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Expression and Prognostic Implications of FOXO3a and Ki67 in Lung Adenocarcinomas
Liu, Hong-Bin,Gao, Xiang-Xiang,Zhang, Qing,Liu, Jian,Cui, Yuan,Zhu, Yan,Liu, Yi-Fei Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
To investigate the significance of FOXO3a and Ki67 in human lung adenocarcinomas. Envision immunohistochemical staining and Western blotting were used to examine the protein expression of FOXO3a in 127 cases of human lung adenocarcinoma specimens. The positive rate in lung adenocarcinoma (55.9%) was lower than that in normal tissues (80%). We found that the expression of FOXO3a was closely related with the degree of differentiation, TNM staging, lymph node metastasis and survival. In addition, significant differences in the different pathological types of lung adenocarcinoma cases (P<0.01). The FOXO3a positive rate of the acini as the main type (APA) (86.7%) and the lepidic as the main type (LPA) (82.4%) was higher than the solid as the main type (SPA) (50.0%), the papilla as the main type (PPA) (42.9%) and the micropapilla as the main type (MPA) (9.4%). Moreover, the expression of FOXO3a was negatively related with Ki67 expression. Our results suggested that the expression of FOXO3a is closely correlated with the aggressiveness of lung adenocarcinoma. It was indicated that disregulation of FOXO3a might play key roles in the occurrence and development of lung a denocarcinoma and joint detection of the two markers might play an important role in diagnosing tumors.
REDUCING SUBSPACES OF A CLASS OF MULTIPLICATION OPERATORS
Liu, Bin,Shi, Yanyue Korean Mathematical Society 2017 대한수학회보 Vol.54 No.4
Let $M_{z^N}(N{\in}{\mathbb{Z}}^d_+)$ be a bounded multiplication operator on a class of Hilbert spaces with orthogonal basis $\{z^n:n{\in}{\mathbb{Z}}^d_+\}$. In this paper, we prove that each reducing subspace of $M_{z^N}$ is the direct sum of some minimal reducing subspaces. For the case that d = 2, we find all the minimal reducing subspaces of $M_{z^N}$ ($N=(N_1,N_2)$, $N_1{\neq}N_2$) on weighted Bergman space $A^2_{\alpha}({\mathbb{B}}_2)$(${\alpha}$ > -1) and Hardy space $H^2({\mathbb{B}}_2)$, and characterize the structure of ${\mathcal{V}}^{\ast}(z^N)$, the commutant algebra of the von Neumann algebra generated by $M_{z^N}$.
Protection of Suburb Green Space: Contradiction of Protection and Use
Liu Bin-Yi,Xing Yang Korean Institute of Landscape Architecture 2004 Journal of the Korean institute of landscape archi Vol.2 No.-
This paper preliminary discussed the important function and faced problems of suburb green space during the process of urban development. As well as it points out the contradiction of protection and making use of. In this paper it takes the green space system planning in Wuxi as an example. Through introducing the classification, distribution, arrangement principles, overall arrangement tactics and concrete protective measures of suburb green space in Wuxi, the paper also puts forward the correct disposal principles for the relationship between protection and making use of toward the suburb green space to realize 'both-win' of them.
( Liu Bin ),( Ning Ning Zhang ),( Chao Zhao ),( Bai Xue Lin ),( Lian Hui Xie ),( Yi Fan Huang ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.10
A xylanase-producing thermophilic strain, Geobacillus sp. TC-W7, was isolated from a hot spring in Yongtai (Fuzhou, China). Subsequently, the xylanase gene that encoded 407 amino acids was cloned and expressed. The recombinant xylanase was purified by GST affinity chromatography and exhibited maximum activity at 75℃ and a pH of 8.2. The enzyme was active up to 95℃ and showed activity over a wide pH range of 5.2 to 10.2. Additionally, the recombinant xylanase showed high thermostability and pH stability. More than 85% of the enzyme`s activity was retained after incubation at 70℃ for 90 min at a pH of 8.2. The activity of the recombinant xylanase was enhanced by treatment with 10 mM enzyme inhibitors (DDT, Tween-20, 2-Me, or TritonX-100) and was inhibited by EDTA or PMSF. Its functionality was stable in the presence of Li+, Na+, and K+, but inhibited by Hg2+, Ni2+, Co2+, Cu2+, Zn2+, Pb2+, Fe3+, and Al3+. The functionality of the crude xylanase had similar properties to the recombinant xylanase except for when it was treated with Al2+ or Fe2+. The enzyme might be a promising candidate for various industrial applications such as the biofuel, food, and paper and pulp industries.
Liu Weiyi,Wang Fang,Sun Yanmei,Yang Lei,Chen Huihai,Liu Weijie,Zhu Bin,Hui Chaomao,Wang Shiwei 한국미생물학회 2020 The journal of microbiology Vol.58 No.11
Dragon bamboo (Dendrocalamus giganteus) is a giant sympodial bamboo species widely distributed in Asia. However, it remains unclear how dragon bamboo and soil microbes interact to affect soil properties. In this study, we investigated the planting patterns (semi-natural and artificial) on different slopes (sunny and shady) to determine the effects on soil properties and microbial community. The results showed that the soil in which dragon bamboo was grown was acidic, with a pH value of ~5. Also, the soil organic matter content, nitrogen hydrolysate concentration, total nitrogen, available potassium, and total potassium of the dragon bamboo seminatural forest significantly improved, especially on the sunny slope. In contrast, the available phosphorus level was higher in the artificial bamboo forest, probably owing to the phosphate fertilizer application. The bacterial and fungal diversity and the bacterial abundance were all higher on the sunny slope of the semi-natural forest than those in the other samples. The microbial operational taxonomic units (OTUs) shared between the shady and sunny slopes accounted for 47.8–62.2%, but the core OTUs of all samples were only 24.4– 30.4% of each sample, suggesting that the slope type had a significant effect on the microbial community. Some acidophilic microbes, such as Acidobacteria groups, Streptomyces and Mortierella, became dominant in dragon bamboo forest soil. A PICRUSt analysis of the bacterial functional groups revealed that post-translational modification, cell division, and coenzyme transport and metabolism were abundant in the semi-natural forest. However, some microorganisms with strong stress resistance might be activated in the artificial forest. Taken together, these results illustrated the influence of dragon bamboo growth on soil physicochemical property and microbial community, which might help understand the growth status of dragon bamboo under different planting patterns.
A J2EE based Management Information System for Higher Vocational Colleges
Bin Lu,Changyu Liu,Cong Li 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.1
Informatization has always been one core competency for effective daily management. Although there are various types of management information systems available, few of them could take into account ever changing management requirements of higher vocational colleges. In this paper, we develop a J2EE based management information system for higher vocational colleges. Firstly, we perform an overview of the entire background and situation of the management informatization for higher vocational colleges. Secondly, according to requirement analysis and use case analysis, we divide the system, which requires three roles, i.e., college administrator, enterprise and graduate, into four functional modules, i.e., user login module, college administrator module, graduate module and enterprise module. Thirdly, for architecture design, we adopt a J2EE four-tier architecture, which are user presentation tier, control treatment tier, business logic tier and data persistence tier. Then, we introduce five entities, which are user information table, enterprise information table, graduate information table, recruitment information table and dynamic news table, for the database design. Furthermore, we also illustrate how we implement the final system.