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Suncheonosides A–D, Benzothioate Glycosides from a Marine-Derived <i>Streptomyces</i> sp.
Shin, Bora,Ahn, Seyeon,Noh, Minsoo,Shin, Jongheon,Oh, Dong-Chan American Chemical Society and American Society of 2015 Journal of natural products Vol.78 No.6
<P>A marine-derived Streptomyces strain, SSC21, was isolated from the sediment of Suncheon Bay, Republic of Korea. Chemical analysis of the bacterial strain resulted in the isolation of four new metabolites, suncheonosides A-D (1-4, respectively), each bearing a,sulfur atom. The planar structures of the suncheonosides were identified as hexasubstituted benzothioate glycosides by combined spectroscopic analyses. Analysis of the configuration of the sugar moieties based on ROESY nuclear magnetic resonance correlations, one-bond H-1-C-13 coupling constant analysis, and chemical derivatizations indicated that the suncheonosides incorporate only L-rhamnose. Suncheonosides A, 13, and ID promoted adiponectin production in a concentration-dependent manner during adipogenesis in human mesenthymal stein cells, suggesting antidiabetic potential.</P>
A New Record of Hadennia nakatanii (Lepidoptera, Erebidae) from Korea
Shin, Bora,Kim, Sung-Soo,Choi, Sei-Woong The Korean Society of Systematic Zoology 2022 Animal Systematics, Evolution and Diversity Vol.38 No.4
One species of the Herminiinae, Hadennia nakatanii Owada is newly recorded from Korea. Hadennia nakatanii can be distinguished by the light blackish forewing with the relatively thick, transverse medial line, a large light yellowish discal dot, the thick blackish slanted band from the apex to the middle part of the dorsum, and the light blackish hindwing, basally suffused with black and medially broadly suffused with black. The female genitalia can be diagnosed by the simple antrum, the long strongly sclerotized ductus bursae, and the large rectangular corpus bursae with a small uplifted signa patch with minute spicules. We provided the figures of adult and the genitalia with short notes on distribution.
Six Newly Recorded Lepidopteran Insects (Lepidoptera) with Notes on Immature Stages in Korea
Shin, Bora,Kim, Sung-Soo,Choi, Sei-Woong The Korean Society of Systematic Zoology 2022 Animal Systematics, Evolution and Diversity Vol.38 No.4
Six species in five families of Lepidoptera were newly recorded from Korea. The adult specimens of these six species were obtained during the rearing caterpillars collected across Korea. Agonopterix omelkoi Lvovsky (Depresariidae) can be distinguished by the ochreous forewing with a dark brown slanted line, a dark brown triangular spot, and a blackish discal dot, and the whitish hindwing. Dichomeris ferruginosa Meyrick (Gelechiidae) can be diagnosed by the light brown forewing with two relatively large blackish dots and suffusion of dark brown along the dorsum and subtermen, and the grayish hindwing. Pseudohedya satoi Kawabe (Tortricidae) can be diagnosed by the dark ochreous forewing with several medially curved dark ochreous medial lines, and the large light grayish tornal marking, and the dark grayish hindwing. Rhodoneura hyphaema (West) (Thyrididae) can be diagnosed by the reddish forewing with a relatively thick postmedial band, and the reddish hindwing with a narrow dark reddish straight medial band. Comibaena subprocumbaria (Oberthür) (Geometridae) can be diagnosed by the greenish forewing with a whitish apical marking that bordered with a brownish or dark reddish line that connected to the termen, and the distal abdominal segments with whitish and dark reddish dots. Perixera absconditaria (Walker) (Geometridae) can be diagnosed by the light brownish forewing with a relatively thick, slanted, dentate brownish postmedial line, and the light brownish hindwing with a small white discal spot. We provide the diagnosis and figures of adults and larvae, and DNA barcoding data.
Shin, Bora,Kim, Byung-Yong,Cho, Eunji,Oh, Ki-Bong,Shin, Jongheon,Goodfellow, Michael,Oh, Dong-Chan American Chemical Society and American Society of 2016 Journal of natural products Vol.79 No.7
<P>A new secondary metabolite, actinomadurol (1), was isolated along with the known compound JBIR-65 (2) from a rare actinomycete, Actinomadura strain KC 191. The structure of 1 was established as a rare member of the bacterial C-19 norditerpenoid class by NMR data and ECD calculations. The absolute configuration of 2, which was previously reported without stereochemical analysis, was determined by using the modified Mosher's method and ECD calculations. Actinomadurol (1) exhibited potent antibacterial activity against pathogenic strains, such as Staphylococcus aureus, Kocuria rhizophila, and Proteus hauseri (MIC = 0.39-0.78 mu g/mL), whereas JBIR-65 (2) showed no antibacterial activity.</P>
Odontopera aurata (Lepidoptera: Geometridae), New to Korea
Shin, Bora,Kim, Sung-Soo,Choi, Sei-Woong The Korean Society of Systematic Zoology 2022 Animal Systematics, Evolution and Diversity Vol.38 No.2
One ennomine species, Odontopera aurata (Prout, 1915) was newly recorded from Korea. Odontopera aurata, a species of Ennominae, is characterized by the dark yellowish forewing that shows centrally mottled with blackish dots, weakly slanted and blackish postmedial line, and undulating termen, and the yellowish hindwing with black postmedial line and short discal dot. Odontopera aurata is externally indistinguishable from O. arida but can be distinguished by the shape of furcal arm of the male genitalia. We provide diagnosis, description of adults and male genitalia, and DNA information.
Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy
Shin, Bora,Park, Woojun MICROBIOLOGICAL SOCIETY OF KOREA 2017 JOURNAL OF MICROBIOLOGY -SEOUL- Vol. No.
<P>The increasing antibiotic resistance of Acinetobacter species in both natural and hospital environments has become a serious problem worldwide in recent decades. Because of both intrinsic and acquired antimicrobial resistance (AMR) against last-resort antibiotics such as carbapenems, novel therapeutics are urgently required to treat Acinetobacter-associated infectious diseases. Among the many pathogenic Acinetobacter species, A. baumannii has been reported to be resistant to all classes of antibiotics and contains many AMR genes, such as bla(ADC) (Acinetobacter-derived cephalosporinase). The AMR of pathogenic Acinetobacter species is the result of several different mechanisms, including active efflux pumps, mutations in antibiotic targets, antibiotic modification, and low antibiotic membrane permeability. To overcome the limitations of existing drugs, combination theraphy that can increase the activity of antibiotics should be considered in the treatment of Acinetobacter infections. Understanding the molecular mechanisms behind Acinetobacter AMR resistance will provide vital information for drug development and therapeutic strategies using combination treatment. Here, we summarize the classic mechanisms of Acinetobacter AMR, along with newly-discovered genetic AMR factors and currently available antimicrobial adjuvants that can enhance drug efficacy in the treatment of A. baumannii infections.</P>
4-Hydroxybenzaldehyde sensitizes Acinetobacter baumannii to amphenicols
Shin, Bora,Park, Chulwoo,Imlay, James A.,Park, Woojun Springer-Verlag 2018 Applied microbiology and biotechnology Vol.102 No.5
<P>Bacterial metabolism modulated by environmental chemicals could alter antibiotic susceptibility. 4-Hydroxybenzaldehyde (4-HBA), which cannot support the growth of Acinetobacter baumannii, exhibited synergism only with amphenicol antibiotics including chloramphenicol (CAM) and thiamphenicol. Interestingly, this synergistic effect was not observed with other growth-supporting, structurally similar compounds such as 4-hydroxybenzoate. Transcriptomic analysis demonstrated that genes involved in protocatechuate metabolism (pca genes) and osmotic stress (bet genes) were significantly upregulated by 4-HBA and CAM treatment. The C-14-labeled CAM influx was lower in a pcaK1 (encoding a transporter of protocatechuate) deletion mutant and was higher in the pcaK1 overexpressing cells relative to that in the wild type upon 4-HBA treatment. Our kinetic data using C-14-labeled CAM clearly showed that CAM uptake is possibly through facilitated diffusion. Deletion of pcaK1 did not result in the elimination of CAM influx, indicating that CAM does not enter only through PcaK1. The amount of 4-HBA in the culture supernatant was, however, unaffected during the test conditions, validating that it was not metabolized by the bacteria. CAM resistant A. baumannii cells derived by serial passages through CAM-amended media exhibited lower level of pcaK1 gene expression. These results led us to conclude that the activation of PcaK1 transporter is probably linked to cellular CAM susceptibility. This is the first report showing a relationship between CAM influx and aromatic compound metabolism in A. baumannii.</P>