대기오염이 기관지 천식의 악화에 미치는 영향

류지원,어수택,김기업,이영목,김양기,홍성아,전창균 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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요양급여 적정성 평가체계 혁신 중장기 계획

김상지,전숙경,이창원,정영애,안재영,안유미,권아영,임상희,최정남,윤미선,변의형,조미현 건강보험심사평가원 2021 HIRA RESEARCH Vol.1 No.2

콩 및 당의 종류의 달리한 매실 콩아이스크림의 품질특성

이숙영,김아영,유지영,이중기,이향섭 중앙대학교 생활과학연구소 2003 생활과학논집 Vol.17 No.-

The purpose of this experiment was to compare the quality characteristics of soy ice creams prepared with soy protein isolate(SPI) or Jinpum-soybean, and different kinds of sweeteners of maltitol and sucrose, xylitol+sucrose, or malitiol. The viscosity of the ice cream mix containing xylitol+sucrose appeared the highest, and that from Jinpum-soybean was higher than that from SPI. The overrun of soy ice creams containing xylitol+sucrose was the highest, and the next was the samples containing maltitol+sucrose. The overrun values of Jinpum-soybean samples appeared higher than those of SPI samples. As for the case of the SPI samples, the melt-down percent was the highest in the sample of maltitol addition, and the next were maltitol+sucrose addition, xylitol+sucrose addition in order. The melt-down percent of Jinpum-soybean was the highest in the sample of maltitol+sucrose addition, and the next were maltitol addition, xylitol+sucrose addition in order. The higher the viscosity of samples, the lower the melt-down percent. In sensory characteristics, the beany flavor, flavor, mouthfeel, overall quality of Jinpum-soybean samples were evaluated better than those of SPI in general. The samples containing xylitol+sucrose evaluated better in beany flavor, mouthfeel, icy feel, and overall quality. The quality characteristics of the samples prepared with Jinpum-soybeans and xylitol+sucrose were evaluated the best.

RAW 264.7 세포에 대한 중국산 천연 광물성 섬유 TAFMAG의 독성효과

임영,한진구,김지홍,김현욱,김은경,김경아,장황신 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3

Objectives : This study was designed to evaluate cytotoxicity of TAFMAG, which is a trade name of natural mineral fiber mined and produced in China. Methods : The cytotoxicity of TAFMAG was evaluated by measuring iron content, lipid peroxidation, erythrocyte hemolysis, and cytotoxicity in vitro. These results were compared with the data of chrystotile and wollastonite as a positive and negative control, respectively. Results : There was significant increase of Fenton activity in TAFMAG and chrysotile with dose-response pattern. The iron chelating agent, desferrioxamine, significantly decreased Fenton activity of the particulates except wollastonite. TAFMAG and chrysotile fibers significantly increased malondialdehyde concentration from lipid peroxidation of the red blood cell membrane. In erythrocyte hemolysis test, TAFMAG & chrysotile had stronger effect on erythrocyte hemolysis than wollastonite with the concentration of 1,000g/ml. Furthermore, TAFMAG was more hemolytic than chrysotile with the concentration of 5,000g/ml. There was a significant cytotoxic effect in TAFMAG and chrysotile on RAW cell compared with wollastonite. Conclusions : In vitro study suggested that TAFMAG may have a similar health hazard as usual asbestos.

화옹호의 부영양화 방지를 위한 영양염류 삭감률 산정

김미아,김영희,이홍근,황대호,김지영 한국물환경학회 2004 한국물환경학회지 Vol.20 No.6

In this study, the reduction rates of nutrients were suggested to prevent eutrophication on the Hwaong reservoir in the year of 2008 and 2012. With EPA's WASP6 model, future water quality were simulated. In 2008, T-N would be 1.36mg/L and T-P 0.100mg/L on average. ; In 2012, T-N 2.66mg/L and T-P 0.128mg/L. With all the water quality management plans that the government authorities are carrying out, these results indicate that the reservoir would be reach the eutrophic or hypertrophic state according to the Vollenweider's trophic states. Therefore, the Hwaong reservoir requires additional plans for nutrients management. Here, the target water quality to prevent eutrophication of the reservoir sets into mesotrophic state ; T-N 0.475mg/L and T-P 0.02mg/L.(median of Vollenweider index for mesotropphic state) The reduction rates of nutrients on Namyang and Eoeun streams were estimated with uniform treatment method to meet the goal. The results showed that nutrients from two streams should be reduced up to 78% in 2008, and 84% in 2012. Since the ratio of T-N/T-P would be higher than 16 at target years, T-N was not considered as the limiting factor and was not reduced.

사회교육으로서의 비서교육기관의 현황

한영아,정지현,홍명이 이화여자대학교 법정대학 비서학과 1992 비서학연구 Vol.- No.12

횡결장에 장중첩으로 발생한 연소성 용종을 가진 3세 소아의 증례

서아영, 이지혁 충북대학교 의학연구소 2019 忠北醫大學術誌 Vol.29 No.2

소아의 대장 용종은 소아 청소년 연령에서 무통 및 재발성 장출혈의 가장 흔한 원인 중 하나이다. 그러나 횡결장의 연소성 용종은 드물다. 하행결장은 후복벽에 고정되어 있기 때문에 소아에서 연소성 용종에 의한 대장-대장 장중첩은 매우 드물다. 그리고 보고된 증례 대부분이 6세 이상이다. 특히 3세 이하의 소아에서 장중첩으로 나타나는 횡결장의 연소성 용종은 매우 드물다. 본 증례보고에서는 장중첩으로 나타난 횡결장의 연소성 용종을 가진 3세 소아를 경험하였기에 사례와 문헌 고찰을 함께 보고하는 바이다.

석유화학공장 근로자에서 발생한 재생불량성 빈혈 1례

박영만,임영,강성규,김지홍,이종욱,최용휴,김경아 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2

Aplastic anemia is characterized by pancytopenia with hypocellular bone marrow. Fifty percent of the cases are idiopathic and the rest are caused by various agents including drugs, chemicals, radiation and viruses. It is difficult to link specific etiologic agents, especially chemicals to the development of aplastic anemia because multiple or unknown exposures may be involved in. Benzene, a common industrial chemical and a component of gasoline, may lead progressively to pancytopenia, aplastic anemia and leukemia when exposed. A petrochemical worker with aplastic anemia was referred to our hospital to evaluate a relationship between the job history and the disease. He worked in the petrochemical plant for 21 years and was exposed to low-level benzene. There was not anyother etiologic agent except benzene and this is the case report of aplastic anemia which possibly due to benzene exposure.

결정형 규산분진에 의한 A549 세포의 독성 및 섬유모세포 증식에 Desferrioxamine이 미치는 영향

김경아,김은경,김지홍,임영 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2

The inhalation of crystalline silica results in the production of reactive oxygen species (ROS). Among these ROS, hydroxyl radical (˙OH) is believed to be the most reactive one. ˙OH is generated in reaction between superoxide and hydrogen peroxide catalyzed by transition metal, especially iron. Therefore iron should be important in the bioactivity of crystalline silica. Desferrioxamine, a iron chelator, may be protective in silica-induced pulmonary reaction. To test this assumption we investigated the protective effect of desferrioxamine on lipid peroxidation of cell membrane, cytotoxicity, production of proinflammatory and chemotactic cytokine and fibroblast proliferation by crystalline silica in vitro model. The results were as follows; 1. Fenton activity of silica and asbestos was significantly higher than that of control. Fenton activity in crocidolite was higher than silica at the same dose. This result correlated with iron content of dust. Fenton activity of silica and crocidolite was decreased by preincubation of silica with desferrioxamine. 2. Silica induced a dose-dependent increase of MDA concentration in lung epithelial cell lysate dose dependently. Marked decrease of MDA was observed in desferrioxamine treated silica group compared with untreated group. 3. As concentration of stimulated silica, silica-induced cytotoxicity was increased. There was significant decrease of cytotoxicity in desferrioxamine-treated silica group compared with untreated group. 4. α-quartz augmented the production of TNF-α and IL-8 from A-549 cell. While desferrioxa-mine suppressed the release of cytokines. 5. Supernatant of silica-cocultured A549 cell induced a significant proliferation of fibroblast, which desferrioxaime blocked this proliferation. From these result, we concluded that desferrioxamine has a protective effect on silica induced pulmonary reaction.

발작성 고혈압을 주소로 한 급성 간헐성 포르피리아 1예

신정아,이지선,변영섭,고충원,이병권,김병옥,이건주 白中央醫療院 2004 仁濟醫學 Vol.25 No.1

Acute intermittent porphyria is a disorder that results from partial porphobilinogen deaminase deficiency and accumulation of overproducted porphyrin and its precusors. This makes variable manifestations such as abdominal pain, nausea, vomiting, contipation, peripheral neuropathy, seizure, psychotic symtoms, respiratory failure, tachycardia, and hypertension. When acute paroxysmal hypertension presents, it is difficult to differentiate from pheochromocytoma. We experienced a case of young female with acute intermittent porphyria presenting paroxysmal recurrent headache, palpitation, chest discomfort and paroxysmal hypertension. Initially blood pressure was 160/100 mmHg and checked high paroxysmally on follow up. Rhythm was sinus tachycardia. She did not complain any other specific symptoms. Although her clinical manifestations were suspicious for pheochromocytoma, laboratory findings were not compatible to it. In searching other causes of secondary hypertension mimickng ph대chromocytoma, elevated urine porphobilinogen level was detected and we could make diagnosis of acute intermittent porphyria. If AIP was not beared in mind as a cause of secondary hypertension, diagnosis would be delayed more.