자일리톨, 후노란, 제2인산칼슘 및 카제인포스포펩타이드배합껌이 법랑질의 광질재침착에 미치는 영향에 관한 실용실험연구

이병진,배광학,박우철,양준영,황수정,노정,백대일,김종배 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

The object of this study was to investigate caries preventive effect of chewing gum containing xylitol, funoran, calcium hydrogen phosphate and casein phosphopeptide by examining Vickers' hardness and surface roughness with confocal laser microscope. Early caries-like lesions were created using 0.1 M lactic acid-sodium hydroxide buffer(pH 4.0). 8 pieces of 3am diameter bovine enamel specimen with early caries-like lesions were mounted into the recesses of lingual surface of the acrylic mandibular removable appliance. 13 subjects were the appliance for daytime and chewed control and experimental gums 7 times in a day, for 3 days. In order to evaluate the remineralization effect of chewing gum on specimens, we measured vickers' hardness number after chewing gum, 1 day, 2 days, 3 days after and calculated surface roughness immediately after chewing gum. Vickers' hardness number of experimental chewing gum was significantly higher than control in 2 and 3 days after. Surface roughness of experimental chewing gum was significantly lower than control immediately after chewing gum. These results showed that experimental gum has more effective in remineralization of bovine tooth enamel, and it is more effective at immediately after chewing.

N-Arylnortropinone 유도체의 합성연구

李龍均,朴유미,鄭大一,金寅植,朴鍾勳,盧信愛,鄭逸守,朴敏洙 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.1

Tropinone 화합물들은 색다른 고리계의 존재로 아주 오래전부터 약리학적으로 매우 흥미로운 연구과제로 주목되어 최근에 그들의 합성법,?? 입체적 구조분석?? 그리고 약리학적인 연구??가 활발히 진행되고 있다. Tropinone 1은 흔히 마약으로 알려져 있는 cocaine 2, 소염작용과 항경련성 작용 및 심장박동수를 조절 등 다양한 약리작용을 하는 tropane spirohy-dantoin ?? 그리고 안과질환을 검사 할 때 눈의 동공을 확장시키는 데 사용하는 atropine ??등을 합성하는 데 중요한 중간체이다. ??????????? Trigo, G, G등 ??은 aliphatic amine과 succinic aldehyde를 acetonedicarboxylic acid와 반응하여 nortropane 유도체를 합성하였으며, 그 후 [3+2] nitrone cycloaddition? 과 [3+4] cyclocoupling? 을 거치는 tropane alkaloid의 새로운 합성법이 개발되었다. 최근 lzquier M. L. 등¹은 acetonedicarboxylic acid를 사용하여 1차 지방족 amine과 succinic aldehyde대신 2,5-dimethoxytetrahydrofuran을 반응시켜 N-alkyl nortropinone 유도체를 합성하였다. 그러나 일반적으로 빙초산 속에서 amine과 2,5-dimethoxytetrahydrofuran을 반응시키면 pyrrole 유도체가 합성되어진다.?? 이러한 사실은 분명히 반응조건(예, 산, 온도)에 따른 다양한 화학이 존재한다고 볼 수 있다. 따라서 우리는 반응조건, 즉 산의 변화 및 온도 변화에 의한 amine과 2,5-dimethoxytetrahydrofuran의 반응을 자세하게 검토하면서 새로운 N-arylnortropinone 유도체를 합성하고자 한다.

한국 어린이와 성인의 표준잇솔규격개발에 관한 연구

이원재,이병진,배광학,김영수,노정,문혁수,백대일,김종배 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

Purpose of this study was to obtain basic anatomical data for developing optimal toothbrush which is appropriate for Koreans Dental study models were examined by measuring the length from labial midline of deciduous canine to distal surface of deciduous second molar, from labial midline of permanent canine to distal surface of second premolar, from mesial surface permanent first molar to distal surface of permanent second molar, cervico-incisal length of deciduous central incisor, cervico-incisal length of permanent central incisor, from mesiobuccal cusp of deciduous maxillary second molar to mesiolingual cusp of deciduous maxillary second molar, from mesiobuccal cusp of permanent maxillary first molar to mesiolingual cusp of permanent maxillary first molar, from distolinual cusp of deciduous mandibular second molar to mesiolingual cusp of deciduous mandibular second molar, from mesiobuccal cusp of permanent mandibular first molar to mesiolingual cusp of permanent mandiblar second molar in 241 subjects. And the width of right hand was examined on each subjects by measuring the length of landmarks which were selected in handwrist X-ray film. Commercial toothbrushes sold in Korea were collected and the head length, head width, bristle length and handle length of toothbrushes were measured. The obtained results were as follows; 1. The head length of toothbrush which were appropriate for Koreans aged 6 to 8 was less than 21.8 mm. The head width length of toothbrush which were appropriate for Koreans aged 6 to 8 was less than 8.4 mm. The bristle length of toothbrush which were appropriate for Koreans aged 6 to 8 was more than 5.7 mm. The handle length of toothbrush which were appropriate for Koreans aged 6 to 8 was more than 84.3 mm. 2. The head length of toothbrush which were appropriate for Koreans aged 9 to 11 was less than 20.4 mm. The head width length of toothbrush which were appropriate for Koreans aged 9 to 11 was less than 8.4 mm. The bristle length of toothbrush which were appropriate for Koreans aged 9 to 11 was more than 9.3 mm. The handle length of toothbrush which were appropriate for Koreans aged 9 to 11 was more than 95.2 mm. 3. The head length of toothbrush which were appropriate for Koreans aged over 12 was less than 25.5 mm. The head width length of toothbrush which were appropriate for Koreans aged over 12 was less than 8.6 mm. The bristle length of toothbrush which wee appropriate for Koreans aged over 12 was more than 9.6 mm. The handle length of toothbrush which were appropriate for Koreans aged over 12 was more than 101.1 mm. 4. Some toothbrush for children was not appropriate because of its big size, and toothbrush sells in Korea must be diversified for appropriate selection.

側面計測女兒顔貌構成要素의 6歲以後2年間變化에 關한 硏究

이영혜,文赫秀,白大日,金鍾培 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.2

The purpose of this study was to obtain data relating to the growth and developmental patterns of faces in Korean female students during two years after six years of age, which were necessary to design the models for estimating the growth and developmental patterns of faces. Since forty two cephalometric measurements representing lateral facial pattern were measured on the lateral radiograms of 210 six year old girls resding in yeon Cheon-Gun county, Kyungki-Do province in 1995, they were longitudinally measured each year until the year 1997. Accoriding to the profile classification criteria reported by Lee and Moon, the profile of 210 six year-old students were classified into seven profile groups. During the two years after six years of age since 1995, the changed forty two cephlometiic measurements representing the growth and development of lateral facial pattern were discussed respectively in the seven profile groups. The obtained conclusions were as follows: 1. Cd-Pog Cd-Gn Ar-LIE Ar-Id Go-LIE Go-LIE Go-Pog and Ba-Pog distances were continued to increase each year after six years of age in all female seven profile group(P<0.01). 2. UIE-UIA/Cd-Or UIE-UIA/PNS-ANS and UIA-UIE/N-A angles were continued to increase each year, but GoI-Me/UIA-UIE angles were continued to decrease each year after six years of age in all female seven profile groups(P<0.01). 3. Sixteen lateral facial pattern composing angle and twenty six lateral facial pattern composing distance had statistially significant differences among seven profile groups at each year. 4. The distance change of PNS-ANS and Sd-Id per 10㎜ per 2years per 10㎜ during 2years had statistically signficant differences among seven profile groups, unlike any other lateral facial pattern composing distance change per 10㎜ per 2years.

S-상 심실중격의 임상적 고찰

이동민,장경식,양종태,장대용,김종오,서영욱,고영엽,홍순표 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background: The sigmoid septum described an anatomical variation in the contour of the left ventricular outlet. It is related to degenerative change with aging. We observed clinical significance of sigmoid septum in Korean. Methods: Echocardiographic examination was performed in 434 patients. Sigmoid septum is defined as discrete bulging of the proximal interventricular septum with that thickness is greater than 1.3cm or the thickness is grater 1.5 times than adjacent mid interventricular septum in apical 3 chamber view. Result: The incidence of patient with sigmoid septum(septum patient) is 24.8% (male 8.4%, female 16.3%) . The incidence increases with age and is more common in women. The patients with sigmoid septum were compared with targeted groups, there was no significant difference in blood pressure between them, but in height and weight, the former were lower. (p<001, p<03). In the patients with sigmoid septum, weight and the surface area of a body have an opposite correlation with increase of age (p<03, r=-0.34) (p<04, r=-0.31) , but no decrease of height was found according to age increase (p=0.47, r=-0.11) The main reason patients with sigmoid septum ask echocardiolography and its clinical symptoms were abnormal results of previous electrocardiography and/or usual chest pain. Compared with control group, interventricular septal thickness is larger in septum patients (p<001). The thickness of interventricular septum located in subaortic left ventricular outflow tract is 1.6±0.3cm. There is another web like structure that continued from interventricualr septum to anterior free wall of left ventricle and the width is 1.6±0.4cm. A sign of insignificant obstruction due to left ventricular outflow was observed from three sigmoid septum patients. Conculusion: Septum patient is largely found in older age group and the body weight and body surface area are lower than control group. The body weight and body surface area are opposite correlation with age. So sigmoid septum is considered as structural change by weight reduction with aging. It is assumed that septum patients are related with asymptomatic ischemia because they have more abnormal ECG finding such as T wave inversion on precordial leads or standard leads, nonspecific ST-T change, LBBB etc. Sigmoid septum is not only proximal interventricular septal bludging but also another web like structure continuing to anterior wall of left ventricle.

Risperidone 조기 중단군 및 장기 유지군의 임상적 특성 비교

김광수,박원명,전태연,배치운,김대진,백인호,이철,김정수,한상익,최보문,장계호,고효진 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : Risperidone 투여후 조기 중단한 환자들과 장기적으로 계속 risperidone을 복용하고 있는 환자의 임상적 특성을 평가하고 나아가 risperidone장기 유지와 조기 중단의 요인을 분석하고 정신병리가 약물 투여에 미치는 영향을 조사하고자 하였다. 방 법 : 연구 대상자는 1996년 1월부터 1996년 12월까지 가톨릭대학교 의과대학 부속 8개 병원 정신과에서 risperidone을 투여 시작한 환자 580명중 DSM-IV기준에 의해 정신분열병으로 진단받고 투여 기간이 6개월 미만(조기 중단군)이거나 2년 이상(장기 유지군)을 경과하였으며 의무기록의 누락이 없는 210명을 선정하였다. 두 군간 임상적 특성을 조사하기 위하여 인구학적 변인, 정신병리학적 변인, 약물 투여기록 및 부작용 등을 과거 의무기록을 근거로 평가하였다. 결 과 : 대상환자 210명 중 조기 중단군이 67명(31.9%)이었고 장기 유지군은 143명(68.1%)이었으며 두 군간 인구학적 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 최대 용량은 유의한 차이가 없었으나 유지용량은 조기 중단군에서 4.49(±1.44)mg,장기 유지군에서 3.67(±1.50)mg으로 유의한 차이가 있었다(t=3.698, p<0.05). 또한, 이전 항정신병약물의 사용 기왕력 변인에서 조기 중단군은 기왕력이 없는 환자가 39명(58.2%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 27명(40.3%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 1명(1.5%)이었고, 장기 유지군은 기왕력이 없는 환자가 58명(40.6%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 77명(53.8%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 8명(5.6%)으로 유의한 차이가 있었다.(x²=6.559, df-=2, p<0.05). 결 론 : 본 연구결과에 의하면 가급적 환자 상태에 따라 낮은 최적 치료 용량을 투여하는 것이 장기잔의 투여를 바람직한 것으로 생각된다. 본 연구와 같은 대규모의 후향적 자연적 연구는 일반 실제 진료에서 risperidone의 효과 및 기타 다른 측면에서의 유용한 정보를 얻을 것으로 기대된다. Objective : This retrospective naturalistic study was designed to compare the clinical characteristics including psychopathology of two groups of patients, long-term maintenance group and short-term drop-out group, who were taking risperidone. Method : Datas were collected for 210 schizophrenic patients with complete medical records among 580 patients who were enrolled with risperidone administration from January 1996 to December 1996 in 8 affiliated hospital of the Catholic University. The short-term drop-out patients group were assigned to whom treatment period was less than 6 month, and the long-term maintained patients group, treatment period was more than 2 years. We assessed demographics, psychopathology, and other variables related with medication based on past medical records. Results : Among subjects of 210, short-term drop-out patients group were 67(31.9%) and long-term maintained patients group were 143(68.1%). Demographics and psychopathology were not significantly different between two groups. The stating and maximal dosage of risperidone was not significantly different between two groups but the maintenance dosage of risperidone was lower in long-term medicated patients group than short-term drop-out patients group(t=3.698, p<0.05). Additionally, the result of this study showed differences in experiences of past antipsychotic use as following. The number of no previous use of antipsychotic was 39(58.2%), the number of high potency amtipsychotic use was 27(40.3%), and the number of no previous use of antipsychotic was 58(40.6%), the number of high potency ntipsychotic use was 77(53.8%), the number of low potency antipsychotic use was8(5.6%) in long-term maintained group.(x²=6.559, df-=2, p<0.05). Conclusions : According to these results, administration of low therapeutic dosage should be recommended for long-term maintenance as if possible. Multi-center based retrospective naturalistic study like this would be useful for getting informations about efficacy and some other aspects of antipsychotic administration in practial field.

Hofmann 전이 반응을 이용한 N-(L-Aspartyl)-1,1-Diaminoethane의 합성

정대일,이용균,정일수,김윤영,김선영,박민수 東亞大學校 1998 東亞論叢 Vol.35 No.-

Some retroisomeric peptide showed an agonistic or antagonistic effect of the parent peptides. So the studies on their synthesis and their structure-activity relationship are currently being investigated. In general, the synthesis of the retroisomeric peptide required N,N'-diacylated gem-diamino compound as an important synthetic intermediate, in which those diacylated group could be removed selectively in different condition. In connection with the development of facile synthetic method for retroisomeric peptide, we tried the synthesis of N-benzoyl-1. l-diaminoethane, intermediate of 1, 1-diaminoethane based Sweetener, from N-benzoyl alanine aimde 28 using improved Hofmann rearrangement as a key step. In this procedure, the N-benzoyl-N'-Cbz-1,1-diaminoethane 29 could be prepared in high yield without any bypreducts. And also this compound was converted to N-benzoyl-1, 1-diaminoethane 30 by hydrogenolysis successfully. From the above result, this method thought to be very convenient synthetic method for these N-acyl-l, l-diamino typed compounds, a intermediate of retroisomeric peptides. And also β-benzyl aspartate, another intermediate of these sweetener, could be prepared from aspartic acid via dibenzylation and selective hydrolysis.

전수면박탈이 정상 성인남자의 인지기능에 미치는 효과

김수용,이성필,김대진,이흥표,고효진 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 본 연구는 36시간 수면박탈 후, 수면박탈이 뇌의 인지기능에 미치는 영향력을 알아보고 또한 수면박탈로 인해 뇌의 어느 영역이 가장 큰 영향을 받는지를 알아보고자 하였다. 방 법 : 18명의 건강한 20대 남자를 대상으로 36시간 동안 수면 박탈을 시행하였으며, 수면박탈 전후에 Luria-Nebraska 신경심리 검사 및 K-WAIS의 산수와 숫자 외우기를 시행하였다. 결 과 : Luria-Nebraska 신경심리 검사상 주의지속력 및 촉각, 시각, 읽기, 쓰기, 산수 및 지적 과정에는 수면박탈의 영향력이 없었으나 운동, 리듬, 수용성 언어, 표현성 언어, 기억력, 복잡한 언어적 산술력은 수면박탈 후 저하되었다. 운동 기능은 속도지연이 많았으며, 복잡한 자의적 운동과 선택적 운동의 실패율이 높았다. 언어 수용력과 표현력의 저하는 주로 운반구 전측 기능과 관련된 논리적이고 문법적인 구조의 이해, 자발적 언어, 유창성, 문법적으로 정확한 단어의 구사의 문자의 정열에서 발생하였다. 또한 국제화 척도에서도 우반구 전두엽 및 측두엽 척도에서 실패율이 높았다. 결 론 : 이상의 결과는 수면박탈이 인지기능을 저하시키며, 특히 운반구 전측 영역이나 피질하 영역과 관련된 인지기능을 저하시킬 가능성이 높음을 시사한다. Objectives : This study carried out to evaluate the effect of acute sleep deprivation of 36 hours on cognitive functions, and investigate which region of brain would dysfunction by sleep deprivation. Methods : We carried out sleep deprivation in the 18 healthy and right handed males in their 20's. We also administered to them Luria- Nebraska Neuropsychological Battery and Calculation and Digit Span task of K-WAIS in order to examine cognitive functions before and after sleep deprivations. Results : There were no difference in freedom from distractability, tactile function, visual function, reading, writing, calculation, and intellectual process function. However, motor function, rhythm, receptive speech, expressive speech, memory, and complex verbal arithmetic function decreased after sleep deprivation. In motor function, delayed speed and high fail rate in complex forms of praxis and selectivity of motor acts were observed. In area of receptive speech and expressive speech, understanding of logical and grammatical structure, spontaneous speech, sequencing and filling in items which are grammatically accurate decreased. All these functions related with dysfunction in right hemisphere anterior region. Also in localization scales, the fail rates of right frontal dysfunction scale and right temporal dysfunction scale increased after deprivation. Conclusion : From these results, we suggest that sleep deprivation has negative effect on the cognitive functions. Especially, sleep deprivation might be associated with dysfunction of anterior region in right hemisphere or subcortical dysfunction.

유전알고리즘을 이용한 배전손실 최소화에 관한 연구

최대섭,이상일,오금곤,정수복,김창석 조선대학교 에너지.자원신기술연구소 2001 에너지·자원신기술연구소 논문지 Vol.23 No.2

This paper presents a new method which applies a genetic algorithm(GA) for determining which sectionalizing switch to operate in order to solve the distribution system loss minimization re-configuration problem. The distribution system loss minimization re-configuration problem is in essence a 0-1 planning problem which means that for typical system scales the number of combinations requiring searches becomes extremely large. In order to deal with this problem, a new approach which applies a GA was presented. Briefly, GA are a type of random number search method, however, they incorporate a multi-point search feature. Further, every point is not is not separately and respectively renewed, therefore, if parallel processing is applied, we can expect a fast solution algorithm to result.

방사선 조사가 폴리에틸렌의 광학적 성질에 미치는 영향

邊大鉉,李秀浣 弘益大學校 1981 弘大論叢 Vol.13 No.-

Thermoluminescence (TL) and thermally stimulated current (TSC) during warming have been found in previously oxidized polyethylene after γ-irradiation in air at room temperature. In high density polyethylene (HDPE), TL and TSC peaks appear at about 320K and 380K. It appears that the presence of crystallites is essential for an appearance of the 380K peak the carbonyl group also contributes to the 380K peak. It may be assumed that the 320 peak is originats from the vinyl radical unsaturation bond. From TSC measurements, the activation energy for 320K and 380K peaks are 0.86eV and 0.98eV, respectively. Ⅰ. 서론(Introduction) Ⅱ. 실험기구 및 방법(Experimental Apparatus and Measurements) Ⅲ. 실험결과 및 논의(Discusing of Results) Ⅳ. 결론(Conclusion) Thermoluminescence (TL) and thermally stimulated current (TSC) during warming have been found in previously oxidized polyethylene after γ-irradiation in air at room temperature. In high density polyethylene (HDPE), TL and TSC peaks appear at about 320K and 380K. It appears that the presence of crystallites is essential for an appearance of the 380K peak the carbonyl group also contributes to the 380K peak. It may be assumed that the 320 peak is originats from the vinyl radical unsaturation bond. From TSC measurements, the activation energy for 320K and 380K peaks are 0.86eV and 0.98eV, respectively.