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이대성,이정현,박재선,김미향 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3
Aplastic anemia following acute hepatitis with or without acute hepatic failure is an uncommon and known to have a poor prognosis. We experienced a case of aplastic anemia following acute hepatic failure in a 13 year-old boy. He had been admitted because of jaundice and lethargy for 2 weeks and clinical findings of acute fulminant hepatitis. Serum studies for antibodies and antigens related to hepatitis A, B, C viruses and cytomegalovirus, Ebstein-Barr virus, and, parvovirus B19 were negative. He had been recovered and discharged. He was readmitted because of lethargy and stuporous mentality 5 months later. Laboratory finding showed pancytopenia in peripheral blood smear and hypocellularity of all hematopoietic elements in bone marrow biopsy. Patient had been treated by s teroid and oxymetholone for a month before he died of sepsis
추간공 경유 경막외 차단술 환자의 합병증에 대한 조사 연구
최선주,배성열,서성화,김상대,김세훈,박정율 대한척추신경외과학회 2004 Neurospine Vol.1 No.1
Objective: To study on the incidence of complications from C-arm guided lumbar transforarninal epidural injections in patients with radiculopathy caused by either lumbar spinal stenosis or herniated intervertebral disc. Materials & Methods: A total of 1200 patients with back/leg pain for more 3 months and received therapeutic injections in recent 1-year period was evaluated. All procedures were performed by one neurosurgeon with careful monitoring by nursing staffs during and after the procedures. Two party observers reviewed medical charts including immediate postprocedure complications using standardized questionnaire. Results: Average 1.9 injections per patient were done. Complications per injection seen included 12 transient headaches (0.9%), 5 increased back pain(0.4%), 4 increased leg pain(0.3%), 4 facial flushing(0.3%), 2 increased blood sugar in an insulin-dependent diabetic(0.2%), I vasovagal reaction(0.08%), and I hypertension(0.08%). All of these complications resolved within several hours to 2 weeks and there were no need for further specific management. There were no major or permanent complications. The incidence of minor complications was 2.3% per injection. All reactions resolved without morbidity. Conclusion: Although effectiveness varies with different pathologies, the C-arm guided lumbar transforaminal epidural injection seems to be a safe and effective procedure for these patients when carefully performed and closely observed with appropriate nursing care.
Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구
강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.
물-공기 계면에서 긴 사슬 양 말단 작용기 분자인 α,ω-13,16-Dimethyloctacosanedioate Dimethylester(C_30DME)의 거동에 관한 연구
이정근,손대원,이관수,송석호,김현명,정선호 한양대학교 자연과학연구소 2001 自然科學論文集 Vol.20 No.-
물-공기 계면에서 표면압력의 증가에 따른 C30DME 분자의 구조 변화를 살펴보았다. 표면압력(π)-표면적(A) 등온선을 통해 표면적이 줄어들 때 C30DME 분자가 선형으로부터 역 U 자형 구조로 변하는 것을 확인하였다. C30DME의 역 U 자형 구조의 형성을 확인하기 위하여 Surface Plasmon Resonance (SPR)와 ellipsometry를 이용하여 Langmuir-Blodgett (LB) film 의 두께를 측정하였고 이 두께는 C30DME 분자의 역 U 자형 구조의 높이와 일치함을 관찰하였다. 또한 Atomic Force Microscope (AFM)을 이용한 표면 거침도 측정의 결과는 선형으로부터 역 U자형 구조로의 구조적 변화가 불연속이라는 것을 보여주었다. We investigated the conformational change of C30DME molecule with an increase on surface pressure at the air-water interface. The surface pressure (π)-area (A) isotherm indicates that the structure of C30DME changed from linear to reverse U-shape as the surface area was compressed. In order to confirm the formation of reverse U-shape, we examined the thickness of Langmuir-Blodgett (LB) film by a surface plasmon resonance (SPR) and an ellipsometry. The result of surface roughness measurement using an atomic force microscope (AFM) showed that the conformational change from linear to reverse U-shape is discontinuous.