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RISS 인기검색어
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- 저자 : ( Choon Goon Jung ) (검색결과 3 건)
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Cho, Eun-Seob,Jung, Choon-Goon,Shin, Yun-Kyung 한국해양학회 2009 Ocean science journal Vol.44 No.2
Genetic responses of non-high temperature exposed and high temperature exposed ark shell (Scapharca broughtonii) cells collected from Dukyang Bay in August 2007 to environmental shock have been compared. In the analysis of two-dimensional electrophoresis, seven protein spots were found. They have no matching protein in the database, but the number of protein (#1) in unstressed ark shells differed from that of stressed ark shells, indicating a strong signal on the gel and had a homology with arginine kinase (molecular weight, 38 kDa; pI 8.3). The predicted tertiary structure of arginine kinase formed finger-like antiparalled b-sheet projections. A small a-helical N-terminal domain is followed by a larger C-terminal domain. Extracted total RNA was reverse transcribed and amplified by PCR with primer used in this study. Mantle, gill and visceral in non-high temperature exposed ark shell showed some levels of arginine kinase transcripts, but not the foot. These cells also showed amplified fragments on the gel exposed to $20^{\circ}C,\;23^{\circ}C$ and $27^{\circ}C$, but the foot cell had no expression of arginine kinase gene at $27^{\circ}C$ for 3 hrs. These findings provide important insights into the possible molecular mechanisms in which no expression of arginine kinase is contributed to preventing the binding of arginine and actin and difficult to move foot muscle.
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이만재,유기동,손현화,정재용,김양수,김태균,서영선,박유환,정춘해,이미자,박종,오윤경 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.2
Purpose: Even though the entire resection is only option for primary cure in case of the localized colorectal cancer. However, recurrence rate is relatively high(30%). The evaluation for chromosome 18 long arm status in the patients who have stage II colon cancer gives a important information about a prognosis and evaluation of the patients. This study was undertaken to evaluate the possible prognostic role of the expression of deleted in colorectal cancer (DCC) protein in the patients with stage II colon cancer. Materials and Methods: The present study analysed 22 patients with stage II &II (AJC TNM 1992 classification) colorectal adenocarcinoma who were admitted to the Chosun University Hospital between March 1989 and February 1992. Clinicopathologic parameters including age, sex, TNM stage, adjuvant chemotherapy, location and tumor differentiation and DCC status were examined. Results: The survival rate of the patients expressing DCC was found to be significantly higher in the patients in whom the DCC was expressed, while 4 (18%) in the other who had not the expression of DCC(P= 0.044). Although the patients with the stage II of the TNM stage have a better prognosis than those with stage III (P=0.046), no significant difference was found between these two groups in terms of the eastern cooperative oncology group (ECOG) performance status of patients (P= 0.525). Conclusion: when the expression of DCC protein is negative in patients with colon cancer staged II need a more aggressive treatments like in the patients with staged III colon cancer and thereafter the more exact operative method is required identifying the expression of DCC protein using the frozen biopsy during operation and thereafter the consideration for the chemotherapy and radiation therapy will be possible.
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손현화,유기동,서영선,김태균,김양수,정재용,박유환,정춘해,홍승민,전제열,이상운 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.2
Background: Cancer has become the major cause of death in Korea. Doctors who treat terminal cancer come across problems which are too difficult to solve. These problems are related with religious, moral and legal problems. These problems are easy death, patients' or family' s refuse of treatment, practice of cardiopulmonary resuscitation(CPR) in terminal cancer, definition of death and so forth. In Korea, studies related with terminal cancer patients and the doctors who treat them are very rare and the hospice system for terminal cancer patients is not organized yet. Objectives: The aim of this study was to identify the opinions of doctors who treat terminal cancer about these problems. Materials ðod: This study was performed on 90 doctors working at Chosun university hospital, who are divided in to three parts as staff, residents and interns. We used questionares related with the above problems, composed of 19 items and six general characteristics. We could confirm 75 questionaires. Results &onclusion: For the question "ve terminal cancer patients was announced their diagnosis and prognosis?"hat was most important to doctors was patients' opinions and the second was their family' s. For the question "eatment which could prolong the life of terminal cancer patients who are unnconscious is performed?"doctors showed a negative opinion. About the easy death of terminal cancer patients, more than half the doctors showed agreement. The prohibition of CPR in terminal cancer patients was agreed by 40%. For the question about the definition of death in terminal cancer patients 76.1% doctors agreed it was brain death. 85.7% subjects answered that they felt moral enmity in treatment of terminal cancer patients. In Korea, the programs for these problems are very poor, and the results of this study can affect the formation of systems and laws about the terminal cancer patients and the doctor's treatment. National support for terminal cancer patients and the hospice care system is required.
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