PGA2-induced HO-1 attenuates G2M arrest by modulating GADD45α expression

Yun-Jeong Choe,고경원,Hyein Lee,이선영,Byung-Chul Kim,Ho-Shik Kim,Ho-Shik Kim 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.4

Prostaglandin (PG) A2, a cyclopentenone PG, arrested the growth of U2OS cells in the G2M phase. While inducing G2M arrest, PGA2 increased the expression of heme oxygenase-1 (HO-1) at the level of transcription along with the accumulation of ROS and the activation of MAPKs including JNK, p38MAPK, and ERK1/2. Among the MAPKs, the inhibition of p38MAPK by a specific chemical inhibitor SB203580, or by RNA interference, but not JNK or ERK1/2, attenuated the PGA2-induced transcription of HO-1. Nacetylcysteine (NAC), a ROS scavenger, prevented PGA2-induced G2M arrest, p38MAPK activation and transcriptional induction of HO-1. PGA2 also stimulated GADD45α expression at the level of transcription, and the knockdown of GADD45α repressed PGA2- induced G2M arrest. Finally, the knockdown of the HO-1 protein elevated PGA2-induced GADD45α expression as well as G2M arrest. Collectively, these results suggest that PGA2 causes an increase in ROS accumulation which initiates both HO-1 transcription via p38MAPK, and G2M arrest via GADD45α transcription, and HO-1 attenuates G2M arrest by modulating the expression of GADD45α.

일부 운수사업장 근로자의 건강진단 유소견자의 사후관리 실행과 관련요인

윤혜은,박종,이영선,강성득,김철호 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Objective : The purpose of this study was to find the relationship between the follow-up management status for medical problem to be treated and various characteristics of some workers at transportation business. Methods : A questionnaire survey was made toward 183 workers with medical problem(C and D2) among 945 examine in 1997. Results: Sixty four point five percent of surveyee received the examination result report and 40.5% were explained about the result 80.3% of surveyee answered that they knew the result of health examination. Most workers felt the necessity of the health examination, but 54.1% were dissatisfied with present health examination system and 66.7% pointed it out as nominal The rate of follow-up management for the medical problem was 62.8% By the multiple logistic regression the follow-up management rate for those who knew the health examination result were 2.98 times higher than those who didn't know the result (OR=2.98, 95% CI 1.41~6.29) The rate for those who perceived the medical problem already were 2.64 times higher than those who perceived the problem for the first time (OR=2.64, 95% CI 1.13~6.15). The rate for those who had subjective symptoms were 2.83 times higher than those who didn't have subjective symptoms. Conclusion : sixty two point eight percent of workers with medical problem performed the follow-up management and perception of health examination result, perception of the problem in the past and experience of subjective symptoms were related with the follow-up management.

마이크로스트립 지연선 여파기에 관한 연구

윤준식,박규호,윤철상,박준석,안달 호서대학교 반도체제조장비국산화연구센터 2000 학술대회 자료집 Vol.2000 No.1

일반적으로 LPA에서는 위상을 조정하기 위해 매우 긴 지연선을 필요로 한다. 지연성능은 고전력이나 저전력 모두에서 임의의 길이의 동축선로를 여러번의 과정을 거쳐 적용해봄으로써 구현된다. 그러나 동축선로형 지연선은 부피나 높은 삽입손실등의 제약이 많이 따른다. 본 논문에서는 마이크로스트립 형태의 지연선 대역통과 여파기를 설계하였고, 실험결과는 지연선여파기가 동축선로를 대신하여 LPA 시스템에 적용이 가능함을 보였다.

파킨슨병 환자에서 Selegiline과 SSRI 병용에 의해 발생한 중추성 세로토닌 증후군

김철호,권석범,정산,윤성희,황성희 최신의학사 2003 最新醫學 Vol.46 No.11-12

유방에서 기원된 전이성 췌장암종 1예 : A case report

김윤신,이미숙,장원재,임성철,기근홍,전호종,서재홍 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Pancreas is known for the unfavorable soil to the metastatic carcinoma, and pancreatic metastasis is achieved after systemic dissemination was developed. The primary tumors of metastatic pancreatic carcinoma are breast, lung, Iymphoma, malignant melanoma, leukemia, stomach. and colon. The breast carcinoma is the commonest tumor to metastasize to pancreas and both tumors are related to estrogen receptor for tumor growth. In the present case, tumor cells had small round nucleus and showed indian file infltrating pattern and lack of cohesion, which are seen in infiltrative breast carcinoma. The patient was underwent radical mastectomy due to infiltrative ductal carcinoma three years ago. And also the tumor cells showed nuclear reactivity to immunostaining for estrogen receptor In combination of the histopathologic. immunohistochemical, and her past history, we concluded that breast carcinoma was metastasized to pancreas, and we report a case of metastatic pancreatic carcinoma from breast with review of literatures.

피질하 혈관성 치매 환자에서 협착성 뇌혈관 병변의 의의 : 자기공명 혈관조영술과 양전자방출단층촬영을 이용한 연구 MR Angiography and ^(18)FDG-PET Study

유경호,이병철,마효일,김윤중,정지향,나덕렬,강연욱 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1

Background and Objective:Subcortical vascular dementia (SVD) incorporates small vessel disease as the primary vascular etiology, represents in MRI by lacunar infarct and deep white matter lesions. In clinical practice, a number of SVD patients present with various vascular risk factors for large artery disease (LAD) i.e., old age, hypertension, and diabetes. However the current diagnostic criteria for SVD did not include angiographic findings as a key feature. Therefore we tried to find out the frequency of large artery disease in SVD and to elucidate whether the presence of LAD affects clinico-radiological manifestations of SVD. Methods:Thirty three patients fulfilling 'Research criteria for SVD' by Erkinjuntti from 17 study centers were recruited. Of these 33 patients, 21 who underwent comprehensive neuropsychological test battery, MRI ^(18)FDG-PET, and MR angiography were classified into two subgroups according to the patterns of MRI abnormality:white matter dominant (WM) type (n=5) and multiple lacunar (LC) type (n=16). Clinical and neuropsychological profile and ^(18)FDG-PET findings of 21 SVD patients with and without LAD were compared. Results: Twelve (57%) of 21 SVD patients had mild stenotic lesions in intracranial large arteries:4 in middle cerebral artery, 8 in posterior cerebral artery, and 4 in vertebrobasilarj artery. There were no differences in vascular risk factors, characteristics of cognitive dysfunctions, and ^(18)FDG-PET findings between SVD with and without LAD. Conclusions:Our results showed that the presence of mild degree of large artery stenosis did not affect the clinical., neuropsychological profile and cerebral metabolism in PET. Therefore, the current 'Research criteria for SVaD' by Erkinjuntti could be used to diagnose SVD as a homogenous clinical group regardless of angiographic abnormalities.

LiCoO₂의 합성 공정변수에 따른 리튬이차전지 정극의 전기화학적 특성 연구

이철태,오치훈,엄의흠,송연호 조선대학교 생산기술연구소 2003 生産技術硏究 Vol.25 No.2

리튬이차전지용 정극활물질 LiCoO₂를 소성법 을 이용하여 합성공정변수를 달리하여 합성하고 합성공정변수가 이들의 물리화학적인 재료특성 및 전기화학적인 특성에 미치는 영향을 조사하였다. 출발 물질로 LiOH · H₂O와 Co₃O₄를 사용하였으며, 750℃, 6시간 이상의 조건에서 결정의 LiCoO₂가 합성되기 시작하였으며, 반응온도가 높아지고 반응시간이 길어질수록 LiCoO₂의 결정성이 증가하였다. 여러 합성 조건 중 가장 우수한 전기화학적 특성을 보이는 조건은 반응옹도 750℃ 반응시간 24시간이었다. 이 조건에서 합성한 LiCoO₂로 Li/1M LiCIO₄ in PC + DME/LiCoO₂의 cell을 구성한 후 0.25mAh/㎠며의 전류밀도로 충 · 방전 하였을 경우 초기 방전 용량은 130mAh/g이였으며, 10cycle 후 방전 용량은 130mA h/g에서 109mAh/g으로 16%의 용량감소가 일어났다. LiCoO₂, the active material of positive electrode in lithium secondary battery, was synthesized by calcination with LiOH · H₂O and C0₃O₄. And relationships between synthesis condition and physical and electrochemical characteristics of LiCoO2 were investigated. Synthesis condition of 750℃, 6hr, LiCoO₄ crystal began to be formed, and the crystallinity of LiCoO₂ increased with reaction temperature and reaction time. LiCoO₂ synthesized by calcination at 750℃ during 24hr showed best electrochemical characteristics. The initial discharge capacity of LiCoO₂ synthesized under this condition was 130mAh/g, and after 10 cycles, the discharge capacity decreased to 109mAh/g.

자동차의 후방 스포일러(Spoiler)가 주행 안정성에 미치는 공기역학적 영향에 관한 수치 해석적 연구

김철호,윤동규,이창민 서울産業大學校 1998 논문집 Vol.47 No.1

Even though an automotive industry has its long manufacturing history, its design and manufacturing technology is mainly based upon the empirical background. Along with the rapid development of the calculating machine a theoretical approach on the research and development in many industrial areas is now tried to for the better research output because the theoretical approach has many advantages compared with the experimental method. In here a theoretical study has been done to understand the effect of the spoiler attached on the booth of the small & medium size sedan on the dynamic geometry such as spoiler attached angle(αs),location, chord, span, etc., the optimized configuration of the spoiler which is well matched to the certain model of a car can be designed. However if the improperly designed spoiler is attached on a car, it may require higher fuel consumption rate because of the higher drag force and in case, have lower controllability of the car because of the higher lift force induced by the mismatched spoiler. For this study, Navier-Stokes equations with the standard (κ-ε) turbulent model was solved. Car running speed(Ucar), spoiler attached angle(αs) were selected as the main parameters. Variation of the drag force (form drag and induced drag) and lift force were analyzed to understand the effect of the spoiler on the dynamic stability and fuel consumption rate of the model cars.

Real-time PCR 기술의 생물학적 폐수처리에서의 응용

엄호섭,이선미,상병인,정윤철 한국물환경학회 2006 한국물환경학회지 Vol.22 No.2

두부손상 환자의 정신과적 합병증에 관한 장애 감정례의 일반 사항에 관한 분석

신석철,왕성근,신윤오,김덕호,김상국,강동숙 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

Authorst ried retrospective analysis to find out general characteristics of the patients undergoing disability evaluation at the department of psychiatry Chungnam National University Hospital from 1986 to 1990. The subjects, who were suffered from psychiatric complications due to head trauma by traffic accident, were 66 patients and they were classified depending on the demographic status, situations of traffic accident, evalaution periods, whether or not perform operation, and rates of evaluated disability and diagnosis. The results were summarized as follows. 1. General background of the subjects were as follows. 1) The frequency order of request were court(59 %) and insurance company(19.7%). 2) The place of accident was more common in large city, common accident vehicle were bus, truck, and cabs. 3) The season of accident were more common in Spring and Autumn. 2. Male(71.2%) was more common than in female and more common in the age group of 5-19 years old(37.9%). The most frequent job of the patients was labour, and the education level was more common in the graduates of elementary school(47.9% ). 3. The interval between accident and evaluation was most frequent in 12-23 months(47.5%), and duration of evaluation was mostly 14 to 21 days. Performed brain operation was 31.8% and non-operated patients was 50.0%. The rates of disability according to the McBride's disability evaluation were mostly belonged to the group of beow 40%(74.1%). 4. The final diagnosis after evaluation were organic personality disorder(45.5%) and dementia(31.8%).