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- 검색키워드
- 저자 : ( Dajeong Lee ) (검색결과 130 건)
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Lee, Dajeong,Kim, Hyuk Soon,Shin, Eunju,Do, Seon-Gil,Lee, Chong-Kil,Kim, Young Mi,Lee, Min Bum,Min, Keun Young,Koo, Jimo,Kim, Su Jeong,Nam, Seung Taek,Kim, Hyun Woo,Park, Young Hwan,Choi, Wahn Soo Elsevier 2018 Biomedicine & pharmacotherapy Vol.101 No.-
<P><B>Abstract</B></P> <P>An allergic reaction occurs when the immune system overreacts to harmless substance called allergen that gains access to the body. Food allergy is a hypersensitive immune reaction to food proteins and the number of patients with food allergy has recently increased. <I>Aloe Vera</I> is used for wellness and medicinal purposes. In particular, <I>Aloe vera</I> has been reported to enhance immunity. However, the effect of <I>Aloe vera</I> on food allergy is not yet known. In this study, we investigated the effects of processed <I>Aloe vera</I> gel (PAG) containing low molecular weight Aloe polysaccharide (AP) on ovalbumin (OVA)-induced food allergy in mice. Allergic symptoms, rectal temperature, and diarrhea were measured in OVA-induced food allergy mice. Other allergic parameters were also analyzed by RT-PCR, ELISA, flow cytometry, and other biochemical methods. As the results, PAG suppressed the decrease of body temperature, diarrhea, and allergic symptoms in OVA-induced food allergy mice. PAG also reduced serum concentrations of type 2 helper T cell (Th2) cytokines (Interleukin-(IL)-4, IL-5, and IL-13) as well as histamine, mast cell protease-1 (MCP-1), and immunoglobulin (Ig)E. PAG blocked the degranulation of mast cells and infiltration of eosinophils in intestine. Furthermore, PAG suppressed the population of Th2 cells in spleen and mesenteric lymph nodes. PAG also increased the production of IL-10 and population of type 1 regulatory T (Tr1) cells in mice with food allergy. Taken together, our findings suggest that PAG suppressed Th2 immune responses through, at least partially, stimulating the secretion of IL-10 in food allergy mice.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Processed <I>Aloe vera</I> gel (PAG) suppresses food allergy in mice. </LI> <LI> PAG inhibits Th2 immune responses in mice. </LI> <LI> PAG increases the production of IL-10 in vitro and in vivo. </LI> <LI> PAG stimulates the activation of Tr1 cells. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Dajeong Lee,Jiwon Lee,Jeehun Lee 대한소아신경학회 2022 대한소아신경학회지 Vol.30 No.3
Purpose: Frontal lobe epilepsy (FLE) has various clinical presentations depending on the anatomy involved. Seizures are brief and can mimic psychiatric conditions, and patients often cannot describe the aura. Therefore, it is difficult to characterize the semiology, especially in pediatric patients. This study investigated the characteristics of pediatric FLE. Methods: We retrospectively reviewed the data of pediatric patients with FLE who underwent long-term video-electroencephalography (EEG) monitoring between January 2010 and June 2020. Patients’ demographic data, seizure-related clinical presentations, semiology, brain magnetic resonance imaging (MRI), and EEG data were analyzed. Results: Fifty-six patients were included (31 males, 25 females). The age of seizure onset varied from 1 month to 14 years (mean±standard deviation, 6.1±4.4 years). Seizures were classified into nine categories, including focal tonic (30/56), aura (22/56), hypermotor (17/56), focal clonic (15/56), versive (13/56), and bilateral asymmetric tonic (4/56). Seventeen patients (30.4%) had abnormal MRI results, including focal cortical dysplasia, heterotopic gray matter, and neuroepithelial tumors. Ictal EEG changes were commonly observed in the dorsolateral premotor and central cortices. In focal tonic seizures, EEG changes often originated in the premotor cortex. The location of the lesions on MRI and EEG coincided in six cases. Conclusion: In pediatric FLE, various seizure types occur depending on the ictal anatomic origin, and individual patients had multiple semiologies. Brain MRI was normal in two-thirds of patients, and interictal EEG did not reveal epileptiform discharges in approximately 25%. Semiology reported on the basis of home videos and interictal EEG will help localize the ictal onset zone.
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Lee, Dajeong,Cho, Jae Yu,Yun, Hee-Sun,Lee, Doh-Kwon,Kim, Taehoon,Bang, Kijoon,Lee, Yun Seog,Kim, Ho-Young,Heo, Jaeyeong Royal Society of Chemistry 2019 Journal of Materials Chemistry A Vol.7 No.12
<P>The influence of the vapor transport deposition (VTD) conditions of tin sulfide (SnS) on the formation of secondary phases, preferred orientation, and solar cell performance is investigated in this study. It is concluded that 600 °C is the optimal growth temperature for the formation of pure SnS absorbers. When the growth temperature was 550 °C, the formation of secondary Sn2S3 and SnS2 phases was detected by Raman analysis. When the growth temperature was 625 °C, a noticeable change in morphology was observed with the plate-shaped grains aligned vertically to the substrate, which is detrimental to solar cell performance. The duration of growth also affected the morphology of the SnS absorber. Thin absorbers exhibited strong (120) preferred orientation. With increased duration of growth, (101) and (111) orientations increased. Such a variation in preferred orientation influenced the SnS/CdS solar cell’s performance. When the absorber thickness was as thin as ∼0.7 μm, the cell was prone to shunting and severe series resistance. When the absorber was as thick as ∼3.0 μm, physical shunting prevailed, worsening the performance of the cell. The highest efficiency of 3.93% with good cell-to-cell uniformity was achieved when the absorber thickness was ∼1.2 μm. The good stability of the best device was also confirmed under continuous illumination and damp-heat conditions for 100 h.</P>
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Lee, Sun Hee,Park, Dongsun,Yang, Goeun,Bae, Dae-Kwon,Yang, Yun-Hui,Kim, Tae Kyun,Kim, Dajeong,Kyung, Jangbeen,Yeon, Sungho,Koo, Kyo Chul,Lee, Jeong-Yong,Hwang, Seock-Yeon,Joo, Seong Soo,Kim, Yun-Bae Steinkopff 2012 EUROPEAN JOURNAL OF NUTRITION Vol.51 No.8
<P>The objective was to confirm the anti-obesity activity of a silk peptide (SP) and a silkworm pupa peptide (SPP) in rats fed a high-fat diet (HFD) and to elucidate their action mechanism(s) in a preadipocyte culture system. In an in vitro mechanistic study, the differentiation and maturation of 3T3-L1 preadipocytes were stimulated with insulin (5 mu g/mL), and effects of SP and SPP on the adipogenesis of mature adipocytes were assessed. In an in vivo anti-obesity study, male C57BL/6 mice were fed an HFD containing SP or SPP (0.3, 1.0, or 3.0%) for 8 weeks, and blood and tissue parameters of obesity were analyzed. Hormonal stimulation of preadipocytes led to a 50-70% increase in adipogenesis. Polymerase chain reaction and Western blot analyses revealed increases in adipogenesis-specific genes (leptin and Acrp30) and proteins (peroxisome proliferator-activated receptor-gamma and Acrp30). The hormone-induced adipogenesis and activated gene expression was substantially inhibited by treatment with SP and SPP (1-50 mu g/mL). The HFD markedly increased body weight gain by increasing the weight of epididymal and mesenteric fat. Body and fat weights were significantly reduced by SP and SPP, in which decreases in the area of abdominal adipose tissue and the size of epididymal adipocytes were confirmed by magnetic resonance imaging and microscopic examination, respectively. Long-term HFD caused hepatic lipid accumulation and increased blood triglycerides and cholesterol, in addition to their regulatory factors Acrp30 and leptin. However, SP and SPP recovered the concentrations of Acrp30 and leptin, and attenuated steatosis. SP and SPP inhibit the differentiation of preadipocytes and adipogenesis by modulating signal transduction pathways and improve HFD-induced obesity by reducing lipid accumulation and the size of adipocytes.</P>
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Lee, Dajeong,Cho, Jae Yu,Heo, Jaeyeong Elsevier 2018 SOLAR ENERGY -PHOENIX ARIZONA THEN NEW YORK- Vol.173 No.-
<P><B>Abstract</B></P> <P>Sb<SUB>2</SUB>Se<SUB>3</SUB> is one of the alternative absorber materials for thin-film solar cells (TFSCs) comprising non-toxic and low-cost elements. The duration of pre-annealing at 100 °C prior to rapid thermal annealing (RTA) influenced the final morphology, crystallinity, and preferred orientation of thermally evaporated Sb<SUB>2</SUB>Se<SUB>3</SUB>. Pre-annealing for 40 min promoted the crystallization of pure Sb<SUB>2</SUB>Se<SUB>3</SUB> phase following RTA; however, a long pre-annealing time such as 100 min rendered morphology similar to that of the reference absorber that was not pre-annealed, as ascertained by detailed scanning electron microscopy, X-ray diffraction, and Raman spectroscopic analyses. Furthermore, Sb<SUB>2</SUB>Se<SUB>3</SUB>/CdS TFSCs were fabricated with Sb<SUB>2</SUB>Se<SUB>3</SUB> pre-annealed for various durations. The highest efficiency of 1.47% was achieved for the optimized 40-min pre-annealed absorber, enabling a smooth current flow. Our results emphasize the detailed optimization of pre-annealing time for achieving efficient TFSCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thin films of antimony selenide (Sb<SUB>2</SUB>Se<SUB>3</SUB>) were deposited via thermal evaporation. </LI> <LI> The duration of pre-annealing at 100 °C influenced the morphology of Sb<SUB>2</SUB>Se<SUB>3</SUB> films. </LI> <LI> Pre-annealing for 40 min resulted in optimized crystallinity of Sb<SUB>2</SUB>Se<SUB>3.</SUB> </LI> <LI> The highest efficiency of 1.47% is achieved for the Sb<SUB>2</SUB>Se<SUB>3</SUB>/CdS heterojunction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Lee, Sooyeun,Kang, So-young,Ji, Dajeong,Baeck, Seungkyung,Lee, Sangki,Oh, Seung Min,Chung, Kyu Hyuck Springer-Verlag 2013 Analytical and bioanalytical chemistry Vol.405 No.10
<P>The chemical castration law, which targets child molesters with recidivism, was introduced in Korea in 2011. For this, leuprolide, a gonadotropin-releasing hormone agonist, is used to decrease testosterone production and suppress libido. In order to achieve efficient law enforcement, it is necessary to monitor intentional ingestion of drugs that antagonize the effect of leuprolide. Therefore, an analytical method for the simultaneous detection of mirodenafil, sildenafil, tadalafil, udenafil, vardenafil, icariin, alprostadil, and yohimbine, which are the major impotence treatment drugs, legitimately or otherwise, in Korea, as well as their selected metabolites, in human urine was established and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). First, different sample preparation methods, two solid-phase extractions with different cartridges and protein precipitation, were compared and protein precipitation was chosen for the entire study because it showed better matrix effects and recoveries. Thus, the drugs and metabolites in urine were extracted by protein precipitation and then filtered and analyzed by LC-MS/MS with polarity switching electrospray ionization. The validation results of selectivity, matrix effect, recovery, linearity, intra- and inter-assay precision and accuracy were satisfactory. The limits of detection ranged from 0.25 to 10 ng/mL, and the limits of quantification were 2.5 to 50 ng/mL. The drugs and metabolites in urine did not show any degradation under storage for 7 and 15 days at 4 and -20 C as well as after three freeze-thaw cycles. The developed method will be very useful for monitoring the illegal use of impotence treatment drugs.</P>
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( Dajeong Lee ),( Young Hwan Park ),( Ji Eon Lee ),( Hyuk Soon Kim ),( Keun Young Min ),( Min Geun Jo ),( Hyung Sik Kim ),( Wahn Soo Choi ),( Young Mi Kim ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.5
Mast cells (MCs) are systemically distributed and secrete several allergic mediators such as histamine and leukotrienes to cause type I hypersensitivity. Dasatinib is a type of anti-cancer agent and it has also been reported to inhibit human basophils. However, dasatinib has not been reported for its inhibitory effects on MCs or type I hypersensitivity in mice. In this study, we examined the inhibitory effect of dasatinib on MCs and MC-mediated allergic response in vitro and in vivo. In vitro, dasatinib inhibited the degranulation of MCs by antigen stimulation in a dose-dependent manner (IC<sub>50</sub>, ~34 nM for RBL-2H3 cells; ~52 nM for BMMCs) without any cytotoxicity. It also suppressed the secretion of inflammatory cytokines IL-4 and TNF-α by antigen stimulation. Furthermore, dasatinib inhibited MC-mediated passive cutaneous anaphylaxis (PCA) in mice (ED<sub>50</sub>, ~29 mg/kg). Notably, dasatinib significantly suppressed the degranulation of MCs in the ear tissue. As the mechanism of its effect, dasatinib inhibited the activation of Syk and Syk-mediated downstream signaling proteins, LAT, PLCγ1, and three typical MAP kinases (Erk1/2, JNK, and p38), which are essential for the activation of MCs. Interestingly, in vitro tyrosine kinase assay, dasatinib directly inhibited the activities of Lyn and Fyn, the upstream tyrosine kinases of Syk in MCs. Taken together, dasatinib suppresses MCs and PCA in vitro and in vivo through the inhibition of Lyn and Fyn Src-family kinases. Therefore, we suggest the possibility of repositioning the anti-cancer drug dasatinib as a treatment for various MC-mediated type I hypersensitive diseases.
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Genome-wide association study and genomic predictions for exterior traits in Yorkshire pigs
Lee, Jungjae,Lee, SeokHyun,Park, Jong-Eun,Moon, Sung-Ho,Choi, Sung-Woon,Go, Gwang-Woong,Lim, Dajeong,Kim, Jun-Mo American Society of Animal Science 2019 Journal of Animal Science Vol.97 No.7
<P> The objectives of this study were to identify informative genomic regions that affect the exterior traits of purebred Korean Yorkshire pigs and to investigate and compare the accuracy of genomic prediction for response variables. Phenotypic data on body height (BH), body length (BL), and total teat number (TTN) from 2,432 Yorkshire pigs were used to obtain breeding values including as response variable the estimated breeding value (EBV) and 2 types of deregressed EBVsㅡone including the parent average (DEBVincPA) and the other excluding it (DEBVexcPA). A final genotype panel comprising 46,199 SNP markers was retained for analysis after quality control for common SNPs. The BayesB and BayesC methodsㅡwith various π and weighted response variables (EBV, DEBVincPA, or DEBVexcPA)ㅡwere used to estimate SNP effects, through the genome-wide association study. The significance of genomic windows (1?Mb) was obtained at 1.0% additive genetic variance and was subsequently used to identify informative genomic regions. Furthermore, SNPs with a high model frequency (≥0.90) were considered informative. The accuracy of genomic prediction was estimated using a 5-fold cross-validation with the K-means clustering method. Genomic accuracy was measured as the genomic correlation between the molecular breeding value and the individual weighted response variables (EBV, DEBVincPA, or DEBVexcPA). The number of identified informative windows (1 Mb) for BH, BL, and TTN was 4, 3, and 4, respectively. The number of significant SNPs for BH, BL, and TTN was 6, 4, and 5, respectively. Diversity π did not influence the accuracy of genomic prediction. The BayesB method showed slightly higher genomic accuracy for exterior traits than BayesC method in this study. In addition, the genomic accuracy using DEBVincPA as response variable was higher than that using other response variables. Therefore, the genomic accuracy using BayesB (π = 0.90) with DEBVinPA as a response variable was the most effective in this study. The genomic accuracy values for BH, BL, and TTN were calculated to be 0.52, 0.60, and 0.51, respectively. </P>
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