and 733.4 (range 302-1008) days for relapsed patients. The median time from CR to relapse was 100.5 (range, 39-159) days. There were limitations to know enough about the characteristics of angiocentric T/NK cell lymphoma because of a small number of patients. In the future, multicenter trials will be neccesary to identify clinical characteristics, optimal treatment mordalities and their responses, and prognostic factors.