두 가족의 가족성 모야모야병 환자 4례

구자성,노재규,박성호,이한보,이용석,윤창호,송치성,송재우 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

임플란트 hexagon 높이에 따른 임플란트와 주위 조직의 응력분포 평가

박성재,김주현,김소연,윤미정,고석민,허중보 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.1

PURPOSE. To analyze the stress distribution of the implant and its supporting structures through 3D finite elements analysis for implants with different hexagon heights and to make the assessment of the mechanical stability and the effect of the elements. MATERIALS AND METHODS. Infinite elements modeling with CAD data was designed. The modeling was done as follows; an external connection type ∅4.0 mm×11.5 mm OsstemUSII (Osstem Co., Pusan, Korea) implant system was used, the implant was planted in the mandibular first molar region with appropriate prosthetic restoration, the hexagon (implant fixture’s external connection) height of 0.0, 0.7, 1.2, and 1.5 mm were applied. ABAQUS 6.4 (ABAQUS, Inc., Providence, USA) was used to calculate the stress value. The force distribution via color distribution on each experimental group’s implant fixture and titanium screw was studied based on the equivalent stress (von Mises stress). The maximum stress level of each element (crown, implant screw, implant fixture, cortical bone and cancellous bone) was compared. RESULTS. The hexagonal height of the implant with external connection had an influence on the stress distribution of the fixture, screw and upper prosthesis and the surrounding supporting bone. As the hexagon height increased, the stress was well distributed and there was a decrease in the maximum stress value. If the height of the hexagon reached over 1.2 mm, there was no significant influence on the stress distribution. CONCLUSION. For implants with external connections, a hexagon is vital for stress distribution. As the height of the hexagon increased, the more effective stress distribution was observed. 연구 목적: 본 연구는 hexagon 높이에 따른 임플란트 각 부위와 주위 지지조직의 응력분포를 3차원 유한요소 해석을 통해 평가하여 hexagon 높이가 기계적 안정성에 미치는 영향을 평가하고자 시행되었다. 연구 재료 및 방법: 외측 연결 형태의∅L4.0 mm×11.5 mm USII (Osstem Co., Pusan, Korea) 임플란트 시스템을 이용하여 하악 제 1대구치 부위에 임플란트를 식립하여 보철 수복한 경우를 연구 모델로 가정하고 임플란트 고정체의 외측 연결부인 hexagon의 높이를 각각 0.0 mm, 0.7 mm, 1.2 mm, 1.5 mm로 적용한 CAD data를 유한요소 모형화하였다. ABAQUS 6.4 (ABAQUS Inc., Providence, RI, USA)를 이용하여 산출된 응력 값 중에서 등가응력을 기준으로 각 요소(상부 치관, 지대주 나사, 고정체, 치밀골, 해면골)에서 나타나는 최대 응력 값을 비교 하였다. 결과:외측 연결을 갖는 임플란트의 hexagon의 높이는 고정체, 지대주 나사, 상부 보철물 그리고 주위 지지골에 대해 응력 분산에 영향을 주었다. Hexagon의 높이가 증가할 수록 임플란트의 응력 분산은 더 잘 이루어졌으며, 최대 응력 값의 감소를 보였다. Hexagon의 높이가 1.2 mm 이상이 되면 응력 분포에 더 이상 크게 기여하지 않았다. 결론: 외측연결을 갖는 임플란트에서 hexagon은 응력 분산에 필수적인 요소이며 그 높이가 증가할수록 더욱 효과적인 응력의 분산이 나타났다.

地區單位計劃의 物理的 規制要素가 街路景觀에 미치는 影響에 관한 硏究

정성구,최민후,윤진보,신남수 대한건축학회 2004 대한건축학회논문집 Vol.20 No.10

Emphasis has recently been laid on the importance of street space that constitutes urban space in stimulating and strengthening the functions of the downtown area In most urban areas, however, street space has deteriorated so much that it reveals barrenness This situation is owing not to the lack of proper understanding about the importance of street space planning, but to the paucity of accumulated study on the correlation between the spatial consciousness of man as the subject of a street space evaluation on the one hand and the constituent elements as the object of spatial formation on the other District unit planning is a social system that is concerned with developing street space It maps out ideal urban space for better urban environment It also aims to better utilize urban space in accordance with the size and complexity of a city The purpose of this thesis is to examine the correlation between urban planning control elements regulating constituent elements of street space and the structure of man's psychological evaluation of the streetscape It explores the influence of physical regulatory elements on the streetscape, thus providing basic data and guidelines for planning a better streetscape It makes a psychological analysis of different applications of controlling elements by employing a semantic differential method and a CG simulation The procedure of my research is first to choose adjectival pairs that describe street space through bibliographical study and preliminary survey, and then to select physical regulatory elements concerning district Unit planning My study also shows the influence of the design control elements of distinct unit planning on the streetscape, by experimenting with those elements by means of CG simulation It examines variables on the axis of psychological factors according to the variation of regulatory elements and the degree of the influence of those variables

IEEE 802.22 WRAN 시스템을 위한 OFDM 프리앰블 설계 및 동기 알고리즘

원재연,심성보,김윤희 경희-다반 ASIC 설계교육센터 2006 경희-다반 ASIC센터 논문집 Vol.7 No.-

IEEE 802.22에서는 사용하지 않는 TV 대역을 찾아 고정 사용자에게 고속 패킷 전송을 제공하는 WRAN 시스템을 논의하고 있다. 본 논문에서는 WRAN 시스템을 위해 단일 프리앰블을 이용한 시간 및 주파수 동기 알고리즘을 제안하고 WRAN에서 고려하는 무선 채널 모형에서 성능을 살펴본다. 제안한 알고리즘은 기존의 시간 동기 메트릭을 간단히 수정하여 시간 동기를 좀 더 안정적으로 찾을 수 있도록 함으로써, 시간동기후에 수행되는 주파수 옵셋 추정기의 성능을 향상시킨다.

主要 眺望點에서 바라본 港灣景觀의 注視特性에 관한 硏究

김은일,정성구,윤진보,신남수 대한건축학회 2004 대한건축학회논문집 Vol.20 No.7

It is necessary to research for environmental features of regions rather than each building and scenery to form desirable city landscape that describes placeness concretely. In case of Korea, vast harbors and industry complex are generally located in the waterfront of port cities because the waterfront is noticed as one factor which supplies a fresh ground. So, waterfront forms a wide and long blackout curtain that causes the destruction of nature, shapes a factory structure curtain, and completely covers hinterland landscape. It makes hard for citizens to access to the seaside, depriving capacity of waterfront for water-familiar, and destructing beautiful seashore environment. This research project is to provide those architects or planners with the design guidelines of improving port and hinterland landscape. To do so, this study is carried out the physiological evaluation making eye fixation behaviors. The main results were summarized as follows: 1) Satisfaction with the ports' scenery turned out being given high estimation according as the objections being seen is more natural, a scale of ports' landscape elements is larger, and shape of landscape elements are simpler. 2) Distribution of a visual point is concentrated on facilities that have unique shapes and is under the influence of seashore line, letters carved in buildings and conspicuous colors. In addition, it tends to gather a visual point that facility's movement would be expected. 3) Eye fixation behaviors stops at unique shapes, structural lines of the physical elements and color factors of the objects. And it was judged that human recognized the object through this. 4) Scenery that include large natural element has a flexible movement of view and make general populace see the object for more long time. Therefore, it is necessary to examine the vista point on view-distance with research on improving port's naturality.

Active Molecular Chitosan alleviate Bleomycin-induced Acute Pulmonary Inflammation in Mice

( Seong-bo Yun ),( Dong-hun Kang ),( Ji-sun Choi ),( Dae-young Kim ) 한국키틴키토산학회 2019 한국키틴키토산학회지 Vol.24 No.3

Generally acute pulmonary inflammation is triggered by damage to alveolar epithelial cells due to the pollutants, viral infection, allergens and toxic substances. The active molecular chitosan (AMC, 5~8 kDa) is known to have non-toxic, bio-degradable, and biological activities including anti-tumor, anti-viral, and anti-inflammatory activities. The purpose of this study was to observe AMC’s preclinical efficacy to acute pulmonary inflammation and evaluate the therapeutic effect of a bleomycin (BLM) induced mouse model using AMC, a final product made by the hydrolysis of chitosan. Our experiments were conducted using male C57BL/6 mouse and BLM (5 mg/kg) was injected once with the intratracheal instillation (IT) method to induce pulmonary inflammation. Each group was conducted with prednisolone (PDS, 6.5 mg/kg) or AMC (100 mg/kg and 200 mg/kg, respectively) for 10 days with oral gavage. The relative lung weight measurements, histological findings in lung tissue specimens and cell counts through bronchoalveolar lavage fluid (BALF) were performed to determine the anti-inflammatory effects of AMC. The AMC treated groups with BLM induction had a decreased tendency of inflammation on our experiments. A dose of 100 mg/kg AMC induce group showed that similar aspect with control group on histological results. In addition, the lymphocyte rate appeared a noticeable on this group. The degree of lymphocyte was remarkably lower. It was inferred that inflammatory improvement in the AMC treated group. We confirmed that the BLM-induced lung disease model that progressed inflammation was inhibited by AMC. Furthermore, AMC performs an anti-inflammation function and has the possibility of use for the treatment of inflammatory disease.

Digital Transformation Theory : Setting of Research Propositions

Bo Seong Yun,Yong jin Kim 한국경영정보학회 2018 한국경영정보학회 학술대회논문집 Vol.2018 No.11

4차 산업혁명 시대를 맞이하여 IT기업이 글로벌 시가총액 Top 5를 장악하고 신흥 디지털 기업이 전통 우량기업을 위협하면서 산업계와 학계 모두 Digital Transformation(이하 ‘DT’)에 높은 관심을 보이고 있다. 본 연구는 DT을 중심으로 조직역량과 기업성과가 긍정적 선·후행 관계가 있음을 9개의 세부 명제로 제시하고, 이를 통해 디지털 시대에서는 혁신이 기업성장의 핵심으로 작용함을 주장한다. 또한 기업이 생존전략으로 DT을 채택함에 당위성을 부여하고 이와 관련한 전략적 의사결정 및 실행에 도움을 주며 연구자들의 DT 관련 가설수립 및 이론정립 시 이정표를 제시할 수 있다.

Oral administration of Grifola frondosa affect lipid metabolism and insulin signaling pathway on BKS. Cg-+Leprdb/+Leprdb/OlaHsd mouse

Seong-Bo Yun,Dae-Young Kim 한국동물생명공학회(구 한국동물번식학회) 2021 Journal of Animal Reproduction and Biotechnology Vol.36 No.4

Diabetic mellitus (DM) is a carbohydrate metabolic disorder that involves high blood sugar because insulin works abnormally. Type 2 diabetes accounts for most of them. However, diabetes treatments such as GLP-1 and DPP-4 inhibitors commonly caused side effects including gastrointestinal disorders. Grifola frondosa (G. frondosa) revealed various pharmacological effects in recent studies. It has a variety of anti-cancer polysaccharides through host-mediated mechanisms. D-fraction in G. frondosa has apoptotic effects, promoting myeloid cell proliferation and differentiation into granulocytes-macrophages. It has also been shown to reduce the survival rate of breast cancer cells. Though, no further study has been conducted on the specific effects of G. frondosa in the db/db mouse. Therefore, we would like to research the blood glucose improving effect of G. frondosa, a natural material, in type 2 diabetes model mouse, in this study. G. frondosa was administered to the disease model mouse (BKS.Cg-+Leprdb/+Leprdb/OlaHsd) for 8 weeks to monitor weight and blood glucose changes every week. And we evaluated anti-diabetes effects by checking biomarker changes shown through blood. Experiment did not show statistically significant weight differences, but control groups showed significantly higher weight gain than G. frondosa administered groups. We collected blood from the tail veins of the db/db mouse each week. As a result, the lowest blood sugar level was shown in the 500 mg/ kg group of G. frondosa. Glucose in the blood was examined with HBA1c, and 7.8% was shown in the 500 mg/kg administration group, lower than in other groups. These results suggest the potential improvements of diabetes in G. frondosa.

Incidence and survival of gynecologic cancer including cervical, uterine, ovarian, vaginal, vulvar cancer and gestational trophoblastic neoplasia in Korea, 1999-2019: Korea Central Cancer Registry

Bo Seong Yun,Eun Hye Park,Johyun Ha,Jung-Yun Lee,Keun Ho Lee,Taek Sang Lee,Kyung Ju Lee,Young Ju Kim,Kyu-Won Jung,Ju-Won Roh 대한산부인과학회 2023 Obstetrics & Gynecology Science Vol.66 No.6

Objective To investigate the incidence, trends, and survival rates of all gynecologic cancers using the Korea Central Cancer Registry (KCCR) database from 1999-2019. Methods Gynecologic cancer data were obtained from the KCCR database between 1999 and 2019. Age-standardized incidence rates (ASRs), annual percentage changes, and average annual percentage changes (AAPCs) were calculated. The relative survival rate (RSR) was reported by age group, stage, and 6-year period (I: 1999-2005, II: 2006-2012, III: 2013- 2019). Results The gynecologic cancer ASRs were 26.2 and 24.9 per 100,000 individuals in 1999 and 2019, respectively. Trends of incidence in gynecologic cancer revealed a decrease in cervical cancer and gestational trophoblastic neoplasia (GTN) with AAPCs of -3.4 and -4.3, respectively. Conversely, the incidence of uterine, ovarian, and vulvar cancers increased with AAPCs of 4.7, 2.3, and 2.1, respectively. AAPC for vaginal cancer showed no change. The 5-year survival rate was highest for GTN (90.5%) and lowest for vaginal cancer (56.6%). An increase in age was correlated with poorer survival rates across all gynecologic cancers, excluding vaginal cancer. For all gynecologic cancer types, the prognosis deteriorates with advancing cancer stages. The RSR of uterine cancer improved consistently across all periods. The ovarian cancer RSR improved more in period III than in periods I or II. Additionally, the vulvar cancer RSR improved more in periods II and III than in period I. Conclusion In Korea, the incidence of cervical cancer and GTN decreased, whereas the incidence of uterine, ovarian, and vulvar cancer increased from 1999 to 2019. The RSR for uterine, ovarian, and vulvar cancers showed consistent improvements over different periods. Effective screening programs and the adoption of advanced treatments may be necessary to further reduce the burden of gynecologic cancer.

Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy.

Kim, Bo Hyun,Cho, Kyoung Im,Kim, Seong Man,Kim, Jee-Yeon,Choi, Bo Gwang,Kang, Ji Hyun,Jeon, Yun Kyung,Kim, Sang Soo,Kim, Seong-Jang,Kim, Yong Ki,Kim, In Joo Japan Endocrine Society 2012 Endocrine journal Vol.59 No.10

<P>This study evaluated the effects of irbesartan and propranolol on thyroid hormone (TH)-induced cardiac functional and structural remodeling. A rat model of thyrotoxicosis was established by daily intraperitoneal injections of L-thyroxine (T(4), 100 μg/kg) for 4 weeks. Forty Sprague-Dawley rats were randomly divided into four groups (n = 10 each): control group, T(4) group (T(4) alone), T(4) plus irbesartan group (T(4)-Irb, 30 mg/kg), and T(4) plus propranolol group (T(4)-Pro, 0.5mg/mL of drinking water). Cardiac chamber size and functional parameters were measured by echocardiography and cardiomyocyte diameter. Heart rate (HR) and cardiac fibrosis were determined. T(4) alone showed significantly increased HR and cardiomyocyte width (25.0 1.77 vs. 18.8 0.84 μm, P < 0.001) with fibrosis, reduced left ventricle (LV) longitudinal strain (S(long); -16.0 6.27 vs. -22.7 5.19 %, P < 0.001) compared with control. When compared with T(4) alone, T(4)-Irb showed significantly improved LV S(long) (-21.4 1.84 vs. -16.0 6.27 %, P =0.017) and reduced cardiomyocyte width (21.0 1.0 vs. 25.0 1.77 μm, P =0.002) with comparable HR (458.4 24.3 vs. 486.6 30.1 bpm, P = 0.086). However, T(4)-Pro showed significantly reduced HR with improved LV S(long) without alteration of cardiomyocyte width and fibrosis compared with T(4) alone. In conclusion, renin-angiotensin system (RAS) blocking by irbesartan could significantly attenuate TH-induced cardiac structural and functional remodeling. However, HR reduction by propranolol could not alternate structural remodeling, which may implicate the RAS as having an important role in thyrotoxic cardiomyopathy beyond tachycardia.</P>