기종성 신우신염 1례

이재욱,구정태,서정일,양창헌,이정호,이동철,이영현,이활,이경섭 동국대학교 경주대학 1997 東國論集 Vol.16 No.1

기종성 신우신염은 주로 당뇨병환자나 폐쇄성 요로질환을 가진 환자에 발생하며 특징적으로 신실질 및 그 주위조직에 가스를 형성하면서 심한 조직괴사를 일으키는 매우 드문 급성 화농성 신감염으로 사망률이 높은 질환이다. 이 질환은 1989년 Kelly와 MacCallum에 의해 처음 보고된 이래 외국문헌에 약 90례 정도가 보고되어 있으며 국내에는 28례가 보고되어 있다. 수액 및 전해질 보충, 인슐린 투여를 통한 적절한 혈당조절 및 항생제 투여등의 내과적 치료와 절개배농 및 신적출술등의 수술적 치료 방법이 있다. 내과적 치료로 가스의 감소가 없는 경우에는 즉각적인 수술적 치료를 시행하여야하므로 이 가스변화에 대한 추적관찰이 중요하다 하겠다. 본 저자들은 당뇨병환자에서 발생한 기종성 신우신염 1례를 내과적 요법을 치험하였기에 문헌고찰과 함께 보고하고자 한다. Emphysematous pyelonephritis is rare, life-threatening infection of the renal parenchyma and perirenal tisseue. This disease is characterized by the production of intrarenal and perirenal gas and is frequently encountered in patients with diabetes mellitus or urinary obstruction. We experienced a case of emphysematouse pyelonephritis in a 62 years old women with poorly controlled diabetes mellitus who had been managed with medical theraphy. So we report this case with a review of the referenced literatures.

Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis

Lee, Jong-Uk,Cheong, Hyun Sub,Shim, Eun-Young,Bae, Da-Jeong,Chang, Hun Soo,Uh, Soo-Taek,Kim, Young Hoon,Park, Jong-Sook,Lee, Bora,Shin, Hyoung Doo,Park, Choon-Sik BioMed Central 2017 Respiratory research Vol.18 No.-

<P><B>Background</B></P><P>Idiopathic pulmonary fibrosis (IPF) is characterized by the complex interaction of cells involved in chronic inflammation and fibrosis. Global gene expression of a homogenous cell population will identify novel candidate genes.</P><P><B>Methods</B></P><P>Gene expression of fibroblasts derived from lung tissues (8 IPF and 4 controls) was profiled, and ontology and functional pathway were analyzed in the genes exhibiting >2 absolute fold changes with <I>p</I>-values < 0.05. <I>CCL8</I> mRNA and protein levels were quantified using real-time PCR and ELISA. <I>CCL8</I> localization was evaluated by immunofluorescence staining.</P><P><B>Results</B></P><P>One hundred seventy eight genes differentially expressed and 15 genes exhibited >10-fold change. Among them, 13 were novel in relation with IPF. <I>CCL8</I> expression was 22.8-fold higher in IPF fibroblasts. The levels of <I>CCL8</I> mRNA and protein were 3 and 9-fold higher in 14 IPF fibroblasts than those in 10 control fibroblasts by real-time PCR and ELISA (<I>p</I> = 0.022 and <I>p</I> = 0.026, respectively). The <I>CCL8</I> concentrations in BAL fluid was significantly higher in 86 patients with IPF than those in 41 controls, and other interstitial lung diseases including non-specific interstitial pneumonia (<I>n</I> = 22), hypersensitivity pneumonitis (<I>n</I> = 20) and sarcoidosis (<I>n</I> = 19) (<I>p</I> < 0.005, respectively). Cut-off values of 2.29 pg/mL and 0.43 pg/mL possessed 80.2 and 70.7% accuracy for the discrimination of IPF from NC and the other lung diseases, respectively. IPF subjects with <I>CCL8</I> levels >28.61 pg/mL showed shorter survival compared to those with lower levels (<I>p</I> = 0.012). <I>CCL8</I> was expressed by α-SMA-positive cells in the interstitium of IPF.</P><P><B>Conclusions</B></P><P>Transcriptome analysis identified several novel IPF-related genes. Among them, <I>CCL8</I> is a candidate molecule for the differential diagnosis and prediction of survival.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s12931-016-0493-6) contains supplementary material, which is available to authorized users.</P>

기관내 삽관을 위한 Atracurium 의 적정량에 대한 임상적 고찰

이혜원,신정순,장성호,임혜자,김종욱,정형근 대한마취과학회 1990 Korean Journal of Anesthesiology Vol.23 No.6

The usefulness of a nondepolarizing muscle relaxant for endotracheal intubation is limited by its relatively slow onset of neuromuscular block compared to that achieved with succinylcholine. Several attempts have been made to produce a more rapid onset of muscle relaxation for endotracheal intubation. A large dose of nondepoarizing muscle relaxant may produce rapid onset but cauae undesirable side effects and a prolonged duration of neuromuscular block. The authors observed the degree of vocal cord relaxation and intubation condition 2 minutes after administration of atracurium and measured changes in mean arterial blood pressure and heart rate at the time of arrival in the operating room, just before abministration of atracurium, 2minutes after administration, and 5mins after intubation. The 40 of patients in this observation were divided into four groups. Group 1; 10patients, received 0.3 mg/kg of atracurium Group 2; 10patients, received 0.4 mg/kg of atracurium Group 3; 10patients, received 0.5 mg/kg of atracurium Group 4; 10patients, received 0.6 mg/kg of atracurium The results were as follows; 1) There were better intubating conditions in Group 3 and 4 than in Group 1 and 2(p$lt;0.001). 2) Mean arterial blood pressure and heart rate did not change significantly after administration of atracurium in all four groups. From the above results we conclude that 0.5~0.6 mg/kg of atracurium provides satisfactory intubation condition 2 minutes after administration without hemodynamic changes.

반복매매모형을 활용한 아파트 매매가격지수

이창무,김병욱,이현 한국부동산분석학회 2002 不動産學硏究 Vol.8 No.2

Stock price index type of housing price indices were commonly used in Korea. However, this type of indices are not suitable for Korean housing market experiencing rapid changes in stock including both new constructions and demolitions. Especially, the recent Korean housing market has experienced substantial changes in housing characteristics. Basically, the stock price index type of housing price index requires a constant survey stock over time in order to maintain the comparability in total housing values. However, the constant stock concept is hard to accept in the Korean housing market accompanying with rapid increase and qualitative changes in housing stock. An alternative is a hedonic price index. However, the basic data requirements for the application of the hedonic model cannot be fulfilled in the Korean housing market where actual sale information is mostly unknown. In order to overcome this structural deficiency, the price indices in Korea are based o periodical price survey with the help of real estate brokers. If we accept the assumption that the whole condominium units belonging to a basic survey unit (an area type in an condominium complex) share the same housing characteristics and the surveyed price, we can use the repeat sale index concept with some modifications. The persistent price survey generates a perfect form of repeat sales data. This paper proposes a practical method for the application of repeat sale index to condominium sales price indexing.

烏貝散이 흰쥐 胃의 Gastrin, Histamine, Somatostatin 면역반응세포에 미치는 영향

이시섭,나현욱,고병문,이광규,이창현 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5

To investigate the elects on the administration of Opae-san in rats. Opae-san (500mg/day) and omeprazole(10mg/day) were administration with stomach tube for 4 weeks and 8 weeks. This experiment were investigated numerical change of immunoreactive cells of gastric, histamine and somatostatin in rat stomach mucosa by the immunohistochemical method. The results were as follows : 1. In Opae-san administration group for 4 weeks, the number of gastric immunoreactive cells were increased in one and a half times than that of control group. In omeprazole administration group for 4 weeks, the number of gastric immunoreactive cells were increased in four times than that of control group. In Opae-san administration group for 8 weeks, the number of gastric immunoreactive cells were increased four times than that of control group. In omeprazole administration group for 8 weeks, the number of gastrin immunoreactive cells were increased in six times than that of control group. 2. In Opae-san administration group for 4 weeks, the number of histamine immunoreactive cells were increased in two times than that of control group. In omeprazole administration group for 4 weeks, the number of histamine immunoreactive cells were increased in six times than that of control group. In Opae-san administration group for 8 weeks, the number of histamine immunoreactive cells were increased three times than that of control group. In omeprazole administration group for 8 week, the number of histamine immunoreactive cells were increased in seven times than that of control group. These results suggest that Opae-san extracts inhibit the secretion of gastric acid and this extract use to therapeutic herb of gastric disorders related to the hyperacidity and gastric ulcer.

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

이식시기가 2년생 인삼의 생장에 미치는 영향

Jang Uk Kim,Young Chang Kim,Jung Woo Lee,Ick Hyun Jo,Dong Hwi Kim,Kee Hong Kim 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.05

Background : This study was conducted to determine the impact of temperature elevated and the effect of transplanting times based on climate change scenario on growth of 2-year-old korean ginseng (Panax ginseng C. A. Meyer.) in temperature gradient chambers (TGC). Methods and Results : As a plant materials, ‘Yunpoong’ was cultivated in TGC at ambient temperature(Amb), Amb+2℃, Amb+4℃ and Amb+6℃ respectively. Ginseng was also transplanted on March 29, April 12 and 26 respectively. Investigation on characteristic of aerial parts were carried out on 28, 56, 84 and 112 days after transplanting and characteristic of roots were conducted on October 19. As transplanting time was faster and temperature was higher, the growth of aerial parts were increased. Compared with those of ginseng transplanted on March 29 with Amb, the root weight which tend to decrease depending on late transplanting time and high temperature decreased about 11.1%, 35.4% and 42.4% in Amb+ 2℃, Amb+4℃ and Amb+6℃ respectively. Ginseng transplanted on April 12 and 26 decreased about 20.9%, 33.9% respectively. Conclusion : Consequently, the more transplanting time extend, the more quantity increased in all temperature treatment. So, it is possible to increase in quantity to advance transplanting time although high temperature will be caused by the climate change.

Monocyte Chemoattractant Protein-1[MCP1] -2518 유전자 다형성과 주요 우울장애

배치운,이지현,신윤경,김태석,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Object : This study was designed to examine the association between monocyte chemoattractant protein-l (MCPl) -2518poly morphism and major depressive disorder (MDD). Methods : Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results : Genotype and allele distributions in patients with MDD were significantly different from those of the controls, In particular, subjects with the allele A were found to have an increased risk of MDD. Conclusion : The present study suggests that the MCPl -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

주요 우울장애가 동반된 혈액 종양 환자에서 Paroxetine의 효과 및 안정성

배치운,이혁재,김정진,이창욱,이수정,이철,백인호 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.4

Objectives : The efficacy and safety of paroxetine in the treatment of depressive disorders are well known, however its efficacy and safety for the treatment of depression in patients with cancer has been poorly studied. This study therefore aimed to evaluate the efficacy and safety of paroxetine in treatment of depressed patients with hematological malignancy (HM). Methods : Fifty-two patients with major depressive disorder (MDD) based on DSM-IV criteria along with comorbid HM were allotted to 8 weeks trial with a flexible-dose regime of paroxetine in combination with their chemotherapy or supportive pharmacotherapy. Treatment response was assessed at baseline, week 2, week 4, and week 8 with 17-item Hamilton Rating Scale for Depression (HAM-D17), Montgomery A sberg Depression Rating Scale (MADRS), and Clinical Global Impression-severity (CGI-S). Side effects were collected with the reported adverse events and laboratory test throughout the study period. Results : 44.2% of 52 patients completed the eight weeks trial. Scores on the HAM-D17, MADRS, and CGI-s (last Observation carried forward, LOCF) at baseline were significantly reduced with mean reduction of 30.5%, 32.8%, and 39.1%, respectively, after 8 weeks treatment with paroxetine. Forty-six patients (88.5%) reported at least one adverse event. The most common adverse event observed in this study was nausea and no serious adverse event was found. Conclusion : In this preliminary study, overall results showed paroxetine could be used for the treatment of depressed patients with HM, but more controlled study is needed to confirm the efficacy and safety of paroxetine in this area.

창공91의 비행 시험을 통한 지면 효과 측정에 관한 연구

황명신,장욱진,이정훈 한국 항공대학교 항공산업기술연구소 1996 航空宇宙産業技術硏究所 硏究誌 Vol.6 No.-

창공-91 비행기를 이용하여 비교적 양항비가 큰 비행기의 지면 효과를 측정하는 연구를 수행하였다. 이착륙 중에는 지면에 의한 영향에 의해 공기역학적인 특성이 변화하며, 따라서 조종 특성에 많은 영향을 준다. 지면 효과에 대한 연구는 특히 시뮬레이터를 설계하는데 기초적인 자료로서 대단히 중요하지만 측정의 어려움 등으로 인하여 거의 연구 자료가 없다. 본 연구에서는 경비행기인 창공-91을 이용하여 여러 가지 비행 형태에 대해 지면 효과를 측정하기 위한 비행 시험을 수행하였다. 비행 형태는 실제 이착륙 조건을 고려하여 플랩 1단, 2단, 3단에 대하여 수행되었으며, 본 연구에서는 적은 비행회수로도 지면 효과를 측정할 수 있는 일정 받음각 방법을 이용하여 비행을 하였다. 실제 비행 시험 결과 지면 가까이에서 양력의 증가를 확인할 수 있었지만 항력과 키놀이 모멘트의 변화를 측정하기는 어려웠다. When an airplane flies close to the ground, at a height of one or two wing spans, it experiences an increase in lift and significant changes in drag and pitching moment. This phenomenon is known as ground effect. A study on the Ground Effect of Chang-Gong 91 was conducted by the flight test. Because of the obvious influence of ground proximity during the takeoff and landing phases, it has been the subject of considerable investigation, especially for simulator design. However, despite this consideration, an adequate amount of reliable ground-effects data does not appear in the literature. A Constant Angle of Attack approach technique was used to measure ground effect on several aircraft configuration. Test results indicate that ground proximity produces and increase in the lift-curve slope for Chang-Gong 91