성인 급성 백혈병의 치료에 관한 연구

김종완,장준,신승훈,윤일국,박철신,김삼용 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

19 adult ALL patients were treated with follwing regimens; VP regimen to 5 patients, VPA regimen to 4 patients, multi-drug combined intensive therapy of Hoelzer regimen to 10 patients. The results of therapy are as follows: 1. Complete remission occured in 3 patients on VP regimen(60%), 4 patients on VPA regimen (100%), 8 patients on Hoelzer regimen (80%), respectively, and overall complete remission rate was 78.9%. 2. Mean survival time of total patients was 13.8 months, and in complete remission group, it was 16.2 month, but in non-complete remission group, it was 1.8 month. 3. Factors favorable for complete remission were absence of organomegaly(P<0.05) and initial leukocyte count under 30,000/㎟(P<0.01), factors favorable for the survival duration were initial leukocyte count under 30,000/㎟(P<0.05) and remission within 4 weeks of treatment.(P<0.01). 4. Recurrence rate were 40% in VP regimen, 50% in VPA regimen, and 20% in Hoelzer regimen. 5. During the remission induction period, common side effects of chemotherapy were alopecia, nausea, vomiting, mucositis, and general weakness and it was severe in VPA regimen and Hoelzer reimen than in VP regimen. But no significant difference was noted between VPA regimen and Hoelzer regimen. From the above results, we could confirm the importance of multiple drug combined intensive chemotherapy of remission regimen and periodic reinduction chemotherapy.

기계시각을 이용한 강구 자동 검사장치

김윤수,박수우,임병훈,김태균,최병재,박철영,이문락,도용태 대구대학교 정보통신연구소 2008 情報通信硏究 Vol.5 No.1

Metal balls are commonly used in mechanical elements and systems including bearings. If there is a defect in a metal ball, it can cause a serious machine failure. By this reason every balls produced are required to be inspected, and the inspection is usually done by human eyes. However, the inspection by human eyes is always with the risk of mistakes, and a need to automate the inspection process is arisen. This paper describes a design of an automatic inspection system for detecting defects on ball surface. A machine vision system is used, and design process and techniques are described in detail. 강구는 베어링을 비롯한 기계 요소 및 장치에서 널리 사용되는 부품이다. 만약 강구에 결함이 있을 시, 이를 사용하는 기계에서 치명적인 결함이 초래될 수 있다. 따라서 제조된 강구에 대해서는 전량검사가 요구되고 있고, 검사과정은 사람의 육안에 의한 검사가 주를 이루고 있다. 그런데 사람에 의한 검사에는 항상 실수의 가능성이 있으므로, 이를 자동화하는 것이 필요하다. 본 논문에서는 강구의 표면 결함을 자동적으로 검사할 수 있는 장치를 설계한다. 기계시각 장치가 사용되었고, 설계에 따른 구체적 절차와 기술들이 서술된다.

올란자핀

김문두,정성훈,김철진 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.1

현재까지의 전통적인 항정신병약물은 음성증상에는 거의 효과가 없었고, 양성증상에만 효과가 있었으며, 그마저도 약 30-40%의 환자들에서는 치료적인 효과가 없었다. 또한 추체외로 증상이나 지발성 운동장애 등의 부작용이 많았다. Olanzapine은 이와 같은 기존의 전형적인 항정신병 약물의 제한점이 크게 개선된 약이며 clozapine과는 달리 무과립구증을 유발하지 않으므로 현재 임상적으로 기대가 크다. Olanzapine은 세로토닌 5-HT2A/C, 도파민 D1, D2, D3, D4, 무스카린M1-5, 아드레날린 alphal, 히스타민 H1수용체에 친화도가 높다. 세로토닌 5-HT2 차단작용이 도파민 D2 차단작용보다 강하여 추제외로 증상의 빈도가 적고 지발성 운동장애의 위험이 적다. 항콜린성 작용과 세로토닌 5-HT2A/C 수용체에 대한 길항작용, 상대적으로 약한 D2길항작용으로 양성 증상 뿐만 아니라 음성증상에도 유의한 효과가 있다. Olanzapine의 주된 대사 경로는 cytochrome P-450-CYPIA2, flavincontaining monooxigenase(FMO 3 system), N-glucuronidation이며, 그외에도 cytochrome P-450-CYP2D6, CYP2C19등으로도 대사가 되기 때문에 어느 한가지 효소에 의해 대사나 약력학이 영향을 받지 않으므로 약물 상호작용도 적다. Olanzapine은 정신분열증의 양성과 음성증상에 모두 효과가 있고 장기 유지치료에도 효과가 있다. 또한 치료불응성 정신분열증에도 치료효과가 있다는 보고들이 있다. 또 정신분열증 뿐만 아니라 분열정동장애, 정신분열양 장애, 양극성 장애, 물질 유도성 정신병적 장애에 모두 사용 가능하다. 용량은 5-20㎎이 추천된다. 치료후 첫 3-6개월에 양성, 음성증상의 호전이 있고 대개는 1년에 고평부(plateau)에 이른다. 그래서 최소 6개월은 사용후 그 효과를 판단해야 한다. Traditional antipsychotics have lack of efficacy in 30% to 40% of patients with schizophrenia, lack of efficacy in the treatment of negative symptoms of psychosis, and are primarily effective in ameliorating the positive symptoms of schizophrenia. Also these agent have a number of side effects, such as extrapyramidal symptoms and tardive dyskinesia. Olanzapine is new drug that has much difference from traditional antipsychotics in view of these limitations of traditional antipsychotics and is spared some of clozapine's major difficulties, such as agranulocytosis. olanzapine has affinity for serotonin 5-HT2A/C receptors, dopamine D1, D2, D3, D4 receptors, muscarinic M1-5 receptors, adrenergic alpha1 receptors, histamine H1 receptors. Olanzapine's ability for blockade of serotonin 5-HT2 receptor is greater than it's ability for blockade of dopamine D2 receptors and olanzapine has low incidence of extrapyranmidal symotoms and low risk for developing tardive diskinesia. Olanzapine also has anticholinergic effect and antagonist actions for serotonin 5-HT2A/C receptor, relatively weak antagonistic actions for dopamine D2 receptor, so olanzapine has significant efficacy for not only positive symptoms but also negative symptoms. The most important pathways for olanzapine metabolism are cytochrome P450-CYP1A2, flavin-containing monooxigenase(FMO 3 system),N-glucuronidation. Minor pathways include cytochrome P450-CYP2D6, CYP2C19. Olanzapine has minimal drug interaction due to it's multiple metabolic pathways. Olanzapine has efficacy for both positive and negative symptoms of schizophrenia, long-term maintenace treatment. Olanzapine also has efficacy for treatment refractory schizophrenia, schizoaffective disorder, schizophreniform disorder, bipolar disorder, substance induced psychotic disorder. Recommended does are 5-20㎎/day. We should decide for effectiveness for olanzapine after using 1 year, since improvements in positive and negative symptoms seen in the first 3 to 6 months often plateaued within 1 year.

韓國不動産流通市場構造의 改善方案에 관한 硏究

金雄坤,張東勳,金澈湖 瑞逸專門大學 1993 論文集 Vol.11 No.-

The real estate brokarage system usually keeps step with the development of social system because it is closely connected with the society. But the real estate brokarage system of our country is different from it. Only the real estate brokerage system is behind the other similar industrial fields. It is the purpose of this thesis to suggest improvement program of real estate brokerage for its development. To begin with, I surveyed the basical matters and then, considered the ethics required to agents. I also studied the several real estate brokerage system of American and Japan, along with advenced countries in Europe, for the purpose of comparative analysis in order to fix real estate brokerage corresponds to given social condition. I have selected and examined a few problems of the brokerage system which prevents real estate brokerage from developing. And then, proposed improvement program. The government should understand the importance of the real estate circulation system on the policy and the problems of the brokerage system with modesty to improve it without a moment, s delay. It will be the desirable method to eliminate the agent, s dissatisfaction and to make the epoch-making turning point on the development of real estate policy.

Correction to: Mode‑Change PWM Method for Improving Efficiency of 3‑Level T‑Type PWM Converter

Lee Woo‑Cheol,Kim Tae‑Hun 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.1

수지진동증후군의 진단시 냉각부하검사에 의한 수지피부온도의 평가

유철인,이지호,이충렬,이헌,최영희,김양호 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.2

목 적 : 진동에 폭로된 근로자들을 대상으로 진동장해의 유무를 평가하고 냉각부하 후 수지피부온도를 측정하여 수지진동증후군의 유형별로 결과를 평가하여 향후 수지진동증후군 진단의 객관적인 지표로 사용하기 위한 기본적인 자료를 확보하고자 본연구를 실시하였다. 방 법 : 진동에 폭로된 근로자 58명을 대상으로 설문조사와 이학적 검사를 실시하였으며 Stock-holm-revised vibration syndrome classification system에 따라 근로자를 평가하였다. 평가 후 연구대상자들을 말초혈관증상군, 말초신경증상군, 특별한 중상이 없는 무증상군으로 분류하여, 10 ℃에서 10분간 냉각부하하면서 수지피부온도를 측정하고, 측정된 수지피부온도를 이용하여 5분 회복율과 10분 회복율을 산출하여 각 군별로 비교하였다. 결 과 : 연구대상자들을 분류한 결과 말초혈관장해를 호소하는 군이 33명이었으며, 말초신경장해만 있는 군은 18명이었으며, 특별한 증상이 없는 무증상군이 7명이었다. 수지냉각부하검사결과 냉각부하가 끝난 다음 5분, 10분 후에 측정한 피부온도와 5분 회복율, 10분 회복율은 혈관증상군이 신경증상군과 무증상군에 비하여 통계적으로 유의하게 낮았다(P<0.05). 결 론 : 냉각부하시 수지피부온도를 이용한 회복율은 수지진동증후군의 말초혈관장해 진단에 객관적인 지표로 사용할 수 있을 것으로 추정된다. Objectives : Various objective tests have been widely used worldwide for diagnosing the hand-arm vibration syndrome. Among these, the cold provocation test has been frequently used to confirm the presence of Raynaud's phenomenon. This study was carried out in order to evaluate finger skin temperature by cold provacation test(10 ℃ for 10 minute) for the diagnosis of hand-arm vibration syndrome Methods : Fifty-eight workers who had been to exposed local vibration were examined. Information concerning age, occupation, types of vibration tools used, presence of subjective symptoms such as vibration induced white finger(VWF), and numbness and tingling were collected. The subjects were classified into three groups according to their symptoms(Vascular, Neural, and No symptom group). In order to examine the applicability of the cold provocation test using water at 10 ℃ for 10 minute, we compared finger skin temperature between the groups. Results : The mean value of the finger skin temperature at 5 minutes and 10 minutes after cold provocation as well as the recovery rate in the vascular group were significantly lower than that seen in the other groups. Conclusions : The evaluation of finger skin temperature by cold provocation test is very useful method for the diagnosis of hand-arm vibration syndrome. The test results will assist in confirming the diagnosis of the hand-arm vibration syndrome.

산소의 첨가가 박막 백금측온저항체의 온도저항계수에 미치는 영향

설철규,김영진,장경훈,이건환,이정희 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

A thin film Pt-RTD(resistance temperature device) was fabricated by using DC magnetron sputtering and laser patterning. A study was fulfilled to adjust the TCR(temperature coefficient of resistance) to 3850 ppm/℃ which is IEC751 standard and the influence of oxygen addition(0 ~ 20 %) on TCR was measured. The resistance of Pt-RTD was set to 1000 Q at 0 ℃ using laser patterning and trimming. The analyses of XRD and AES were used to characterise the platinum thin film. The TCR of Pt-RTD was measured by a high precision oil bath. When the addition of oxygen flow rate was 1 %, TCR was 3850 ppm/℃.

구리 지역에서 조사한 고혈압의 인지도, 치료률 및 관리률

홍철호,김순길,홍택원,이제,신진호,이재웅,김경수,김정현,임헌길,이방헌 대한간질학회 2003 대한간질학회지 Vol.9 No.1

신성고혈압쥐에서 혈관내피층이 Phorbol Ester에 의한 수축에 미치는 영향

정수아,김형,차경훈,전제열,윤평진,염철호,박진,조남수,홍순표 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

중추에서 Prostaglandin계가 Renin-angiotensin System에 미치는 영향

최영태,김종승,문성호,오형균,김재훈,전제열,염철호,윤평진 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1

Role of prostaglandins on the renin-angiotensin system in the central nervous system was examined in normotensive and 2-kidney, 1 clip (2K1C) hypertensive rats. The experiment was done under thiopental (50 ㎎/㎏, IP) anesthesia. Captopril and indomethacin were injected into the right lateral cerebral ventricle. Arterial blood pressure and heart rate were recorded from the femoral artery. Intracerebroventricular (ICV) captopril (1 ㎎) caused a decrease in mean arterial pressure in both normotensive and 2K1C hypertensive rats. The depressor response to captopril was more sensitive in hyper-tensive rats than in normotensive rats. Indomethacin treatment (ICV, 200 ㎎) altered the depressor response to captopril neither in normotensive nor in hypertensive rats. These results suggest that the cardiovascular effect of renin-angiotensin system in the central nervous system may not be mediated via prostaglandin systems in normotensive and 2KlC hypertensive rats.