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Lee, Kyu Min,Jang, Sun Mi,Oh, Seo Young,Kim, Do Young,Lee, Geewon,Kim, Ahrong,Kim, Min Ji,Kim, Tae Hwa,Park, Joon Woo,Lee, Kwangha,Kim, Ki Uk,Lee, Min Ki,Eom, Jung Seop The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
We presented a case of unusual endobronchial inflammatory polyps as a complication following endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in a patient with tuberculous lymphadenitis. EBUSTBNA of the right hilar lymph node was performed in a 29-year-old, previously healthy man. The patient was confirmed with tuberculous lymphadenitis and received antituberculosis medication over the course of 6 months. Chest computed tomography, after 6 months of antituberculosis therapy following the EBUS-TBNA showed nodular bronchial wall thickening of the right main bronchus. Histological and microbiological examinations revealed inflammatory polyps. After 7 months, the inflammatory polyps regressed almost completely without need for removal.
( Kyu Min Lee ),( Sun Mi Jang ),( Seo Young Oh ),( Do Young Kim ),( Geewon Lee ),( Ahrong Kim ),( Min Ji Kim ),( Tae Hwa Kim ),( Joon Woo Park ),( Kwangha Lee ),( Ki Uk Kim ),( Min Ki Lee ),( Jung Seo 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
We presented a case of unusual endobronchial inflammatory polyps as a complication following endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in a patient with tuberculous lymphadenitis. EBUSTBNA of the right hilar lymph node was performed in a 29-year-old, previously healthy man. The patient was confirmed with tuberculous lymphadenitis and received antituberculosis medication over the course of 6 months. Chest computed tomography, after 6 months of antituberculosis therapy following the EBUS-TBNA showed nodular bronchial wall thickening of the right main bronchus. Histological and microbiological examinations revealed inflammatory polyps. After 7 months, the inflammatory polyps regressed almost completely without need for removal.
Kim, Joo-Yeun,Shin, Na Ri,Kim, Ahrong,Lee, Hyun-Jeong,Park, Won-young,Kim, Jee-Yeon,Lee, Chang-Hun,Huh, Gi-Young,Park, Do Youn The Korean Society of Pathologists and The Korean 2013 KOREAN JOURNAL OF PATHOLOGY - Vol.47 No.1
<P><B>Background</B></P><P>Gastric cancers with microsatellite instabilities (MSI) have been reported to be associated with favorable prognosis. However, the significance of the effect of MSI on the clinicopathological features, as well as its association with mucin phenotype, remains unclear.</P><P><B>Methods</B></P><P>MSI status was assessed in 414 cases of gastric cancer using polymerase chain reaction analysis of five microsatellite loci, as recommended by National Cancer Institution criteria. The expression of mucins (MUC5AC, MUC6, MUC2, and CD10) was assessed.</P><P><B>Results</B></P><P>Out of 414 total cases of gastric cancer, 380 (91.7%), 11 (2.7%), and 23 (5.6%) were microsatellite stable (MSS), low-level MSI (MSI-L), and high-level MSI (MSI-H), respectively. Compared to MSS/MSI-L, MSI-H gastric cancers were associated with older age (p=0.010), tumor size (p=0.014), excavated gross (p=0.042), intestinal type (p=0.028), aggressive behaviors (increase of T stage [p=0.009]), perineural invasion [p=0.022], and lymphovascular emboli [p=0.027]). MSI-H gastric cancers were associated with tumor necrosis (p=0.041), tumor-infiltrating lymphocytes (≥2/high power field, p<0.001), expanding growth patterns (p=0.038), gastric predominant mucin phenotypes (p=0.028), and MUC6 expression (p=0.016). Tumor necrosis (≥10% of mass, p=0.031), tumor-infiltrating lymphocytes (p<0.001), intestinal type (p=0.014), and gastric mucin phenotypes (p=0.020) could represent independent features associated with MSI-H gastric cancers. MSI-H intestinal type gastric cancers had a tendency for poor prognosis in univariate analysis (p=0.054) but no association in Cox multivariate analysis (p=0.197).</P><P><B>Conclusions</B></P><P>Our data suggest that MSI-H gastric cancers exhibit distinct aggressive biologic behaviors and a gastric mucin phenotype. This contradicts previous reports that describe MSI-H gastric cancer as being associated with favorable prognosis.</P>
포용적(Inclusive) 접근의 무용예술교육을 위한 기초연구 - 교육의 방향성을 중심으로 -
김아롱 ( Kim Ahrong ),조은숙 ( Cho Eun-sook ) 한국무용예술학회 2021 무용예술학연구 Vol.84 No.4
The objective of the study is to examine the concept of ‘Inclusive’ arts which has contributed to enhance the field of disability arts. Korea has recently paid attention to the Alice Fox’s principles of inclusive arts activities, in order to suggest directions for the dance education of inclusive approaches. As the starting point for applying an inclusive approach to dance education, this study discusses three applications as follows. First, a reconsideration on dance education for the disabled in terms of special education. Second, a post-learning viewpoint on disability. Third, establishing a mutual subjective relationship between the disabled and non-disabled. The study is expected to draw attention on the disability arts education in the fields of dance education and to provide a foundation to make the dance education done for all by respecting equality and diversity.
( Joong Keun Kim ),( Ki Uk Kim ),( Sun Mi Jang ),( Kyung Hwa Shin ),( Jung Seop Eom ),( Hae Jung Na ),( Geewon Lee ),( Ahrong Kim ),( Byeong Gu Song ),( Dong Hun Shin ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
A 62-year-old female patient with a 10-month history of palliative chemotherapy for adenocarcinoma of the lung was diagnosed with a focal liver lesion on a follow-up CT scan. It was presumed initially to be due to metastasis. However, PET/CT scan showed no abnormal uptake, and thus histopathological confirmation was required. An ultrasound- guided biopsy was performed, and pathology revealed that the lesion was a benign tuberculosis pseudotumor. Primary hepatic tuberculosis, especially the macronodular form, remains very rare, even in a country where tuberculosis is prevalent. Hepatic tuberculosis should be included in the differential diagnosis of patients with underlying malignancies such as lung cancer, to avoid missing this rare but curable disease.
Jang, Sun Mi,Kim, Min Ji,Cho, Jeong Su,Lee, Geewon,Kim, Ahrong,Kim, Jeong Mi,Park, Chul Hong,Park, Jong Man,Song, Byeong Gu,Eom, Jung Seop The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.4
We present a case of an unusual infectious complication of a ruptured mediastinal abscess after endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), which led to malignant pleural effusion in a patient with stage IIIA non-small-cell lung cancer. EBUS-TBNA was performed in a 48-year-old previously healthy male, and a mediastinal abscess developed at 4 days post-procedure. Video-assisted thoracoscopic surgery was performed for debridement and drainage, and the intraoperative findings revealed a large volume pleural effusion that was not detected on the initial radiographic evaluation. Malignant cells were unexpectedly detected in the aspirated pleural fluid, which was possibly due to increased pleural permeability and transport of malignant cells originating in a ruptured subcarinal lymph node from the mediastinum to the pleural space. Hence, the patient was confirmed to have squamous cell lung carcinoma with malignant pleural effusion and his TNM staging was changed from stage IIIA to IV.
Lee, So Jeong,Kim, Ahrong,Kim, Young Keum,Park, Won Young,Kim, Hyun Sung,Jo, Hong-Jae,Oh, Nahmgun,Song, Geum Am,Park, Do Youn Elsevier 2018 Human pathology Vol.78 No.-
<P>Endoscopic resection is widely recognized as a first-line treatment for T1 colorectal cancers (CRC), although additional surgical intervention may be indicated based on the risk of lymph node (LN) metastasis. However, risk factors for LN metastasis in T1 CRC not fully established. We investigated the clinicopathological features of T1 CRC and evaluated their association with lymph node metastasis in 133 cases of T1 CRC, consisting of 87 cases with first-line endoscopic resection (EMR) followed by additional surgery and 46 cases with primary surgical resection. Among the total 133 cases, 16 cases (12.0%) showed LN metastasis; 13 cases (13/16, 81.25%) were included in endoscopic resection cohort. These were all of the non-pedunculated gross type and most of LN+ tumors invaded submucosa over 1000 mu m (surgical cohort versus endoscopic resection cohort; 3 versus 11). However, there was no statistical difference in the depth of submucosal invasion between the LN+ and LN in both surgical cohort (2799.42 mu m 401.56 versus 3000.00 mu m 721.69, P=.897) and endoscopic resection cohort (2066.55 mu m 142.96 versus 2305.77 mu m 345.62, P=.520). Conversely, presence of and a higher number of tumor budding foci were associated with an increase in the incidence of LN metastasis in both cohort (P<.0001). Positive resection margins as well as absence of adenoma component were also an independent predictive factor for lymph node metastasis in 87 cases with first-line endoscopic resection followed by additional surgery. We found that tumor budding was the most reliable LN metastasis predictor in T1 CRC in both surgically resected and endoscopic resection specimens.</P>
Park, Won-Young,Lee, So-Jeong,Kim, Young-Keum,Kim, Ahrong,Park, Do Youn,Lee, Bong-Eun,Song, Geun-Am,Kim, Gwang Ha Elsevier 2018 Pathology, research and practice Vol.214 No.1
<P><B>Abstract</B></P> <P><B>Aims</B></P> <P>Endoscopic resection is a safe and effective method to treat gastric epithelia dysplasia (GED). However, the development of metachronous and synchronous lesions after treatment has become a major concern. In this study, we investigated clinicopathologic features of 105 GED lesions from endoscopic resections between January 2008 and December 2009. Our goal is to find histologic factors that predict synchronous and metachronous lesions after ESD treatment. We assessed the degree of intestinal metaplasia (IM) and atrophy, type of IM, presence of gastritis cystica profunda, and crypt dysplasia in the adjacent mucosa.</P> <P><B>Methods and results</B></P> <P>We divided 105 GED lesions into three groups: a single group without metachronous or synchronous GED or adenocarcinoma (n=35); a multiple synchronous group (n=30, group with synchronous occurrence of GED or adenocarcinoma after treatment); and a multiple metachronous group (n=40, group with metachronous occurrence of GED or adenocarcinoma after treatment). The multiple metachronous and synchronous groups showed larger sizes (p=0.003) and higher grades (p=0.021) as compared with the single group. Furthermore, marked IM and atrophy in adjacent mucosa were more easily seen in the multiple metachronous and synchronous groups as compared with the single group (p<0.0001). Interestingly, the presence of incomplete type of IM (p=0.025) and crypt dysplasia (p<0.0001) in background mucosa was associated with occurrence of metachronous and synchronous lesions following endoscopic resection of GED.</P> <P><B>Conclusions</B></P> <P>The histological features of background mucosa, such as intestinal metaplasia, atrophy, and crypt dysplasia could be used as indicators of occurrence of metachronous and synchronous lesions after endoscopic treatment of GED.</P>
Ahn, Sangjeong,Lee, So-Jeong,Kim, Yonugkeum,Kim, Ahrong,Shin, Nari,Choi, Kyung Un,Lee, Chang-Hun,Huh, Gi Yeong,Kim, Kyong-Mee,Setia, Namrata,Lauwers, Gregory Y.,Park, Do Youn Wolters Kluwer Health, Inc. All rights reserved. 2017 The American journal of surgical pathology Vol.41 No.1
<P>Gastric cancers have recently been classified into several types on the basis of molecular characterization, and the new taxonomy has shown to have clinical relevance. However, the technology required for thorough molecular classification is complicated and expensive, currently preventing widespread use. We aimed to reproduce the results of molecular classification using only simple techniques, that is, immunohistochemical analysis and in situ hybridization. We classified a cohort of 349 successive gastric adenocarcinomas into 5 subtypes, on the basis of protein or mRNA expression of MLH1, E-cadherin, p53, and Epstein-Barr virus. We observed that the subtypes presented distinct clinicopathologic characteristics and corresponded to the molecular classifications previously reported. Epstein-Barr virus-positive tumors were more common in male individuals and in the body of the stomach. Microsatellite-unstable (MSI) tumors, which showed aberrant MLH1 expression, were correlated with increased age and intestinal histology. Both types showed better overall survival than the other types. Gastric cancers with reduced expression of E-cadherin, corresponding to the epithelial to mesenchymal transition or genome stable subtypes, showed the poorest overall survival, with a high prevalence of poorly cohesive carcinoma (ie, diffuse type, of the Lauren classification system). In conclusion, we were able to reproduce a previously reported molecular classification of gastric cancers using immunohistochemical analysis and in situ hybridization. We verified the effectiveness and applicability of this method, which shows promise for use in a clinical setting in the foreseeable future.</P>