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Hyoung-Chul Oh,Jeffrey J. Easler,Ihab I. El Hajj,James Watkins,Evan L. Fogel,Lee McHenry,Stuart Sherman,Hyun Kang,Glen A. Lehman 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.6
Background/Aims: A calcineurin inhibitor may alter pancreatic function and inflammatory reaction. This study aimed to determine the possible pharmacologic effect of the calcineurin inhibitor, tacrolimus, on pancreatic function, and to determine its preventive effect on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in liver transplantation (LT) patients. Methods: The serum amylase and lipase values before and after LT were compared. The frequency of post-ERCP pancreatitis was compared between non-LT and LT patients, using propensity score matching method. Results: Median serum amylase values (normal range, 19 to 86 U/L) were 49.0 U/L (38.0 to 68.0) before LT and 27.0 U/L (19.3 to 36.8) after LT, and median serum lipase values (normal range, 7 to 59 U/L) were 40.0 U/L (26.5 to 54.0) before LT and 10.5 U/L (6.0 to 21.0) after LT. Both serum amylase and lipase values significantly decreased after LT (p < 0.001), and to a level comparable to chronic pancreatitis. There was a marginal significant difference between the non-LT and LT groups before the propensity score matching with respect to frequency of post-ERCP pancreatitis (16 [3.2%] in non-LT group vs. 2 [0.9%] in LT group, p = 0.069). After propensity score matching, a marginal significant difference still existed with respect to frequency of post-ERCP pancreatitis (7 [4.8%] in non-LT group vs. 1 [0.7%] in LT group, p = 0.067). Conclusions: The immunosuppression with calcineurin inhibitor may reduce not only the pancreatic enzyme dynamics but also inciting inflammatory event including post-ERCP pancreatitis.
Epidemiologic and clinical study of cholinergic urticaria for the recent 10 years
( Jung Eun Kim ),( Hyun Ju Yu ),( Do Hyun Lee ),( Young Sun Eun ),( Young Min Park ),( Hyun Jeong Park ),( Dong Su Yu ),( Hoon Kang ),( Sang Hyun Cho ),( Chul Jong Park ),( Si Yong Kim ),( Jun Young L 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.3
Adaptive Run-time Overhead Adjustments for Optimizing Multiple Continuous Query Processing
Hyun-Hon Lee,Hong-Kyu Park,Jin-Chul Park,Won-Suk Lee,Kil-Hong Joo 보안공학연구지원센터 2014 International Journal of Software Engineering and Vol.8 No.11
The time-varying characteristics of infinite data streams require continuous queries to be adaptively processed. The order in which multiple join operations are evaluated has serious consequences for the algorithm performance because the selectivity of each join operation can differ significantly from the selectivity of the other operations. The evaluation order may be effectively determined using the k-EGA and A-SEGO schemes, as proposed in previous studies. These methods optimize target continuous queries by monitoring a set of their promising subplans simultaneously. Each scheme also employs a user-defined cost-bound parameter for controlling the number of monitored subplans. A more optimized global plan may be generated by using a more highly configured cost-bound parameter. However, this approach can increase the overhead associated with monitoring the subplans. This paper proposes a new scheme, Adaptive Run-time Overhead Adjustment (AROA), which provides a novel method for adaptively determining the value of a cost-bound parameter based on the system environment. Unlike the previously described A-SEGO scheme, the scheme proposed here automatically selects the cost-bound parameter to reflect the system workloads (e.g., the input tuple rate, and other parameters). This method not only augments the probability of generating an optimized execution plan, it reduces the run-time delay caused by the optimization process. Experimental verification of the proposed scheme AROA demonstrated that AROA outperforms the previous schemes.
Lee, Hyun Ji,Kim, Shine Young,Lee, Sun Min,Heo, Jeong,Kim, Hyung Hoi,Chang, Chulhun L.,Lee, Eun Yup,Son, Han Chul The Korean Society for Laboratory Medicine 2012 Annals of Laboratory Medicine Vol.32 No.6
<P><B>Background</B></P><P>Treatment for chronic hepatitis B aims to suppress virus replication and virus sequestration in hepatocytes. Covalently closed circular (ccc) DNA is the template for transcription of viral genes and is responsible for viral persistence. However, limited data are available for quantification of hepatitis B surface antigen (HBsAg) in Korea.</P><P><B>Methods</B></P><P>We evaluated the Elecsys HBsAg II quant assay (Roche Diagnostics, USA) for within-run, between-run, and between-day precisions, linearity, carryover, and clinical specificity. In total, 156 serum samples were evaluated for correlation between HBsAg and hepatitis B virus (HBV) DNA. Serial samples were obtained from 10 patients at 0, 12, 24, 48, 72, and 96 weeks during follow-up.</P><P><B>Results</B></P><P>The assay detected HBsAg in a linear range of 0.5-48,696 IU/mL. Within-run, between-run, and between-day CVs were 2.9-4.1%, 0-1.5%, and 1.5-4.9%, respectively. Cross-reactivity between potentially interfering substances was absent, and the carryover rate was 0.00002%. The correlation of measurements between the Elecsys assay and HBV DNA PCR was weak (r=0.438, <I>P</I>=0.002). For predicting virologic response, cutoff values of 10,275 IU/mL and 3,846 IU/mL at 12 and 24 weeks after treatment initiation showed positive predictive values of 77.1% and 85% and negative predictive values of 84.6% and 50%, respectively.</P><P><B>Conclusions</B></P><P>The Elecsys HBsAg II quant assay showed good performance for precision, linearity, carryover rate, and specificity. HBsAg level at baseline, 12 weeks, and 24 weeks after treatment initiation can predict virologic response, and the assay can be used for HBsAg quantification in clinical practice.</P>
Kim, Chul-Min,Je, Byoung-Il,Piao, Hai-Long,Park, Soon-Ju,Kim, Min-Jung,Park, Sung-Han,Park, Jin-Young,Park, Su-Hyun,Lee, Eun-Kyeong,Chon, Nam-Soo,Won, Yong-Jae,Lee, Gi-Hwan,Nam, Min-Hee,Yun, Doh-Won,L Plant molecular biology and biotechnology research 2002 Plant molecular biology and biotechnology research Vol.2002 No.-
Many aspects of epigenetic phenomena have been elucidated via studies of transposable elements. An active transposable element frequently loses its ability to mobilize and goes into an inactive state during development. In this study, we describe the cyclic activity of a maize transposable element dissociation (Ds) in rice. in rice genome, Ds undergoes the spontaneous loss of mobility. However, and inactive state of Ds can be Changed into an active state during tissue culture. The recovery of mobility accompanies not only changes in the methylation patterns of the terminal region of Ds, but also alteration in the steady state level of the activator (Ac) mRNA that is expressed by a constitutive CaMV 35S promoter, Furthermore, the Ds-reactivation process is not random, but stage-specific during plantlet regeneration. Our findings have expanded previous observation on Ac reactivation in the tissue Culture of maize.
Post-ERCP Bleeding in the Era of Multiple Antiplatelet Agents
Hyoung-Chul Oh,Ihab I. El Hajj,Jeffrey J. Easler,James Watkins,Evan L. Fogel,Lee McHenry,Glen A. Lehman,Jung Sik Choi,Hyun Kang,Stuart Sherman 거트앤리버 소화기연관학회협의회 2018 Gut and Liver Vol.12 No.2
Background/Aims: This study aimed to determine the risk of post-endoscopic retrograde cholangiopancreatography (post-ERCP) bleeding among patients taking antiplatelet agents (APAs), particularly in the era of multiple APAs. Methods: The primary outcomes were the frequency, type, and severity of ERCP-related bleeding according to the use of APAs. Results: The frequencies of post-ERCP bleeding among the four different groups were 16 of 2,083 (0.8%) in the no drug group, 12 of 256 (4.7%) in the aspirin group, 3 of 48 (6.3%) in the single APA group, and 4 of 48 (8.3%) in the multiple APA group (p<0.001). In the univariate analysis, post-ERCP bleeding was associated with age, pull-type sphincterotomy, and APA and was inversely associated with balloon dilation of the biliary orifice. In the multivariate analysis, pull-type sphincterotomy (odds ratio [OR], 7.829; 95% confidence interval [CI], 1.411 to 43.453; p=0.019) and country (Korea: OR, 0.124; 95% CI, 0.042 to 0.361; p<0.001) were associated with post-ERCP bleeding. Conclusions: The frequency of post-ERCP bleeding was statistically higher in patients on any APA within 6 days prior to ERCP. However, in the multivariate analysis, APA use was not associated with post-ERCP bleeding. Until a large, adequately powered study to detect differences is performed, caution is recommended when considering invasive procedures during ERCP in patients on APAs.
김광현(Kwang Hyun Kim),성명훈()Myung Whun Sung,이효정(Hyo Jeong Lee),이동욱(Dong Wook Lee),박범정(Bum Jung Park),성원진(Weon Jin Seong),민양기(Yang Gi Min),이철희(Chul Hee Lee),이재서(Chae Seo Rhee),이상준(Sang Jun Lee),노종열(Jong L 대한두경부종양학회 2002 대한두경부 종양학회지 Vol.18 No.1
Background and Objectives: To determine if laser endoscopic microsurgery is a reliable and appropriate approach in the treatment of laryngeal carcinomas. Materials and Methods: Retrospective study of 62 patients treated with CO2 laser from June 1988 to November 2000 at Seoul National University Hospital for laryngeal squamous cell carcinoma. All patients were treated with curative intention. Fifty three untreated patients with laryngeal carcinoma (39 glottic and 14 supraglottic carcinoma patients) had primary carbon dioxide laser microsurgery. Nine radiation failure patients were treated. Postoperative radiotheray was done for 17 patients. Neck dissection was performed simultaneously for 4 supraglottic cases with cervical nodal metastasis. Mean follow-up duration was 40 months. Results: In primary laser surgery group, distribution of tumors (American Joint Committee on Cancer, 1997) were 38 cases with Tl, 13 cases with T2, 2 cases with T3. Cure rate was 88.7%(47/53) and local control rate was 92.5%(49/53). Larynx was preserved in 94%(50/53) of patients. The overall 5-year survival rate(Kaplan-Meier) was 81.5%. In radiation failure group, 56% of patients were recurred after laser surgery. Conclusion: Laser surgery could be a better treatment modality for early laryngeal cancers and selected advanced cases. Additional radiation therapy should be considered if resection margin is not satisfactory.