브로콜리 추출물의 향장활성 효과

김대용ㆍ조석철ㆍ권혁선ㆍ김미경(Dae Young KimㆍSeok chul ChoㆍHyuk sun KwonㆍMee Kyung Kim) 한국인체미용예술학회 2016 한국인체미용예술학회지 Vol.17 No.1

In this study, we investigated the anti-oxidative effects, antimicrobial, and anti-inflammatory activities of the extracts from broccoli to evaluate its use as a functional ingredient in cosmetics. The extracts are WE (water extract at RT), MWE (mineral water extract at RT), EE (70% ethanol extract at RT), and USEE (heat process for 12 hours at 60℃ after ultrasonification for six hours with 70% ethanol). The measurements of the total polyphenol content from broccoli extracts were highest in EE at 425.24±13.9 mg/g dry. The result of electron donating ability of EE was the highest at 10,000 ㎍/㎖ as 97.81% and increased in a concentration-dependent manner. The ferric reducing antioxidant powder (FRAP) of EE was the highest at 10,000 ㎍/㎖ as 1235.6 μM. In an antimicrobial activity test, the EE showed significant antimicrobial activity against S. epidermidis, S. aureus, E. coli, P. acnes, and P. ovale. Furthermore, broccoli extract exhibited no cytotoxicity in RAW 264.7 cells. Also anti- inflammatory activity by NO assay showed LPS-induced NO was significantly inhibited following treatment with EE of 1,000 ㎍/㎖. Therefore, the broccoli ethanol extract can be used as a resource of natural cosmetic material for functional cosmetics.

십이지장궤양 환자의 정신신체의학적 특성 : 감정표현불능증을 중심으로 Focused on Alexithymia

김대혁,임효덕,김성국 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

본 연구는 감정표현불능증의 특성에 초점을 두고 십이지장궤양의 정신신체의학적 특성을 알아보고자 십이지장궤양 환자 30명과 대조군으로 정신분열증환자 30명, 신경증환자 33명, 정상군 30명, 총 123명을 대상으로 자기보고형 척도 4가지, 관찰평가척도 1가지 , 투사적 검사기법 1가지 등, 모두 6가지의 검사를 시행하였다. 전체적으로 볼 때 MMPI와 SCL-90-R은 신경증군, 정신분열증군, 십이지장궤양군, 정상군과 같은 순서로 척도별 점수가 높게 나타나 각 군의 특성이 뚜렷이 구분되었으며 모두 정상 범위에 들었다. 십이지장궤양환자들은 MMPI에서 건강염려증, 우울증, 히스테리, 강박증 등의 인격특성이 정상인들보다 유의하게 더 높은 것을 나타났고(p<0.05), SCL-90-R에서는 신체화 증상이 정상인들보다 유의하게 더 높았다(p<0.05). BIQ점수는 십이지장궤양군에서 다른 군들에 비해 매우 증가된 소견을 보였고 정상군보다 유의하게 높았다(p<0.05). MMPI-A와 TAS검사에서는 네 군간에 통계적으로 유의한 차이가 없었다. 또한 전체 TAS 평균점수는 감정표현불능증의 절단점인 74점 이상으로 나온 군이 하나도 없었다. 9장의 TAT카드 모두에 대한 전체단어량은 정상군에서 다른 군에 비해 유의하게 높았으며 드 다음은 신경증군, 정신분열증군이었고 십이지장궤양군은 가장 낮게 나타났다(p<0.05). 정동단어량은 신경증군, 십이지장궤양군, 정상군, 정신분열증군의 순서로 높게 나타나 일관성이 없었다. 9장의 TAT카드 각각에 대한 정동단어량은 카드 2,4,16,19에서 네 군간에 유의한 차이를 나타내었으며 이 4가지 카드 모두 신경증군에서 가장 높은 점수를 보였다. 이상과 같이 BIQ검사와 TAT의 전체단어량 검사에서는 십이지장궤양군이 다른 군들보다 유의하게 감정표현불능증 경향이 높은 것으로 나타나 이 두가지 검사도구는 감정표현불능증의 평가에 어느 정도 유용한 것으로 보인다. 하지만 TAS 검사와 MMPI-A, TAT의 정동단어량 검사에서는 네 군간에 유의한 차이가 나타나지 않고 각 군들이 뚜렷이 구분되지 않아 감정표현불능증에 대한 평가결과가 일관되게 나타나지 않았다. 따라서 감정표현불능증을 정신신체질환의 고유한 특성으로 보았던 가정은 본 연구의 결과로는 명확한 검증이 어려웠다. 하지만 기존의 연구들을 토대로 할 때 본 연구결과는 감정표현불능증이 감정의 상징화와 조절에 대한 자아의 결손으로서 신경증 등의 정신병리와는 독립된 특성이지만 정신신체질환에만 국한되지 않고 여러 정신질환군에서 혼재되어 나타날 수 있다는 최근의 견해를 어느 정도 반영하고 있는 것으로 볼 수 있을 것이다. 끝으로 이러한 소견들에 대해 먼저 본 연구에서 사용된 평가도구들이 한국에서의 신뢰도 및 타당도가 불명확하다는 점과 연구 대상의 수가 적고 십이지장궤양 하나만으로 전체 정신신체질환을 대표하기에는 부족하다는 점, 외국사람을 대상으로 만들어진 척도의 국내 적용에 있어서 한국인의 문화적, 정서적 차이를 충분히 반영하지 못했던 점 등이 한계로서 고려될 수 있다. 향후 정신신체질환과 감정표현불능증의 관계에 대해 본 연구의 한계점을 보완한 다양한 연구가 계속되어야 할 것이다. Objectives : The purpose of this study was to evaluate the psychosomatic characteristics, especially focusing on alexithymia, the latest issue in psychosomatic medicine, in patients with duodenal ulcers compared with other control groups. Methods : The study subjects consisted of duodenal ulcer group(N=30), schizophrenia group(N=30), neurosis group(N=33) and normal healthy group(N=30). All the subjects completed six psychological tests, including four self-reporting scales(MMPI, SCL-90-R, MMPI-A and TAS), one observer-rated questionnaire(BIQ) and one projective test(TAT), as well as psychiatric interview. Results : All the groups were in the normal range of the scores of MMPI and SCL-90-R. And the decreasing orders of severity were shown by neurosis, schizophrenia, duodenal ulcer and normal healthy group, and all the groups were clearly distinguished by both inventories. On the MMPI and SCL-90-R scales, the duodenal ulcer group showed significantly higher scores in the hypochondriasis, depression, hysteria, psychasthenia and somatization subscales, compared with the normal control(p<0.05). On the BIQ, the duodenal ulcer group showed significantly higher mean score, compared with the other control groups(p<0.05). All the mean scores of the MMPI-A and total TAS were, however, below the alexithymic level and had no significant differences among the four subject groups. The total word count combined from nine TAT cards showed significant differences among the four subject groups(p<0.0001). The normal control group scored the highest in total word count among all the groups. On the contrary, the duodenal ulcer group showed the lowest score and it was significantly lower than in the normal group(p<0.05). The neurosis group scored the highest, while the duodenal ulcer group had no significant differences compared with the rest of the groups, in the affective word count combined from nine TAT cards. Conclusion : First of all, there are significant tendencies of hypochondriasis, depression, hysteria, psychasthenia and somatization in BIQ and total word count of TAT may be useful in evaluating alexithymic trait in psychosomatic patients compared with normal healthy people and other psychiatric patients. Thirdly, the assumption that alexithymia is the unique personality trait of the classical psychosomatic diseases can't be confirmed because of inconsist results in this study. Fourth, these inconsistent results may be related to a recent opinion that there is considerable variation in the prevalence of the alexithymic trait among different psychiatric diseases as well as psychosomatic diseases, and that alexithymia may coexist with, but may be independent from, neurotic psychopathology. Finally, further studies are required to clarify the impact of alexithymia on various psychosomatic diseases in the context of biopsychosocial approach.

벡터기반 주파수 예약 알고리듬

김대수,장혁수 明知大學校 産業技術硏究所 2000 産業技術硏究所論文集 Vol.19 No.-

핸드오프가 빈번히 발생하는 마이크로 셀룰러 시스템에서 제한된 주파수 자원을 보다 효율적으로 사용하고자 하는 알고리듬들이 제안되어 왔으나 핸드오프를 위해 사용자의 실제 이동 방향에 관계없이 주위 셀 모두의 핸드오프 용 주파수를 예약하는 방식이 주로 사용되었고 그것은 주파수 자원의 낭비를 초래하여 왔다. 본 논문은 사용자의 이동 방향 및 속도가 고려된 벡터 파라미터를 사용하여 실제 이동 방향과 관계 있는 셀에 대해서만 핸드오프 용 주파수를 예약하는 방식을 제안하고 성능분석을 통하여 주파수 자원을 절약할 수 있음을 보여준다.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

광섬유를 이용한 고감도 압력센서의 개발

김창원,권대혁,김진섭,이정희,손병기 경북대학교 센서기술연구소 1995 연차보고서 Vol.1995 No.-

KOH 수용액을 이용하여 실리콘 식각공정기술을 확립하였으며, 이를 이용하여 실리콘 기판 위에 스트레스 균형이 이루어진 150 ㎚-Si_3N_4/300 ㎚-SiO_2/150 ㎚-Si_3N_4 두께를 가지는 구조의 평탄한 3층 유전체 멤브레인을 제작하였다. 본 실험에서 사용되는 파장인 1.3 ㎛ 근방에서 다이아프레임의 광투과도는 약 50 %로 광반사막으로 사용이 불가능하였다. 따라서, 다이아프레임 뒷면에 약 1000 Å의 금을 증착하여 N/O/N/Au박막의 광투과도를 수 %정도로 감소시킴으로써, 센서의 광반사막으로 사용할 수 있었다. source fiber를 단일모드로 했을 때 다이아프레임의 크기에 따라 감도는 각각 0.52㎻/torr(3×3 ㎟), 0.65 ㎻/torr(4×4 ㎟), 0.77 ㎻/torr(5×5 ㎟)였다. 광손실을 최소화하기 위해 광전송용 다모드 광섬유를 사용하였을 때는, 2×2 ㎟의 다이아프레임의 크기에 대해 0∼800 torr의 넓은 측정범위에서 거의 선형적인 압력특성을 나타내었다. Using KOH solution, silicon etching technology has been established and stress-balanced flat 600 ㎚ thick triple dielectric membrane(150 ㎚-Si_3N_4/300 ㎚-SiO_2/150 ㎚-Si_3N_4) on silicon substrate has been fabricated. At the wavelength of the sensor light source near 1.3 ㎛, the optical transmittance of the diaphragm was about 50 %, it was impossible to be used as a reflecting film. To decrease to a few percents, the back-side of the diaphragm was deposited 1,000 Å thick gold layer, which is sufficient enough to be used as a light reflection layer of the sensor. When was used 8/126 ㎛ single-mode fiber, the respective sensitivities for diaphragm size were 0.52 ㎻/torr(3×3 ㎟), 0.65 ㎻/torr(4×4 ㎟), 0.77 ㎻/torr(5×5 ㎟). When was used 62/126 ㎛ multi-mode fiber for the light transmission to minimize optical loss, the pressure characteristics was showed almost linearly curve in a wide pressure range, 0 torr∼800 torr, for the 2×2 ㎟ diaphragm in dimensions.

인트라넷에서 멀티미디어 생방송 서비스를 제공하기 위한 효율적인 멀티캐스트 알고리즘

김대수,장혁수 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

Many of the multicast applications such as video broadcasts and teleconferencing need to support dynamic multicast sessions wherein the membership of the multicast group changes with time. Most existing multicast servers require layer 3 or layer 4 switches to support dynamic multicast sessions, thou호 the switches are not affordable to the small and medium size organizations such as colleges. In this paper, we propose and algorithm to provide live multimedia service without the switches.

자궁외 임신의 임상적 고찰

김대중,박성훈,정혁 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background : This study is a clinical evaluation and statistical analysis on the cases of ectopic pregnancies who were surgically treated and histopathologically confirmed at the department of obstetrics and gynecology at Chosun university from January, 1995 to October, 1999. Results : 1. The hospital incidence of ectopic pregnancy was 1 in 10 deliveries and the most frequently age group was in 30~34 years of ages(33.3%). 2. Nulligravida was in 22.2% and the percentage of cases who had 1, 2, and 3 or more artificial abortion were in 30.0%, 19.8%, and 28.0% respectively and nullipara was in 35.4% and the percentage of cases who had 1, 2, and 3 or more deliveries were in 26.3%, 24.7%, and 13.6% respectively. 3. A previous history of appendectomy was in 12.3% and other abdominal surgeries were in 17.4%, pelvic inflammatory disease in 5.8%. 4. On symptomatology skipped menses was observed in 87.2%, lower abdominal pain in 86.0%, and bloody vainal discharge in 60.9%. 5. The mean duration from the first day of the last menstrual period to the date of operation was about 7 weeks. 6. The urine pregnancy test was positive in 75.5% and culdocentesis in 94.2%, Average serum β -hCG(human chorionic gonadotropin) level was about 3,200mIU/mL. 7. The most common site of ectopic pregnancy was salpinx in 91.7%. In the cases of tubal pregnancy, the lesion was most commonly located at the ampulla portion(82.3%) and ruptured tubal pregnancies were in 54.3%. 8. The amount of intraperitoneal free blood was 101~500ml in 29.2%, 501~1000mL in 31.3% and 1001~2000mL in 26.4%.91. Other abnormal pelvic conditions were noted in 30.5% and adhesion was in 13.6%. 10. The operative procedures were salpingectomy in 80.7%, salpingo-oophorectomy in 6.5%, corneal resection in 6.2%, and were laparoscopic operation in 24.3%, laparotomy in 75.7%. 11. There was no fatal case in 243 ectopic pregnancy.

PDA 밸브에 의한 연소실내의 연소특성에 관한 연구

김대열,한영출,조재명,김양술,주신혁,박병완 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-

An experimental study presents characteristics of combustion in a combustion chamber by port deactivation valve for economy and emissions standards. In order to use combustion properties data, it is necessary to build some data base, which use cylinder pressure sensor, etc. Port deactivation valve has been developed to satisfy requirement of achieving sufficient swirl generation to improve the combustion. A feasibility and necessity of combustion pressure based cylinder spark timing control has been examined. So, this was obtained the Coefficient of Variation(COV) and the mass-burned(MFB). The characteristics of pressure ratio fraction is similar to that of mass-burned fraction. Using the results of the test, the effects of the combustion chamber can be improved combustion stability by port deactivation.

기업물류경쟁력확보를 위한 물류용기 풀시스템 도입성과 분석

김대기,김상철,김정혁 한국로지스틱스학회 2002 로지스틱스연구 Vol.10 No.1

본 연구의 목적은 물류용기 풀시스템 도입효과에 대한 이론적이고도 계량적인 근거를 제시함으로써 기존의 물류용기 사용 관행에서 오는 낭비요인을 찾아 제거하고, 이를 통해 물류표준화 및 공동화의 필요성을 강조하고자 함에 있다. 물류용기표준화 및 공동화의 도입효과를 분석하기 위하여, 국내의 한 완성 차 업계의 실 데이터를 이용한 Box Pool System 시뮬레이션 모델을 구축하였다. 평균 상차시간, box 보유량, 평균 box 체류시간 등의 성과척도를 중심으로 BPS도입효과를 분석한 결과, 평균 상차시간은 62%, 시스템 내 box 체류시간은 38% 감소하였으며, 기존의 약 1/3수준의 box보유만으로도 시스템을 효율적으로 운영할 수 있다는 긍정적인 결론을 도출하였다. 즉, 물류용기 표준화 및 공동화 작업은 물류비용절감과 물류서비스 개선을 통한 기업물류경쟁력 확보의 가장 기초적이고도 필수적인 조건이다. The purpose of the study is to provide theoretical and qualitative grounds to the introduction of container pool system. By finding our and eliminating wastes from our everyday routine practices, we emphasize the importance of joint utilization and standardization of containers. In order to qualitatively measure the effects of joint utilization and standardization of containers, we constructed BPS : 62% reduction in average loading time, 38% reduction in system queue time, and 68% reduction in box inventories in the system. That is, standardization and joint utilization of containers is the most fundamental and requisite condition to secure business logistics competitiveness, which is realized by logistics cost reduction as well as logistics service improvement.

재발한 지주막하 포도낭미충증의 Albendazole 치험 1예

김성범,박대원,이재갑,정혜원,송준영,손장욱,김민자,박승철,제보경,김정혁,이진수 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

뇌실이나 뇌기조에 발생하는 포도낭미충증은 매우 드물며 유구조충 유충의 머리부분이 변성되면서 발생하는 낭성 막의 비정상적인 성장을 특징으로 한다. 이러한 유형의 병변은 지름술 후에도 진행적인 경과를 보이며 아직까지 항기생충제를 이용한 치료 사례들이 적고, 따라서 가장 적절한 치료 기간도 알려져 있지 않다. 본 증례 보고는 재발한 실비우스 틈새의 포도낭미충증 환자에서 4주간의 albendazole과 스테로이드로 효과적으로 치료하였던 예이다. 환자는 praziquantel과 뇌복막지름술로 치료를 받고도 포도상의 뇌실질외형의 병변이 악화되어, 뇌척수액 투과가 좋은 것으로 알려진 albendazole로 치료제를 바꾼 뒤 병변의 수와 크기가 감소였으며 이후 2년 간의 추척기간동안 다른 발작 없이 잘 지내고 있다. 지주막하의 포도낭미충증은 albendazole과 corticosteroid 치료에 잘 반응하는 것으로 보인다. The so-called racemose cysticercosis, a rare variety of neurocysticercosis occurring in ventricles or basal cisterns, is characterized by abnormal growth of cystic membranes with degeneration of Taenia solium heads (scolex). Although lesions of this type are known to follow a progressive course even after ventricular shunting, there are limitations of case series treated with antiparasitic drugs, and the optimal duration of the treatment is not yet known. We report a case of relapsed racemose cysticercosis in the Sylvian fissure, who has been successfully treated with albendazole and adjunct corticosteroid for 4 weeks. The patient had been previously treated with praziquantel and ventricul-operitoneal shunt, and maintained on the anticonvulsant drug for one year, but returned to the hospital due to seizure recurrence. The patient has been well in seizure-free state for the follow-up 2 years after albendazole therapy. The subarachnoid racemose cysticercosis seems to respond well to treatment of corticosteroid along with prolonged albendazole.