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Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea
논문 : 동북아지역(東北亞地域)에서의 다뉴경(多뉴鏡) 부장묘(副葬墓)의 전개(展開)
이청규 ( Chung Kyu Lee ) 단국사학회 2012 史學志 Vol.44 No.-
청동기는 생업도구의 수준에서 벗어나 전쟁무기와 종교의기로 제작·보급되었다. 이논문은 종교의기이자 무구(巫具)로서 제사장들이 보유했던 청동거울, 그 가운데서도 다뉴경을 중심으로 다뉴경이 부장된 무덤들의 역사문화적 의미를 고찰한다. 다뉴경은 대릉하유역부터 한반도를 거쳐 일본 구주(九州)지역에 이르는 범(汎) 십이대영 자문화권(十二臺營子文化圈)을 나타내는 유물이다. 다뉴경 부장묘는 이 문화권에 속한 고조선, 부여, 한 왜(倭)의 범주에 속하는 소국(小國)들의 수장들의 무덤으로서, 다뉴경뿐만 아니라 다른 청동기 및 토기부장품들이 부장되어 있다. 이 부장품들은 당시의 chiefdom 사회의 수장들을 중심으로 한 정치상황뿐만 아니라 범 대영자문화권 내의 기술교류를 반영한다. 다뉴경은 중국 동북지역에서 한반도와 일본열도에 걸쳐 당시 엘리트들이 제사장의 신분과 지위를 과시하는 위세품인데, 전파과정에 따라 대릉하지역의 A형 다뉴경, 요동과 길림지역의 B형 다뉴경, 한반도 서남부와 일본 구주지역의 C형 다뉴경으로 발전되어갔다. A형 다뉴경으로부터 B형 다뉴경의 등장은 연(燕)나라의 동진으로 고조선의 강역이 이동한 것에 기인한다. C형 다뉴경은 중국 동북지역에서는 발견되지 않고 한반도 서북한과 서남한 지역, 일본 구주(九州)지역에서 발견된다. 이는 다뉴경을 최고 위세품으로 채용하는 계층이 상위급 수장(首長)에서 차상급 이하의 엘리트로 내려갔음과 일본 구주 지역의 소국들이 한반도 서남부지역의 마한(馬韓)지역과 교류하고 있었음을 보여준다. The geometric-design bronze mirrors of which numbers about 80, are assumed to be as ritual tools and political symbols of priest-king during the 8th~2nd century BCE. Those are classified into three types, that are A, B, and C, and each of them is assumed to be made and used in 800~400BCE, 400~200BCE, and 200~50BCE. The distributional range of three types were changed under the historical conditions, which includes Yen(燕)`s advance toward the northeastern China and Wiman(衛滿) becoming a king of Gojoseon(古朝鮮). The first A type mirrors were distributed mainly in northeastern China, B type ones in the geographical range from northeastern China to the Korean peninsular, and C type ones from the Korean peninsular to the Japanese archipelago. The size and numbers of mirrors are reflective of the social position of the person with whom are buried in the grave, and so the graves with mirrors in each type are those of the most unfluential leaders of ``Kuk(國)``―the political and regional groups at the time. In A type mirror stage, the graves with most abundant artefacts are located in Liaoning pronince(遼寧省); the graves with most abundant artefacts in B type mirror stage are in Chung-nam(忠南) province; and the graves with C type mirrors in Cheon-nam(全南) province. Each region with those burials was the trade-center in Korea connecting China and Japan, and is assumed to be the location of the most influential ``Kuk(國)`` in old Korea.
Infliximab으로 호전된 장관 증상없이 발생한 구강-안면 크론병
정보용 ( Bo Yong Jung ),이석호 ( Suck Ho Lee ),정승규 ( Seung Kyu Chung ),이창균 ( Chang Kyun Lee1 ),이태훈 ( Tae Hoon Lee ),정일권 ( Il Kwun Chung ),김선주 ( Sun Joo Kim ),조현득 ( Hyun Deuk Cho ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6
Crohn`s disease is a chronic inflammatory bowel disease that can involve the whole gastrointestinal tract. The orofacial manifestation of Crohn`s disease, which is rare, can develop irrespective of intestinal involvement. These orofacial lesions are often misdiagnosed as simple oral ulcers. Corticosteroids are the mainstay of therapy for orofacial Crohn`s disease. However, infliximab, the chimeric monoclonal antibody to tumor necrosis factor-α, is now considered as a primary treatment because of the disease`s relatively high rate of steroid resistance. We present a case of deep oral ulcer and periorbital swelling in a 65-year-old woman. She was diagnosed with intestinal Crohn`s disease 7 years ago, which was in remission after treatment with an immunosuppressive agent (azathioprine). The patient was given the diagnosed with orofacial Crohn`s disease and successfully treated with infliximab. (Korean J Gastroenterol 2012;59:437-440)
흰쥐 肝臟의 組織發生에 관한 組織化學的 및 電子顯微鏡的 硏究
鄭鎬三,李圭植,張世榮 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.1
Numerous workers have intensively studied for physological and histochemical aspects on the histogenesis and differentiation of mammalian livers focusing attention on its hematopoietic function. In early fetal life hepatic diverticulum formed caudal part of the foregut in separated into two parts by the mesodermal septum each being developed into primordia later. The author has undertaken histological and histochemical studies to persue the morphological and functional changes to occur in hepatic lobules during development and differential period. The pregnant albino rats, Wistar strain, were sacrificed every day starting from 15th to 20th day of gestation. The specimens obtained from the fetal liver were fixed with 10% formalin and stained with hematoxylin-eosin to observe the morphological development and differentiation of the liver. The activities of acid and alkaline phosphatase were observed by the Gomori's methods(1931, 1941) and ATPase activity by the Wachstein-Meisel's method(1957). And also another liver specimens fixed with 4% glutaraldehyde in 0.1M cacodylate buffer(pH 7.4) at 4℃ by the Eranko's method(1952) were examined with electron microscope to investigate phosphatase activities in the hepatic parenchymal cells. The results were as follows. 1. In the liver of the 15th day of the fetus, undifferentiated hepatic parenchymal cells were constituted and a few nucleated erythocytes were spread at the intercellular region, and at the 16th and 17th day of the fetus a number of hematocytoblast were distributed and primitive hepatic cord and hepatic sinusoid were formed. 2. In the Liver of the 18th, 19th and 20th day of the fetus, hematopoietic cells were reduced but the differentiation of he hepatic parenchymal cells, hepatic cord and hepatic sinusoid were observed. 3. The activity of the acid phosphatase increased from the 17th to 20th day of the fetus. High activity of the enzyme at the peripheral and central zone and trace activity at the lysosome and rough endoplasmic reticulum were observed. 4. Moderate activity of the alkaline phosphatase was observed in the liver of the 19th and 20th day of the fetus at the nuclear membrane of the parenchymal cell and at the villi of the bile canaliculi. 5. The activity of the adenosine triphosphatase was observed in the liver of the 18th day of the fetus, and positive activity at the plasma membrane and weak activity at the rough endoplasmic reticulum were observed at the 19th and 20th day of the fetus, respectively.
Dimethylformamide가 Mouse 肝細胞의 微細構造에 미치는 影響
이형록,정호삼,이규식 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2
Dimethylformamide (DMF) has been widely used in the synthetic textile industry as an organic solvent. However, it is known that DMF irritates to skin and mucous membranes and causes several toxic symptoms when dermal and respiratory exposure to DMF is prolonged. It is supposed that DMF provoked toxic reaction in the liver during the metabolic process of the DMF-injected experimental animal. Therefore, the authors observed changes cytoplasmic organelles of the hepatic parenchymal cells in order to demonstrate the effect of DMF on the mouse liver. Healthy male mice of ICR strain were used in this experiment and the weight of the experimental animals were around 20gm. The animals of the experimental group were administered DMF diluted in the water for injection, by intraperitoneal injection in a dose of 1.5ml per kg of body weight in a volume of 0.2ml. The animals of the control group were amdinistered only water for injection. The experimental animals were killed at intervals of 6, 12, 24 and 48 hours after administration of DMF, respectively. Liver specimens of 1mm³ size were prefixed in the 2% glutaraldehyde-2.5% paraformaldehyde phosphate buffer solution (pH 7.2) and post-fixed in the 1% osmic acid. After specimens were dehydrated and embedded in the epon 812, ultrathin sections(600-800A°thickness) were made and double stained with uranyl acetate and lead citrate. These preparations were observed with JEM 100B electron microscope. The results obtained were as follows: 1. Cisternae of rough endoplasmic reticulum were intensely dilatated and fragmented partly. 2. Smooth endoplasmic reticulum was markedly proliferated and glycogen particles were markedly decreased or depleted. 3. The atrophies of the Golgi complex were found. 4. Primary lysosomes and secondary lysosomes-residual bodies, autophagic vacuole and multivesicular bodies were increased in number. 5. Numerous lipid droplets of irregular size were produced. Consequently, it is concluded that DMF would induce the degenerative changes in cytoplasmic organelles of the hepatic parenchymal cell in the mouse.
Mitomycin이 Mouse의 肝細胞 내 Pyronin 好性顆粒에 미치는 影響
鄭鎬三,李圭植,白斗鎭 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.1
Mitomycin, one of the mitosane antibiotics, is isolated from Streptomyces caespitosus which has anticancer effect. It is well known that mitomycin inhibites DNA synthesis in mammalian cells. The major machanism accounting for the inhibitory effect of mitomycin is interference of the template activities of the DNA by cross linking to DNA double helix. The auther has investigated the effect of mitomycin on the liver of mice, observing the distribution and disaggregation of the pyroninophilic granules in the hepatic parenchymal cells. A total of 52 healthy mice of ICR strain (the weight 20g) were divided into two groups; The control and the mitomycin treated groups. All experimental animals were given food and water ad libitum. The animals of the mitomycin treated groups were administered 4mg per kg of body weight of mitomycin diluted in the water for injection by intraperitoneal injection. The animals of the MC treated groups were sacrified at intervals of 6, 12, 24 and 36 hours after administration of mitomycin Histochemical preparations were stained with the methyl green-pyronin method for the pyroninophilic granules in the hepatic parenchymal cells. A marked reduction or disappearance of the pyroninophilic granules were observed in the entire hepatic lobule at 24 hours after administration of mitomycin. Consequently, it is suggested that mitomycin causes the loss of pyroninophilic granules in the hepatic parenchymal cells of the liver in the mitomycin treated mice.
위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동
이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.
이헌,이규식,정호삼 漢陽大學校 環境科學硏究所 1984 環境科學論文集 Vol.5 No.-
Malathion은 유기인제 화합물이며 인체에 대한 독성이 비교적 약하고 농작물의 병충해를 매개하는 곤충에 대한 살충제로 널리 사용되고 있다. Malathion(O, O-dimethyl S-[1,2-dicarbethyl-ox yethyl] phosphonodithioate)은 parathion(O,O-diethyl O-p-nitrophenyl phosphorothioate), methyl parathion(O,O-dimethyl O-p nitrophenyl phosphorothioate), TEPP(tetraethyl pyrophosphate) 및 Diazinon (O,O-diethyl O-[2-ispropyl 4-methyl-6-pyrimidyl] phosphorothioate) 보다 그 독성이 약하며 쉽게 가수분해되고 생체내 축적이 적으나 많은 양을 섭취했을 때는 급성 중독증상이 나타난다. Malathion도 중독이 되면 생체의 혈액과 조직내에 있는 cholinesterase의 활성을 억제하는 반면 acetylcholinesterase를 축적시켜 부교감신경계의 과잉자극과 같은 증후를 나타낸다. 두통, 현기증, 피로감, 구토, 경련, 설사, 발한, 축동(miosis), 유연, 근육의경련, 반사작용 및 괄약근 제어력 손실, 호흡부전과 운동실조를 나타낸다. 유기인제 살충제인 Ethoxy-p-nitrophenoxyphenylphosphine sulfide(EPN)을 실험동물에 투여하면 간장의 간소엽 중심대와 중간대의 간실질세포에 종창, 공포출현 및 지방침착을 야기시킨다고 보고되어 있다. 저자는 유기인제 살충제중 가장 안전한 malathion이 다른 간독성 화합물과 같이 간장에서 해독과정을 거칠 때에 간실질세포에 독성으로 작용할 것으로 사료되어 mouse에 malathion을 투여하고 간장의 변화를 조직학적으로 추구하였다. 실험동물은 체중 20gm 내외의 건강한 ICR계웅성 mouse를 택하였다. Malathion은 mouse의 체중 kg당 100mg되게 olive유에 희석하여 0.2ml를 복강내 주사하여 6시간, 12간, 24시간 및 36시간경과 후에 희생시켜 간장을 적출하였다. 적출한 간조직은 10% 중성 formalin용액에 고정하여 hematoxylin 및 eosin염색을 하여 간장의 조직학적 변화를 관찰하고 일부의 간조직은 oil red O 염색을 하여 간실질세포내 지질의 축척을 관찰하여 다음과 같은 결과를 얼었다. 1. Malathion투여 12시간 경과군의 mouse간장에서는 간소엽 중심대와 중간대의 간실질세포에서 중등도의 소포와 세포종창이 일어났고,24시간 경과군의 mouse간장에서는 간소엽 전역의 간실질 세포에서 대다수의 소포와 심한 세포종창이 일어났으며,36시간 경과 후의 mouse 간장에서는 간실질 세포에 약간의 소포와 미약한 세포종창이 관찰되었다. 2. Malathion투여 6시간 경과 후에는 간소엽 중심대와 중간대의 중간대의 간실질세포에 경도의 지방침착이 일어났고, 24시간경과 후에는 간소엽 중심대에 현저한 지방침착이 일어났으나, 36시간 경과 후에는 간소염중심대에 중등도의 지방침착이 관찰되었다. 이상의 소견을 미루어 malathion은 mouse의 간장에 초기에는 손상을 야기시키나 시간이 경과됨에 따라 점차 회복된다고 사료된다. Malathion (0-dimethyl S-1, 2-dicarbethyloxyethyl phosphonodithioate) is one of the several organic phosphorus compounds now in common use as insecticides. As malathion is hydrolyzed, it is not accumulate in the tissue. Although its toxicity is relatively low, malathion has caused poisoning in man when absorbed in sufficient amounts. Therefore, the author demonstrated the effect of malathion on the liver of the mouse, observing the histological change and accumulation of fat in the hepatic parenchymal cells. A total of 32 heathy male ICR strain mouse were divided into the control and malathion treated group. 0.2ml of 100mg per kg of body weight of malathion in olive oil was injected each experimental animals, intraperitoneally. Animals of the control group were given the same volume of olive oil by intraperitoneal injection. The animals were killed at the 6,12,24 and 36 hours after an administration of malathion or olive oil. The specimens, which were obtained from the left anterior lobe of the liver, were stained with H-E and oil red 0 methods and observed with light microscope. The results were obtained as follows: 1. Cellular swelling accompanied with vesicular formation are revealed in the hepatic parenchymal cells of the central and intermediate zone of hepatic lobule at the 6,12 and 24 hours after adminstration of malathion. 2. It is observed that the fat deposits are revealed in the hepatic parenchymal cells of central and intermediate zone of the hepatic lobule at the 6.12 and 24 hours after administration of malathion. 3. There is no significant histological change in the hepatic parenchymal cell of the liver at 36 hours after administration of malathion Consepuently, it is suggested that malathion would induce the cellular swelling associated with vesicular degeneration and fatty degeneration of the hepatic parenchymal cells in the albino mice.
이성자,정규림,박영국 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.3
경희의료원 치과병원 교정과에 내원한 부정교합자 전신 건강 상태가 양호한 123명의 좌측 수완부골 방사선 사진을 이용하여, 초경과 골격성숙도간의 상관관계를 연구한 결과 다음과 같은 결론을 얻었다. 1. 초경 발현 연령은 평균 12.31세, 최소 9.6세, 최고 15.6세로 개체간 변이가 심하였다. 2. 초경시 골성숙 상태는 SMI 7,8단계(73%), 즉 제5중절골의 골단이 골간을 둘러싸거나 제3말절골의 골간과 골단이 융합되는 단계이며, 초경시의 골격성숙도는 초경 발현 연령에 관계없이 일정하였다. 3. 골성숙단계에 따른 초경 후 경과기간에는 유의한 차이가 있었다. 4. 요골의 융합은 초경 후 평균 1년 8개월이 지나면 시작되었다. 5. 초경 발현 연령에 따른 성장 속도의 비교에서, 만기성숙아(초경을 늦게 경험하는 여아)는 초경 후 14개월이 지나면 요골의 융합이 시작되었고, 조기성숙아(초경을 일찍 경험하는 여아)는 초경후 22개월, 평균성숙아는 초경후 20개월이 지나면 요골의 융합이 시작되었다. The 123 left hand-wrist radiographs and menarcheal ages attained by direct questioning to patients or her mothers are used, in order to exploit the relationship between the bone maturity and the menarcheal age of girls in adolescence. The results were as follows ; 1. The mean age at menarche was 12.31±0.99. 2. The onset of menarche was correlated with skeletal age rather than chronological age. 3. There was statistically significant difference among the time passed from menarche according to skeletal maturity level. 4. The distal epiphyseal union of radius began at about 20 months after menarche. 5. In comparision of the time intervals from menarche to radial epiphyseal fusion among early, average, and late menarche age groups, late group had lesser time interval than other two groups.