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소변배출, 유산소 운동, 음식 및 물섭취가 생체전기 저항법을 이용한 신체조성측정에 미치는 영향
조채은 ( Chaeeun Cho ),이세원 ( Sewon Lee ) 한국운동생리학회 2021 운동과학 Vol.30 No.4
PURPOSE: Body composition is strongly associated with cardiometabolic risk factors, and accurate measurement of body composition is vital for the management of chronic diseases. In this study, we assessed whether major factors such as urination, aerobic exercise, food, and water consumption had significant effects on body composition by segmental bioelectrical impedance analysis (BIA). METHODS: To achieve the goal of this study, research was conducted on 32 healthy young males (n=18) and females (n=14). All participants underwent body composition analysis in four different conditions (both pre- and post-urination, moderate-intensity aerobic exercise for 30 minutes, immediately after food and water consumption, 30, 60, and 120 minutes after each treatment), and segmental BIA was performed using Inbody720. RESULTS: We found that after urination, body weight, skeletal muscle mass, and basal metabolic rate (BMR) significantly decreased. However, water intake significantly increased body weight, body fat mass, and body fat percentage. Furthermore, an acute 30-minutes aerobic exercise significantly decreased body weight, fat mass, and fat percentage, and increased skeletal muscle mass and BMR. In addition, impedance decreased immediately and increased 120 minutes after the acute aerobic exercise. Finally, food ingestion significantly increased the body weight, skeletal muscle mass, and BMR. CONCLUSIONS: Our study suggests that variables such as urination, exercise, food consumption, and water intake should be considered to accurately assess body composition.
Small-chain fatty acid activates astrocytic odorant receptor Olfr920
Cho, TaeHo,Lee, ChaeEun,Lee, NaHye,Hong, Yu Ri,Koo, JaeHyung Academic Press 2019 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Odorant receptors are the largest subfamily of G protein-coupled receptors and were recently suggested to play critical roles in nonolfactory tissues. However, the expression and function of odorant receptors in astrocytes, the most abundant cells in the brain, are not well known. We demonstrate that Olfr920 is highly expressed and propose that it functions as a short-chain fatty acid sensor in primary cortical astrocytes. The short-chain fatty acid isobutyric acid (IBA) was identified via a luciferase assay as an Olfr920 ligand. We show that IBA activates the G<SUB>s</SUB> protein-adenylyl cyclase-cAMP pathway via Olfr920 in primary cortical astrocytes by using cAMP and knockdown analyses. In addition, IBA reduces lipopolysaccharide-induced glial fibrillary acidic protein expression in reactive astrocytes. These results suggest that astrocytic Olfr920 is a potential novel target for increased reactive astrocytes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> RNA-seq identifies odorant receptor Olfr920 expression in cortical astrocytes. </LI> <LI> The small-chain fatty acid isobutyric acid (IBA) is identified as an Olfr920 ligand. </LI> <LI> IBA activates the G<SUB>s</SUB>-adenylyl cyclase-cAMP pathway via Olfr920. </LI> <LI> IBA activation of Olfr920 blocks LPS-induced GFAP expression. </LI> <LI> These findings suggest a novel function for Olfr920 in primary cortical astrocytes. </LI> </UL> </P>
( Hyun Namgoong ),( Chaeeun Cho ),( Sewon Lee ) 한국운동영양학회 2018 Physical Activity and Nutrition (Phys Act Nutr) Vol.22 No.3
[Purpose] Previous studies have indicated that Kv7 channels have an important role in the regulation of blood vessel reactivity, including in the coronary, renal, and cerebral arteries. The present studies examined whether Kv7 channels regulated vascular reactivity in the mouse aorta and investigated the mechanisms involved in the reactivity. [Methods] Wild-type (WT) male C57BL/6 mice, between 10 and 15 weeks old, were used in this study. The vascular function of the aorta in WT male mice was assessed by using a pin myography system (Model 620; DMT, Denmark). [Results] Vasorelaxation by an endothelial-dependent vasodilator, acetylcholine (ACh, 1 nM - 10 μM) and an endothelial-independent vasodilator, sodium nitroprusside (SNP, 1 nM - 10 μM) was induced in the aorta in a dose-dependent manner. Pre-incubation with the nitric oxide synthase inhibitor, L-NAME (100 μM, 20 min), completely abolished ACh-induced vasorelaxation, but did not block retigabine-induced vasorelaxation, which suggested that retigabine caused vasorelaxation in the aorta via smooth muscle activation rather than via endothelial cells. Pre-application of the Kv7 channel blocker, linopirdine (10 μM), resulted in a greater contractile response compared with that induced by vehicle in the aorta. In addition, pre-incubation with linopirdine (10 μM, 20 min) reduced retigabine-induced vasorelaxation (1-50 μM). [Conclusion] This study has provided evidence that Kv7 channels may play a role in the regulation of aortic blood flow via smooth muscle activation.
CNT/다공성 PDMS와 poly(ethylene oxide) 결합 기반의 웨어러블 자가 발전 압력 감지 소자
조창우(Changwoo Cho),이채은(Chaeeun Lee),오제훈(Je Hoon Oh) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11
The development of technologies such as artificial intelligence and the Internet of Things has increased the demand for wearable self-powered pressure sensors. Triboelectric nanogenerator (TENG)-based self-powered pressure sensors have emerged as a solution to meet this demand. However, the measurement of static and small pressure ranges remains a challenge. In this paper, we propose a self-powered pressure sensing device based on the combination of carbon nanotube (CNT)/porous polydimethylsiloxane (PDMS) composite and poly(ethylene oxide) (PEO) film. The proposed device could continuously and reliably measure static and small-range pressure through capacitive pressure sensing while harvesting energy based on the triboelectric effect. The device exhibited a remarkable sensitivity of 1.37 ㎪-1, due to the incorporation of high-k materials (i.e., CNTs) in its porous structure and dielectric layer. It also had a power density of 15 ㎽/m² due to the triboelectric interaction between PDMS and PEO. Finally, the fabricated device was connected to a microcontroller unit to perform energy harvesting and pressure sensing simultaneously, demonstrating its great potential as a wearable device.
Chan Chung,Hee Jin Cho,ChaeEun Lee,JaeHyung Koo 생화학분자생물학회 2022 BMB Reports Vol.55 No.2
Odorant receptors (ORs), the largest subfamily of G proteincoupledreceptors, detect odorants in the nose. In addition, ORswere recently shown to be expressed in many nonolfactorytissues and cells, indicating that these receptors have physiologicaland pathophysiological roles beyond olfaction. ManyORs are expressed by tumor cells and tissues, suggesting thatthey may be associated with cancer progression or may becancer biomarkers. This review describes OR expression invarious types of cancer and the association of these receptorswith various types of signaling mechanisms. In addition, theclinical relevance and significance of the levels of OR expressionwere evaluated. Namely, levels of OR expression in cancerwere analyzed based on RNA-sequencing data reported in theCancer Genome Atlas; OR expression patterns were visualizedusing t-distributed stochastic neighbor embedding (t-SNE); andthe associations between patient survival and levels of OR expressionwere analyzed. These analyses of the relationships betweenpatient survival and expression patterns obtained froman open mRNA database in cancer patients indicate that ORsmay be cancer biomarkers and therapeutic targets.
한국형 식품 FEMS 실증을 통한 식품공정 에너지 절감율 평가
김동주(Dongju Kim),임채영(ChaeYoung Lim),여채은(ChaeEun Yeo),이형아(Hyungah Lee),조우진(Woojin Cho),구재희(Jae-hoi Gu) 한국환경에너지공학회 2023 한국열환경공학회 학술대회지 Vol.2023 No.1
본 연구는 대상 식품공장에 한국형 식품 FEMS을 구축하고 이를 기반으로 식품 생산 핵심 공정(열에너지 공급공정, 살균공정)의 에너지원 공급 제어를 통한 에너지 절감율을 실증하였다. 식품공장에서 식품생산을 위해 요구되는 열에너지(스팀)을 생산, 공급하기 위한 열에너지 공급공정에 적용한 1 차 에너지 공급 미세비례제어 시스템을 통해 식품공장의 열에너지(스팀) 수요에 맞춰 1 차 에너지의 공급량을 제어하는 기술을 적용하였다. 또한, 살균공정에 공급되는 스팀의 공급량을 제어할 수 있는 PID 컨트롤 시스템을 통해 살균공정의 요구온도예 따라 열에너지 공급량을 최적화하는 기술을 적용하여 각 공정별 에너지 절감율을 도출하였다. 에너지 절감율 평가를 위한 기준 에너지 소비량을 산출하기 위해 IPMVP M&V 프로토콜에 따라 수집된 데이터 기반 에너지 소비 Baseline 모델을 도출하였으며, 이를 바탕으로 에너지 절감율을 평가하였다. 각 공정별 에너지 소비 Baseline 모델을 통해 산출된 에너지 소비 예측값 대비 에너지 절감기술 적용 후 수집된 에너지 소비 데이터를 기반으로 평가된 에너지 절감율은 열에너지 공급공정 6.81 % 및 살균공정 4.71 %로 확인되어 FEMS 실증을 통한 식품공정에서의 유의미한 에너지 절감 효과를 도출하였다. 추후 지속적인 공정데이터 모니터링을 통해 에너지 절감율의 평가를 진행 예정이며, 추가적으로 공정배출 에너지(응축수)의 회수를 통한 공정 에너지절감 연구를 수행하고 있어 이를 통한 에너지 절감율 증대효과를 기대한다.