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지용화,최보람,허경회,안창현,이삼선 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.2
The present study reports a case of inverted papilloma of the nasal cavity and infiltrating into the maxillary sinus. Inverted papilloma is an uncommon and locally aggressive benign tumor of the sinonasal region. The patient, 51-year-old male, presented with unilateral nasal obstruction and periodic swelling on the palate without pain. Enhanced CT scan revealed a heterogeneously enhancing solid mass in the nasal cavity and infiltrating into the right maxillary sinus, as well as an incidental, secondarily infected residual cyst m the periapical area of the right maxillary canine. The sinonasal mass was revealed as an inverted papilloma on histopathologic examination.
邊龍聖,金東碩,邊東壽,崔雲行,洪慶和,鄭寶鉉 弘益大學校 1991 弘大論叢 Vol.23 No.2
A great many students are working for their mathematics learning in secondary schools and nevertheless its learning effect is rather low. This phenomenon is largely due to a biased social recognition. Furthermore the educational environment including big class size and ability differences enlarge such a difficulty. This study aims at seeking an improving device to enhance learning efficiency under the circumstances. Questionaires about problem finding of teachers educational activity and mathematics teaching were distributed and collected. Data were analyzed to establish a desirable mathematics education and teaching. Devices for individualized instruction and learning tasks and evaluation methods were proposed. This recommendations are supposed to be an improving way for students' mathematics learning. In relation to this result, a further study is strongly required and adminstrative supports by government are badly needed to achieve such a goal.
Hypoxia-inducible factor-1α-mediated SERPINE-1 expression in ischemic urinary bladder
Choi Bo-Hwa,조태진,이택,Park Chang-Shin 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2
Background Increasing cyclic pressure on the bladder in urodynamic changes results in tissue hypertrophy, triggering hypoxia-related molecular mechanisms, and promoting bladder tissue remodeling. The etiology and causative mechanisms of Hif-1α-derived tissue remodeling remain unclear. Objective This study aimed to examine the hypothesis that hypoxia-related pathways and potent gene expression profi les may be associated with pathological symptoms such as detrusor over-activity and increased urinary frequency. Thus, we suggest that Hif-1α-mediated target gene expression is related to the major connections between urodynamic changes and diff erentially expressed genes (DEGs) in one control (Sham) and two experimental models, partial bladder outlet obstruction (PBOO), and de-obstructed (DeObs) rats. Results In cystometric measurements, the pressure and volume of the PBOO and DeObs rat groups showed signifi cant diff erences compared to the sham group, but there were no signifi cant diff erences between the PBOO and DeObs groups. Among the DEGs, the expression levels of many genes largely altered in the PBOO group were normalized in the DeObs group. These diff erences between the activities of cystometric parameters and RNA-seq-based DEGs patterns, identifi ed in the comparisons of the three groups, were not consistent. In contrast, the fi ve genes ( ALDH3A1, CYP1A1, SERPINE1, CYBB, and PLOD2 ), based on the FPKM units, were the most predictable, and Hif-1α-induced SERPINE1 and PLOD2 genes might be related to the progression of bladder tissue remodeling, such as hypertrophy and fi brosis. SERPINE1 dominantly expressed in BSMCs was one gene matched between protein expression levels and enriched FPKM values. Conclusions Expression of Hif-1α-mediated SERPINE 1 induced under hypoxia may be linked to pathological bladder tissue remodeling outcomes. Thus, we propose that alterations in SERPINE 1 expression induced in cyclic hypoxia-exposed bladders may be related to tissue hypertrophy and/or fi brosis.
Bo-Hwa Choi,Goutam Chakraborty,백광희,Ho Sup Yoon 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.10
Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38 and induced the nuclear translocation of Bcl-2 and its phosphorylation. These events inhibited cancer cell proliferation and subsequently enhanced MCF-7 breast cancer cell apoptosis. Bcl-2knockdown using small interfering RNA (siRNA) delayed apoptotic cell death, which correlated with increased proliferation following aspirin exposure. In contrast, Bcl-2 overexpression enhanced the onset of aspirin-induced apoptosis, which was also associated with a significant increase in Bcl-2 phosphorylation in the nucleus. Therefore, this study may provide novel insight into the molecular mechanism of aspirin, particularly its anticancer effects in Bcl-2- and estrogen receptor-positive breast cancer cells.
Genomic Sequence Variability of the Prion Gene (PRNP) in Korean Cattle
Choi, Sang-Haeng,Chae, Sung-Hwa,Choi, Han-Ho,Kim, Jeong-Seon,Kang, Bo-Ra,Yeo, Jung-Sou,Choi, Inho,Lee, Yong-Seok,Choy, Yun-Ho,Park, Hong-Seog Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.5
In this study, we have investigated sequence variants in the PRNP gene of 20 individuals belonging to the Korean cattle, and have analyzed and compared genetic features between varieties of other cattle breeds. Of the 73 sequence variants identified in Korean cattle, 27 were identified for the first time in this study, whereas 46 of these polymorphisms had previously been isolated. We discovered a 2.6 kb SNP hot spot region localized on the putative promoter region of the PRNP gene. Furthermore, the copy numbers of the octapeptide repeat (24 bp indel) which is detected on the coding sequence (CDS) of the PRNP exhibited a completely homozygous 6/6 genotype which is dominant in other cattle breeds. We also characterized a new 19 bp/10 bp allele located on the putative promoter region of the PRNP gene, which represented 0.71 in allele frequency. To the best of our knowledge, this report is the first to address polymorphisms of the PRNP gene structure in Korean cattle in which BSE has yet to be discovered. Therefore, our findings may prove useful with regard to our current understanding of allelic diversity in bovine species, and may also provide new insights into the genetic factors associated with susceptibility or resistance to BSE.