Dong-Chun Lecture : Cell-based High Content Screening (HCS) for action modes of drug targets by using systematic deletion mutants of Schizosaccharomyces pombe

( Dong Uk Kim ),( Im Seon Woo ),( Mi Sun Won ),( Young Joo Jang ),( Kyung Sook Chung ),( Han Oh Park ),( Hyang Sook Yoo ),( Kwang Lae Hoe ),( Doo Sik Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-

확장형 칼만필터를 이용한 현수교의 감쇠성능 평가

박동욱(Park Dong-Uk),김남식(Kim Nam-Sik) 대한토목학회 2011 대한토목학회논문집 A Vol.31 No.2A

감쇠비는 현수교에 있어서 교량진동을 평가하기 위한 중요한 동적 요소 중 하나이다. 하지만, 실재 현수교에서 계측된 상시 진동신호로부터 감쇠비를 직접적으로 추정하는 것은 현실적으로 매우 어려운 일이다. 뿐만 아니라, 한정된 계측자료를 이용하여 추정된 감쇠비로부터 공기역학적 감쇠와 마찰 감쇠를 구분하는 것은 더욱 어렵다. Macdonald는 2005년 발표한 자료에서 공기 역학적 감쇠성능은 풍속에 따라 선형적으로 증가한다고 하였으며, Park등은 감쇠성능은 진동의 크기에 따라 변화할 수 있다고 하였다. 따라서 본 논문에서는 이러한 감쇠비, 풍속, 진동의 크기 사이의 관계를 연구하여, 추정 감쇠비로부터 공기역학적 감쇠와 마찰 감쇠를 구분하고자 하였다. 본 논문에서 감쇠비 추정대상으로는 전라남도 고흥에 위치한 소록대교를 선택하였으며, 감쇠비 추정에는 Hilbert 변환법을 이용한 방법과 확장형 칼만필터를 이용하였다. 또한 두 방법으로 추정된 감쇠비들을 상호 비교를 실시하였다. 그 결과, 상시진동 자료와 차량재하실험으로부터 얻어진 자료를 이용하여 추정된 감쇠비와 풍속, 그리고 가속도의 크기를 이용하여 추정 감쇠비로부터 공기역학적 감쇠 성능과 마찰 감쇠 성능의 구분이 가능하다는 것을 알 수 있었다. The damping ratio as an index of bridge vibration could be considered as one of the important dynamic characteristics of a suspension bridge. But estimating of damping ratio on an existing suspension bridge under ambient vibration condition could be a laborious task. Moreover, it is not simple to directly distinguish aerodynamic damping and friction damping from apparent damping. According to previous studies, the aerodynamic damping properties can be linearly affected by wind speed level, and apparent damping ratio can be affected by amplitude of vibration. Therefore, in this article, the relationships among damping ratio, wind speed level and amplitude of acceleration were studied for separating extract aerodynamic damping and friction damping from apparent damping. Damping ratios on Sorok Bridge, a suspension bridge which is a located in Go-Heung, Korea, were estimated by two different methods as using Hilbert transform and extended Kalman filter which were well known as effective estimation methods for non-linear state. It was possible to distinguish aerodynamic damping and friction damping from apparent damping using averaged normal components of wind speed, RMQ values of acceleration, and estimated damping ratios from wind-induced vibration responses and vehicle loading responses.

水原 華城行官의 復元을 위한 基礎的 硏究

朴彦坤,金東旭 弘益大學校 1983 弘大論叢 Vol.15 No.2

The palace was built for the king's temporary dwelling apart from the main palace. In the Chosun Dynasty(1392~1910), there were many palaces for temporary use all over the country. The Hwasung palace was built in 1796 near the grave of King Chong jo's father, so as to be used when kings visited the grave. Most of the buildings of the Hwasung palace weree ruined and the site was replaced by public buildings and private houses. But there remained some records on the building of the palace. Hwasung-Sungyuk-Eukwe was the most detailed one, which offered the full record on the scale of each building material. The restoration of the plan of the Hwasung palace became possible by those records. The restored plan offered the fact that the Hwasung palaced had the following characteristics. It had and the fomality of any ordinary palace of the Chosun Dynasty, while some buildings of it consisted of parts of the residence of the upper class, Ondol and Rou-maru.

뇌출혈이 합병된 감염성 심내막염 1례

박동건,이재욱,권삼,이동철,강승완 동국대학교 경주대학 1997 東國論集 Vol.16 No.2

감염성심내막염에 의한 신경계 합병증은 색전성 뇌경색, 색전성 뇌출혈, 두개내 패혈성 동맥류, 뇌농양, 뇌막염등 다양한데 항생제 요법의 발달과 판막치환술에도 불구하고 그 빈도는 감소되지 않고 있다. 이 중 두개내 패혈성 동맥류의 파열에 의한 뇌출혈은 사망률이 80%로 치명적일 수 있어 조기 발견 및 적절한 치료가 필요하다. 저자들은 두통, 열감, 근육통 등의 증상으로 내원하여 감염성 심내막염으로 진단받고, 항생제 치료로 임상증세의 호전중에 심한 두통과 전신적 발작이 있은 후 갑자기 발생한 두개내 뇌출혈을 심장초음파 및 뇌 컴퓨터 단층촬영을 통하여 진단, 경험하였기에 문헌고찰과 함께 보고하는 바이다. The complications of infective endocarditis may involve any organ system ie, cardia, neurologic, vascular, dermatologic, and kidney. Extracardiac complications are usually caused by either embolization of vegetations or deposition of immune complexes. Neurologic complications remain a significant problem in bacterial endocarditis and have been reported to occur in up to 20% to 40% of cases of infective endocarditis. The various types of central nervous system disease seen in patients with infective endocarditis are cerebral embolism (with infarction or with intracerebral hemorrhage), intracranial mycotic aneurysm, seizures, brain abscess, meningitis, mental change, psychiatric disorder. Mycotic aneurysms are uncommon but not rare and are an important cause of local or systemic sepsis and acute hemorrhage following aneurysmal rupture. Cerebral mycotic aneurysms have been noted in 2∼10% of cases of bacterial endocarditis and account for 2.5∼6.2% of all intracerebral aneurysms. We have experienced a case of neurologic complication due to infective endocarditis in a 23 year-old female patient, who admitted to our hospital because of fever, chill, headache, myalgia. This case was diagnosed by echocardiography, brain computed tomography. The patient died of sudden intracerebral hemorrhage in the 53th hospital day despite intensive medical treatment. We report one case of intracerebral hemorrhage complicated with infective endocarditis.

일개 중소도시에서 PC방을 이용하는 중·고등학생의 인터넷중독과 VDT증후군

박성은,이동욱,이인구,배재익,성낙진,박기흠 대한보건협회 2003 대한보건연구 Vol.29 No.1

Background : It is one of the important daily activities for Korean students to use the Internet, and most of them go to FC bang. However, students uncontrolled Internet use causes compulsive Internet use, so called the Internet addiction. So we investigated the relationship between students internet use pattern and their Internet addiction. And also examined how internet addiction causes VDT syndrome. Method: We conducted survey with self-registered questionnaires for 1 months, from January to February 2000. On the questionnaire, we asked Internet use pattern to students in suburban area. To test the Internet addiction, this research adopted Dr. Young s Internet addiction self test, and also major 8 symptoms of VDT syndrome were tested. Results : There was not much difference in computer using time between at home and at PC bang, and among student s grade. We found 30.1% of the objects addicted to the internet, however, there was no relationship between Internet addiction and student s grade. We found statistically significant relationship between Internet addiction and VDT syndrome (p<O.o5) except ocular symptoms and dry mouth. Conclusion : As a result, we found that Internet adhction is related with the spending time on computer use, although there is no relationship between Internet addiction and student s grade. There are significant correlations between internet addiction and VDT syndrome. So internet addiction is not only social and psychiatric problem but a physiologic dsorder whch affect student s health.

위험평가(Risk Assessment)에 의한 업종별 위험(Risk)의 구분

박동욱,박덕묵,정광수,윤충식,김태형,노영만,이경남,이송권,김현욱 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

A total of 514 workplaces in 17 industries were inbestigated through walk-through survey. These industries were all small companies with less than five workers and didn't have work environmental measurement data. These industries were ranked by risk that was evaluated by combination of toxicity and possibility of exposure to chemical hazardous agents produced at operations of industry. Risk Index(RI) was qualitatively combined by the combination between hazard and potential of exposure to chemical hazardous agents. Industries that were regarded as having the highest risk were wood and products of wood, chemicals and chemical products, basic metals, other vehicles, trailers and semi-trailers, and fumiture manufacturing. These industries were found to have operations with higher risk than other industries. This study found that more attentions should be paid to these industries with that more attentions should be paid to these industries with high risk.

천연두 백신 접종 후 발생된 급성 심근염 1예

박옥성,김종환,이광욱,윤성훈,강동구,이승욱,조상기 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Acute myocarditis complicating coronary vasospasm after smallpox vaccination is very rare complication that can be generally developed within less than 30 days after vaccination. Clinically and biochemically, this disorder is often mimic and highly suggestive of acute myocardial infarction. We report 21 years old man that had a history of a smallpox vaccination 3 weeks ago and prodromal symptoms(fever, malaise etc) a few days ago. hIe visited to our hospital because of abrupt onset of severe substernal chest pain, dyspnea and diaphoresis. At admission, electrocardiography was ST elevation in lead Ⅰ, aVL, V4, V5, and V6. The CK-MB level was 68 U/L, LDH level was 760 U/L, Troponin-Ⅰ was 24.64 ng/㎖, and Troponin-T was positive. 2D-echocardiograpy was normal left ventricular function, Clinically we presumed this disorder as acute myocardial infarction and we promptly performed the coronary angiography and revealed focal spasm in distal left coronary artery territory without critical stenosis in both coronary arteries. We diagnosed this disorder as coronary vasospam complicating acute myocarditis that is different with acute myocardial infarction, and we prescribed nitroglycerin and nifedipine. After discharge, he is now well without any symptoms and has been following up monthly at our outward department for 6 months.

American Medical Association 5판을 근거로 한 한국형 말초신경계 장애 평가기준 개발

박동식,김병조,황선철,송인욱,손병철,장성호,정두신 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.14 No.3

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수입각증후군에 의한 급성 복증 1례

정은욱,지삼룡,이영태,박지훈,김동기,제인수,채두근,박성재,박은택,이연재,이상혁,설상영,정정명 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Afferent loop syndrome is an uncommon complication of a gastrectomy and Billroth Ⅱ reconstruction. It may cause symtoms at any time from the first postoperative day to many years after the gastrectomy. Afferent loop syndrome is characterized by abdominal pain, vomiting and elevation of serum amylase. Thus, it is difficult to differentiate afferent loop syndrome from other cause of acute pancreatitis. However, the history of gastrectomy can be an important clue for diagnosing afferent loop syndrome. We experienced one case of chronic afferent loop syndrome with acute pancreatitis. After appropriate management, the abdominal pain disappeared and serum amylase level decreased. We report this case with a review of relevant literatures.

농약살포자 혈중 콜린에스테라제 활성도의 변화 및 농약성분

신동천,이순영,정상혁,원종욱,박종세,박송자 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

In order to ascertain the status of health damage among Korean farmers who spray pesticides regularly in summer, blood and urine samples were collected for 88 volunteers during July to September in 1990. Serum cholinesterase activity, parent compounds of pesticides in blood and urine, SGOT, SGPT, blood pressure, pulse rate were measured. The results were as follows; 1. Mean cholinesterase activity after spraying pesticides was significantly lower than that before spraying. While proportion of abnormal cholinesterase activity(<1990 U/L) group was 2.3% before spraying pesticides, the proportion of the group after spraying was 22.8%. 2. Cholinesterase activity were decreased over 50% in 14.7% of the subjects who can be classified into poisoning group 3. While pulse rate and blood pressure were slightly increased in poisoning group, those were significantly decreased in non-poisoning group. 4. Consecutive spraying of pesticide caused further reduction of cholinesterase activity. 5. Five parent compounds of pesticides frequently used during summer farming were analyzed using 106 blood samples. IBP in one sample and Isoprothiolane in four samples were detected. No parent compounds were detected in urine samples.