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아실옥시-9-보라비시클로〔3.3.1〕노난을 통한 트리스디에틸 아미노수소화알루미늄 리튬에 의한 카르복시산의 알데히드로의 전환
이재철,서정법,김종미,차진순 嶺南大學校附設 基礎科學硏究所 1988 基礎科學硏究 Vol.8 No.-
Carboxylic acids are readily reduced to the corresponing aldehydes in high yields by treatment of acyloxy-9-borabicyclo[3.3.1]nonanes (1) with lithium tris(diethylamino)aluminum hydride (LTDEA) in the presence of pyridine at 0℃. However, in the absence of pyridine, the yields of aldehydes are low. The role of pyridine in this reduction is discussed.
Inhibitory Effects of Silsosangami on the Platelet Aggregation
Kim, Jong Soo,Kim, Beob Jin,Kim, Han Geu,Ahan, Jong Chan,Lee, Soo Kyung,Chung, Tae Wook,Choi, Dall Yeong,Kim, Cherl Ho,Park, Won Hwan 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.4
The thrombosis importantly came to the front as the risk factor of these circulation system's disease. SilsoSanGami(SSG) was used for investigating the inhibitory effect on platelet-activating factor-induced platelet aggregation about drugs that used to improvement various symptoms created by the thrombosis in oriental medicine. In this study, the water-extracted SSG was investigated for its possible antithrombotic action on platelets. The antithrombotic activity of water-extracted SSG was deduced from its ability to suppress platelet aggregation, ATP-exocytosis, and the generation of prostaglandin E_2 and thromboxane A_2 by human platelets, stimulated with arachidonic acid. Water-extracted SSG dose-dependently suppressed the aggregation of human platelets, the release of endogenous ATP, and the formation of PGE_2 and TXB_2, both the latter usually detected to estimate the activity of COX and TXS, respectively. Since the IC_50 values necessary to inhibit COX (115 ㎍/㎖ SSG) and TXS(74 ㎍/㎖ SSG) were in the same range, inhibition of COX is suggested to be the primary target of water-extracted SSG, thus suppressing the formation of PGE_2 which is metabolized by TXS to TXA_2. We considerated that SSG has practical applicational value of clinical trial in the thrombosis caused by platelet aggregation.
침윤성 자궁경부암 환자의 임상적 양상 및 예후에 관한 연구
김법종(Beob Jong Kim),이재규(Lee Jae Kyu),이주헌(Joo Heon Lee),유상영(Sang Young Ryu),김종훈(Jong Hoon Kim),김병기(Byoung Gie Kim),박상윤(Sang Yoon Park),이의돈(Eui Don Lee),이경희(Kyung Hee Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9
목적: 침윤성 자궁경부암은 우리 나라 여성에서 가장 높은 발생 빈도를 보이는 질환으로 그 동안 국내 자궁경부암 환자의 예후에 관한 여러 연구에도 불구하고 생존 여부의 조사에 있어서의 어려움으로 신뢰할만한 자료가 거의 없는 실정이므로, 이 연구를 통하여 임상적 양상과 실제 5년 생존율을 알아보고자 하였다. 연구방법: 연구 대상은 1992년 1월부터 12월까지 1년간 본 원자력병원 산부인과에서 침윤성 자궁경부암으로 진단 및 치료를 시행한 489명의 환자를 대상으로 하였다. 환자들의 의무기록을 통하여 연령, FIGO 임상 병기, 조직학적 양상, 림프절 전이, 치료 방법 등 임상적 양상을 확인하였으며, 환자의 생존 여부는 행정전산망 및 경찰의 전산망, 통계청의 조사자료 등을 통하여 확인하였다. 결과: 환자의 연령별 분포는 51세에서 60세 사이가 32.7%로 가장 많았으며, FIGO 임상 병기는 IIb기가 32.5%로 가장 높은 빈도를 보였다. 임상병기 Ib기 및 IIa기의 치료방법은 수술적 치료가 주로 시행되었으며(65%), 이 이상의 병기에서는 방사선 치료가 주로 시행되었다(97%). 림프절의 전이는 Ib기 6%, IIa기 29% IIb기 36%로 IIb기 이상에서 높은 빈도를 보였다. 실측 5년 생존율은 72.2%였고 병기에 따른 생존율은 Ia기 100%, Ib기 94%, IIa기 82%, IIb기 63% IIIa기 36%, IIIb기 47%, IV기 0%였다. 임파절 전이여부에 따른 5년 생존율은 수술적으로 임파선 전이여부를 확인한 Ib-II기 환자에서 임파선 전이가 없는 군이 91.9%인데 비해 전이가 수술적으로 확인된 군은 73.1%를 보였다. 5년 생존율에 영향을 미치는 예후 인자는 FIGO 임상 병기와 림프절의 전이였으며, 연령 및 조직학적 유형은 통계학적 의의를 확인할 수 없었다. 결론: 1992년 1월부터 12월까지 1년간 본 원자력병원 산부인과에서 침윤성 자궁경부암으로 진단 및 치료를 받은 489명 환자의 실측 5년 생존율은 72.2% 였고, 5년 생존율에 영향을 미치는 예후인자는 FIGO 임상병기와 림프절의 전이였다. Objectives: This non-randomized retrospective study was to investigate the clinical characteristics and to evaluate the actual 5-year survival rate of the patients with invasive cancer of the cervix. Methods: 489 evaluable patients with invasive cancer of the cervix were treated at Korea Cancer Center Hospital from January to December 1992. In this retrospective study, we studied the clinico-pathologic characteristics(age, FIGO stage, histologic type, nodal metastasis) and treatment modalities by the review of medical records. Especially, the survival was confirmed by the support of the police and government office. Results: The most common subsets of patients were found in the group of FIGO stage IIb(32.5%) and age between 51 and 60(33%). Surgery was the main treatment in stage Ib/IIa(65%) and radiation in stage IIb or more(97%). Nodal metastasis were surgically identified in 6% of stage Ib, 29% of stage IIa and 36% of stage IIb. Overall actual 5-year survival rate was 72.2%; stage Ia(100%), Ib(94%), IIa(82%), IIb(63%), IIIa(36%), IIIb(47%), and IV(0%). The five-year survival rate according to LN status in surgically confirmed FIGO stage Ib-II patients were 91.9% in negative patients and 73.1% in positive patients respectively. Five-year survival rate was significantly different according to stage(P < 0.02) and nodal metastasis(p < 0.01). However, age and histologic type did not show any significant differences in survival. Conclusion: Overall actual five-year survival rate of 489 evaluable patients with invasive cancer of the cervix who were treated at Korea Cancer Center Hospital from January to December 1992 was 72.2%. Five-year survival rate was different according to stage and nodal metastasis.