위내시경으로 진단된 소화성궤양의 임상적 고찰

진춘조,박형석 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

A clinical analysis was performed on 1958 patients with peptic ulcer who were diagnosed by gastroduodenoscopy at Kon-Kuk University Min-Joong Hospital from Jan. 1983 to Dec. 1992. The results were as follows: 1) Of the total 1958 cases, duodenal ulcer were 1055 cases, gastric ulcer 750 cases, and combined ulcer 153 cases respectively. The mean age of gastric ulcer(46.4) was statistically higher than that of duodenal ulcer(38.3)(p<0.05). The male to female ratio of gastric ulcer was 3.3 : 1, duodenal ulcer 3.5 : 1, and combined ulcer 5.1 : 1 respectively. 2) The proportion of gastric ulcer among the peptic ulcer decreased from 49.2% to 33.6% during the period of 1983 to 1992, and that of duodenal ulcer increased from 43.7% to 60.0%. 3) The most frequent symptom was epigastric pain(78.7%). Duodenal ulcer patients complained hunger pain more frequently than gastric ulcer patients(21.5% vs 15.3%) but it was not statistically significant(p>0.05). 4) The most prevalent site of gastric ulcer ws lesser curvature(52.1%) and antrum(34.1%). The most favorable site of duodenal ulcer was anterior wall of bulb(41.0%). 5) Among the gastric ulcer, active stage was 66.3%, healing stage 28.0%, and scarring stage 5.7% respectively, and the commonest shape was round(38.3%). 6) Among the duodenal ulcer, active stage was 58.6%, healing stage 22.7%, and scarring stage 18.7% respectively, and commonest shape was ovoid(37.5%). 7) The complications of peptic ulcer were hemorrhage(7.3%), stenosis(1.7%), and perforation(0.1%).

피부단자시험을 이용한 알레르기성 비염의 원인적 고찰 및 감감작 요법의 치료효과

진준조,박형석 건국대학교 1992 學術誌 Vol.36 No.2

We performed prick test using 120 kinds of antigens to the 121 consecutive patients who were diagnosed as allergic rhinitis. The results were as follows ; 1) The results of skin test was positive in 85 cases(70.2%) and negative in 36 cases(29.8%). 2) The rate of positive result was peak in second decade(100%) and followed by third decade(79.1%). 3) 14 cases(16.5%) who showed positive skin test reacted with single allergen and remaining 71 cases (83.5%) reacted with multiple allergens. 4) Among 271 positive reactions in 71 cases, (+++)reaction was 118 cases, followed by (++) 116 cases, (+) 41 cases, and (++++) 6 cases respectively. 5) The most frequent reacting allergen was housedust mite(50), and followed by housedust(29) and cockroach(21) in order. 6) Desensitization including housedust mite and other antigen was done in 36 cases for 16.2 months. The result was excellent 10 cases, good 18 cases, poor 4 cases, and no response 2 cases respectively. 7) The higher desensitization effect was shown with housedust mite antigen with 2∼3 antigen mixed cases. 8) The change of serum IgE level between before and after desensitization was not remarkable. In summary, prick test was useful in detection of causative antigens in alleragic rhinitis, and desensitization therapy was effective in relief symptoms of allergic rhinitis.

복강내 Polyadenylic-Polyuridylic acid 투여에 의한 악성복수의 치료효과

박형석,진춘조 건국대학교 1994 學術誌 Vol.38 No.2

Intracavitary antitumor chemotherapeutic agents such as nitrogen mustard, 5-FU and bleomycin have been used for the treatment of malignant effusions to kill the tumor cells in the effusions. But because of many side effects such as anorexia, nausia, hepatic and renal dysfunction, other therapeutic agents have been tested. In this study, we have investigated the use of intraperitoneal infusion of polyadenylic-polyuridylic acid, a synthetic double stranded helical ribopolynucleotide complex, which stimulates both humoral and cell mediated immune response and enhances the NK cell activity in 17 patients of malignant ascites. Following results were obtained ; 1) The mean age of patients was 50.2 and male to female ratio was 1.4 : 1. Primary tumor site was stomach 15 cases, colon 1 case, primary unknown 1 case. The diagnostic methods of malignant ascites were peritoneoscopic biopsy 5 case, positive cancer cell in ascites 4 case, characteristics of ascites 8 cases, respectively. 2) Among the 17 cases who recieved infusion treatment, 14 cases were able to evaluate the response 8 cases (57.1%) were responded to treatment and 6 cases(42.9%) were not responded. The mean effect duration was 10.6 weeks. 3) There was no difference in clinical and laboratory finding between response group and non-response group. The response rate was higher in case of positive cancer cell in ascites and short interval from the diagnosis to development of ascites, although statistically non-significant. 4) There was no side effect except 1 case of febrile reaction. Laboratory finding of pre and post treatment was not changed. In conclusion, the peritoneal administration of polyadenylic-polyuridylic acid seems to be effective and safe method in the patients with malignant ascites.

상부 소화관 내시경으로 진단된 각종 위질환 10,770예에 대한 임상적 고찰

박형석,진춘조 건국대학교 1992 學術誌 Vol.36 No.2

A clinical analysis was carried out on 10770 cases who were examined by panendoscope in the department of internal medicine, Minjoong Hospital, Konkuk University from Jan. 1982 to Dec. 1990. The results obtained are as fellows; 1) Of the 10,770 cases, 5,419 cases were male, and 5351 were female. Their mean age was 39.7 years. 2) The most frequent endoscopic finding was gastritis(60.1%), followed by peptic ulcer disease(16.6%), gastric cancer(2.6%), gastric polyp(0.7%), duodenitis(0.6%), esophageal varix(0.4%) in order. 3) The mean age of gastric ulcer(45.7) was statistically higher than that of duodenal ulcer(37.5) (p <0.05). The ratio of male to female was 2.9 : 1 in gastric ulcer and 3.2 : 1 in duodenal ulcer respectively. 4) The male to female ratio of gastric caner was 1.8 : 1 and the mean age was 55.1 years. The most frequent type of advanced gastric cancer was type III (50.6%) according to Borrmann's classification. 5) In patients with upper gastrointestinal bleeding, the most frequent endoscopic finding was duodenal ulcer (32.5%), followed by gastric ulcer (22.2%), hemorrhagic gastritis(14.5%), gastric cancer(12.8%), esophageal varix(10.3%), and Marrory-Weiss syndrome(3.4%) in order. In summary, gastrointestinal endoscopic examination was very useful method in the diagnosis of upper gastrointestinal tract disease.

십이지장 궤양 환자와 만성 위염 환자의 염증 분포의 차이 및 H. pylori 집락도와 염증도의 상관관계

유광하,진춘조,박형석,이재동,김예리,윤성욱,이수인,윤호상 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-

An inflammatory difference between the gastric antrum, body and fundus was studied in 39 H.pylroi positive duodenal ulcer and 29 H. pylori chronic gastritis patients. Also we studied correlation of H. pylori colony count and inflammatory severity. Patients with newly diagnosed duodenal ulcer and chronic gastritis were endoscoped and two biopsy secimens each taken from the antrum, body and fundus. Although intestinal metaplasia in antrum and inflammatory activity in fundus were more severe in chronic gastritis patients. another inflammatory difference was equally likely to be found between two groups. There was no definite histological inflammatory difference between duodenal ulcer and chronic gastritis patients. A positive correlation was found between the number of H. pylori and the severity of inflammation.

당뇨가 위장관 운동에 미치는 영향

박형석,진춘조 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

The application of new measurement techniques in patients with diabetes mellitus has demonstrated a high prevalence of disordered motility in all segments of the gastrointestinal tract. In the past these were invariably considered a consequence of autonomic neuropathy, but acute hyperglycemia can now be seen to be a major reversible influence at every level of the gastrointestinal tract that has been studied. Conversely, gastrointestinal function affects glycemic control; approaches to modify the rate of gastric emptying are being Investigated for their utility In the management of diabetes.

혀에 작용하는 capsaicin에 관한 감각 정보의 특성

이배환,김기석,김기영,진춘조,나흥식,홍승길 한국심리학회 1999 한국심리학회지 생물 및 생리 Vol.3 No.1

본 연구는 혀에 작용하는 capsaicin이 유발하는 감각 정보의 특성을 알아보기 위해 수행되었다. α-chloralose로 마취한 고양이에게 기계적 자극, 미각자극, capsaicin을 혀에 도포하고, 동통 유발 물질과 capsaicin을 혀의 동맥에 주입하면서 고삭신경과 설신경에서 신경의 활동을 기록하였다. 고삭신경에서 혀에 도포한 capsaicin에 대한 반응은 미각 자극 및 혀의 동맥에 주입한 동통 유발 물질에 대한 반응과 상관이 있었다. 혀의 혈관에 주입한 capsaicin에 대한 고삭신경의 반응은 혀에 도포한 capsaicin 및 혀의 혈관에 주입한 동통 유발 물질에 대한 반응과 상관이 있었다. 설신경에서 혀에 도포한 capsaicin에 대한 반응은 동맥에 주입한 동통 유발 물질에 대한 반응과 상관이 있었다. 혀의 혈관에 주입한 capsaicin에 대한 설신경의 반응은 혀에 도포한 capsaicin 및 혀의 혈관에 주입한 동통 유발 물질에 대한 반응과 상관이 있었다. 이러한 결과는 capsaicin이 혀에 작용할 때 동통뿐만 아니라 미각에 관한 정보도 유발한다는 것을 시사한다. 이때 미각에 관한 정보는 고삭신경을 통해 중추로 전달되며, 동통에 관한 정보는 설신경을 통해 전달되지만, 동통에 관한 정보가 고삭신경을 통해 전달될 가능성도 배제하지 못한다. The present study was performed to investigate the characteristics of sensory information produced by capsaicin in the tongue. Activities of the chorda tympani(CN) and lingual nerves(LN) were recorded while taste stimuli and capsaicin were being applied topically, and capsaicin and algesics were being injected intra-arterially to the tongue of cats anesthetized with α-chloralose. Responses of the CN fibers to topically applied capsaicin were correlated with those to taste stimuli and intre-arterially injected algesics. Responses of the CN fibers to intra-arterially applied capsaicin were correlated with those to topically applied capsaicin and intra-arterially injected algesics. Responses of the LN fibers to topically applied capsaicin were correlated with those to intra-arterially injected algesics. Responses of the LN fibers to intra-arterially aplied capsaicin were correlated with those to topically applied capsaicin and intra-arterially injected algesics. These results suggest that capsaicin provoke taste as well as pain sensation in the tongue. Taste information produced by capsaicin is conveyed to the brain via the CN and pain information via the LN. However, the possibility that pain information may be conveyed via the CN can not be excluded.

유산소 운동 능력의 차이가 점증최대운동부하 후 피로회복과정에 미치는 영향

송영주,권대근,성동진,황정윤,박천조,김춘우 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This study was conducted to investigate the effects of aerobic capacity on blood lactate changes after supramaximal progressive loaded exercise. The subjects were divided into Handball players(HB, n=6)group and Control(CT, n=6)group. All subjects exercised according to the protocol by bicycle erogometer. Blood lactate concentration was also measured during the test time. The RER values of CT group were relatively higher than that of HB group. In particular, the RER values of HR group at exercise 8 & 12min were significantly lower than that of CT group(P<0.05). The blood lactate concentration of HB group was significantly lower than that of CT group at 12min during the exercise(P<0.05). During the recovery times the blood lactate concentration of HB group were significantly lower than that of CT group. In addition, blood lactate clearance of HB group was also higher than that of CT group during the recovery time. From these results, it was suggested that lactate clearance during the supramaximal exercise may be affected by the level of endurance exercise performance.

혈액투석 환자에서 대퇴신경범증으로 발현된 장골근 및 요근 농양 1예

이준상,강동구,신상열,윤재호,조영일,고성은,유영범,전혜정,진춘조,송종오 대한신장학회 2004 대한신장학회잡지 Vol.23 No.1

Regional Spinal Cord Blood Flow on Cord Traction : An Experimental Cat Model

Jo, Tai Hoon,Baik, Min Woo,Kang, Sae ki,Kang, Joon Ki,Park, Chun Kun,Huh, Choon Woong,Song, Jin Un CATHOLIC MEDICAL CENTER 1983 Bulletin of the Clinical Research Institute Vol.11 No.1

The tethered syndrome is a clinical entity manifested by progressive motor and sensory changes in the legs, incontinence, back or leg pain and scoliosis. In order to elucidate the pathophysiology involved in the tethering effect of the cord, regional spinal cord blood flow (rSCBF) and somatosensory evoked potential (SEP) were measured in tethered cord animals. Studies in experimental tethered cord models indicate marked reduction of rSCBF, and suppressed SEP at the adjacent area of traction (L_1) L_1 under traction with greater weight (5 or 10 gm). It is assumed that prolonged and progressive neuronal dysfunction may lead to structural damage of neurons caused by impairment of blood flow. Untethering procedures in tethered cord may improve blood flow and probably facilitate the repair mechanism of injured neurons.