http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
염산 메트폴민을 함유하는 경구방출제어형 제제의 제조 및 용출특성
구본철,김정수,이계원,지웅길 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-
Metformin is an antihyperglycemic agent of the biguanide class used in the treatment of non-in-sulin-dependent diabetes mellitus. Metformin hydrochloride has intrinsically poor permeability in the lower portion of the GI-tract leading to absorption almost exclusively in the upper part of the GI-tract. Its oral bioavailability is in the range of 50 to 60%. It also has a very high water solubility. In this study, we prepared sustained release matrix system containing metformin hydrochloride using various characteristics of polyethylene oxide (PEO). The metformin hydrochloride matrix tablets were prepared by direct compressed method and wet granulation compressed method with various molecular weight of PEO. Even though the molecular weights of PEOs used were 900K, 2,000K, and 5,000K. Moreover, three types of matrix tablets were formulated compositions were same, the hardness was different. The release kinetics were studied for 9 hours in pH 1.2 simulated gastric fluid and pH 6.8 simulated intestinal fluid, using a dissolution tester at 37.5℃, 50 rpm. As the molecular weight of PEO increased, the release rate decreased due to the slower swelling and dissolution of PEO. For the effect of hardness of matrix tablets, the rate of drug release was decreased with increasing hardness.
구본철 ( Bon Cheol Goo ),이주희 ( Ju Hee Lee ),이광훈 ( Kwang Hoon Lee ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.10
Pseudoxanthoma elasticum-Like papillary dermal elastolysis is a disorder of the dermis, characterized by clinical features similar to pseudoxanthoma elasticum and the pathologic features of elastolysis limited to the papillary dermis, such as sun-protected, intrinsically-aged skin. A 64-year old woman presented with a 7 year history of a localized skin lesion on the back of her neck. Physical examination revealed skin to yellow colored, non-follicular grouped uniform papules, sized 5~8㎜, and coalescent plaques localized below the hair line. Histopathologic and immunohistochemical findings of decrease and elastolysis of the elastic fibers in the papillary dermis confirmed the diagnosis. In this article, we report a case of pseudoxanthoma elasticum-like papillary dermal elastolysis which presented with typical clinical and pathologic features. (Korean J Dermatol 2006;44(10):1228~1230)