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Ye, Byoung Seok,Seo, Sang Won,Lee, Yunhwan,Kim, Seong Yoon,Choi, Seong Hye,Lee, Young Min,Kim, Do Hoon,Han, Hyun Jeong,Na, Duk L.,Kim, Eun-Joo S. Karger AG 2012 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS Vol.34 No.3
<P>Abstract</P><P><B><I>Background:</I></B> Amnestic mild cognitive impairment (aMCI) is regarded as a prodromal stage of Alzheimer’s disease (AD). Given that patients with early-onset AD (EOAD) and with late-onset AD (LOAD) are known to have different clinical courses, symptoms and neuroimaging findings, early-onset (EOMCI) and late-onset aMCI (LOMCI) might be expected to have similar differences as EOAD versus LOAD. <B><I>Methods:</I></B> Our study involving 425 patients with aMCI (124 EOMCI, 301 LOMCI), who were followed for around 1.5 years, and 958 normal control subjects (NC) investigated neuropsychological characteristics and prediction of progression to AD in patients with EOMCI versus LOMCI. Neuropsychological scores were compared between EOMCI, LOMCI and NC with analyses of covariance controlling age, gender, education and disease duration. The risk of AD conversion was evaluated by Cox proportional hazard analyses. <B><I>Results:</I></B> The baseline neuropsychological performances were comparable between EOMCI and LOMCI. Visuospatial memory for EOMCI and verbal memory scores for LOMCI were significant predictors of AD conversion. <B><I>Conclusion:</I></B> Our study indicates that EOMCI with visuospatial memory impairment, which implies underlying right predominant pathology, and LOMCI with poor verbal memory, which suggests underlying left predominant pathology, are individual conditions at an increased risk of conversion to AD.</P><P>Copyright © 2012 S. Karger AG, Basel</P>
Hong, Myunghee,Ye, Byong Duk,Yang, Suk-Kyun,Jung, Seulgi,Lee, Ho-Su,Kim, Byoung Mok,Lee, Soo Bin,Hong, Jeonghoon,Baek, Jiwon,Park, Sang Hyoung,Han, Buhm,Li, Yi,Liu, Wenting,Haritunians, Talin,Taylor, Oxford University Press 2018 JOURNAL OF CROHNS AND COLITIS Vol.12 No.6
<P>Conclusions: Our findings of new loci not previously associated with IBD support the importance of studying inflammatory bowel disease genetics in diverse populations.</P>
( Hiroshi Nakase ),( Bora Keum ),( Byoung Duk Ye ),( Soo Jung Park ),( Hoon Sup Koo ),( Chang Soo Eun ) 대한장연구학회 2016 Intestinal Research Vol.14 No.3
Background/Aims: Inflammatory bowel disease (IBD) management guidelines have been released from Western countries, but no adequate data on the application of these guidelines in Asian countries and no surveys on the treatment of IBD in real practice exist. Since there is a growing need for a customized consensus for IBD treatment in Asian countries, Asian Organization of Crohn’s and Colitis performed a multinational survey of medical doctors who treat IBD patients in Asian countries. Methods: A questionnaire was developed between August 2013 and November 2013. It was composed of 4 domains: personal information, IBD diagnosis, IBD treatment, and quality of IBD care. Upon completion of the questionnaire, a web-based survey was conducted between 17 March 2014 and 12 May 2014. Results: In total, 353 medical doctors treating IBD from ten Asian countries responded to the survey. This survey data suggested a difference in available medical treatments (budesonide, tacrolimus) among Asian countries. Therapeutic strategies regarding refractory IBD (acute severe ulcerative colitis [UC] refractory to intravenous steroids and refractory Crohn’s disease [CD]) and active UC were coincident, however, induction therapies for mild to moderate inflammatory small bowel CD are different among Asian countries. Conclusions: This survey demonstrated that current therapeutic approaches and clinical management of IBD vary among Asian countries. Based on these results and discussions, we hope that optimal management guidelines for Asian IBD patients will be developed.
Kim, Geon Ha,Im, Kiho,Kwon, Hunki,Seo, Sang Won,Ye, Byoung Seok,Cho, Hanna,Noh, Young,Lee, Jong Min,Kim, Sung Tae,Park, Sang Eon,Kim, Hojeong,Hwang, Jung Won,Kang, Sue J.,Jeong, Jee Hyang,Na, Duk L. Frontiers Media S.A. 2016 FRONTIERS IN AGING NEUROSCIENCE Vol.8 No.-
<P>The purpose of this study was to demonstrate the potential alterations in structural network properties related to physical activity (PA) in healthy elderly. We recruited 76 elderly individuals with normal cognition from Samsung Medical Center in Seoul, Korea. All participants underwent the Cambridge Neuropsychological Test Automated Battery and 3.0T brain magnetic resonance imaging (MRI). Participants were subdivided into quartiles according to the International Physical Activity Questionnaire scores, which represents the amount of PA. Through graph theory based analyses, we compared global and local network topologies according to PA quartile. The higher PA group demonstrated better performance in speed processing compared to the lower PA group. Regional nodal strength also significantly increased in the higher PA group, which involved the bilateral middle frontal, bilateral inferior parietal, right medial orbitofrontal, right superior, and middle temporal gyri. These results were further replicated when the highest and the lowest quartile groups were compared in terms of regional nodal strengths and local efficiency. Our findings that the regional nodal strengths associated with the attentional network were increased in the higher PA group suggest the preventive effects of PA on age-related cognitive decline, especially in attention.</P>
점막하 종양으로 10년간 추적관찰 중 진단된 위선암 1예
김원,김병관,송인성,정현채,김용일,박수철,김주성,이종열,예병덕 대한소화기학회 2001 대한소화기학회지 Vol.37 No.4
Gastritis cystica profunda (GCP) is an uncommon condition showing multiple cystic gastric glands within the submucosa of the stomach. These lesions usually have been found at the site of gastroenterostomy but may occur in the stomach without a previous history of surgery. Macroscopically, GCP may present as submucosal tumor (SMT), solitary or diffuse polyps and giant gastric mucosal fold. We report a case of gastric adenocarcinoma and GCP diagnosed after being followed up as submucosal tumor for 10 years. The SMT was detected 10 years ago endoscopically and has been followed up by upper gastrointestinal study. In the latest study, there was a newly developed ulceration on the top of the SMT, but no change in the size of the SMT. The lesion was mainly located in the high body, greater curvature side of the previously unoperated stomach.