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金公朱,박미라,강영의,김애순 全北大學校 1994 論文集 Vol.38 No.-
In one bath dyeing system of silk/cellulose triacetate(triactate) fiber blend fabric with acid/disperse dyes, adsorption behvior of acid dyes and disperse dyes on silk and triactate fabrics were examined. In the dyeing of triactate with the C.I. Disperse Red 19(Red 19) and the C.I. Disperse Red 60(Red 60) at 100℃, dye uptake with the Red 19 was higher than that with the Red 60. When the silk/triaceetate was dyed with Red 19 and the Red 60 at 100℃, dye uptake on triacetate was influenced by affinity of the dye to the silk fabric dyed together. In the treatment of the silk fabric dyed with the Red 19 and Red 60 in desorption bath with and without undyed triacetate, desorption of the dyes from the silk fabric was influenced by the affinity of the dyes to the triacetate. When the silk/triacetate was dyed with the Blue 80/Red 19 and Red 60 at 100℃, color of triacetate dyed with the Red 19 and Red 60 was not influenced by the Blue 80 but silk dyed with the Blue 80 was influenced by the Red 19.
정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 예비연구
유소영,이경진,강도형,이승재,하태현,위휘,이애라,송지연,김성년,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1
Objectives : The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods : Symptomatic individuals judged at high risk for schizophrenia ('clinical high risk') within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results : Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the Cli-nical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion : This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis.
Kang, Ae Ra,Oh, Young Rim,Kim, Heung Yeol,Park, Min Jung,Joo, Bo Sun,Choi, Won Jun,Lee, Ji Young,Jung, Min Hyung,Ji, Yong Il,Choi, Jong Soon Springer-Verlag 2012 Archives of gynecology and obstetrics Vol.285 No.5
<P><B>Purpose</B></P><P>To investigate the effect of alendronate on the expression of <I>Id</I> genes in osteoblast differentiation.</P><P><B>Methods</B></P><P>C2C12 cells were treated with alendronate for various concentrations and time periods. For evaluation of alendronate-induced osteoblast differentiation in C2C12 cells, alkaline phosphatase (ALP) activity was measured. The expression of osteoblast differentiation markers such as ALP, type-1 collagen (Col 1), and osteocalcin (OCN), and the expression of Id-1 and Id-2 were measured by RT-PCR. In order to understand the mechanism underlying the regulation of <I>Id</I> genes, the promoter region of the <I>Id</I>-<I>1</I> gene was identified. Database analysis of the promoter region for <I>Id</I>-<I>1</I> using known consensus sequences identified several putative response elements, including CCAAT/enhancer-binding protein beta (C/EBPβ).</P><P><B>Results</B></P><P>Alendronate treatment significantly increased not only ALP activity but also the expression of ALP, Col 1, and OCN, Id-1 and Id-2. C/EBPβ and alendronate cooperatively increased the promoter activity and expression of Id-1.</P><P><B>Conclusions</B></P><P>These results suggest that C/EBPβ-mediated <I>Id</I>-<I>1</I> transcriptional activation may regulate alendronate-induced osteoblast differentiation of C2C12 cells.</P>
강애라 ( Ae Ra Kang ),신정호 ( Jung Ho Shin ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.11
자궁내막증은 흔하고 만성적인 부인과적인 양성질환이다. 자궁내막증은 에스트로겐의 영향을 받으며 골반통, 생리통, 불임의 원인이 된다. 재발이 매우 흔하므로 가능한 한 완전한 병소의 수술적 제거가 원칙이며, 바로 임신을 원하는 경우가 아니라면, 재발을 억제하기 위해 수술 후 약물치료가 필요한 경우가 많다. 생식샘자극호르몬 분비호르몬 작용제, 다나졸, 프로게스토겐, 경구피임제들이 전통적으로 자궁내막증의 약물치료로 사용되어 왔다. 그러나 이들 약제의 전신적인 부작용으로 장기간의 치료에 한계가 있어, 최근에는 자궁내막증의 병태생리에 기초한 다양한 다른 약제들이 자궁내막증의 수술 후 재발방지 목적으로의 사용이 시도되고 있다. Levonorgestrel 분비 자궁내장치, 방향화 효소 억제제 (aromatase inhibitor), 선택적 프로게스테론수용체 조절제 (SPRM), COX-2 억제제 등이 새롭게 자궁내막증의 약물적 치료로 이용되고 있으며, 앞으로 자궁내막증에 대한 분자 생물학적인 이해가 깊어질 수록, 더욱 선택적이고 효과적인 약물의 개발이 가능해 질 것이다. Endometriosis is a common, benign and chronic gynecologic disorder. It is an estrogen dependent disease that can cause pelvic pain, dysmenorrhea and infertility. Because of its high rate of recurrence, medication after surgery is inevitable. GnRH agonist, Danazol, progestogen and oral contraceptive have been conventionally used for the medical treatment of endometriosis. However, systemic side effects of those agents restrict their usage as long-term management. Increasing knowledge about the pathogenesis of endometriosis has introduced new agents which were more targeted and specified for the prevention of recurrence of endometriosis.
일차 항결핵제 모두에 과민반응을 보인 환자의 성공적 탈감작 결핵 치료 1예
이애라 ( Ae Ra Lee ),김수정 ( Soo Jung Kim ),김정현 ( Jung Hyun Kim ),박주희 ( Ju Hee Park ),이정규 ( Jung Kyu Lee ),김주영 ( Ju Young Kim ),이서영 ( Suh Young Lee ),강혜련 ( Hye Ryun Kang ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4
Tuberculosis is an infectious disease that can be treated using a combination of antitubercular drugs. First-line antitubercular agents such as isoniazid and rifampin are considered pivotal to successful treatment. However, they are also known to have relatively high rates of adverse events including hypersensitivity reactions. Discontinuing the first-line agents in the event of hypersensitivity may significantly compromise the cure rate of tuberculosis. Drug desensitization can be an effective method allowing continued use of the first-line agents and achieving successful cure of tuberculosis. A 70-year-old man was diagnosed with culture proven pulmonary tuberculosis and treated with first-line antitubercular agents (isoniazid, 300 mg; rifampin, 600 mg; pyrazinamide, 1,500 mg; and ethambutol, 800 mg). After 2 weeks of treatment, generalized erythematous papular rash and fever developed, for which all drugs were discontinued. Since he had hypersensitivity to all 4 first-line antitubercular agents, we tried desensitization for all 4 drugs one by one to resume antituberculosis treatment. After successful desensitization of all 4 first-line antituberculosis drugs, 6 months-antitubercular therapy was completed without any complications. We report here a case of multiple desensitization in a pulmonary tuberculosis patient having hypersensitivity to all of the 4 first-line antitubercular drugs, successfully completing 6-month antitubercular therapy without any complications. (Allergy Asthma Respir Dis 2013;1:395-399)
Corn silk extract improves benign prostatic hyperplasia in experimental rat model
So Ra Kim,Ae Wha Ha,Hyun Ji Choi,Sun Lim Kim,Hyeon Jung Kang,Myung Hwan Kim,Woo Kyoung Kim 한국영양학회 2017 Nutrition Research and Practice Vol.11 No.5
BACKGROUND/OBJECTIVES: This study was conducted to investigate the effect of a corn silk extract on improving benign prostatic hyperplasia (BPH). MATERIALS/METHODS: The experimental animals, 6-week-old male Wistar rats, were divided into sham-operated control (Sham) and experimental groups. The experimental group, which underwent orchiectomy and received subcutaneous injection of 10 mg/kg of testosterone propionate to induce BPH, was divided into a Testo Only group that received only testosterone, a Testo+Fina group that received testosterone and 5 mg/kg finasteride, a Testo+CSE10 group that received testosterone and 10 mg/kg of corn silk extract, and a Testo+CSE100 group that received testosterone and 100 mg/kg of corn silk extract. Prostate weight and concentrations of dihydrotestosterone (DHT), 5α- reductase 2 (5α-R2), and prostate specific antigen (PSA) in serum or prostate tissue were determined. The mRNA expressions of 5α-R2 and proliferating cell nuclear antigen (PCNA) in prostate tissue were also measured. RESULTS: Compared to the Sham group, prostate weight was significantly higher in the Testo Only group and decreased significantly in the Testo+Fina, Testo+CSE10, and Testo+CSE100 groups (P < 0.05), results that were consistent with those for serum DHT concentrations. The concentrations of 5α-R2 in serum and prostate as well as the mRNA expression of 5α-R2 in prostate were significantly lower in the Testo+Fina, Testo+CSE10, and Testo+CSE100 groups than that in the Testo Only group (P < 0.05). Similarly, the concentrations of PSA in serum and prostate were significantly lower in the Testo+Fina, Testo+CSE10, and Testo+CSE100 groups (P < 0.05) than in the Testo Only group. The mRNA expression of PCNA in prostate dose-independently decreased in the Testo+CSE-treated groups (P < 0.05). CONCLUSIONS: BPH was induced through injection of testosterone, and corn silk extract treatment improved BPH symptoms by inhibiting the mRNA expression of 5α-R2 and decreasing the amount of 5α-R2, DHT, and PSA in serum and prostate tissue.