Toluene, Xylene, Trichloroethylene 투여가 흰쥐의 시상하부와 뇌하수체의 GnRH, GnRH Receptor, Pit-1 유전자 발현에 미치는 영향

기노석,이종태,강대성,김대환,이채관,이헌,전진호,김정호,이채언 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

The workplace exposure of chemicals has steadily increased, therefore the concern for subsequent effect on reproductive outcome has been an important issue in occupational medicine. In previous studies, higher rates of spontaneous abortion, reduced fertility and menstrual disorder among women, and an impairement of sperm quantity and quality among men have been associated with a wide variety of chemical agents. This study was conducted to evaluate the effects of toluene, xylene and trichloroethylene(TCE) injection on the mRNA levels of GnRH, GnRH receptor and Pit-1 genes in male rats hypothalamus and pituitary and the effects on the plasma levels of FSH, LH, prolactin and testosterone. Sprague-Dawley male rats were divided into five groups of five each according to concentration of toluene, xylene and TCE. The rats were injected subcutaneously to 0, 50, 100, 200, 400 mg/kg body weight/day of toluene, xylene and TCE, respectively for 6 days. Rat brains were excised and hypothalamus and pituitary were separated. Reverse transcription-polymerase chain reaction (RT-PCR) and RNase protection assay(RPA) were used to evaluate the GnRH, GnRH receptor and Pit-1 mRNA levels. Plasma concentrations of FSH, LH, prolactin and testosterone were assayed by radioimmunoassay(RIA). The results were as follows; 1. GnRH, GnRH receptor and Pit-1 mRNA levels in toluene and xylene injected groups, and GnRH receptor mRNA levels in TCE injected group were lowered dose-dependently. Especially, GnRH receptor and Pit-1 mRNA levels in 200mg/kg of toluene injected group, and GnRH, GnRH receptor and Pit-1 mRNA levels in 400mg/kg of toluene injected group were significantly lower than control group (p<0.05). GnRH receptor and Pit-1 mRNA levels in 400mg/kg of xylene injected group, and GnRH receptor mRNA levels in 400mg/kg of TCE injected group were significantly lower than control group(p<0.05). 2. The plasma levels of prolactin and testosterone in 400mg/kg of toluene injected group, and LH in 100, 200 and 400mg/kg of xylene injected group, and testosterone in 400 mg/kg of TCE injected group were significantly lower than control group(p<0.05). In conclusion, we speculated that toluene and xylene affected reproductive system secondarily through hypothalamus-pituitary axis, and TCE affected directly through steroidogenesis. And we recommended that further study for assessment of the reproductive toxicity of mixed organic solvent exposures should be conducted.

내장형 시스템을 위한 재목적 링킹 로더

李大憲,禹德均,表昌祐 弘益大學校 科學技術硏究所 2000 科學技術硏究論文集 Vol.11 No.-

In a development environment for embedded system with a connection between host and target system, the linking loader of host system links the cross-compiled object file and a modules of target system and downloads the linked object file to the target system. In this research, we separate this linking loader into the module dependent on object file format and the module independent on object file format. The dependent module gets the linking information independent of file format from the object file, and the independent module actually does the linking process with this linking information. We implemented the dependent module by using BFD library of GNU development environment, and this implementation can improve the portability of our linking loader for a new target system or object file format. Currently, we developed this linking loader in the embedded system development environment ESTO to be prepared for a commercial product.

5일 보존용 채혈백에 따른 보존일자별 농축혈소판의 생화학 및 성상 분석

이동범,유태종,김태전,김승곤,신종관,양대형,고광임,박성훈 임상병리검사과학회 2002 임상병리검사과학회지 Vol.34 No.2

Biochemical changes and icon of platelets on platelet concentrates preserved for a 5day term in several plastic containers were investigated. The authors evaluated the TOTM-PVC second generation container produced by Green Cross Medical Corp. and Boin medica. Blood obtained from 40 persons was manufactured for platelet concentrates within 4 hours and each divided into 20 units of platelet concentrations. Samples were taken at 0, 3, and 5days and the platelet count, pH, pO_(2), pCO_(2), HCO_(3)-, glucose, LDH, lactate, electrolytes, and mineral element were tested The number and MPV, for platelets icon, were well preserved on two different platelet concentrates during storage. A test for biochemical function appeared to be effective data. pH was maintained above 6.8 on two different platelet concentrates during storage. The results suggest that the TOTM-PVC second generation platelets storage container produced by Green Cross Medical Corp. and Boin medica was able to preserve platelets for at least five days without lesion and was it concluded to have biochemical efficacy on patients with transfusions.

르 꼬르뷔지에의 건축에 있어서 '기본 볼륨의 가치'에 관한 고찰

이은석,조대희,김종헌 慶熙大學校 1997 論文集 Vol.26 No.-

Making a simple form in architecture has been a major concern of modern architects. Such tendency has been shown explicitly in the works of Le Corbusier, who was one of the most influencing architects in modern age. This study aims to find how Le Corbusier came to find out the value of the primary volume, and also what importance the houses of his early works carry. Further more, this study examines the value of the inner space, which is defined by the simple cubic outer shape. The result of this study reveals the inadequate view which argues that the simplicity of modern architecture was derived only from the functionalism.

시간축이동법을 이용한 발전기 보수유지계획의 수립에 관한 연구

이동인,김영훈,이광식,도대호 嶺南大學校 工業技術硏究所 1993 工業技術硏究所論文集 Vol.21 No.2

The proper resource allocation is a very important topic in power system problems, especially in operation and planning. One of such problems is optimal maintenance in operation and planning. The least cost should be the subject to be pursued in this study. A simulation model of a probablistic operation which is called cumulant method, is applied to the problem of optimal maintenance scheduling. A new technique called time axis shift method is developed. This method is similar to dynamic programming successive approximation.

2차 통계량을 이용한 도래 방향 추정 알고리즘의 성능평가

이민혁,노현민,정대훈,장은영,변건식 東亞大學校附設情報技術硏究所 2005 情報技術硏究所論文誌 Vol.12 No.2

it is needed high quality and big capacity according to fast supply of mobile communication medium. Therefore, adaptive array antenna is actively studied to supply demand. DOA(Direction of Arrival) estimation is important position in adaptive array antenna. The purpose of this paper is to estimate DOA. and compare with the existing algorithm.

생약추출물 섭취와 운동이 비만 Zucker 쥐의 혈청 IGF-1/IGFBP-3 수준에 미치는 영향

이헌규,조인호,양대승 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

The purpose of this study was the investigation of the effect of embro and regular exercise on blood glucose. insulin and IGF-1 and IGFBP-3(Insulin Like Growth Factor Binding Protein) level against obese zucker ratfa/fa. In general. IGF-Ⅰ play important role in the regulation somatic growth. metabolism. cellular proliferation/differentiation. With insulin, IGF-Ⅰ is another regulation factor for blood glucose concentration. For this study, obese zucker rats(n=21) were divided into three group: the control(no exercise, CON, n=7), embro group(no exercise but supplement embro, emb개, n=7). and embro+exercise(n=7). Animals in exercise group were run on treadmill for 12week (5day/week^(-1), 1h^(-1)/day^(-1), 20m/min^(-1) speed). After 12 week, All animals (CON and EX) were anesthetized by sodium pentobarbital and blood was extracted and frozen for further analysis. Plasma glucose and insulin concentration were significantly decreased in embro and embro+ exercise than CON(P<.05). and Blood IGF and IGFBP-3 level were significantly increased in embro and embro+ exercise group(P<.05). Thus. These results suggest that embro and regular exercise may has protective effect in insulin resistance by controlling blood glucose and increasing IGF-1/ IGFBP-3 in obese zucker rat.

[논문]스트렷-타이 모델에 의한 사각형 단면 코벨의 설계 기법

김대성,김태완,이승훈,엄장섭,진치섭 釜山大學校生産技術硏究所 2004 生産技術硏究所論文集 Vol.63 No.-

콘크리트 코벨은 D-영역을 갖는 대표적인 구조물로서 복잡하고 다양한 형상의 파괴메커니즘을 보인다. 이는 응력집중과 기하학적인 불연속으로 일반적인 보 이론의 적용이 불가능하여 해석 및 설계에 어려움이 많다. 본 연구에서는 지압파괴,압축파괴 및 전단파괴를 유발하는 복잡한 파괴메커니즘을 형성하고 있는 사각형 단면 코벨의 거동 및 파괴형상을 예측하고 스트릿-타이 모텔을 적용하여 해석 및 설계를 하였다. 또한 현행의 설계방법과의 비교를 통하여 스트렷-타이 모델이 보다 합리적이고 경제적인 설계방법임을 보였다.

Junctional Rhythm을 보인 한국형 출혈열 1례

이성원,이수훈,최대현,손영기,차광수,손춘희,정원태,김성은,김종성 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

초인지 수업 모형이 자기장 개념 형성에 미치는 효과

이희정,강대훈,백성혜 한국초등과학교육학회 2003 초등과학교육 Vol.22 No.2

The objective of this research was to study the impact of metacognitive lesson models on the formation of magnetic field concepts. The subjects of this research was eighty students from two sixth grade classes. One class of forty of these students was the experimental group, which the metacognitive strategic lesson model was applied, and the other class of forty students was the control group which the traditional lessons were conducted. As the result of the experiment, the experimental group and the control group, which previously did not show difference in terms of achievement of conceptualizing magnetic field, displayed a significant difference. According to the comparison between the pre-experiment test on the students' previous concepts and the achievement of the students after the experiment, the middle group showed difference between the experimental group and the control group in a small degree. The lower group showed a notable difference between the two groups and the higher group showed no difference. In terms of achievements shown in different questions asked, there was little difference in the questions that were stated in the textbook while there was a significant difference in the questions that applied the contents of the textbook. The higher academic group, according to the test on the previous concepts, did not show much difference between the experimental group and the control group when they were asked about the concepts of the textbook. In terms of the comparison in the metacognitive levels, both the higher and lower metacognitive experimental groups' average grade was higher than the control groups' and showed an important statistical difference.