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박영배,이영우,김종환,박재형,최윤식,오병희,서정돈,주승재,전은석 대한내과학회 1987 대한내과학회지 Vol.32 No.2
Cardic involvement in neurofibromatosis is uncommon, but congenital heart disease, especially pulmonary stenosis, is often observed. Both pulmonary stencsis and cafe-au-lait spots can ccc~ur in the Leopard syndrome, the Watson syndrome, and neurofibromatosis. We report a case of pulmonary valvular and infundibular stenosis associated with neurofibromatosis in a 30-year-old male.
Sphingosylphosphorylcholine induces proinflammatory signaling via activation of mast cells in skin
( Hyeong Rae Kim ),( Dae Kyoung Choi ),( Kyung Cheol Sohn ),( Myung Im ),( Young Lee ),( Chang Deok Kim ),( Jeung Hoon Lee ),( Young Joon Seo ),( Ji Hye Park ),( Chong Won Choi ),( Ga Young Lee ),( So 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.3
Chemical Modification of Carbon Nanotubes and Preparation of Polystyrene/Carbon Nanotubes Composites
Ham, Hyeong-Taek,Koo, Chong-Min,Kim, Sang-Ouk,Park, Yeong-Suk,Chung, In-Jae The Polymer Society of Korea 2004 Macromolecular Research Vol.12 No.4
Single-walled carbon nanotubes (SWNTs) have been chemically modified through the formation of carboxylic acid functionalities or by grafting octadecylamine and polystyrene onto them. We purified SWNTs with nitric acid to remove some remaining catalysts and amorphous carbon materials. After purification, we broke the carbon nanotubes and shortened their lengths by using a 3:1 mixture of concentrated sulfuric acid and nitric acid. During these purification and cutting processes, carboxylic acid units formed at the open ends of the SWNTs. Octa-decylamine and amino-terminated polystyrene were grafted onto the cut SWNTs by condensation reactions between the amine and carboxylic acid units. The cut SWNTs did not disperse in organic solvents, but the octadecylamine-grafted and polystyrene-grafted SWNTs dispersed well in dichloromethane and aromatic solvents (e.g., benzene, toluene). Composites were prepared by mixing polystyrene with the octadecylamine-grafted or polystyrene-grafted SWNTs. Each composite had a higher dynamic storage modulus than that of a pristine polystyrene. The composites exhibited enhanced storage moduli, complex viscosities, and unusual non-terminal behavior when compared with a monodisperse polystyrene matrix because of the good dispersion of carbon nanotubes in the polystyrene matrix.
태생기 단백영양결핍 백서의 산화스트레스 및 항산화 방어체계
이종호,이홍규,김성연,박경수,전현정,조은영,박형규,김숙경 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.3
Background: Free radical-mediated oxidative damage has been implicated in a variety of pathological processes such as diabetes mellitus, aging and atherosclerosis. The susceptibility of a given organism to oxidative damage is influenced by the overall balance between the degree of oxidative stress and antioxidative capabilities. Nutrition plays an important role in determining the cellular antioxidative defense mechanism. Thus, the aim of this study is to investigate the effects of fetal protein malnutrition on oxidative stress and antioxidative capabilities. Method: Rats were fed a low-protein (8% casein) diet throughout pregnancy and lactation. Male offspring were weaned onto either a control (18% casein) diet (group 2) or a low-protein diet (group 3). Offspring from rats fed a control diet were weaned onto a control diet (group 1). The activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and the concentration of thiobarbituric acidreactive substances (TEARS) were determined at 10 and 15 wk in liver and skeletal muscle from offspring. Results: SOD activities of liver in group 3 were significantly lower than those in group 1 at 10 wk (4.14±0.65 U/mg protein, 9.09±0.85 U/mg protein) and 15 wk (4.18±0.58 U/mg protein, 7.63±0.74 U/mg protein), respectively. But SOD activities of skeletal muscle were not different between groups. Whilst GPx activities of liver were not different at 10 wk, GPx activities in group 2 (1.80±0.16 U/mg protein) were significant higher than those in group 1 (1.24±0.15 U/mg protein) at 15 wk. GPx activities of skeletal muscle were not different between groups. The TBARS concentrations in liver or skeletal muscle were not different between groups at 10 and 15 wk. There was a significant negative correlation between SOD activities and TBARS concentrations in liver (r=-0.359). Conclusion: In offspring of rats fed a low-protein diet throughout pregnancy and lactation, the antioxidant enzyme activities were significantly decreased, compared with offspring of rats fed a control diet. These alterations were not fully restored in low-protein offspring even when weaned onto a control diet. These results suggest that fetal protein malnutrition impair the antioxidative defense system.