고혈압과 비만증이 심초음파도상 좌심실기능에 미치는 영향에 관한 연구

유창범,김성구,권영주 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

비만증은 관상동맥질환의 위험인자로 작용함과 동시에 고혈압과 밀접한 관계가 있다. 비만증은 심장에 구조적변화와 기능적 장애를 유발하며 이에 대한 임상적, 혈역학적, 생화학적 방법에 의한 연구는 많이 있었으나 심초음파도 및 도플러(Doppler) 혈류검사를 이용한 연구는 많지 않다. 대상 및 방법 : 고혈압과 비만증이 있는 군(Ⅰ군, 13명)과 혈압은 정상이나 비만증이 있는 군(Ⅱ군, 21명), 혈압이 정상이고 비만증도 없는 군(Ⅲ군, 14명)을 대상으로 비만도, 혈압측정, 생화학적 검사, 심전도, 심초음파도 및 도플러 혈류검사를 시행하였다. 결과 : 1. 초음파 검사에서 Ⅰ군의 심실중격 및 후벽의 두께, 좌심방내경, 좌심실질량이 Ⅲ군보다 유의하게 컸으며, Ⅱ군에서는 좌심방내경이 Ⅲ군 보다 유의하게 컸다. 2. 승모판 도플러 검사에서 Ⅰ군의 A파 최대속도와 A-TVI는 Ⅲ군 보다 유의하게 컸으며, Ⅱ군의 A파 최대속도와 A-TVI는 Ⅲ군 보다 큰 경향이 있었다.(P〈0.06) 3. 비만증에서 체지방 비율과 비만도는 심실중격 및 좌심실후벽의 두께, 좌심방내경, 좌심실질량, 승모판혈류의 A파 최대속도 및 A-TVI와는 유의한 상관관계가 있었다. 결론 : 비만증환자의 심초음파도 및 도플러 혈류 검사에서 좌심실과 좌심방의 구조적 변화 및 기능장애가 관찰되었고 이는 비만정도와 상관관계가 있었다. Background : Obesity is a risk factor for coronary artery disease and is associated hypertension. Obesity increases the cardiac dimension and functional abnormality and many studies on clinical, hemodynamic and biochemical method have been done but few studies on echocrdiographic and doppler flow method have been done. Methods: We performed obesity measurement, measurement of blood pressure, biochemical labs, electrocardiogram, echocardiogram and doppler flow echocardiogram in obese patients with hypertension (Group I, 13cases), obese normotensive (Group Ⅱ, 21 cases) and lean normoterive patient(Group III, 14 cases) and used to compare with the characteristics of these groups and their relation to obesity. Results: 1. In echocardiogram, interventricular septal thickness, left ventricular posterior wall thickness, left atrial dimension, and left ventricular mass were greater in group I than group III. Group II had greater left atrial dimension than group III. Left ventricular dimension showed tendency to more increasing in group I and II than group III. 2. In doppler mitral flow, A peak velocity and A-TVI were greater in group I than group III. A peak velocity and A-TVI showed tendency to more increasing in group II than in group III(P<0.06). 3. Total body fat and obesity index in obese patients correlated with the interventricular septal thickness, left ventricular posterior wall thickness, left atrial dimension, left ventricular mass index and A peak velocity and A-TVI in doppler mitral flow. Conclusion: The present study demonstrates that obese patients have left ventricular and left atrial structural and functional abnormality in echocardiogram and doppler mitral flow and it correlates with degree of obesity. Obese patients with hypertension had greater degree of abnormalities.

공기재생용 고온건식탈황제의 가압유동층 반응기에서의 사이클 성능실험

조성호,이봉희,이중범,류청걸,진경태,이창근 한국화학공학회 2002 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.40 No.2

고온고압 기포유동층 반응기에서 분무건조기로 성형제조한 아연계 탈황제(ZAC C)에 대하여 총 6회 황화-재생 반복실험을 500℃, 5atm 조건에서 수행하였다. 1% H_2S를 포함한 석탄모사가스를 반응기에 주입하여 황화반응을 시킨 결과 배출가스 중 H_2S 농도는 10ppmv 이하로 유지되었다. ZAC C의 황흡수력은 6회 황화반응 동안 각각 11.1, 10.9, 11.1, 11.1, 10.9, 10.5g S/100g sorbent으로 유지되어 초기 황흡수력을 유지하였다. 공기를 이용한 500℃ 재생반응에서 배출되는 SO_2의 최대농도는 양론적으로 이론값과 일치하였다. 재생반응에서 탈황제 층의 온도는 발열반응에 의해 500℃에서 최대 750℃까지 상승하였다. 연속 70시간 동안 유동층 반응기내에서 실시된 ZAC C 탈황제의 비산되어 유출된 양은 1.07%이고, 실험 후 탈황제의 크기와 조직특성의 변화도 적었다. 고온고압반응기 multi-cyclone 실험결과 ZAC C 탈황제는 이론 황흡수력의 50% 이상을 유지하였고, 공기를 사용한 500℃의 재생반응이 원활하고 완전히 이루어졌고, 황산염생성과 같은 부반응이 없었다. Two desulfurization-regeneration experiments for a spray-dried zinc-based sorbent(ZAC C) were performed at 500℃ and 5 atm in a fluidized-bed reactor(ID 0.097㎜) facility. The H_S concentration after each desulfurization run was maintained below 10 ppmv from a simulated coal gas of 1% H_2S. The estimated sulfur absorption capacities of ZAC C sorbent were 11.1, 10.9, 11.1, 11.1, 10.9, 10.5 g S/100g sorbent, and the sorption capacity of sorbent was maintained in spite of six times sorption experiments. The maximum SO_2 concentration in regeneration effluent gas agreed with a stoichiometric value of 500℃(ca. 14vol%). In regeneration run, the peak temperature of sorbent bed in the reactor reached up to 750 due to the vigorous exothermicity of regeneration reaction with neat air. While entrainment rate for 70h continuous run in fluidized-bed reactor is 1.07%, the size and the textural properties of ZAC C sorbent also show a little change. Multi-cycle tests in fluidized-bed show that ZAC C sorbent maintains over 50% of its theoretical sorption capacity during 70h run and regeneration reaction undergoes smoothly and completely without side reactions such as sulfate formation.

Changes in Total Polyphenol, Total Flavonoid Contents and Antioxidant Activities of Hibiscus cannabin us L.

Ryu, Seung-Won,Jin, Cheng-Wu,Lee, Han-Shin,Lee, Ji-Yeon,Sapkota, Kumar,Lee, Beom-Goo,Yu, Chang-Yeon,Lee, Myoung-Ku,Kim, Myong-Jo,Cho, Dong-Ha The Korean Society of Medicinal Crop Science 2006 한국약용작물학회지 Vol.14 No.5

This study purposed to look for its uses by analyzing useful substances in kenaf (Hibiscus cannabin us L.) leaves based on the total polyphenol and flavonoid contents in the leaves, DPPH radical scavenging activity of leaf extract, SOD activity, etc. by different growth stage and variety. According to the results of experiment, the total polyphenol content was highest in Everglade-41 (27.9 mg/g dw.), the total flavonoid content was highest in Tainung-2 (42.3 mg/g dw.), and SOD activity was highest in Dowling (96.1 %). However, DPPH radical scavenging activity was similar among the three varieties.

Bacteremia With Nontyphi Salmonella and Therapeutic Implication

( Chang Beom Ryu ),( Myugn Lyel Lee ),( Eun Kyung Namgoong ),( Shin Young Kee ),( Wee Gyo Lee ),( Jun Hee Woo ) 대한내과학회 1995 The Korean Journal of Internal Medicine Vol.10 No.2

Changes in Resistance to Fluorquinolone in E. coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa in vitro

Ryu, Chang Beom,Rha, Eun Seon,Woo, JunHee 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.2

목적 : 세균의 효소인 DNA gyrase와 작용하여 감수성이 있는 세균에서 DNA-supercoiling을 저해하는 oflozacin과 ciprofloxacin은 그람음성간균에 의한 감염증에 탁월한 효과를 보이는 경구용 항균제의 대표이다. 최근들어 상당히 많은 감염증에 사용되고 있어 내성이 임상적으로 문제가 되고 있다. 저자들은 그람음성 간균 가운데 대장균, K.pneumoniae, 녹농균의 ofloxacin, ciprofloxacin에 대한 감수성의 변화를 조사하기 위하여 최소억제농도를 측정하였다. 방법 : 1989-1990년 환자의 혈액 배양에서 분리 동정된 17균주의 녹농균과 대장균, 14균주의 K.pneumoniae와 1994년에 환자의 혈액뇨, 객담 배양에서 분리 동정된 16균주의 녹농균, 18균주의 대장균, 20균주의 K.pneumoniae를 대상으로 배지회석법에 의한 최소억제농도를 측정하여 감수성의 변화를 비교하였다. 성적 : 1) Ciprofloxacin 대하여 녹농균은 1990년 17균주에서 1균주(5.8%), 1994년에 16균주중 6균주(37.5%)에서 감수성이 감소되었다.(p=0.03) 2) Cirprofloxacin에 대하여 Klebsiella는 1990년 14균주에서 0균주(0%), 1994년 20균주중 4균주(20%)에서 감수성이 감소하였다.(p>0.05) 3) Ciprofloxacin 대하여 대장균은 1990년 17균주에서 1균주(5.8%), 1994년에 18균주중 1균주(5.5%)에서 감수성이 감소되었다. 4) Ofolxacin에 대하여 녹농균은 1990년 17균주에서 3균주(17.6%), 1994년에 16균주중 4균주(25%)에서 감수성이 감소되었다. 5) Ofloxacin에 대하여 Klebsiella는 1990년 14균주중 3균주(16%), 1994년 20균주중 2균주(10%)에서 감수성이 감소하였다. 6) Ofloxacin에 대하여는 대장균은 1990년 17균주중 4균주(23.5%), 1994년 18균주중 4균주(22%)에서 감수성이 감소하였다. 결론 : 대장균은 4년간에 ciprofloxacin과 ofloxacin에 대한 감수성은 rkat하지 않았으나 K.pneumoniae의 내성은 ciprofloxacin에 대하여 증가하는 경향이 관찰되고, 녹농균은 ciprofloxacin에 내성이 증가하는 것이 관찰되었다. 그러므로 전신적 감염증환자에 fluoroquinolone은 더욱 주의를 기울여 투여하여야겠다.

대장 및 직장의 악성 폐색 환자에서 자가확장형인공관 삽입술에 대한 연구

유창범 ( Chang Beom Ryu ),김환열 ( Hwan Yeol Kim ),권강안 ( Kang An Kwon ),정인섭 ( In Sup Jung ),홍수진 ( Su Jin Hong ),김진오 ( Jin Oh Kim ),조주영 ( Joo Young Cho ),이준성 ( Joon Sung Lee ),이문성 ( Moon Sung Lee ),심찬섭 ( Cha 대한장연구학회 2003 Intestinal Research Vol.1 No.1

Background/Aims: The optimal palliative treatment of unresectable colorectal malignant obstruction is still debated. Recently, successful short-term palliation of malignant colorectal obstruction using self-expandable metal stents has been reported by several groups of investigators. Aims: The aim of this study was to evaluate the clinical usefulness of these self-expandable metal stents (SEMS) through the scope for the treatment of malignant colorectal cancer. Methods: Between May 1999 and December 2002, 35 patients (M:F=19:16) with malignant colorectal obstruction were treated for relief from the obstruction with endoscopically guided intubation of a SEMS through the working channel of an endoscope. Uncovered stents were intserted in 29 patients and covered stents in 6 patients. The technical and clinical success rates and complication were evaluated. Results: The sites of obstructions were on the rectum (n=3), sigmoid colon (n=9), descending colon (n=9), transverse colon (n=8) and ascending colon (n=6). SEMS insertion was successful in 34 of 35 patients (97%). In 31 of 34 patients with successful placement of the stent, symptoms of obstruction resolved within 72 hours. Two patients underwent the formal bowel preparation and elective single-stage surgery without complication 10 and 60 days after stent placement. Perforation occurred in 1 patients during stent placement and died. The mean follow up was 144 days (5-610 days). Stent migration occurred in 7 patients during follow-up who were 2 (33.3%) of 6 patients with covered stent and 5 (17.8%) of 28 patients with uncovered stent. After migration of stents, another stent was reinserted in 3 of 7 patients. Obstruction of the stent because of tumor ingrowth and overgrowth was observed in 4 patients with uncovered stent. Conclusions: SEMS placement through the working channel of an endoscope provide not only palliative decompression in cases with inoperable malignant colorectal obstruction but preoperative decompression to undergo the one-step surgery in patients with malignant colorectal obstruction. (Intestinal Research 2003;1:45-50)

『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 근거하여 지실치자탕(枳實梔子湯) 투여 후 호전된 만성피로증후군 1례

류희창,노영범,Ryu, Hee-Chang,Rho, Yeong-Beom 대한상한금궤의학회 2017 대한상한금궤의학회지 Vol.9 No.1

Objective : The purpose of this paper is to report the improvement of patient with Chronic Fatigue Syndrome(CFS) treated by herb medication based on Shanghanlun disease pattern identification diagnostic system. Methods : According to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions', the patient was diagnosed with Eumyangyeokchahunobok-byung, number 393 provision, and took Jisilchija-tang herb medication for 75days. The changing symptom of chronic fatigue syndrome was estimated by QOL-CFS(Chalder Fatigue Scale) and VAS(Visual Analogue Scale). Results : The QOL-CFS changed 21 to 8 and VAS changed 10 to 1. Conclusions : It is existing theory that Eumyangyeokchahunobok-byung is caused by 'having too much sex relation'. But the author diagnosed Eumyangyeokchahunobok-byung as 'Symptoms worsen when awaken at night, and sleep at day caused by poor sleep pattern' according to the palaeography about shanghanlun, and got a good results.

A case report of papillary eccrine adenoma on heel

( Chang Min Kim ),( Hee Won Jang ),( Jae Beom Park ),( Jung Jin Shin ),( Hwa Jung Ryu ),( Il Hwan Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Papillary eccrine adenoma is a rare disease in dermis which presents as small, solitary nodule in extremities, especially in black women. In pathologic view, papillary eccrine adenoma is similar to tubular apocrine adenoma but its tubular structure consists of eccrine gland instead of apocrine gland. It also shows papillary projections toward the lumina. A 23-year-old female patient presented with hard subcutaneous nodule on right heel, which appeared 3 years prior to the visit. Under the initial impression of callus, soft tissue sonography was performed to examine the lesion. The result was nonspecific soft tissue tumor and no specific diagnosis could be made. Under the final impression of epidermal cyst, excision of the lesion was performed. The initial pathologist report was consistent with tubular adenoma. To further evaluate the tubular structure, S-100 and CEA stain was performed. Both stain results were positive, indicating eccrine gland proliferation within the tumor. Therefore the mass was finally diagnosed as papillary eccrine adenoma of right heel. Papillary eccrine adenoma was reported a few times in Korea. However, no Korean report of this tumor on heel could be found. Herein we report a rare case of papillary eccrine adenoma arising on heel.

Lower extremity lymphatic leakage and lymphedema secondary to punch biopsy

( Chang Min Kim ),( Bo Young Kim ),( Jung Jin Shin ),( Jae Beom Park ),( Deok Woo Kim ),( Yoo Chan Kim ),( Hwa Jung Ryu ),( Il Hwan Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Punch biopsy is a relatively safe procedure compared with other biopsy methods, so there has been very low incidence of complications after punch biopsy. Lymphatic leakage and secondary lymphedema can be one of those complications. ICG lymphography is one of the popular methods to diagnose lymphedema, recently. A 60-year-old female patient presented with asymptomatic crusted erythematous macule with continuous clear discharge on left lower leg after punch biopsy, which was done 50 days prior to the visit. Under the initial impression of lymphatic leakage due to trauma, indocyanine green(ICG) lymphography was performed to examine blockage of lymphatic drainage. During the ICG lymphography, Dermal backflow(DB) pattern was found on the left lower leg. Under the final diagnosis of secondary lymphedema and lymphatic leakage, lymphatic vessel ligation was performed on department of plastic surgery. No recurrence of lymphatic leakage or lymphedema has been reported till now. Although secondary lymphedema due to sentinel lymph node biopsy has been reported a few times, there was no report of simple skin punch biopsy induced secondary lymphedema and lymphatic leakage. Herein we report a rare case of secondary lymphedema and lymphatic leakage, the complication induced by punch biopsy.

Free Amino Acids, Collagen Solubility, and Meat Quality in Pork (Longissimus Muscle of Yorkshire) as a Function of Chiller Temperature and Aging

Beom-Young Park,Kyoung-Mi Park,Jin-Hyung Kim,Soo-Hyun Cho,Nam-Kuk Kim,Min-Jin Song,Chang-Soo Lee,In-Kyung Cho,Ho-Sung Choe,Kyeong-Seon Ryu,In-Ho Hwang 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.1

This study was conducted to identify the effect of chilling temperature (-3 and 6℃) and aging (1- and 7-day) on objective meat quality, collagen solubility, and free amino acids in pork (longissimus muscle of Yorkshire). Warner-Bratzler (WB)-shear force indicated that variation in chilling temperature had no detectable effect on meat tenderness and tenderization during the 7-day aging period. Among the 13 detected free amino acids, only 3 amino acids (histidine, valine, leucine) were significantly affected by the temperature treatment (p<0.05). Collagen solubility was significantly increased at 6℃ treatment (p<0.05). There was a significant linear relationship (r=0.67, p<0.05) between changes in free amino acids and WB-shear force during the 7-day aging period. These results confirmed that chilling conditions had significantly affected collagen solubility, and meat tenderization occurred in direct proportion to an increase in free amino acids.