A case of bullous pemphigoid induced by clobazam

( Howard Chu ),( Jae Won Lee ),( Dongyun Shin ),( Hee Ju Kim ),( Min Geol Lee ),( Daesuk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Bullous pemphigoid (BP) is an acquired autoimmunebullous dermatosis resulting in subepidermal blistering. Although usually idiopathic, certain medications are known to be associated, which is referred as drug-induced BP. Herein, we report a novel case of a patient who developed BP after taking clobazam, an anticonvulsant agent. A 50-year-old female presented with a 1cm-sized tense yellowish bulla and few 3mm-sized vesicles on her right shin. When she was six, she started to havedevelopmental delay on her left face and arm. Also, she has a prolonged history of recurrent episodes of seizures since she was 30 years old, and had continuously taken anti-epileptic medications since then. Her seizures were relatively well-controlled until May, 2014, when she arrived at the emergency room with another episode of seizure, and clobazam was added. After taking clobazam for about a month, she visited our dermatology clinic with the skin lesions described above. Biopsy was done and it revealed subepidermal blister containing eosinophils and neutrophils. Although the result for direct immunofluorescence was negative, her clinical features and histological results were highly suggestive of BP. This adverse reaction of clobazam has never been reported before.Further studies are required to clearly determine this drug as the causative agent, yet cautions should be taken before starting treatment with clobazam.

P039 : Analysis of human blood follicular helper T cells in patients with psoriasis

( Dongyun Shin ),( Dae Suk Kim ),( Jung Hwan Lee ),( Sung Hee Kim ),( Hee Joo Kim ),( Do Young Kim ),( Soo Min Kim ),( Min Geol Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Follicular helper T (Tfh) cell is a recently characterized subset of helper T cells, with a distinct gene expression and a specialized role in supporting antibody response. Recently, blood Tfh cells are reported to be altered in patients with autoimmune disorders. However, there is no report about Tfh cell in patients with psoriasis. Objectives: To analyze the human blood Tfh cells in patients with psoriasis. Methods: Peripheral blood mononuclear cells from 16 psoriasis patients (PSO) and 11 healthy controls (HC) werestained with antibodies against CD4, CXCR5, PD-1, ICOS and analyzed with flow cytometry. Clinical and laboratory parameters were also measured. Results: The portions of CD4+CXCR5+ T cells in CD4+ T cells were not significantly different between PSO and HC. However, interestingly, the portions of CXCR5+PD-1 T cells in CD4+ T cells were significantly lower in PSO than HC (4.45% vs 2.14%, p=0.0421, respectively). The portions of CXCR5+PD-1 T cells in CD4+ T cells were also negatively correlated with ESR (p=0.0238, r=-0.5188), and significantly lower in patients with higher ASO titer (p=0.0445). Conclusion: CD4+CXCR5+PD-1+ T cells, which are known as activated subsets of Tfh cells, were significantly less expressed in PSO compared to HC, and negatively correlated with laboratory parameters of psoriasis. These results suggest that Tfh cells and B cell immunity could be altered in psoriasis.

The Grid-Cluster Combination Routing algorithm for Wireless Sensor Networks

Dongyun Shin,Byungrak Son,Dongkyu Kim,Junggyu Kim 대한전자공학회 2008 ICEIC:International Conference on Electronics, Inf Vol.1 No.1

In this research, we have developed an algorithm called GCCR(Grid Cluster Coupling Routing) to solve the problem relating with TTDD(Two-Tier Data Dissemination) which does not provide a movement of sink nod It creates a cluster with location information of sensor node. GCCR has a good energy efficiency on whole network because it is possible to reduce the number of hops by using the shortest path of data forwarding from source nodes to sink nodes. It also does not take part in the limited path on formation of grid. We have evaluated the total energy consumption and the rates of data transmission with various number of sink nodes and source nodes. As a result of this research, we could recognize that the total energy consumption can be reduced about 2 to 5 times on GCCR with α; the size cell of TTDD.

Large unstained cell values can be a valuable marker to aid in diagnosis of Sezary syndrome

( Dongyun Shin ),( Jimyung Seo ),( Minseok Lee ),( Hee Joo Kim ),( Min Geol Lee ),( Dae Suk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Erythroderma is caused by many factors. Although the majority of erythroderma are caused by benign diseases, it is very important to differentiate malignancy-related erythroderma, especially Sezary syndrome(SS). Therefore, it is important to find differentiating markers for SS among the patients with erythroderma. Objectives: We have evaluated the results of complete blood cell tests in patients with erythroderma to find whether it can be a useful marker for differentiating erythroderma patinets. Methods: We evaluated the number and the percentages of white blood cells, basophils, neutrophils and LUC of 63 erythroderma patients. Results: In multivariate binary logistic regression analysis, #LUC and %basophils showed significant association with the presence of SS. #LUC was the strongest predictor for the presence of SS in erythroderma patients(OR 1334.9, 95% CI 2.934-607446.629, P=0.021) and %basophils was also significant predictor(OR 7.951, 95% CI 1.036-61.014, P=0.046), too. ROC curve was created and the area under the curve(AUC) of #LUC was 97.76%(95% CI 94.24-101.3%, P=0.0004), and AUC of %basophils was 93.97%(95% CI 86.79-101.1%, P=0.0012). ROC curve analysis suggested that the optimal cut-off points for predicting SS were 0.33x103/レL for #LUC(100% sensitivity, 93.1% specificity) and 1.05% for %basophils(80% sensitivity, 94.83% specificity). Conclusion: We suggest that #LUC and %basophils can be a useful marker for differentiating SS from erythroderma.

A case of linear basaloid follicular hamartoma

( Dongyun Shin ),( Jung Soo Lee ),( Kee Yang Chung ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1

P040 : Superficial spongiotic dermatitis as a sign of regressing verruca plana: histopathological analysis

( Dongyun Shin ),( Do Young Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Histologic findings of verruca plana in“regressing phase” are considered different with those of the classic verruca plana, but there are just anecdotal reports in the literature. Objectives: To analyze the clinical and histopathological characteristics of spontaneously regressing verruca plana. Methods: A retrospective single-center analysis. A total 25 patients who showed typical clinical features of verruca plana, and the lesions disappeared spontaneously within 4 weeks after skin biopsy was included. Clinical characteristics evaluated based on review of medical records and photographs, and histological characteristics were analyzed. Results: Most common involved area was face(60%), followed by arms(36%) and legs(20%). Eight patients (32%) had been treated with recent ablating procedure. Histopathological findings include superficial perivascular lymphocytic infiltrations(96%), spongiosis and exocytosis(84%), focal basal vacuolization(64%), parakeratosis(64%), apoptotic keratinocytes(56%), and band-like lichenoid infiltration(28%). These pathological findings were more compatible with pityriasis rosea or pityriasis lichenoides chronica, rather than classic verruca plana. Conclusion: The histopathologic findings of spontaneously regressing verruca plana were different with those of classic verruca plana. Therefore, if clinically typical verruca plana showed superficial spongiotic dermatitis in histology, observation could be a treatment of choice.

ON MINIMAL E-PROJECTION OF OPERATOR SPACES

SHIN, DONGYUN,LEE, SA-GE,CHO, SUNG JE Korean Mathematical Society 1989 대한수학회논문집 Vol.4 No.2

인쇄업의 입지변화

신동윤(Dongyun Shin),김지희(Jihui Kim),이송이(SongI Lee),진미란(Miran Jin),최영은(Youngeun Choi),김하영(Hayeong Kim),유예영(Yaeeyoung Yoo),현시아(Sia Hyun),홍진영(Jinyeong Hong) 성신여자대학교 한국지리연구소 2015 應用地理 Vol.- No.32

인쇄업이란 계약 또는 수수료에 의하여 인쇄물 및 출판물을 각종 제판술로 인쇄해내는 산업 활동을 일컫는데, 산업 특징상 노동집약적인 중·소기업형 영세업종의 형태가 보편적이다. 또한, 인쇄업은 주문에 의해 생산이 진행되는 수주산업이기 때문에 소기업 간 경쟁이 매우 치열하다. 더불어 인쇄업은 높은 시장 지향성을 띄는 도시형 산업으로, 예로부터 서울로, 그중에서도 유동인구가 많고 중심업무기능이 밀집해있는 곳으로 입지하기 시작하였다. 2013년 통계청 자료를 기준으로 서울특별시 내의 인쇄업체 수는 7,997개이며, 그중 중구에 위치한 인쇄업체 수는 5,450개이다. 이로써 중구는 서울시 전체 인쇄업체의 약 68%를 차지하고 있는 인쇄업의 중심지라고 할 수 있다. 본 연구에서는 국내 유일의 인쇄업 집적지인 중구의, 그중에서도 을지로 일대의 인쇄업이 언제, 어디서부터 시작되었는지 또한 시간의 흐름에 따라 인쇄업체의 입지 이동이 어떻게 진행되어 왔는지에 대해 분석해봄으로써 중구 인쇄업 집적지의 의의를 파악하고자 한다, 중구 지역은 조선시대부터 전통적으로 인쇄업의 중심지다. 1403(태종3)년에 주자소가 설치되었고 1800년대 이후 근대 인쇄업 또한 중구 을지로 2가를 중심으로 점차 주변 지역으로 확산되었다. 이후 1980년대 도심 재개발 정책에 따라 인쇄업 일부가 서울 외곽지역으로 이전하였지만, 최근 소규모 영세업체들이 다시 중구 을지로 일대로 재입지하는 추세를 보이고 있다. 또한, 답사를 통해 연구지역인 중구의 10개 동을 잘 정돈된 골목과 하청업체가 많은 곳, 낡고 좁은 골목들로 영세업체들이 밀집된 곳, 규모가 크고 첨단화된 곳으로 3가지의 큰 특징으로 분류하였다. 이로써 중구 을지로 일대는 시대의 흐름에 발맞춰 고유의 발전을 이룩한 우리나라 최대의 인쇄업 클러스터 지역이라고 할 수 있으며, 도시형 제조업인 인쇄업의 특성상 계속해서 중구 일대에 집적지를 이룰 것이다. Printing Business is called an industry activity that printing publication and printed matter by contract or commission. By the industry characteristic of printing business, it is universal pretty type of industry that labor-intensive of small business. Because printing business is an order made production industry, the competitions of a small-scale enterprises are very intensive. In addition, printing business is a city type industry that market oriented, so printing business has been concentrated in Seoul, that has many floating population and concentrated main function from old times. By the data of National Statics Office in 2013, there are 5,450 printing enterprises in Jung-gu and printing enterprises in Seoul are 7,997. So Jung-gu is a center of printing business that located 68% of printing enterprises. In this study, we look forward to know about Jung-gu that domestic unique printing cluster"s meaning by analysis when started cluster the whole region of Eulji-ro and moved location process as times goes by. Jung-gu has been traditional center of printing business from the Joseon period. When king Taejong period, in 1403 the typefoundry was set up and after 1800s printing business was spread out by the Eulji-ro-2-ga, Jung-gu. Since 1980s, some of the printing business enterprises relocated in outside of seoul by the urban redevelopment policy. But recently, small-scale enterprises are tend to relocate in Eulji-ro, Jung-gu area. Also, we classify 10 dong in Jung-gu into 3 groups by the big characteristics- At First, well arranged alleys and a lot of subcontractors, Second, concentrated small-scale enterprises in old and narrow allays and Third, big scale and modern region. So Eulji-ro, Jung-gu is one of the biggest printing clusters in Republic of Korea that indigenous development industry as times goes by. And printing cluster will stay in Jung-gu area by the characteristic of urban manufacturing.

Mobile IP 환경에서 Real-time services를 위한 효율적인 핸드오프 방안

신동윤(Dongyun Shin),장기수(Kisoo Chang) 한국통신학회 2001 한국통신학회 학술대회논문집 Vol.2001 No.7

리눅스 파일 I/O 스택을 위한 순수 I/O 처리 시간 기반 성능 분석 기법

신동윤(Dongyun Shin),임성수(Sung-Soo Lim) 한국정보과학회 2015 한국정보과학회 학술발표논문집 Vol.2015 No.6