사상 : 농암 김창협의 학문 수용과 지각론

김영훈 ( Young Hoon Kim ),전선숙 ( Sun Suk Jeon ),신창호 ( Chang Ho Shin ) 영산대학교 동양문화연구원 2012 동양문화연구 Vol.11 No.-

본 연구는 조선시대 유학자인 농암(農巖) 김창협(金昌協, 1651-1708)의 학문 수용 과정을 지각론을 중심으로 살펴본 것이다. 김창협은 율곡학파 계열의 학자이지만 퇴계 이황의 학설에 호감을 갖고 이를 긍정하여 자신의 학파와 절충하는 독특한 사상을 전개하였다. 율곡 이이의 사단칠정론에 대해 반대한 것은 아니지만 비판적 입장을 취하면서, 리발(理發)을 중심으로 하는 퇴계 이황의 이론을 수용하였다. 그것은 호락논쟁으로 이어지면서 김창협의 학문적 성숙을 유도하였고, 마침내 지각설이라는 이론 체계로 드러났다. 그의 지각론은 첫째, 성(性)은 성즉리(性卽理)의 입장에서 파악해야 하고 지(智) 또는 리(理)를 중심으로 해석해야 한다는 것, 둘째, 지(智)는 분별의 리(理)로 해석하는 것이 옳고, ‘밝게 비춘다’라는 구절의 해석에서 기미와 색상은 자연스럽게 드러난다는 점, 셋째, 지(智)는 사물의 시비득실(是非得失)의 차별을 구별하고 판단하는 기준이 된다는 점 등이 강조되었다. 다시 말하면, 인간은 사물을 접하게 마련이고, 심(心)의 지각은 이를 감각 기관을 통하여 받으며, 지각을 통해 받아들인 것은 인의예지신(仁義禮智信)의 성(性)에 의해 정해지고, 인간은 자신의 행동을 결정하며, 지는 인간의 내부에서 구체적인 정(情)의 작용인 측은지심, 수오지심, 사양지심, 시비지심의 모습으로 나타난다는 것이다. 이러한 인식은 인간을 주체이고 능동적 역할을 하는 존재로 부각시키는 사상적 근거가 된다. This research aimed to review the process regarding acceptance of studies about Nongam Kim Chang-Hyeop who was a confucian of Joseon Dynasty with the theory of intelligence and perception as the central figure. Being the scholar of Yulgok school, Kim Chang-Hyeop was interested in Toegye Lee Hwang`s theory, agreed with it, made a compromise with his school, and developed his unique thought. Although he did not object to Yulgok Lee Yi`s Sa Dan Chil Jeong Non(四端七情論, it is a theory regarding Sa Dan which are perfect virtue, righteousness, courtesy, and perception according to the theory of Mencius. and Chil Jeong which are pleasure, anger, sadness, joy, love, hate, and avariciousness), he took a critical attitude regarding it and accepted Lee Hwang`s theory with Li Bal(理發, appearing principle law) as the central figure. It was followed by Ho Rak Non Jaeng(湖洛論爭, it is an argument regarding whether human nature and thing`s nature are same or not), led the maturity of Kim Chang-Hyeop`s study, and finally appeared with the theoretical system of intelligence and perception. His theory of intelligence and perception emphasized that first, nature is perceived by "nature is principle law" and interpreted by intelligence or principle law. Second, it is right that intelligence is interpreted by principle law of discernment and smell, taste, and color naturally appear with interpretation of "shine brightly on." Third, intelligence is the criterion of discernment and judgement regarding differentiation of Si Bi Deuk Sil(是非得失, right, wrong, obtaining, and losing) about things. In other words, a person always faces any things, intelligence and perception of mind is arranged through sense organ, things accepted through intelligence and perception are determined by the nature of In Ui Ye Ji Sin(仁義禮智信, perfect virtue, righteousness, courtesy, intelligence, and trust), people determine their action, intelligence appears with the working of feeling which are Cheuk Eun Ji Sim, So O Ji Sim, Sa Yang Ji Sim, and Si Bi Si Sim. This perception becomes a foundation of thought which emphasizes human beings as a active role and a subject.

Long second toe: its nail and skin changes

( Geun-hwi Park ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Nail can be affected by trauma, infection, and systematic disorders. In particular, the toe nails are exposed to the repeated and cumulative minor traumas, which usually result in thickened, splitted, and discolorated nails. Considering these, it can be inferred that the long second toe can be related to various nail and skin changes by repeated minor traumas such as friction in shoes, but the study or report on this topic hasn’t been done yet. Objectives: The purpose of this study was to introduce various nail and skin changes on long second toe. Methods: We analyzed the kinds of nail/skin changes of 50 patients with long second toe, enrolled at Pusan National University Hospitals (Busan and Yangsan) from 2013 to 2018. Results: There was no significant difference in the incidence of left and right toe and toenail, and 7 (14%) patients presented bilateral distribution. The most common nail change on long second toe was melanonychia (23, 46%), followed by subungual hematoma (15, 30%), onycholysis (2, 4%), subungual hyperkeratosis (2, 4%), onychomadesis (1, 2%), and retronychia (1, 2%). The most common skin change was corn (9, 18%), followed by paronychia (2, 4%). Twenty (20/50, 40%) patients also had other toe or toenail changes. Among them, the most common site was big toe/nail (13, 62%), and the most common change was subungual hematoma (8, 42%). Conclusion: Through this study, the dermatologists can recognize and diagnose the nail and skin changes of long second toe.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

Correlation between skeletal and dental changes after mandibular setback surgery-first orthodontic treatment

Chang-Hoon Rhee,Youn-Kyung Choi,Yong-Il Kim,Seong-Sik Kim,Soo-Byung Park,Woo-Sung Son 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.2

Objective: To investigate skeletal and dental changes after application of a mandibular setback surgery-first orthodontic treatment approach in cases of skeletal Class III malocclusion. Methods: A retrospective study of 34 patients (23 men, 11 women; mean age, 26.2 ± 6.6 years) with skeletal Class III deformities, who underwent surgery-first orthodontic treatment, was conducted. Skeletal landmarks in the maxilla and mandible at three time points, pre-treatment (T0), immediate-postoperative (T1), and post-treatment (T2), were analyzed using cone-beam computed tomography (CBCT)-generated half-cephalograms. Results: The significant T0 to T1 mandibular changes occurred ?9.24 ± 3.97 mm horizontally. From T1 to T2, the mandible tended to move forward 1.22 ± 2.02 mm, while the condylar position (Cd to Po-perpendicular plane) shifted backward, and the coronoid process (Cp to FH plane) moved vertically. Between T1 and T2, the vertical dimension changed significantly (p < 0.05). Changes in the vertical dimension were significantly correlated to T1 to T2 changes in the Cd to Po-perpendicular plane (r = ?0.671, p = 0.034), and in the Cp to FH plane (r = 0.733, p = 0.016), as well as to T0 to T1 changes in the Cp to Poperpendicular plane (r = 0.758, p = 0.011). Conclusions: Greater alterations in the vertical dimension caused larger post-treatment (T2) stage skeletal changes. Studying the mandibular position in relation to the post-surgical vertical dimension emphasized the integral importance of vertical dimension control and proximal segment management to the success of surgery-first orthodontic treatment.

‘뉴노멀(New ’시대의 도래, 무엇을 그리고 어떻게 설교할 것인가?

김창훈(Chang Hoon Kim) 신학지남사 2021 신학지남 Vol.88 No.4

주지하는 것처럼, 오늘날 한국 교회는 여러 면에서 심각한 위기 가운데 있다. 설상가상으로 우리 사회는 문화적으로, 환경적으로 그리고 기술적으로 이전에 거의 예상치 못한 엄청난 변화를 경험하고 있다. 그러한 변화의 상황을 흔히 ‘뉴노멀(New Normal)’이라고 부른다. 쉽게 이야기하면, 이전과는 많이 다른 새로운 시대가 도래했으며 우리는 그 변화된 상황에 적응해야 한다는 것이다. 그런데 우리 사회가 경험하고 있는 변화의 내용과 성격을 잘 규정지어 주는 용어들이 있는데, 그것은 ‘포스트모더니즘(Postmodernism),’ ‘포스트(또는 위드) 코로나(Post or With Corona),’ 그리고 ‘4차 산업혁명(The Fourth Industrial Revolution)’이다. 최근 여러 신학자들이 사회적 측면에서, 신학적 측면에서, 목회적 측면에서 그리고 설교학적 측면에서 오늘날 한국 교회의 위기와 뉴노멀 시대의 여러 현상들을 분석, 평가하며 한국 교회가 나아가야 할 방안들을 제시하고 있다. 그런데 필자는 오늘날의 위기와 사회적 변화들을 좀 더 종합적으로 분석하고 평가할 필요가 있다고 생각한다. 왜냐하면 이러한 현상들과 변화들이 우리에게 따로 따로 분리되어서 다가오는 것이 아니라 종합적으로, 동시에 그리고 상호영향을 미치면서 다가오기 때문이다. 본고에서 필자는 복잡하게 급변하는 오늘날의 현상들을 정리 분석하고, 청중분석의 관점에서 그러한 현상들로 인해 교회와 성도들에게 어떤 변화가 있었는지 살펴본 후에, 이 시대에 적실하고 효과적이며 능력 있는 설교를 위해 설교학적으로 중요한 부분이 무엇인지 제안하였다. As is well known, todays Korean churches are in a serious crisis in many ways. To make matters worse, our society is experiencing enormous changes that were almost unexpected before culturally, environmentally, and technologically. Such a situation of change is often referred to as ‘New Normal’. In other words, a new era has arrived that is much different from before and we have to adapt to the changed situation. However, there are terms that define the content and nature of the changes that our society is experiencing, which are ‘Postmodernism,’ ‘Post or With Corona,’ and ‘The Fourth Industrial Revolution.’ Recently, several theologians have analyzed and evaluated the crisis of the Korean church and various phenomena of the New Normal era in terms of social, theological, pastoral, and preaching, suggesting ways for the Korean church to move forward. However, I think it is necessary to more comprehensively analyze and evaluate todays crises and social changes. This is because these phenomena and changes do not approach us separately, but come comprehensively, simultaneously, and mutually. In this paper, I summarized and analyzed todays complexly and rapidly changing phenomena, examined what changes have been made to churches and believers from the perspective of audience analysis, and suggested what is important for proper, effective, and competent preaching in this era.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Factors associated with inflammatory change of epidermal cyst

( Jisang Yun ),( Kyung-nam Bae ),( Jin-hwa Son ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byungsoo Kim ),( Moon-bum Kim ),( Kihyuk Shin ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1

Background: Epidermal cysts (EC) are the most common tumors found on the skin and accompanying inflammation is also frequent. However, the predictors for inflammatory change have not been investigated yet. Objectives: This study was performed to investigate the difference between inflamed and uninflamed epidermal cysts, and to assess associated factors for inflammatory change. Methods: We analyzed the biopsy-proven 1723 epidermal cysts (515 inflamed and 1208 uninflamed) at two tertiary hospitals from 2011 to 2021. Results: The proportion of inflamed epidermal cysts (IEC) and uninflamed epidermal cyst (UIEC) were 29.9 % and 70.1 %, respectively. Inflammatory change was less frequently observed on the face (25.5 %) than the other sites (32.1 %) (p=0.0046). The anatomic location with the highest rate of inflammatory change was back (40.8 %, p=0.0004). Mean duration of inflammatory change from UIEC to IEC on the face was shorter than the other sites (12.5 months vs 17.9 months, respectively, p= 0.0473). On ultrasonography, long axis of IEC (20.7mm) was generally longer than that of UIEC (15.7mm) (p=0.0218). Moreover, Inflammatory change was more frequent on the EC with punctum compared to those without punctum (35.3 % vs 30.3 %, P=0.0471). Conclusion: Based on the location, size and presence of punctum, decision on the optimal treatment strategies can be established when encountering patients with EC.

FC 2-8 : Factors associated with inflammatory change of epidermal cyst

( Jisang Yun ),( Kyung-nam Bae ),( Jin-hwa Son ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byungsoo Kim ),( Moon-bum Kim ),( Kihyuk Shin ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-

Background: Epidermal cysts (EC) are the most common tumors found on the skin and accompanying inflammation is also frequent. However, the predictors for inflammatory change have not been investigated yet. Objectives: This study was performed to investigate the difference between inflamed and uninflamed epidermal cysts, and to assess associated factors for inflammatory change. Methods: We analyzed the biopsy-proven 1723 epidermal cysts (515 inflamed and 1208 uninflamed) at two tertiary hospitals from 2011 to 2021. Results: The proportion of inflamed epidermal cysts (IEC) and uninflamed epidermal cyst (UIEC) were 29.9 % and 70.1 %, respectively. Inflammatory change was less frequently observed on the face (25.5 %) than the other sites (32.1 %) (p=0.0046). The anatomic location with the highest rate of inflammatory change was back (40.8 %, p=0.0004). Mean duration of inflammatory change from UIEC to IEC on the face was shorter than the other sites (12.5 months vs 17.9 months, respectively, p= 0.0473). On ultrasonography, long axis of IEC (20.7mm) was generally longer than that of UIEC (15.7mm) (p=0.0218). Moreover, Inflammatory change was more frequent on the EC with punctum compared to those without punctum (35.3 % vs 30.3 %, P=0.0471). Conclusion: Based on the location, size and presence of punctum, decision on the optimal treatment strategies can be established when encountering patients with EC.

Label-free DNA detection with a nanogap embedded complementary metal oxide semiconductor

Kim, Chang-Hoon,Jung, Cheulhee,Lee, Kyung-Bok,Park, Hyun Gyu,Choi, Yang-Kyu IOP Pub 2011 Nanotechnology Vol.22 No.13

<P>A nanogap embedded complementary metal oxide semiconductor (NeCMOS) is demonstrated as a proof-of-concept for label-free detection of DNA sequence. When a partially carved nanogap between a gate and a silicon channel is filled with charged biomolecules, the gate dielectric constant and charges are changed. When the gate oxide thickness reduces, the threshold voltage is significantly affected by a change of the charges, whereas it is scarcely influenced by a change of the dielectric constant. In the case of DNA, those two factors act on the threshold voltage oppositely in an n-channel NeCMOS but collaboratively in a p-channel NeCMOS because of the negative charges of DNA. Hence, a p-channel NeCMOS with a thin gate oxide is more attractive for DNA detection because it enhances the shift of threshold voltage; that is, it improves the sensitivity of DNA detection. In addition, the shift of threshold voltage according to the nanogap length is also investigated and the longer nanogap shows more shift of the threshold voltage.</P>

충주시 고등학생의 최근 4년간(1988-2001) B형간염 표면항원 및 항체 양성률 조사

김형수,이건세,장성훈,박수경,김청식,이창희,권혁중,정순섭 한국역학회 2002 Epidemiology and Health Vol.24 No.2

Objective : Since Korea has been known to be of the endemic area for hepatitis B virus(HBV) infection, vaccination for HBV has been recommended for all neonates in Korea. After starting vaccination in 1983, the change of sero-positivity of HBsAg and HBsAb is expected. This study was carried out to investigate the seropositive rate of hepatitis B virus surface antigen and antibody in high school freshmen students in Chungju-city. Methods and Materials : From 1998 to 2001, a total of 11,735 who were born in 1982 to 1986, were enrolled in this study. HBsAg and anti-HBs were tested by reversed passive hemagglutination and passive hemagglutination, respectively. Results : The study population was 11,735 students who were composed of 5,813 males (49.6%) and 5,914 females (50.4%). The HBsAg sero-positivity of male and female students was 3.25% (n=381) and 2.59% (n=153) respectively. The anti-HBs sero-positivity of male and female students was 62.2% (n=3,154) and 64.1% (n=2,969) respectively. There are significant difference observed in comparison of HBsAg and anti-HBs seropositivity according to sex (p<0.05). From 1982 to 1986 on birth year, anti-HBs sero-positivity has been increased significantly from 63.3% to 73.3%. But the change of HBsAg sero-positivity has not been changed significantly. Conclusions : As compared with previous studies of HBsAg and anti-HBs, the sero-positive rate of HBsAg has not been changed but that of HBsAb has been increased significantly. This result revealed that the effect of HBV vaccination program was successful.