신경섬유종증-제 2형의 진단과 치료 : 16례의 임상경험 Experience of 16 Cases

김정은,백선하,김종수,이상형,오창완,김동규,정희원,김현집,조병규,한대희,최길수 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.12

Neurofibromatosis type 2(NF-2) is a dominantly inherited disorder characterized by the occurrence of bilateral acoustic neurinomas and the frequent association of other central nervous system tumors. We present a retrospective review of 16 patients with NF-2 who were treated at our hospital from 1984 to 1995 in 13 cases, the diagnoses of Nf-2 were based on the criteria developed at the Consensus Development Conference of National Institute of Health in the United States, and in another 3 cases. the criterias of NF-2 were not fully satisfied, but the diagnoses of NF-2 were highly suspected. The average age of the patients was 27.6 years, ranging from 13 years to 56 years. The most common symptom was hearing difficulty : intervals between symptom onset and deafness ranged from 8 months to 6 years(mean : 2.9 years) One family of NF-2 was documented consisting of a sister a brother and their mother. Nine patients underwent operations on unilateral acoustic neurinomas : these were subtotally removed in eight patients and totally in one patient Among these patients five were deaf on the ipsilateral side at surgery. Among the other four patients with useful hearing before surgery, hearing was preserved to preoperative status in two patients. Four patients with diagnoses of meningioma, received operations to relieve mass effect with subtotal removal in two patients and total removal in the other two. Early diagnosis and treatment are the most important in the management planning of patients with NF-2 for reasons of early manifestation and rapid progression of the disease.

STRESS DISTRIBUTION OF ENDODONTICALLY TREATED MAXILLARY SECOND PREMOLARS RESTORED WITH DIFFERENT METHODS : THREE-DIMENSIONAL FINITE ELEMENT ANALYSIS

임동열,김현철,허복,김광훈,손권,박정길 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.1

본 연구의 목적은 근관치료 된 치아를 구조와 물성이 다른 post와 core 그리고 전장관으로 수복한 후 과도한 교합하중을 가했을 때 치아에 나타나는 응력분포를 조사하기 위함이다. 발치 된 상악 제2소구치를 micro-CT로 단층촬영하고 3D Doctor로 윤곽선을 추출한 다음 HyperMesh Ver. 6으로 삼차원 치아모형을 만들고 다음과 같은 세 가지 방볍으로 수복한 유한요소모형을 제작하였다. 1) 스테인레스 스틸 포스트와 복합레진 코어 그리고 도재소부전장금관으로 수복한 모형 2) fiber 포스트와 복합레전 코어 그리고 전부도재관으로 수복한 모형 . 3)포스트, 코어와 전장관이 일체형인 간접복합레진 EndoCrown으로 수복한 모형. 형성된 모형의 협측 또는 설측교두에 500N의 하중을 가하였으며 하중의 방향은 치아 장축에 대해 45도 이었다. 치관부와 치근부의 von Mises 응력을 ANSYS 9.0 프로그램으로 분석한 결과 포스트와 코어의 형태보다는 전장관 재료의 탄성계수가 근관치료된 상악 소구치의 응력분포를 좌우하였다. 치관부에서는 재료의 탄성계수가 높은 전장관으로 수복한 모형이 낮은 응력분포를 보였다. 치근부에서는 재료의 탄성계수가 낮은 전장관으로 수복한 모형이 낮은 응력분포를 보였다 The purpose of this study was to evaluate the influence of elastic modulus of restorative materials and the number of interfaces of post and core systems on the stress distribution of three differently restored endodontically treatcd maxillary second premolars using 3D FE analysis Model 1, 2 was restored with a stainless steel or glass fiber post and direct composite resin. A PFG or a sintered alumina crown was considered. Model 3 was restored by EndoCrown. An obliquc 500 N was applied on thc buccal (Load A) and palatal (Load B) cusp. The von Mises stresses in the coronal and root structure of each model were analyzed using ANSYS. The elastic modulus of the definitive restorations rather than the type of post and core system was thc primary factor that influenced the stress distribution of endodontically treated maxillary premolars. The stress concentration at thc coronal structure could be lowered through the use of definitive restoration of high elastic modulus The stress concentration at the root structure could be lowered through the use of definitive restoration of low elastic modulus.

확률론적 해석법에 의한 연직배수 영향인자 민감도 분석

유남재,전상현,정길수,김동건 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B

A probabilistic analysis model, one of reliability analysis methods introducing the concept of probabilistic variables, was developed to investigate the uncertainty of dominant factors influencing the degree of consolidation in the radial consolidation theories. Based on the developed probabilistic analysis model, sensitivity study of those factors was performed to find their trends of affecting the degree of consolidation in the vertical drain method. Various radial consolidation theories, Proposed by Barron(1948), Hansbo(1979), Yoshikuni(1979) and 0noue(1988), were used for this parametric study with the influencing factors such as size of smear zone, reduction ratio of permeability in the smear zone, discharge capacity, permeability for horizontal flow and coefficient of consolidation for horizontal flow. As results of this sensitivity study, for the given consolidation theory, contribution of each factor to the degree of consolidation was figure out and compared to each other. For the given value of each factor, the sensitivity to the degree of consolidation in the various theories was evaluated and their applicability and limitations were assessed.

니코틴과 트리암시놀론 아세토니드를 함유하는 생분해성 마이크로스피어의 제조시 분무건조법과 용매증발법의 비교

박선영,조미현,이종화,김동우,지웅길 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.4

The microspheres have been developed as a new drug delivery system. Although many particulate drug carriers, such as liposome, niosome and emulsion, have been introduced, injectable and biodegradable microspheres appears to be a particularly ideal delivery system because the local anesthesia is not necessary for the insertion of large implants and for the removal of the device after the drug release is finished. Biodegradable microspheres with nicotine and triamcinolone acetonide are prepared and evaluated. As biodegradible polymers, PLA (M.W. 15,000, PLA-0015), PLGA (M.W. 17,000, RG 502) and PLGA (M.W. 8,600, RG 502H) are used. This study attempted to prepare and evaluate the nicotine and triamcinolone acetonide-incorporated microspheres, which were prepared by two methods, solvent-evaporation and spray-drying methods. The microspheres, as a disperse system for injections, were evaluated by particle size, size distribution, entrapment efficiency, and in vitro drug release patterns. The differences of preparation method, partition coefficient, types of polymer, and preparation conditions of microspheres influence the particle size, entrapment efficiency, and in vitro drug release patterns.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Residual Characteristics of Fungicides Amisulbrom and Dimethomorph in Cnidium officinale Makino

Dong Yeol Lee,Dong Kyu Jeong,Won Min Jeong,Young Sook Kil,Seung Mi Sin,Young Min Goo,Sang Gon Kim 한국농약과학회 2020 한국농약과학회 학술발표대회 논문집 Vol.2020 No.11

비구면 유리렌즈 열변형 보정에 관한 연구

이동길(Dong Kil Lee),김현욱(Hyun Uk Kim),차두환(Du Hwan Cha),이학석(Hak Suk Lee),김혜정(Hye-Jeong Kim),김정호(Jeong-Ho Kim) Korean Society for Precision Engineering 2010 한국정밀공학회지 Vol.27 No.5

수온 및 절식에 따른 넙치 (Paralichthys olivaceus) 근육의 물리화학적 특성 변화

심길보 ( Kil Bo Shim ),이소정 ( So Jeong Lee ),윤호동 ( Ho Dong Yoon ),임치원 ( Chi Won Lim ),신윤경 ( Yun Kyung Shin ),정민환 ( Min Hwan Jeong ),이동길 ( Dong Gil Lee ),박태일 ( Tae Ii Park ) 한국수산과학회(구 한국수산학회) 2012 한국수산과학회지 Vol.45 No.5

The effects of low temperature and starvation on the physiochemical characteristics of the muscle of the olive flounder Paralichthys olivaceus, were examined. Fish were deprived of feed for 28 days at 2, 4, 6, 8, 10, 12, and 20°C in order to establish suitable conditions for live fish transportation. Throughout most of the 4 weeks of feed restriction, the physiochemical characteristics of the muscle of olive flounder were found to be dependent on the acclimation temperature. The breaking strength of muscle did not show a significant reduction during feed restriction at 2 and 4°C. With increasing temperatures, however, the breaking strength of muscle differed significantly according to the individual and feed restriction period (P<0.05). The moisture content in muscle acclimated at 10, 12, and 20°C increased steadily over the feed-restriction period, while the crude lipid content decreased during the same period (P<0.05). At water temperatures above 2-8°C, no significant differences were shown during the same period. After it reached 6, 8, 10, 12, and 20°C, the muscle had an accumulation of lactate, and a loss of ATP. There was no change in the lactate or ATP content during the feed restriction period at 2 and 4°C, although there were differences among the water temperature groups, These results clearly show that temperature can have an important influence on the of muscle of physiochemical characteristics of muscle during live fish transportation.

보행자의 충돌 후 이탈각도에 관한 연구

정동훈(Jeong, Dong-Hun),김길배(Kim, Kil Bae),정우택(Jeong, U-Taek) 대한교통학회 2012 대한교통학회 학술대회지 Vol.67 No.-

일개 대학병원에서 경험한 자리공 중독 환자의 임상적 특성

정동길 ( Dong Kil Jeong ),문형준 ( Hyung Jun Moon ),이정원 ( Jung Won Lee ),박세훈 ( Sae Hoon Park ),이현정 ( Hyung Jung Lee ),설승환 ( Seung Whan Seo ),김아름 ( Ah Reum Kim ),최재형 ( Jae Hyung Choi ),김재우 ( Jae Woo Kim ) 대한임상독성학회 2012 대한임상독성학회지 Vol.10 No.2

Purpose: Although Pokeweed intoxication is relatively less severe, thereis little data onthe clinical presentation ofPokeweed intoxication in Korea. This study examined the clinical aspectsto providebasic data for evaluating Pokeweed intoxication. Methods: A retrospective study by a chart review was performedon 19 patients who ingested Pokeweed and presented to anacademic emergency department with an annual census of 40,000 between March 2012 and May 2012. Results: Nineteen patients were identified. All patients wereintoxicated unintentionally. The most common symptoms were vomiting with diarrhea and abdominal pain. The onset time varied, but occurs 30 minutes to 5 hours post ingestion of Pokeweed. All patients were discharged without fatal complications. Conclusion: Compared to previous reports, mostpokeweed poisoning patients complain of gastrointestinalsymptoms. Supportive care is the mainstay of the management of pokeweed intoxication. All symptoms were resolved over a 24 to 48 hour period.