Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

Association of Change in Smoking Status and Subsequent Weight Change with Risk of Nonalcoholic Fatty Liver Disease

Jeong Seogsong,Oh Yun Hwan,Choi Seulggie,Chang Jooyoung,Kim Sung Min,Park Sun Jae,Cho Yoosun,Son Joung Sik,Lee Gyeongsil,Park Sang Min 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.1

Background/Aims: Smoking is considered a risk factor for the development of nonalcoholic fatty liver disease (NAFLD). However, the association of a weight change after a change in smoking status and the risk of NAFLD remains undetermined. Methods: This study used the Korean National Health Insurance Service-National Sample Cohort. Based on the first (2009 to 2010) and second (2011 to 2012) health examination periods, 139,180 adults aged at least 40 years were divided into nonsmoking, smoking cessation, smoking relapse, and sustained smoking groups. NAFLD was operationally defined using the fatty liver index. The adjusted odds ratio (aOR) and 95% confidence interval (CI) were calculated using multivariable-adjusted logistic regression. Results: Compared to nonsmoking with no body mass index (BMI) change, the risk of NAFLD was significantly increased among subjects with BMI gain and nonsmoking (aOR, 4.07; 95% CI, 3.77 to 4.39), smoking cessation (aOR, 5.52; 95% CI, 4.12 to 7.40), smoking relapse (aOR, 7.51; 95% CI, 4.81 to 11.72), and sustained smoking (aOR, 6.65; 95% CI, 5.33 to 8.29), whereas the risk of NAFLD was reduced among participants with BMI loss in all smoking status groups. In addition, smoking cessation (aOR, 1.76; 95% CI, 1.35 to 2.29) and sustained smoking (aOR, 1.64; 95% CI, 1.39 to 1.94) were associated with higher risk of NAFLD among participants with no BMI change. The liver enzyme levels were higher among participants with smoking cessation and BMI gain. Conclusions: Monitoring and management of weight change after a change in smoking status may be a promising approach to reducing NAFLD.

Giant hidroacanthoma simplex combined with variable eccrine tumors mimicking clonal seborrheic keratosis

( Jae Hong Oh ),( Byeong Chang Ko ),( Hee Jae Park ),( Seung Pil Ham ),( Mira Choi ),( Sik Haw ),( Hai-jin Park ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Hidrocanthoma simplex(HAS) is a rare benign intraepidermal neoplasm arising from eccrine duct. Clinically, it appears as brownish or verrucous plaque on the lower extremities. Histologically, HAS can exhibit intraepidermal cell nests which are called “Borst-Jadassohn phenomenon”. It could be observed in the HAS, clonal seborrheic keratosis (SK), Bowen’s disease and actinic keratosis. An 86-year-old female presented with several decades history of huge brown, verrucous plaque on the right buttock. At initial biopsy, intraepidermal clonal expansion of polygonal basaloid cells were observed within acanthotic epidermis. She was diagnosed as clonal SK, and was removed by CO2 laser ablation. After 3 months, she returned with polypoid grouped papules on the previously treated area. Histologic examination showed intraepidermal proliferation of small to medium-sized polygonal basaloid cells as well as large cells with abundant clear cytoplasm. Atypical cells with large, hyperchromatic nuclei were observed. There was a component of eccrine syringofibroadenoma which is characterized by thin, anastomosing cords of epithelial networks with duct formation extending from the base of the tumor. Tumor cells were stained with EMA and PAS. Final diagnosis was HAS combined with eccrine poroma, eccrine syringofibroadenoma and focal malignant changes. Herein we report a case showing natural history of eccrine tumor from HAS to malignant changes over time.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

인터넷 방송 재생 품질과 시청 만족도와의 관계

장활식,오창규 釜山 大學校 經營 經濟 硏究所 2000 經營 經濟 硏究 Vol.19 No.1

인터넷 방송의 성장가능성과 시장성은 급속도로 증가하고 있는 반면, 실제적인 방송 품질은 기존의 대중 매체와 비교할 때 미흡하다. 본 연구에서는 인터넷 방송이 가져야 되는 방송 품질을 전송 후 재생 품질 수준으로 한정짓고, 이러한 품질 수준이 시청 만족도에 어떻게 그리고 어느 정도 영향을 미치는가를 살펴보기 위해 실험연구를 수행하였다. 이를 통해 인터넷 방송을 시청하는 최종사용자의 시청 품질 만족도 수준을 규명함으로써 인터넷 방송 운영자가 내릴 수 있는 현실적인 대안을 제공하였다.

Enamel matrix derivative(EMDOGAIN^(R))을 이용한 상악 소구치의 자가이식 치험례

오유향,김효식,정현구,조태식,위유민,이창섭 조선대학교 구강생물학연구소 2002 Oral Biology Research (Oral Biol Res) Vol.26 No.2

The success of tooth transplantation or replantation depends on the viability of periodontal ligament in the transplanted tooth. Mechanical injury to periodontal tissues frequently results in dental root resorption and ankylosis, which leads to the failure of transplantation or replantation. Enamel matrix derivative (EMD) has been recently used to induce periodontal regeneration. In this report, we show a clinical case of EMD application in the transplantation of an inversely impacted and immature tooth. An impacted second premolar was found in the right maxilla of a 14 year-old girl. The tooth was inversely impacted and the root formation was incomplete. When transplantation was carried out. EMD was applied to the periodontal tissues of the extracted premolar. The tooth was fixed at the correct position and the clinical condition was followed for evaluation for 3 months. Radiographs after 3 months exhibited new bone formation surrounding the transplanted tooth. There were no signs of root resorption or ankylosis, and reconstruction of the bone defect area at the maxilla was also found. Short-term results from this case indicated that EMD application was effective in the transplantation of an inversely impacted and immature tooth. In adddition, EMD might contribute to obtain good healing without ankylosis. Further follow-up observations are necessary to evaluate the regenerative effects of EMD.

고교 장거리 선수의 신체적 및 생리적 특성에 관한 비교 고찰

최충식,오인환,오창석 龍仁大學校 體育科學硏究所 1995 體育科學硏究論叢 Vol.5 No.1

The purpose of this study was to analyze the contribution of anthro pometrical physiological characteristics underlying 5000 meter running performance in high school male distance runners. It has been pointed out that a number of anthropometrical nd physical attributes such as body size, body composition, running economy, pulmonary function, cardiovascular-respiratory function and running history as well as maximal oxygen consumption have relatively association with success in the long distance running performance. Based on the statistical analysis, significant difference (p<0.05) was found between high group runners and low group runners. Enclosed is a summary of the lab test result, field test result. 1. The significant factor determining competitive success in the 5000meter run for high school male long distance runners were their maximal oxygen consumption and the level of Lactate acid.(r=0.87, r=0.86) 2. The reslationship between height and weight 5,000 meter running performance was not significant for high group and low group(r=0.37, r=0.49) 3. There was no significant relationship between percent body fat and body comosition and 5,000meter performance for both.

산란계 사료첨가제로서 크릴분말의 효과

김종덕,장재익,유문일,정흥우,권찬호,오두식,김창현 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.1

본 시험은 크릴 분말의 사료적 특성을 조사하고, 산란계 사료에 첨가하였을 때 계란의 생산성과 품질을 비교하기 위하여 수해하였다. 크릴 분말을 산란계 사료에 0, 1 및 2% 수준으로 첨가하여 216수에 6주간 사양시험을 실시하였다. 크릴분말의 일반성분은 수분 8.25%, 조단백질 50.52%, 조지방 16.67%, 조회분 15.72%로 단백질과 지방이 높은 동물성 사료원료였다. 그리고 무기질(15.72%), astaxanthin (10ppm) 및 콜레스테롤 함량 (780ppm) 또한 많았다. 산란율, 연파란율, 일일사료섭취량 및 난중은 처리간에 유의적인 차이가 없었다. 황고 및 난황색도는 크릴의 첨가수준이 높을수록 유의적으로 높아 산란계의 난질을 향상시키는 첨가제로서의 가능성을 보였다. 이상의 결과를 볼 때 크릴 분말은 단백질과 지방이 높은 동물성 사료이며, 산란계에서 천연착색제로의 가능성을 보였다. This experiment was conducted to evaluate the chemical composition of Antarctic Krill(Euphausia superba Dana) meal as feed, and to investigate the effect of its supplementation on productivity and egg quality of laying hen. A total of 216 layers at the age 43 weeks in commercial cage were fed for 6 weeks with 3 different diets containing 0, 1, and 2% Krill meal (KM). The chemical composition of KM was consisted of moisture 8.25%, crude protein 50.52%, crude fat 16.67%, curde ash 15.72%, indicating that KM contains large amount of protein and fat. Krill meal also contains large amounts of mineral(15.72%), astaxanthin(10ppm) and cholesterol(780ppm). No differences were found in egg production, broken and soft eggs, and feed intake among treatments. Dietary supplementation of KM resulted in increased egg yolk height(6.1㎜) and yolk color (2) compared with those of control, suggesting that KM can be used as a feed additive for yolk quality improvement. According to the results of this study, Krill meal can be supplemented in laying hen diets as protein and fat sources, and natural coloring pigment.

초소형 구조물의 부착 방지를 위한 새로운 자기 집합 물질에 대한 연구

김봉환,오창훈,전국진,정택동,변장웅,이윤식 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

In order to achieve stiction-free polysilicon surfaces, we have suggested a new chemical grafting precursor and confirmed their excellent characteristics. When dichlorodimethylsilane(DDS, C_(2)H_(6)SiCl_(2)), a dialkyldichlorosilane widely used in silicon machining, have been used as a precursor, experimental results were clearly comparable to those of monoalkyltrichlorosilanes octadecyltrichlorosilane (OTS, C_(18)H_(37)SiCl_(3)) or 1H,1H,2H,2H-perfluorodecyltrichloro-silane (FDTS, C_(10)H_(4)F_(17)SiCl_(3)) in terms of stiction reduction. The polysilicon cantilevers were fabricated in the carefully controlled conditions and laser interferometer indicated that their residual stress gradient was 2 MPa/μm upward from the substrate. The SEM images of polysilicon cantilever beams with DDS coating are upward and no stiction is observed up to 2 mm in length.

點播粒數에 따른 靑刈大豆의 生育反應 및 飼料成分變化

趙南棋,吳章植,朴良門,宋昌吉 濟州大學校亞熱帶農業硏究所 1997 亞熱帶農業硏究 Vol.14 No.-

本 硏究는 濟州道에 있어서 點播粒數에 따른 濟州在來大豆의 生育反應 및 飼料成分에 미치는 影響을 究明하기 위하여 1996年 5月 10日부터 8月 16日까지 遂行하였던 結果를 要約하면 다음과 같다. 1. 草長은 4粒區에서 115cm로 가장 길었으며, 1粒區에서 110cm로 가장 짧았다(Y=-0.527X^2+3.885X+107.110). 2. 莖直徑, 分枝數, 葉數 等의 形質은 點播粒數가 많아질수록 減少되는 傾向이었다. 3. 生草收量은 4粒區에서 10a當 3633kg으로 가장 많았으며, 3粒과 5粒區는 中間이었고, 1粒區에서는 2349kg으로 가장 적었다.(Y^*=-125.088X^2+995.387X+1510.790) 4. 乾草收量은 4粒區에서 839kg으로 가장 많았으며, 5粒과 6粒區에서는 中間이었고, 1粒區에서는 509kg으로 가장 적은 편이었다.(Y^*=-23.839X^2+221.255X+279.720) 5. 組蛋白賃과 粗脂肪은 點播粒數가 많아질 수록 增加하였으며, 粗纖維와 粗灰分은 減少되었다. 6. 草長은 生草收量과 正의 相關을 나타내었고, 莖直徑·分枝數·葉數·葉重 等의 形質과는 高度로 有意한 正의 相關을 나타냈으며, 粗焉白質과는 負의 相關을 나타냈다. The study has been conducted to clarify the effects of number of seeds per hill in dibbling on the growth and feed composition of Cheju Local Soybean from May 10 to August 16 in Cheju-Do. The results obtained are summarized as follows ; 1. Plant height when four seeds per hill in dibbling(115cm) was the longest, while one seeds per hill in dibbling(110cm)was the shortest(Y=-0.527X^2+3.885X+107.110). 2. The diameter of stems, number of branches and number of leaves per plant decreased with the number of seeds per hill in dibbling increased. 3. Fresh yield per 10a when four seeds per hill in dibbling(3633kg) were the greatest and three seeds per hill in dibbling, when five seeds per hill in dibbling were intermediate but one seeds per hill in dibbling(2349kg) was the lightest. (Y^*=-125.088X^2+995.387X+1510.790) 4. Dry yield per 10a when four seeds per hill in dibbling(839kg) were the heaviest and when five, six seeds per hill in dibbling were intermediate but one seeds per hill in dibbling(509kg) was the lightest(Y^*=-23.839X^2+221.255X+279.720). 5. Crude protein and crude fat increased with the number of seeds per hill in dibbling increased, but crude fiber and crude ash decreased. 6. There was positive correlation between plant height and fresh yield, and further highly positive correlation between plant height and the diameter of stems, number of branches, number of leaves, or the weight of loaves and negative correlation between plant height and crude protein.