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Ja Kyung Lee,Eu Jeong Ku,Su-jin Kim,Woochul Kim,Jae Won Cho,Kyong Yeun Jung,Hyeong Won Yu,Yea Eun Kang,Mijin Kim,Hee Kyung Kim,Junsun Ryu,June Young Choi 대한외과학회 2024 Annals of Surgical Treatment and Research(ASRT) Vol.106 No.1
Purpose: Current clinical practices favor less or no thyroid-stimulating hormone (TSH) suppression for low- to intermediate-risk thyroid cancer patients who receive thyroid lobectomy. The association of TSH suppression on healthrelated quality of life (HR-QoL) in patients after thyroid lobectomy is not well studied. This study aimed to evaluate the effect of TSH suppression on patient HR-QoL after thyroid lobectomy. Methods: This study included patients enrolled in an ongoing, multicenter, randomized controlled study investigating the effects of TSH suppression. Patients were randomized to either the low-TSH group (TSH target range, 0.3–1.99 μIU/mL) or the high-TSH group (TSH target range, 2.0–7.99 μIU/mL). The HR-QoL, hyperthyroidism symptom, and depression symptom questionnaires performed preoperatively and 2 weeks and 3 months postoperatively were evaluated. Results: Total of 669 patients (low-TSH group, 340; high-TSH group, 329) were included. Although total HR-QoL score changes were not different between the 2 groups, the high-TSH group had a significantly higher score in the physical domain at postoperative 3 months (P = 0.046). The 2 groups did not have significant differences in hyperthyroidism and depression scores. Conclusion: In the short-term postoperative period, the physical HR-QoL scores in thyroid lobectomy patients were better when they did not receive TSH suppression. This study suggests the importance of considering HR-QoL when setting TSH suppression targets in thyroid lobectomy patients.
Grave-to-cradle: human embryonic lineage tracing from the postmortem body
Choi Seock Hwan,Ku Eu Jeong,Choi Yujin Angelina,Oh Ji Won 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Curiosity concerning the process of human creation has been around for a long time. Relevant questions seemed to be resolved with the knowledge of how cells divide after fertilization obtained through in vitro fertilization experiments. However, we still do not know how human life is created at the cellular level. Recently, the value of cadavers as a resource from which to obtain “normal” cells and tissues has been established, and human research using postmortem bodies has attracted growing scientific attention. As the human genome can be analyzed at the level of nucleotides through whole-genome sequencing, individual cells in a postmortem body can be traced back to determine what developmental processes have transpired from fertilization. These retrospective lineage tracing studies have answered several unsolved questions on how humans are created. This review covers the methodologies utilized in lineage tracing research in a historical context and the conceptual basis for reconstructing the division history of cells in a retrospective manner using postzygotic somatic variants in postmortem tissue. We further highlight answers that postmortem research could potentially address and discuss issues that wait to be solved in the future.
Association of ADIPOR2 polymorphism with diabetic macrovascular complications in Korean type 2 DM
( Jin Yong Park ),( Myoung Jin Ji ),( Eu Jeong Ku ),( Tae Keun Oh ),( Seong Soo Koong ),( Hyun Jeong Jeon ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Adiponectin, an adipose tissue-derived peptide, may play a pivotal role in atherosclerotic changes in vessels. This study is investigated the association of adiponectin receptor 2 (+795G/A) polymorphism and diabetic macrovascular complications in Korean type 2 diabetes. A total of 808 patients with Korean type 2 diabetes were enrolled in this study. Diabetic macrovascular complications were evaluated by the available medical records included images and lab findings. All subjects were genotyped for the adiponectin receptor-2 (795G/A) polymorphism using the polymerase chain reaction. The prevalence of cerebrovascular disease was no significant difference in the patient with AA genotype compared to those with AG+GG genotype (11.8% vs. 14.0%, p value 0.877). The prevalence of cardiovascular disease was no significant difference in the subject with AA genotype compared to those with AG+GG (5.5% vs. 6.9%, p value 0.246). And the prevalence of peripheral artery disease was no difference in the patient with AA genotype compared to AG+GG genotype (5.5% vs. 6.9%, p value 0.88). This study showed that adiponectin receptor-2 (795G/A) polymorphism may not related to macrovascular complications in Korean type 2 diabetes. Further investigations will be needed to define clearly which polymorphism is the true functional variants conferring risk factors for macrovascular complications of diabetes.
Trabecular bone score as an indicator for skeletal deterioration in diabetes.
Kim, Jung Hee,Choi, Hyung Jin,Ku, Eu Jeong,Kim, Kyoung Min,Kim, Sang Wan,Cho, Nam H,Shin, Chan Soo Issued for the Endocrine Society by the Williams & 2015 The Journal of clinical endocrinology & metabolism Vol.100 No.2
<P>Trabecular bone score (TBS) is a novel texture index that evaluates the pixel gray-level variations in lumbar spine dual-energy X-ray absorptiometry images and is related to bone microarchitecture independent of bone mineral density (BMD).</P>
S-411 Evaluating the value of BMD loss as a risk factor for fragility fractures in Koreans
( Seo Young Lee ),( Jung Hee Kim ),( A Ram Hong ),( Hyung Jin Choi ),( Eu Jeong Ku ),( Nam H. Cho ),( Chan Soo Shin ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Summary: Baseline total hip BMD is important factor for estimating fragility fracture risk in Korea, while the rate of BMD losss at femur neck is important for predicting fragility fracture in non-osteoporotic men. Introduction: Whether BMD loss predicts the fragility fracture regardless of baseline BMD is not clear. We investigated that the accelerated loss of BMD increased the fragility fractures independent of baseline BMD in elderly Koreans. Methods: This is an ongoing prospective cohort study of BMD measurements at both 2009 and 2011 year at community-based Ansung cohort, which was originally recruited in 2001-2002. A total of 840 men and 1,005 postmenopausal women aged over 50 years from Ansung cohort were categorized according to the rate of BMD loss within 2009 and 2011. Primary outcome was the incident fragility fracture. Results: During a median follow-up of 5.8±0.2 years, incident fragility fractures occurred in 51 (6.1%) men and 96 (10.6%) women. Among baseline BMD measurements at lumbar spine, femur neck, and total hip, only total hip BMD was a significant risk factor for fragility fractures in both genders. Hazard ratio (HR) of baseline total hip BMD was 1.50 (95% confidential interval [CI], 1.03-2.07; p=.03) for men and 1.44 (95% CI, 1.09-1.90; p<.01) for women. In the subgroup analysis according to baseline BMD, non-osteoporotic men with accelerated loss of BMD at femur neck had a higher risk for fragility fractures (HR=3.55, 95% CI: 1.27-9.92; p<.02) after adjustment for covariates including baseline BMD. Conclusions: Measurement of baseline total hip BMD is the most important factor for estimating fragility fracture risk in Korean men and women. Rate of BMD loss in femur neck was an independent risk factor for fragility fractures in non-osteoporotic Korean men.