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A case of peritoneal dialysis-associated peritonitis by Rothia mucilaginosa
( Byeong Gwan Kim ),( A Young Cho ),( Sang Sun Kim ),( Seong Hee Lee ),( Hong Shik Shin ),( Hyun Ju Yoon ),( Jeong Gwan Kim ),( In O Sun ),( Kwang Young Lee ) 대한신장학회 2015 Kidney Research and Clinical Practice Vol.34 No.3
Rothia muciliaginosa (R. mucilaginosa) is a facultative, Gram-positive coccus that is considered to be part of the normal flora of the mouth and respiratory tract. There are sporadic reports of the organism causing endocarditis in patients with heart valve abnormalities, as well as meningitis, septicemia, and pneumonia associated with intravenous drug abuse. However, it is an unusual pathogen in cases of peritoneal dialysis (PD)-associated peritonitis. Although R. mucilaginosa is generally susceptible to penicillin, ampicillin, cefotaxime, imipenem, rifampicin, and glycopeptides, there are no guidelines for the treatment of PD-associated peritonitis. Herein, we report a case of PD-associated peritonitis due to R. mucilaginosa that was resolved with intraperitoneal antibiotic treatment.
크론병에서 항문 주위 병변의 임상상과 치료에 대한 반응
김현대 ( Kim Hyeon Dae ),김찬규 ( Kim Chan Gyu ),김지원 ( Kim Ji Won ),김상균 ( Kim Sang Gyun ),김병관 ( Kim Byeong Gwan ),김주성 ( Kim Ju Seong ),정현채 ( Jeong Hyeon Chae ),송인성 ( Song In Seong ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Background/Aims: The aim of this study was to assess the clinical features and therapeutic responses of perianal lesions in Crohn`s disease. Methods: We retrospectively reviewed medical records of 94 cases with perianal lesions among 231 cases registered as Crohn`s disease in Seoul National University Hospital between January 1975 and June 2001. The cases were investigated after dividing into two different groups. One group included the cases registered between January 1975 and December 1996 and the other group between January 1997 and June 2001. Results: The perianal lesions were observed in 41% of the cases. Perianal lesions were more frequent in colonic Crohn`s disease after 1997, but not before 1996. Fistula was significantly prevalent, followed by abscess, fissure, and stricture. Perianal lesions preceded intestinal symptoms such as abdominal pain and diarrhea in 25% of the cases. The remission rate with non-specific conservative treatment (10%) was lower than that before 1996. The remission rate after specific treatment (77%) was higher than that after surgery (53%). In cases of specific treatment, cumulative relapse rates were 7% in 1 year and 39% in 5 years. Conclusions: Crohn`s disease should be considered in young male patients who have the refractory perianal lesions. Perianal lesions should be managed initially with medical treatment. (Korean J Gastroenterol 2003;42:128-133)
유당분해효소 결핍증의 진단을 위한 십이지장 점막의 자당분해효소 대 유당분해효소 활성도 비
김병관(Byeong Gwan Kim),김선미(Sun Mi Kim),김유선(You Sun Kim),문선희(Sun Hi Moon),이국래(Kook Lae Lee),정현채(Hyun Chae Jung),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2
N/A Background/Aims: Jejunal biopsy with direct quantitative analysis of mucosal enzyme activities is the standard diagnostic method of lactase deficiency. But this test is seldom used in the clinical setting, because it is incovenient and cumbersome. On the contrary, sucrase to lactase activities ratio in duodenal mucosa is easy to measure and comp]iant with patients. We performed this study to investigate the value of sucrase to lactase activities ratio in duodenal mucosa as a diagnostic method of lactase deficiency. Methods: The 36 cases(22 men, 14 women) of this study were selected from healtby adults free from gastrointestinal symptom. We performed H breath test and syptom analysis after lactose load. And then, we obtained the duodenal mucosa by endoscopic biopsy and measured enzyme activities of the duodenal mucosa. Results: In 36 subjects, there were 21 subjects(58%) who had the intolerant symptoms and had more than a 20ppni increase in breath hydrogen. Sucrase to lactase activities ratio of the 21 subjects was more than 8. By the definition of sucrase to lactase activities ratio, the prevalence of lactase deficiency was 86 percent. This result was sirnilar to the previous prevalence(84%) defined by jejunal mucosa enzyme assay in Korean adults. Conclusion: Sucrase to lactase activities ratio of duodenal mucosa is a useful diagnostic tool for lactase deficiency. (Korean J Gastroenterol 1997;29:175 -181)
수용성 단백질로 활성화된 호중구에 대한 Rebamipide 의 효과
김주성(Joo Sung Kim),김정목(Jung Mogg Kim),김병관(Byeong Gwan Kim),김상균(Sang Gyun Kim),김지원(Ji Won Kim),김찬규(Chan Gyoo Kim),정현채(Hyun Chae Jung),송인성(In Sung Song) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.1
Background/Aims: Helicobacter pylori (H. pylori) infection induces persistent neutrophil infiltration in gastric mucosa. The expression of cyclooxygenase (COX)-2 and inhibition of apoptosis in the neutrophils could contribute to the pathogenesis of H. pylori infection. Rebamipide, a mucosal protective and ulcer-healing drug, has been known to inhibit neutrophil activation. The aim of this study was to evaluate the effect of rebamipide on the neutrophils activated by Helicobacter pylori water-soluble proteins. Methods: After neutrophils were stimulated with H. pylori water extract (HPWE) or pretreated with rebamipide, the expression of COX-2 mRNA and protein was assessed by quantitative RT-PCR and Western blotting, respectively. Prostaglandin (PG) E2 synthesis was determined by radioimmunoassay. Neutrophil apoptosis was evaluated by cytosolic oligonucleosome-bound DNA ELISA and caspase-3 activity was measured by the detection of p-nitroanilide after cleavage from labeled substrate. Results: Stimulation with HPWE upregulated COX-2 expression and PGE2 secretion, and inhibited neutrophil apoptosis. Rebamipide suppressed PGE2 secretion from neutrophils in a dose-dependent manner. However, rebamipide did not affect neutrophil apoptosis and caspase-3 activity. Conclusions: Rebamipide effectively suppresses PGE2 secretion from neutrophils activated by H. pylori water-soluble proteins. This is another possible mechanism of gastric mucosal protection by rebamipide. (Korean J Gastroenterol 2002;39:13-21)
염증성 장질환에서 IL-10과 TNF-α 유전자의 단염기 다형성
김지원 ( Ji Won Kim ),김찬규 ( Chan Gyoo Kim ),김현대 ( Hyeon Dae Kim ),김병관 ( Byeong Gwan Kim ),김태호 ( Tae Ho Kim ),이국래 ( Kook Lae Lee ),이동호 ( Dong Ho Lee ),김주성 ( Joo Sung Kim ),정현채 ( Hyun Chae Jung ),송인성 ( In 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 염증성 장질환의 병태생리에 중요한 역할을 하는 IL-10과 TNF-α유전자의 단염기 다형성과 염증성 장질환과의 연관성을 살펴봄으로써 염증성 장질환의 발생에 관여하는 유전적 원인을 규명하고자 하였다. <방법> 궤양성 대장염 환자 76명(남 37, 여 39), 크론병 환자 60명(남 41, 여 19)과 정상 대조군 203명(남 1129, 여 84)을 대상으로 혈액을 채취하였다. IL-10 유전자 촉진자의 일부인 ?082, -819,-592 및 +1
반월형 사구체신염이 병발된 T 림프구 기원의 원발성 간림프종 1 예
김용일,정철원,이현순,김홍빈,박동영,이효석,김성권,소영,김노경,김병관,김선미,이기형,허대석 대한내과학회 1997 대한내과학회지 Vol.53 No.1
The primary lymphoma of the liver is a rare disease. We report a case of primary hepatic T-cell lymphoma associated with crescentic glomerulonephritis. The case, a 53-year-old male was presented with a 2-year history of hepatic mass and a 1-month history of foamy urine, rapidly progressive azotemia, and oliguria. The kidney biopsy revealed diffuse crescentic glomerulonephritis. The result of immunohistochemical study of liver biopsy specimen was consistent with non-Hodgkin's lymphoma in T-cell lineage. Because renal function was deteriorated rapidly and there were signs of volume overload, hemodialyses were performed. Although the patient received 2 cycles of combination chemotherapy with CHOP(cyclophosphamide, vincristine, prednisolone, and doxorubicin), he did not respond and died of sepsis.
Stretchable and transparent electrodes based on in-plane structures
Kim, Kukjoo,Kim, Joohee,Hyun, Byung Gwan,Ji, Sangyoon,Kim, So-Yun,Kim, Sungwon,An, Byeong Wan,Park, Jang-Ung The Royal Society of Chemistry 2015 Nanoscale Vol.7 No.35
<P>Stretchable electronics has attracted great interest with compelling potential applications that require reliable operation under mechanical deformation. Achieving stretchability in devices, however, requires a deeper understanding of nanoscale materials and mechanics beyond the success of flexible electronics. In this regard, tremendous research efforts have been dedicated toward developing stretchable electrodes, which are one of the most important building blocks for stretchable electronics. Stretchable transparent thin-film electrodes, which retain their electrical conductivity and optical transparency under mechanical deformation, are particularly important for the favourable application of stretchable devices. This minireview summarizes recent advances in stretchable transparent thin-film electrodes, especially employing strategies based on in-plane structures. Various approaches using metal nanomaterials, carbon nanomaterials, and their hybrids are described in terms of preparation processes and their optoelectronic/mechanical properties. Some challenges and perspectives for further advances in stretchable transparent electrodes are also discussed.</P>
김태동 ( Kim Tae Dong ),오희주 ( O Hui Ju ),김국현 ( Kim Gug Hyeon ),김성목 ( Kim Seong Mog ),김준환 ( Kim Jun Hwan ),장병익 ( Jang Byeong Ig ),김태년 ( Kim Tae Nyeon ),정문관 ( Jeong Mun Gwan ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.1
Background/Aims: Pancreatic cancer is fatal with a dismal 6-month median survival from diagnosis. Diabetes mellitus is reported to be present up to 33.3 percent of patients with pancreatic cancer. The reason for the high frequency of diabetes is unknown. We studied the prevalence and duration of diabetes in patients with pancreatic cancer and the relationship between the two diseases. Methods: A total of 152 patients with pancreatic cancer diagnosed at Yeungnam University Hospital from January 1999 to December 2001 were enrolled in this study. Clinical features, family history, smoking history, and characteristics of the tumor were compared between diabetic and non-diabetic groups. Results: Among 152 patients with pancreatic cancer, 43 patients (28.3%) had diabetes. In diabetic group, mean age of diagnosis was significantly younger than non- diabetic group (62.0±7.2 vs. 65.0±8.8, p<0.05). Most of the patients with diabetes had non-insulin dependent diabetes mellitus (NIDDM) and did not have family history. Diabetes was diagnosed within 2 years after the diagnosis of pancreatic cancer in 35 patients (74.3%) of the diabetic group. There were no differences in the location and stage of tumor, chief complaints, presence of weight loss, and body mass index between the two groups. Conclusions: Diabetes mellitus occurs frequently in patients with pancreatic cancer and does not influence clinical features of pancreatic cancer. Pancreatic cancer should be suspected in patients with recent onset diabetes, especially in patients without family history of diabetes and with type of NIDDM. (Korean J Gastroenterol 2004;43:35-40)
Measurement Method and System of Optical Fiber-Based Beam Width Using a Reflective Grating Panel
Yeon-Gwan Lee,Byeong-Wook Jang,Yoon-Young Kim,Jin-Hyuk Kim,Chun-Gon Kim 한국항공우주학회 2011 International Journal of Aeronautical and Space Sc Vol.12 No.2
An optical fiber-based beam width measurement technique is presented. The proposed system can be applied to the optical fiber industry in applications such as lensed fiber, optical fiber based laser beam source, and fiber optic sensor. The measurement system is composed of optical fiber, which is used as a transceiver, and a single grating panel which consists of a multi-reflection area with an even non-reflection area. The grating panel is used to vary the reflected light. When the widths of the reflection area and non-reflection area are larger than the optical beam width, the reflected light is varied at the interface between the reflection area and the non-reflection area by the movement of the grating panel. Experiments were conducted in order to verify the feasibility of the proposed technique. Multi-mode fiber combined with a collimator was selected as an emitter and a receiver, and the beam width measurement system was contrived. Subsequently, the proposed method and the system were verified by comparing the experimental results with the results of the conventional charge-coupled device technique.