정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

常虛 劉錫昶博士 追募記

金斗憲 건국대학교 1976 學術誌 Vol.20 No.1

人間性의 解明

金斗憲 全北大學校 1958 論文集 Vol.2 No.-

지형 재구출을 통한 커뮤니티 거점 구성에 대한 제안 : 구 도심 소외지역의 접근 장애지형을 대상으로

김헌,박두권 경희대학교 디자인연구원 2005 예술· 디자인학연구 Vol.8 No.1

As looking into the phenomena in the undeveloped old downtown nowadays, the topography is the cause to arise the inaccessibility and the disconnection with other city environment in terms of inter-cities. There is lack of city community because the topographic obstacles result in loss of the pedestrian circumstances, and the external space is not yet formed. Two objectives in this research are as follows. First, This thesis makes an attempt to organize community anchors which can maintain the pedestrian circumstances through the application for a constructive tool and program to overcome the topographic obstacles in isolated old downtown. Second, These thesis takes the objective on the proposal for organizing community anchor which can be a path out of the isolated old downtown, if anchors attain the pedestrian circumstances through outer-space interaction and transplant the factors that are involved in community in other effective places, and then these factors get networked undergoing strong and weak interaction. This study is expected to contribute to the new path that can open the existing old downtown by spreading out factors of various anchors and overcome the topography positively and develop city construction where produces various communities.

Retinoic Acid가 흰쥐 태자 혀조직의 분화와 Laminin 합성에 미치는 영향에 대한 연구

김혜주,정호삼,서윤경,백두진,김원규,윤지희,이방헌 대한췌담도연구회 2000 대한췌담도연구회지 Vol.5 No.4

LLCE법에 의한 천연산 은어의 휘발성 향기성분 분석

김훈,조우진,안준석,조두희,김지혜,차용준 창원대학교 생활과학연구소 2003 생활과학연구 Vol.- No.7

The volatile compounds in natural sweet smelt were analyzed by liquid liquid continuous extraction/gas chromatography/mass spectrometry (LLCE/GC/MS) methods. A total of 64 compounds were detected in sample, and these were mainly composed of lipid oxidative compounds such as aldehydes, ketones, alcohols, acids and hydrocarbons besides terpens and aromatic compounds. Among these, 9-carbon compounds including (E)-2-nonenal, (E,Z)-2,6-nonadienal and (E,Z)-3,6-nonadien-1-ol were suspected to have a key role on odor of natural sweet smelt because these compounds have low odor threshold and water melon-like and melon-like odor, characteristic odor in sweet smelt.

?? 착물의 구조적 특성

김복조,윤두천,박기훈,주언정,오창언 嶺南大學校 基礎科學 硏究所 1998 基礎科學硏究 Vol.18 No.-

Five-coordinated complex of Cu(Ⅱ) complex, [CuCl(1,10-phenanthroline)₂]·Cl·6H₂O·CH₃OH, was synthesized by adding an aqueous solution of Cu(Ⅱ) to a methanol solution of 1,10-phenanthroline. Its crystal structure was detemined by single crystal X-ray crystallography. Crystal data are are as fllow: [CuCl(phen)₂]·Cl·6H₂O·CH₃OH, monoclinic, space group C2/c (#15), a = 23.309(5), b = 30.270(6), c = 7.491(2) A, B = 97.83(2)˚, V = 5236 A³, Z = 8,2745 data with I >3σ(I) (R = 00.64, Rw = 0.087). In the crystal structure of ??, the Cu(Ⅱ)is five-coordianted with four nitrogen and one chlorine atom. The geometry around Cu(Ⅱ) is somewhat distorted trigonal bipyramid and Cu(Ⅱ) is locted nearly (0.0280 A˚) on the least-squares plane of the two nitrogen atoms and one chlorine atom.

시간 종속 특징을 갖는 다층 셀 구조 이동 통신 시스템의 성능분석

김두용,김태훈 순천향대학교 부설 산업기술연구소 1998 순천향 산업기술연구소논문집 Vol.3 No.3

In order to meet the increasing demands of personal mobile communication with developed wireless mobile communication services and solve the burden on system traffic, mobile communication systems with multi-layer cell structure is proposed. Mobile communication systems with multi-layer cell structure not only have steady state characteristic but also have time-dependent and nonstationary conditions. Therefore, queueing network models is proposed for performance evaluation of time-dependent mobile communication systems with multi-layer cell structure. Using the queueing network models, the proposed performance evaluation methods provide the convenience for solving complex numerical methods.

Self-Focusing을 이용한 공진기 없는 공 쌍안정성

김두철,유영훈 제주대학교 1990 논문집 Vol.31 No.-

We have studied the phenomenon of optical bistability based on the self-focusing. Our experiments were performed with a sodium and single reflecting mirror without cavity. It is found that the results of experimernts are consistent with brief theoretical results and the optical bistability is insensitive to a frequency of input light.