Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration

Yin Bin Chen,Yu Fang Wang,Wei Hou,Ying-Ping Wang,Sheng-Yuan Xiao,Yang Yang Fu,Jia Wang,Si Wen Zheng,Pei-He Zheng 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.2

Background: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drugenutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after their oral administration. The study results will provide valuable theoretical guidance for the combined utilization of ginseng and B-complex vitamins. Methods: Ginsenoside Re with or without B-complex vitamins was orally administered to mice to evaluate its antifatigue effects and to rats to evaluate its bioavailability. The antifatigue activity was evaluated by the weight-loaded swimming test and biochemical parameters, including hepatic glycogen, plasma urea nitrogen, and blood lactic acid. The concentration of ginsenoside Re in plasma was determined by liquid chromatographyetandem mass spectrometry. Results: No antifatigue effect of ginsenoside Re was noted when ginsenoside Re in combination with Bcomplex vitamins was orally administered to mice. B-complex vitamins caused to a reduction in the bioavailability of ginsenoside Re with the area under the concentrationetime curve from zero to infinity markedly decreasing from 11,830.85 2,366.47 h$ng/mL to 890.55 372.94 h$ng/mL. Conclusion: The results suggested that there were pharmacokinetic and pharmacodynamic drugenutrient interactions between ginsenoside Re and B-complex vitamins. B-complex vitamins can significantly weaken the antifatigue effect and decrease the bioavailability of ginsenoside Re when simultaneously administered orally.

Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir

( Bin Yin ),( Chen Xi Hu ),( Zheng Chen ),( Wen Jun Zhao ),( Li Rong Wei ),( Yan Wen Zheng ),( Chao He ),( Yan Zeng ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.2

Vesicular Stomatitis Virus G Glycoprotein and ATRA EnhancedBystander Killing of Chemoresistant Leukemic Cells by HerpesSimplex Virus Thymidine Kinase/Ganciclovir

The Relationship on Risk Type, Risk Management and Business Performance - Evidence from Korean FDIs in China

Heng-Bin Yin,Bo-Hyun Kim,Hong-Joo Jung 한국무역학회 2019 Journal of Korea trade Vol.23 No.5

Purpose - As the well-known Structure-Conduct-Performance paradigm implies, risk structure of a corporation may affect its risk management activity and the activity may in turn determine its performance. Depending on its goal, Foreign Direct Investment (FDI) can shape its risk structure, risk management and its performance. Under this assumption, we investigate the relationship between the goals of FDI and risk management for the first time in academics. Design/methodology - This empirical research uses a survey of 279 current Korean enterprises’ FDIs in China with the recently developed business risk quadrant model. Companies are classified into either a market- or an efficiency-seeking group, to identify how each group perceives and manages risks, and values the performance of risk management. Also, we apply integrated risk management method that multinational corporations have introduced in China, then verify the mediating effect between risk factors and performance. Findings - Our research shows the FDIs can expose themselves to differing risk structure although risk management activities simply represent the level of empowerment given to local management by headquarter due to limit of sample size despite diversity of risk and risk management tools. To sum, market seekers are found to have more strategic risk (revenue related risk) than efficiency seekers with financial risk (cost related risk). The market seekers can manage their risk by empowering their local organisation while the efficiency does the opposite ways. The risk management appears to be successful in general. Originality/value - Previous studies on small and medium enterprises’ FDIs to China have concentrated on the analysis of entry determinants, withdrawal factors and individual risk management. Meanwhile, this research establishes enterprise-wide risk factors faced by the companies that advance into China, according to the method of the classification by ERM and verifies if they could synthetically improve performance through risk corresponding measures.

Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration

Chen, Yin Bin,Wang, Yu Fang,Hou, Wei,Wang, Ying Ping,Xiao, Sheng Yuan,Fu, Yang Yang,Wang, Jia,Zheng, Si Wen,Zheng, Pei He The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.2

Background: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drug-nutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after their oral administration. The study results will provide valuable theoretical guidance for the combined utilization of ginseng and B-complex vitamins. Methods: Ginsenoside Re with or without B-complex vitamins was orally administered to mice to evaluate its antifatigue effects and to rats to evaluate its bioavailability. The antifatigue activity was evaluated by the weight-loaded swimming test and biochemical parameters, including hepatic glycogen, plasma urea nitrogen, and blood lactic acid. The concentration of ginsenoside Re in plasma was determined by liquid chromatography-tandem mass spectrometry. Results: No antifatigue effect of ginsenoside Re was noted when ginsenoside Re in combination with B-complex vitamins was orally administered to mice. B-complex vitamins caused to a reduction in the bioavailability of ginsenoside Re with the area under the concentration-time curve from zero to infinity markedly decreasing from $11,830.85{\pm}2,366.47h{\cdot}ng/mL$ to $890.55{\pm}372.94h{\cdot}ng/mL$. Conclusion: The results suggested that there were pharmacokinetic and pharmacodynamic drug-nutrient interactions between ginsenoside Re and B-complex vitamins. B-complex vitamins can significantly weaken the antifatigue effect and decrease the bioavailability of ginsenoside Re when simultaneously administered orally.

Lipid accumulation mediated by adiponectin in C2C12 myogenesis

( Chang Jun Yin ),( Qin Qiang Long ),( Ting Lei ),( Xiao Dong Chen ),( Huan Long ),( Bin Feng ),( Yin Peng ),( Yan Ling Wu ),( Zai Qing Yang ) 생화학분자생물학회 2009 BMB Reports Vol.42 No.10

중국 그림자금융이 상업은행의 안정성에 미치는 영향 -수익성과 유동성을 중심으로-

윤현빈 ( Heng Bin Yin ),진탁 ( Zhuo Chen ) 한국국제통상학회 2015 국제통상연구 Vol.20 No.4

본 연구는 중국 그림자금융의 규모가 확대됨에 따라 상업은행의 안정성에 어떠한 영향을 미치는가에 대한 것이다. 기존 선행연구에서 제시된 대부분의 연구방법이 중국 그림자금융규모의 측정 또는 그림자금융이 상업은행의 수익성에 어떤 영향을 미치는지를 확인하는 것이었다면 본 연구의 목적은 그림자금융이 수익성에 미치는 효과에 그치지 않고 더 나아가 유동성리스크를 초래하게 할 수 있는 요인을 찾아내는 데에 있다고 하겠다. 중국 그림자금융이 상업은행의 수익성에 미치는 영향을 파악하기 위해 총자산수익률을 종속변수로 하고, 당해와 전년 그림자금융규모, GDP증가율, 비이자 수익비율, 예대비율, 부실채권비율을 독립변수로 선정해 상관관계를 실증분석 하였다.분석결과 예대비율,부실채권비율은 수익성에 부(-)의 영향을 미치고 비이자 수익비율은 수익성에 정(+)의 영향을 미치며 통계적으로 유의하다. 그리고 중국그림자금융이 상업은행의 안정성에 미치는 영향을 파악하기 위해 유동성리스크를 결정할 수 있는 요인을 분석해 보았다. 분석결과 총자산수익률은 유동성리스크에부(-)의 영향을 미치고, 당해 그림자금융 규모의 증가율, GDP증가율, 화폐공급량은 유동성리스크에 정(+)의 영향을 미치고 있다. 이러한 결과는 통계적으로 유의할 뿐만 아니라 경제논리에도 부합함을 보여주고 있다. This study explored the impact of the expansion of China``s shadow banking on the commercial banks`` stability. The previous studies were either the measurement of the shadow banking``s scale or the exploration of the imp act on the profitability of commercial banks. This study, however, focused on the exploration of the factors resulting in the liquidity risk. This study employed ROA as the dependent variables, the shadow banking``s scale of the current and the previous year, GDP growth rate, non-interest income ratio, loan to deposit ratio, non-performing loan(NPL) ratio an d M2 as the independent variables to indicate the impact on the commercial bank``s profitability. The research findings are as below; Firstly, the loan to deposit ratio and the NPL ratio have negative impact on the profitability, while the non-interest income ratio has positive impact. Secondly, ROA has the negative impact on the liquidity risk, while the growth rate of the current year``s shadow banking scale, GDP growth rate and the M2 have the positive impact.

중국 진출 한국기업의 무역 및 투자 리스크 연구동향과 향후과제

윤현빈(Heng-Bin Yin) 성균관대학교 무역연구소 2017 Asian Trade Risk Management(ATRM) Vol.1 No.2

본 연구는 중국 진출 한국기업의 무역 및 투자 리스크관리 분야의 기존 학술 및 학위논문, 각종 교재, 코트라 사이트의 내용을 분석 및 정리하여 연구추세를 검토하고 미진한 연구 분야를 식별하여 향후 연구방향을 제시하고자 하는 문헌연구이고, 특히 연구동향의 검색범위는 RISS 검색시스템에서 “對 중국 무역 및 투자리스크”로 설정하였다. 선행연구에서는 무역리스크 및 투자리스크 결정요인, 무역분쟁 사례분석, 해외직접투자 리스크 투자성과, 리스크관리, 투자철수의 결정요인에 대한 논문들이 있었지만 무역리스크 혹은 투자리스크 요인에 따른 리스크관리성과에 관해 실증적으로 검증된 논문은 검색되지 않았다. 향후에는 무역 및 투자 리스크관리 및 관리성과, ERM관리방안 개발에 관한 논문이 추가되어야 할 뿐만 아니라 투자철수, 직접투자구조의 변화에 따른 산업별, 진출동기별 실증분석, 사례분석의 논문들이 강화될 필요가 있다. This research aims to review existing academic and thesis research, various textbook, KOTRA site on risk management in trade and FDI of Korean firms in China, discriminate incomplete research area and to suggest a future area for further research, And established research range is “Trade and FDI risk of Korean firms in China” on RISS Researching engine. Literature review includes the thesis about the determinants of Trade risk and FDI risk, Trade disputes case analysis, FDI firms investment performance, Investment Satisfaction, Risk Management, determinants of divestment. However the thesis or article regarding “Risk management performance follow Trade risk or FDI risk” can not be researched. Future research may include the thesis on Trade and FDI firms Risk Management and Management Performance, Develop ERM management plan and Consolidate in Divestment, Case analysis and Empirical analysis by industry and motivation needs to be strengthened according to the changes of structures on FDI.

Weakly almost periodic points and chaotic dynamics of discrete amenable group actions

Bin Ling,Xiaoxiao Nie,Jiandong Yin 대한수학회 2019 대한수학회지 Vol.56 No.1

The aim of this paper is to introduce the notions of (quasi) weakly almost periodic point, measure center and minimal center of attraction of amenable group actions, explore the connections of levels of the orbit's topological structure of (quasi) weakly almost periodic points and study chaotic dynamics of transitive systems with full measure centers. Actually, we showed that weakly almost periodic points and quasi-weakly almost periodic points have distinct orbit's topological structure and proved that there exists at least countable Li-Yorke pairs if the system contains a proper (quasi) weakly almost periodic point and that a transitive but not minimal system with a full measure center is strongly ergodically chaotic.

Research on Modeling Improvement of Rubber Isolators by Considering Multi-loading Conditions

Yin-Yan Zhao,Wen-Bin Shangguan,Nong Cheng,Xiao-Jing He 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.

The stress-strain relationships of a rubber material in uniaxial tension, equi-biaxial tension and plane shear loading conditions are tested here. Constitutive parameters in different constitutive models, such as Mooney-Rivlin model, Van Der Waals model and Marlow model can be obtained by least square method using measured and calculated stress-strain relations. The rubber isolators in two rubber mounts are investigated here. Rubber mount I bears stretching/compression deformation or shear deformation, while mount II bears both deformations simultaneously. Using obtained constitutive constants, the rubber isolators’ static stiffness values in three mutually perpendicular directions are calculated, analyzed and compared with their measured results. Based on Mooney-Rivlin model, the effects of these constitutive constants on static stiffness of the two mounts are discussed by comparison. The effects of different models on static force-displacement characteristics of rubber mount I are also analyzed. The conclusion is that it is necessary to choose a relatively accurate constitutive model and appropriate methods for obtaining the model constants in describing rubber characteristic.

The Synthesis of CuS Hexagonal Nanosheet-Graphene for Use as a High Performance Photocatalyst

BIN ZENG,Yang Yin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.5

CuS hexagonal nanosheet/graphene was fabricated by a facile one-pot microwave-thermal method. The samples possess excellent photocatalytic activity for degradation of organic pollutant under visible light. The high photocatalytic activity was attributed to the deposition of CuS hexagonal nanosheet onto graphene. CuS nanosheet serves as a transporter which efficiently inhibits the recombination of the photo-induced charge carriers in the nanocomposites. The developed method demonstrates a facile approach towards the synthesis of two-dimensional semiconductor-graphene nanocomposites with excellent photocatalytic performance under visible light.