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Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11
<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>
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이동윤 大邱大學校出版部 1990 法政論叢 Vol.5 No.-
It is unavoidable that the imtervention of state in private life is gradually expanded by various reason in the contemporary state. And above all expropriation against private property is expanded. But despite of the public and social character of property, it is violation of the spirit of the guarantee of property that the loss of an individual caused by expropriation is left. That is to say. to guarantee the equal burden and realize the public welfare and regulate the public and private interest relevantly, it is adaquate to disperse and transfer the special sacrifice to the burden of the whole society by admitting the compensation against the special sacrifice in case that it is violation of justice or principle of equity to leave the accidental and special sacrifice of an individual encountered by public necessity. We can say that this is the very realization of social justice. The property is not guaranteed without just compensation. And it is difficult to expect the guarantee of the right of the freedom and the social right in the society which the property is not guaranteed. Because it will be gradually expanded to expropriate the property by public necessity, it is reguested to balance the public and private interest prudently for the realization of the principle of a social constitution state. To realize it. it is necessary to prepare the optimal countermeasure by the precedent and theory.
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서영수,김용관,신동환,공보금,이정구,박정환,윤성환,정치영,이상경,김영훈 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2
Objectives : This open prospective study was performed in order to evaluate the efficacy and extrapyramidal adverse effects of nemonapride in the schizophrenic patients, and was compared wit one of typical antipshchotics. haloperidol and one of atypical antipsychotics, risperidone. Methods : Thirty male and female schizophrenic patients(DSM-Ⅳ) were treated for 12 weeks with haloperidol(n=10), risperidone(n=10) and nemonapride(n=10). The overall efficacy was assessed at baseline, 1st week, 2nd week, 4th week, 8th week, and 12th week by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS). Also the overall safety was assessed in the same time period by the Extrapyramidal Symptom Rating Scale(ESRS). Results : There were no significant differences in PANSS scores(total, positive, negative, and general psychopathology subscale) among haloperidol, risperidone, and nemonapride groups, Treatment responders, defined as at least 20% reduction of baseline total PANSS score, were achieved by 8 patients(80%) in haloperidol group, 10 patients(100%) in risperidone group, and 8 patients(80%) in nemonapride group. And there were no significant differences in ESRS total scores among haloperidol, risperidone, and nemonapride group. Inter-group comparison among haloperidol, risperidone and nemonapride group, as assessed by the ESRS, revealed no significant differences in the shifts to the maximum score, 9.4(±9.4), 6.2(±8.4), and 11.3(±8.1) respectively, and also revealed no significant differences in the mean time reaching the maximum score, 4.5(±4.5) week, 7.8(±4.8) week, and 4.6(±4.4) week, respectivily. Conclusion : There wee no significant differences in the efficacy and extrapyramidal adverse effects among haloperidal, rispecridone and nemonapride groups. These results suggest that nemonapride was as efficacious and safe in he treatment of schizophrenia, as well known and widely used antipsychotics, haloperidol and risperidone.
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대두품종(大豆品種)과 선발(選拔) Rhizobium japonicum간의 숙주(宿主) 친화성(親和性)
김창진,이윤,김성훈,유익동,민태익,Kim, Chang-Jin,Rhee, Yoon,Kim, Sung-Hoon,Yoo, Ick-Dong,Mheen, Tae-Ick 한국토양비료학회 1986 한국토양비료학회지 Vol.19 No.4
우수(優秀) 대두접종제(大豆接種劑)로 이용할 균주(菌株)의 선발을 목적으로 국내(國內)에서 선발한 R. japonicum 균주(菌株)들과 현재 대두장려품종으로 보급되고 있는 대두품종들과의 상호(相互) 접종실험(接種實驗)을 통하여 숙주친화성(宿主親和性) 정도를 조사하였다. 얻어진 결과는 다음과 같다. 1. 공시(供試) 근류균주별(根瘤菌株別) 대두품종(大豆品種)과의 친화성(親和性) 정도를 보면 R. japonicum R-214, R-138 균주(菌株)가 근류형성능(根瘤形成能), 질소고정활성(窒素固定活性) 및 총(總) 질소흡수량(窒素吸收量)도 높아 대두품종(大豆品種)과 친화성(親和性) 범위가 비교적 넓었으며 R. japoncum R-224 균주(菌株)는 아주 낮은 것으로 판단되었다. 2. 대두품종별(大豆品種別) 근류균(根瘤菌)과의 친화성(親和性)은 황금(黃金)콩, 장백(長白)콩 등이 높았으며 그 다음이 장엽(長葉)콩, 단엽(短葉)콩, 백운(白雲)콩, 동북태(東北太) 등의 순이었고 방사(放射)콩이 제일 낮았다. 3. 일반적으로 질소고정활성(窒素固定活性)이 우수(優秀)한 균주(菌株)가 열등한 균주(菌株)보다 숙주친화성(宿主親和性) 범위가 넓은 것으로 판단되었다. In order to select suitable strains for utilization as soybean inoculants, the affinity between Rhizobium japonicum strains isolated from the domestic field and the several soybean varieties being distributed as recommended species was investigated by cross-inoculation experiments. The results obtained are as follows: 1. Rhizobium japonicum R-214 and R-138 showed broad affinity range to varies soybean species in terms of the nodule forming ability, the nitrogen fixing activity and the amount of total nitrogen absorption. In contrast, Rhizobium japonicum R-224 showed very low affinity to the same soybean groups. 2. The affinity of Hwang-Keum Kong and Jang-Paeck Kong to the rhizobium strains was the most signigicant, and that of Jang-Yeop Kong, Dong-Buk Tae, Paeck-Woon Kong and Dan-Yeop Kong was also significant. On the other hand, Pang-Sa Kong showed low affinity to the strains. 3. In general, the strains having high nitrogen-fixing activity seemed to possess the broad affinity range to the soybean hosts.
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교통사고 및 산업재해로 두부외상을 받은 후 보상문제로 의뢰된 환자들의 정신의학적 고찰
윤애리,신동균,이병윤 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.3
The aim if this study is to compare and analyze the findings of psychological tests which were obtained from the 184 subjects who suffered from head trauma by traffic and industrial accidents who were imvolved in compensation problems. The subjects were classified into the brain injury group and the cerebral concussion group, according to the existence or non-existence of abnormal findings revealed in the neurological evaluation including brain CT, skull x-ray and CSF studies right after traumatic events. The data were analyzed according to the general liner models procedure of statistical analysis system and Duncan's multiple range test. The results were as follows: 1. In the copy method of the Bender-Gestalt test, the retrogression, simplification, and elaboration scales out of Hutt's seventeen psychopatholoical ones showed significantly higher scores in the cerebral concussion group by industrial accidents than the other groups. The result shows defensive position, oppositional tendency, impairment of impulse and ego control in the cerbral concussion group by industrial accidents. In the reproduction method, there were statistically significant differences among the three groups in the reproduction time of card A and card 2. But a further study is needed about these findings. 2. Of the results of MMPI, the elevation of the scores of F scale in all the groups was characteristic, and especially, the score of the brain injury group was significantly high. The result shows that all the subjects have an intention of faking bad under these particular conditions. 3. In the KWIS test, the whole IQ score of the cerebral concussion group by industrial accidents was the lowest. The result suggests that the subjects' intention of faking bad had a considerable influence on the test. But a further study is needed about the result that the IQ score of the cerebral concussion group by industrial accidents was lower than that of the same group by traffic accidents. 4. In the Rorschach test, the response time was delayed in all the groups. The response time of card Ⅱ with red color was delayed significantly more in the brain injury group than in the cerebral concussion group. The result shows that the subjects' intense anxiety related to the actual scene of the accident had a considerable influence on the test. In conclusion, this study suggested that the patients who suffered from haed trauma by traffic and industrial accidents who were involved in the compensation problems revealed some characteristic personality traits such as immatunity, weakened ego control, and impulsive tendency, and that their intentional attitudes had a considerable influence on the psychological tests. Therefore, a more careful consideration is needed in the psychiatric evaluation of these patients. And another complementary study of the patients who suffered from head trauma by traffic and industrial accidents but were nor involved in the compensation problem is required first and foremost.
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장티푸스균 Vi 항원의 정제와 만성 보균자 검출을 위한 혈청학적 검색법 개발
이광호,조명제,박정규,임동균,국윤호,차창룡 대한감염학회 1988 감염 Vol.20 No.4
The Vi antigen was purified to improve the usefulness of Vi serology to detect typhoid carriers. The purification of Vi antigen from S. typhi Ty 2 and C. feundii was carried out through saline extraction, enzyme treatment, and cationic detergent treatment. The recovery rate of Vi antigen from S. typhi Ty 2 and C. freundii was 0.024%, 0.096%, respectively. The purified antigens were identified by the double immuno-diffusion test and the mouse protective activity test. The 50% protective dese for the mice challenged intraperitoneally with ?? cells of S. typhi Ty 2 per mouse was 13.8 ng. The quantity of contamination of lipopolysaccharide was less than 15 ng per 10 ㎍ of purfied Vi antigen. The purified Vi antigen was incorporated into a passive haemagglutination(PHA) test and an enzyme immunosorbent assy(ELISA). The optimal concentration of Vi antigen for the sensitization of sheep RBC was 10 ug per ml in the passive haemagglutination test. The optimal condition for coating Vi antigen to polystyrene(PS) plate was pH 10.6 and 10 μlg/ml in the enzyme immunosorbent assay. These methods were sensitive and specific for measuring the anti-Vi antibody titers of rabbits immunized with the S. typhi Ty 2.
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