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Kim, Dong-eun,Jung, Sunhee,Ryu, Hyung Won,Choi, Miri,Kang, Mingu,Kang, Hyunju,Yuk, Heung Joo,Jeong, Hyejeong,Baek, Jiyeon,Song, Jae-Hyoung,Kim, Janghwan,Kang, Hyojeung,Han, Sang-Bae,Oh, Sei-Ryang,Cho, Elsevier 2018 Journal of Functional Foods Vol.42 No.-
<P><B>Abstract</B></P> <P>Lytic induction of latent Epstein-Barr virus (EBV) has been considered as a therapeutic approach for efficient treatment of EBV-associated malignancies. Here, we established a robust assay system quantitatively measuring EBV lytic induction and identified three <I>Euphorbia</I> extracts as strong inducers from a screen of Korean medicinal plant extracts library. Expression of lytic genes were efficiently induced by each <I>Euphorbia</I> extract in SNU-719 (EBV-positive gastric carcinoma cells). <I>Euphorbia pekinensis</I>, out of three extracts, exhibited the most potent lytic-inducing activity. Importantly, treatment with <I>E. pekinensis</I> extract led to an obvious cytotoxic effect on SNU-719 cells, but little on MKN-74 cells (EBV-negative gastric carcinoma cells), indicating the selective oncolytic effect on EBV-positive gastric carcinoma. We further revealed that lytic-inducing activity of <I>E. pekinensis</I> was mediated by PKC/MEK signal. Moreover, we defined two structural analogs of PMA with strong lytic-inducing activity, suggesting their therapeutic applicability for the treatment of EBV-associated gastric carcinoma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Identification of three <I>Euphorbia</I> extracts with EBV lytic-inducing activity. </LI> <LI> <I>Euphorbia</I> extracts efficiently induce lytic replication in most of cell population. </LI> <LI> <I>Euphorbia</I> extracts induce EBV reactivation through modulating PKC/MEK pathway. </LI> <LI> PMA analogs in <I>Euphorbia</I> extracts contribute to lytic induction of EBV. </LI> <LI> <I>E. pekinensis</I> extract has an oncolytic effect selectively on EBV-positive gastric carcinoma cells. </LI> </UL> </P>
Kang, Myung-Ji,Kwon, Eun-Bin,Yuk, Heung Joo,Ryu, Hyung Won,Kim, Soo-Yeon,Lee, Mi-Kyeong,Moon, Dong-Oh,Lee, Su Ui,Oh, Sei-Ryang,Lee, Hyun-Sun,Kim, Mun-Ock Informa UK (TaylorFrancis) 2017 Bioscience, Biotechnology, and Biochemistry Vol.81 No.12
<P>In the course of screening to find a plant material decreasing the activity of triacylglycerol and cholesterol, we identified Tripterygium regelii (TR). The methanol extract of TR leaves (TR-LM) was shown to reduce the intracellular lipid contents consisting of triacylglycerol (TG) and cholesterol in HepG2 cells. TR-LM also downregulated the mRNA and protein expression of the lipogenic genes such as SREBP-1 and its target enzymes. Consequently, TR-LM reduced the TG biosynthesis in HepG2 cells. In addition, TR-LM decreased SREBP2 and its target enzyme HMG-CoA reductase, which is involved in cholesterol synthesis. In this study, we evaluated that TR-LM attenuated cellular lipid contents through the suppression of de novo TG and cholesterol biosynthesis in HepG2 cells. All these taken together, TR-LM could be beneficial in regulating lipid metabolism and useful preventing the hyper-lipidemia and its complications, in that liver is a crucial tissue for the secretion of serum lipids.</P>
Hyeong Dong Yuk,Minyong Kang,Jung Keun Lee,Sung Kyu Hong,Ja Hyeon Ku,Seok-Soo Byun,Cheol Kwak,Hyeon Hoe Kim,Sang Eun Lee,Chang Wook Jeong 대한비뇨기종양학회 2017 대한비뇨기종양학회지 Vol.15 No.3
Purpose: To evaluate the clinicopathologic and oncological outcomes of advanced metastatic testicular cancer in Korean men who underwent retroperitoneal lymph node dissection (RPLND) following chemotherapy. Materials and Methods: Data of 26 patients with testicular cancer who underwent RPLND after chemotherapy at 2 hospitals in Korea between September 2004 and June 2016 were retrospectively analyzed. Clinical and histopathological variables such as stage of the testicular cancer, age of the patients during surgery, size of the retroperitoneal lymph nodes (RPLNs), histopathological results, duration and complications related to the surgery, cancer recurrence, and mortality were analyzed. Results: During testicular surgery, the T stage was pT1, pT2, and pT3 in 50% (n=13), 26.9% (n=7), and 15.3% (n=4) of the patients, respectively. Mixed germ cell tumor was the most common finding, seen in 73.1% (n=19) of patients. The indications for RPLND were residual lymph nodes after chemotherapy, 84.6% (n=22); and disease progression and remission, 7.7% (n=2). Pathological analysis revealed viable tumors in 19.2% of patients (n=5), necrotic/fibrotic tissue in 42.3% (n=11), and teratoma in 34.6% (n=9). Intraoperative and postoperative complications occurred in 23.1% (n=6) and 19.2% of patients (n=5). The median duration of follow-up was 27.5 months (interquartile range, 1.3–108.2 months); 11.5% (n=3) patients had recurrence, and 3.8% (n=1) died of progressive metastatic testicular cancer. Conclusions: Viable germ cell tumors were present in 19.2% of patients with testicular cancer who underwent RPLND after chemotherapy. This is the first study of its kind in the Korean population.