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특발성 과호산구 증후군 환자의 치료 도중 발생한 간혈종 1례
이영태,김동기,박지훈,김윤정,김기향,박보민,권민정,김애란,이원식,주영돈,손창학 白中央醫療院 2005 仁濟醫學 Vol.26 No.1
Idiopathic hypereosinophilic syndrome is characterized by marked elevation of eosinophil count ( >1,500/㎣) in peripheral blood without explaining etiology. It shows tissue involvement in many organs such as liver, G-I tract, myocar dium, lung, skin, kidney and nerve. Some case of hypereosinophilic syndrome with hepatic involvement have been reported, but not much. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 40 year old man who presented with RUQ pain. By abdominal CT, ill- defined subcapsular hematoma was detected. Liver biopsy showed eosinophilic infiltration within the portal tract and sinusoid. Drain procedure and corticosteroid adminiiatbrought marked improvement of clinical manifestation, hematologic abnormality and radiologic abnormality.
베체트병 환자에서 Azathioprine으로 유발된 급성 췌장염 1례
김기향,권민정,김동기,김애란,김윤정,박지훈,이영태,박보민,김동욱 白中央醫療院 2005 仁濟醫學 Vol.26 No.1
Although many drug are thought capable of initiating acute pancreatitis, following azathioprine administration represents the 5% incidence by far the highest recorded incidence to date. We report a 35-year-old male who developed acute pancreatitis in the course of treatment with azathioprine for Behcet's disease. He was admitted due to abdominal pain, diarrhea, and fever for 10 days. Serum amylase and lipase levels were 510U/L and 3702U/L respectively. The abdominal CT scan revealed diffuse enlargement of the pancreas. There was no history of alcohol use or gall bladder disease. We considered drugs, especially azathioprine, as the cause of acute pancreatitis. We diagnosed it as acute pancreatitis. The patient was treated conservatively with hydration and analgesics. The symptom subsided within four days. Five days later, azathioprine was resumed. And the patient complained of abdominal pain. The elevated levels of serum amylase and lipase confirmed the recurrence of pancreatitis. His symptom subsided when azathioprine intake the stopped, and the serum amylase and lipase levels returned to normal level within five days.
인간 배아줄기세포의 feeder-free 배양 환경에 사용된 다양한 기질 고찰
윤보애 ( Bo Ae Yoon ),문신용 ( Shin Yong Moon ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2010 人口醫學硏究論集 Vol.23 No.-
Human embryonic stem cells(hESCs) have been derived and cultured in various condition. Culture of undifferentiated hESCs traditionally requires mouse fibroblasts as a feeder cell layer. The hESC culture using mouse fibroblasts makes clinical application of the hESCs difficult because that the mouse fibroblasts could give a risk of contamination with xeno-pathogens. Therefore, replacing feeder cells with defined human extracellular matrix(ECM) components or synthetic biomaterials would be ideal for the maintenance of clinical-grade hESCs. In this review, we discuss with recent advances in the use and development of substrates suitable for feeder-free culture condition.
윤보애 ( Bo Ae Yoon ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2013 人口醫學硏究論集 Vol.26 No.-
Human embryonic stem cells (hRSCs) have unlimited potentials of proliferation and differentiation and these properties of hESCs make them considered as most interesting cell types for tissue engineering, cell therapy, and drug screening. Stem cell bank mainly do quality control of stem cell lines including best practice in culture, preservation and provide information for the choice of proper embryonic stem cell (ESC) line to proceed further studies. Currently, USA and UK are leading counties for stem cell research and banking. This paper reviews, the current state of the USA and the UK stem cell bank and compared the differences between two banks.
윤보애 ( Bo Ae Yoon ),설혜원 ( Hye Won Seal ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2012 人口醫學硏究論集 Vol.25 No.-
Human embryonic stem cells (hESCs) are one of the most interesting cell types for tissue engineering, cell therapy, basic scientific research, and drug screening. Fast advancement in these areas requires the availability of large amounts of safe and well-characterized hESCs from hESC banks. The sensitivity of hESCs to cryopreservation, however, has severely limited the utility of these cells. It was observed that the characteristics of hESCs changed during long-term culture. Therefore, it is crucial to preserve early-passage cells by effective freezing and thawing methods. This paper reviews the current state of cryopreservation as it pertains to hESCs. We focused on the research of cryopreservarion method of hESCs.
세포 배양 시 마이코플라즈마의 검출 및 제거 방법에 대한 연구 동향
윤보애 ( Bo Ae Yoon ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2011 人口醫學硏究論集 Vol.24 No.-
Mycoplasma contamination may have multiple effects on cultured cells and can also have significant influences on the results of scientific studies. Therefore, the elimination of mycoplasma contamination from cell cultures is necessary. This review provides an overview of the following research trends: (1) mycoplasma contamination in cell cultures; (2) various techniques available for the detection of mycoplasma; (3) four method types available for the elimination of mycoplasma We will discuss the problems of mycoplasma contamination in cell cultures and present a concise overview on the biology of mycoplasma with suggestions on efficient methods for its detection and elimination, and proposing steps to be taken to prevent the problems.
Ecological Characteristics of Korean Native Bumblebee, Bombus hypocrita sapporoensis
Hyung Joo Yoon,Kyeong Yong Lee,MI Ae Kim,Yeong Bo Lee,Sun Yeoung Kim 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
The post-hibernated queens of Korean native bumblebee, Bombus hypocrita saporoensis were collected in Jeong-Sun, Korea to investigate their ecological characteristics and reared under the laboratory conditions; 27℃, 65% R.H. and darkness. The average weight of collected queens was 0.87±0.14g and 0.8g class was most abundant (34.7%) among eight weight classes. The rates of colony initiation, colony foundation and progeny-queen production were 76.3%, 60.0% and 42.5%, respectively. The durations up to colony initiation and colony foundation were 12.0±6.7 days and 49.3±2.4 days, respectively. The duration up to first worker, male and queen emergence were 22.2±3.0 days, 63.4±6.5 days and 63.5±8.7 days, respectively. The number of progenies was 108.5±26.0 workers, 186.7±70.7 males and 39.1±30.3 queens. The longevity of colony founded queen was 90.2±19.9 days whereas that of non-colonized queen was 35.9±30.3 days. Copulation time was 29.5±9.6 min. The number of eggs per egg cell laid new queen was 9.3±2.3 grains. An egg shaped as banana and it’s size was 1.12±0.10 mm in a width, 3.54± 0.16 mm in a length and 2.26±0.34 mg in a weight.
Yoon, Sang Nam,Roh, Seon Ae,Cho, Dong Hyung,Kim, Moon Bo,Hyun, Young-Lan,Ro, Seonggu,Kim, Byung Sik,Kim, Seon Young,Kim, Yong Sung,Kim, Jin Cheon G. Thieme 2010 Hepato-gastroenterology Vol.57 No.99
<P>BACKGROUND/AIMS: This study was performed to determine the efficacy of histone deacetylase inhibitors in gastric cancer, together with other established regimens. METHODOLOGY: The chemosensitivities of 93 gastric cancer patients to established drugs, and three histone deacetylase inhibitors (SAHA, PXD101, and a novel candidate, CG-2) were evaluated using the histoculture drug response assay. RESULTS: Tumor growth inhibition rates were the highest with cisplatin, followed by PXD101, taxol, docetaxel, and TS-1, in descending order. The response rates were 41.9-68.8%, and 37.6-47.3%, respectively, at an inhibition rate cutoff value of 30%. Synergistic activity was evident with most combinations of established drugs and histone deacetylase inhibitors. Diffuse- or mixed-type carcinomas on Lauren classification were closely associated with increased chemosensitivity to TS-1 (p = 0.044). Node-positive and 'other than tubular type' tumors on WHO classification were chemosensitive to cisplatin (p = 0.011 and 0.014, respectively). CG-2 chemosensitivity was markedly associated with low preoperative CA724 level (< or = 4 U/ml) (p = 0.046). CONCLUSIONS: This in vitro chemosensitivity assay validates the comparable chemo-response of gastric cancers to histone deacetylase inhibitors and established drugs, indicating considerable therapeutic efficacy of these agents. Additionally, a number of clinicopathological parameters are significantly associated with specific regimens.</P>
Applicability of histoculture drug response assays in colorectal cancer chemotherapy.
Yoon, Yong Sik,Kim, Chan Wook,Roh, Seon Ae,Cho, Dong Hyung,Kim, Gyu Pyo,Hong, Yong Sang,Kim, Tae Won,Kim, Moon Bo,Kim, Jin Cheon Potamitis Press 2012 Anticancer research Vol.32 No.8
<P>The present study, using the histoculture drug response assay (HDRA) compared chemosensitivity with the clinical response of a treatment regime in patients with advanced colorectal cancer (CRC).</P>