Acute exacerbation of interstitial lung disease; subgroup analysis for causes, risk factors for mortality rate, and steroid responsiveness

( Seung Hyun Yong ),( Ah Young Leem ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Moo Suk Park ),( Hye Jin Jang ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Interstitial Lung Disease (ILD) has known as a poor prognosis disease, particularly idiopathic pulmonary fibrosis (IPF). Corticosteroid is widely used for treatment of acute exacerbation (AE)-ILD. This study aims to clarify efficacy of corticosteroid use, and compare the mortality rate depending on the subgroups of ILD. Materials and Methods: We collected the data from the patients who have diagnosed ILD and visited emergency room (ER) with the respiratory symptoms from January 1, 2016 to December 31, 2018. We classified AE-ILD patients into 3 groups depending on methylprednisolone dose per kilogram. Also, we compared the mortality of IPF patients to that of non-IPF patients. Results: A total case of AE-ILD visited ER from 2016 to 2018 was 209 cases, including IPF cases (n=122) and non-IPF cases (n=87). We divided total patients (n=209) into three groups depending on steroid use, and these include group 1 of 0-0.49 mg/kg (n=78), group 2 of 0.5-0.99 mg/kg (n=58), and above 1.0 mg/kg (n=41), each. We found poor prognosis from the cases of IPF compared to non-IPF cases (p=0.029, OR 2.463). Furthermore, there was significant differences of mortality rate according to steroid dose (p=0.036, OR 1.712), CRP elevation (p=0.016, OR 1.004), and intubated case (p=0.000, OR 8.152). Also, we categorized IPF (n=122) to non-IPF cases (n=87) and analyzed the mortality rate. Most of the patients were death from ILD itself (n=23, 63.9%), Pneumonia(n=8, 22.2%), and Lung cancer (n=5, 13.9%). Bacterial infection (n=26) was dominant cause of AE, followed by fungal infection (n=15), and viral infection (n=10). Conclusions: This retrospective analysis of corticosteroid treatment shows more fatal outcome when we use high dose steroid in AE-ILD cases, and there was significant difference in mortality rate depending on the subgroup of ILD and medical background, such as intubation status, higher CRP level, and IPF cases.

사설시조의 여성화자와 여성 섹슈얼리티

박애경 한국여성문학학회 2000 여성문학연구 Vol.3 No.-

사설시조에는 여성화자가 주도하는 성담론이 두드러지게 나타나고 있다. 이 글은 여성화자의 성담론이 당대 현실과 관계 맺는 양상을 살피기 위해, 여성화자의 존재양상을 정황에 따라 나누어 살펴보고, 여기에 나타나는 발화 방식과 태도를 점검해 보았다. 여성화자의 성담론에는 훼손된 성을 드러내는 비교적 균일한 목소리도 간혹 드러나지만, 대개 간통, 성에 편향된 자아를 고백하는 분열된 목소리가 압도적으로 나타나고 있다. 어조의 분열은 시점의 불일치, 비현실적 상황 설정, 화자와 논평자의 분리로 가시화되고 있다. 이것은 사설시조에 나타난 여성화자와 실질적 발화의 주체와의 분리를 의미한다. 이 글은 이러한 문제 의식에서 출발하여 사설시조에 나타난 여성화자가 실은 기방 등 남성이 주도하는 유흥 공간에서 성욕을 대리 체험하고 대리 진술하는 욕망의 투사체로 기능하고 있음을 살펴보았다. 이 순간 여성화자는 남성의 일탈적 욕망의 대상으로 혹은 희화화된 ‘관음’의 대상으로 고정화되고 만다. 이는 사설시조의 여성화자가 적극적 태도, 도발적 포즈에도 불구하고 ‘타자성’에서 벗어나지 못했다는 의미로 해석할 수 있을 것이다. Sasul-Sijo is censuring in many aspects. In this study, I focused female narrator and its discourse of sexuality in Sasul-Sijo. Sexuality is the main process to understand the esthetic value of Sasul-Sijo, is known as being coincident with irregular form of this genre. Female narrator in Sasul-Sijo is escaping from the 'Model of the woman' that is restricted notion of Middle Ages. They express sexual desire, sexual experience and illicit love without hesitation. To make clear the meaning of female narrator and its discourse, I examined the aspects of discourse including tone and poetic circumstances, being related with reality at that time, and then was revealed its discord of tone, lack of unity. It is to say that the female narrator is not consistent with the real subject of speaking. It is the man who control the sexual discourse of female narrator. Therefore, we can conclude that female narrator is not the provision of expressing the desire and emotion of woman but the projection of man's sexual desire something like deviating. Female narrator is showed as the subject of expressing sexual desire and experience in place of man, sometimes the object of ridicule. And the characteristic of female narrator in Sasul-sijo is consistent with the image of Kisaeng. It means that however active on the surface, female narrator in Sasul-Sijo is not free from the meaning of the 'object'.

화학적으로 유도한 랫드 간세포 암화과정에서 단백질 식이가 생체막 안정도와 glutathione 의존성 효소계에 미치는 영향

박경애 가야대학교 2001 가야대학교 논문집 Vol.10 No.-

The purpose of this study is to determine the effect of dietary proteins on the membrane stability and drug-metabolizing enzyme activities during chemically induced rat hepatocarcinogenesis. Weanling Sprague-Dawley rats were fed the diet containing 20% casein or soy protein isolate and 15% beef tallow for 10 weeks. Hepatocarcinogensis was initiated with diethylnitrosamine(DEN), and the rats were fed diets containing 0.02% 2-acetylaminofluorene (AAF) followed by 0.05% phenobarbital (PB). Relative liver weights were significantly increased by AAF and PB treatment in rats. Glucose 6-phosphatase (G6Pase) activities, an index of membrane stability, were not influenced by AAF and PB treatment, but were higher in soy protein diet compared to casein diet groups treated with carcinogen. Lipid peroxide values also were increased by AAF and PB treatment and were higher in soy protein diet compared to casein diet groups. NADPH-cytochrome P450 reductase activity were significantly increased by AAF and PB treatment in casein diet group and aniline hydroxylase activities were increased by AAF and PB treatment. Glutathione S-transferase enzyme activities were increased by AAF and PB and higher in soy protein diet compared to casein diet groups treated with carcinogen. Glutathione peroxidase and g1utathione reductase were influenced by AAF and PB. Our results suggest that soy protein maintain the membrane stability and influence the glutathione S-transferase during chemically induced rat hepatocarcinogenesis. Soy protein may be protective against the stage of promotion of hepatocarcinogenesis induced by chemical carcinogen. KEY WORD ; glutathione S-transferase, hepatocarcinogenesis, membrane stability, soy protein.

대전 충남지역 국민학교의 학교급식 실태에 관한 조사

박영숙,이경애,김연순 순천향대학교 기초과학연구소 1995 순천향자연과학연구 논문집 Vol.1 No.1

The foodservice management of school-lunch program was studied to certify the fulfillment of it's objectives. One hundred thirtheen primary schools in Taejon and Chungnam province were participated in our survey. The results of this study were as follows: 1. Average cost per meal for each student was 772 won, that was less in central kitchen system. Productivity in terms of meals per worker was also higher in centralized kitchen system. 2. The menu was mostly planned weekly and not cyclic. 3. The dietitian's work covered all 5 parts of material handling duties in conventional system which were described in the school-lunch program laws. However it was mainly concentrated on 2 parts of the food purchase order and of the inspection of delivered foods in co-management and central kitchen systems. 4. Our results indicated that nutrition education in school-lunch program especially in co-management and central kitchen systems was almost neglected. It was stressed that school-lunch program should be extended without omitting its objectives especially nutrition education, which is important for the young.

급성 췌장염의 합병이 추정되는 한국형 출혈열 1예

박영수,김창오,김영근,홍성관,장경희,허애정,염준섭,송영구,김준명 대한감염학회 2001 감염 Vol.33 No.5

The Korean hemorrhagic fever (KHF) is an acute febrile disease with characteristic of fever, bleeding tendency, and renal failure. There are many complications of Korean hemorrhagic fever such as infection, anemia, internal bleeding, hypopituitarism, respiratory, and neurologic complication. A few cases were reported on acute pancreatitis with hemorrhagic fever abroad, but there was no case about Korean hemorrhagic fever with acute pancreatitis in this country. We experienced a case of Korean hemorrhagic fever associated with suspected acute pancreatits. With review of articles, we report a case of 51 year-old woman with KHF, where acute pancreatitis developed during management, (Korean J Infect Dis 33:376∼379, 2001)

Antenatal Treatment of Ambroxol Hydrochloride and Dexamethasone for the Prevention of Respiratory Distress Syndrome

박은애,이경은 이화여자대학교 이과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

연구목적: 미숙아에 대한 치료 한계가 점점 어린 연령, 적은 체중으로 햐향되면서 미숙아에서 발생하는 호흡곤란증(respiratory distress syndrome)은 출생 후 치료 뿐만 아니라 출생 전 예방에 더 많은 관심을 가지게 되었다 이에 본 저자는 산전 ambroxol hydrochloride와 dexamethasone치료가 미숙아 호흡곤란증 예방과 신생아 감염에 미치는 영향을 알아보고자 본연구를 시행하였다. 방법: 조기 진통으로 미숙아를 분만하게 되는 101명의 산모에서 무작위로 ambroxol hydrochloride와 dexamethasone을 투여하였다. 이들에서 분만 된 113명의 신생아가 연구에 포함되었으며, 이들 환아를 대상으로 뇌실 내 출혈 및 신생아 감염의 빈도에 대한 평가도 이루어졌다. 결과: 대상 환아의 두 군간에 평균 재태연령, 출생시 체중, 조기양막파수의 빈도, 아프가 점수 등의 차이는 없었다. Ambroxol투여군에서 호흡곤란증후군의 발생 빈도가 20.6%로 dexamethasone군의 38%에 비해 낮았으나 통계적 의의는 없었다(p>0.05). 또한 인공 폐포 활성물질의 투여를 요구하는 중증의 호흡곤란증후군 빈도가 인공호읍기, 산소 치료, 입원 기간도 두 군간에 차이가 없었다. 신생아 감염의 경우 ambroxol 투여군에서 4.8%로 dexamethasone군의 24%에 비해 의미있게 낮았다(p<0.05). 결론: Ambroxol hydrochloride의 산전 치료 효과는 미숙아 호흡곤란증의 예방에는 dexamethasone과 비슷한 효과를 보였으며, 신생아 감염에서는 더 낮은 감염률을 보였다.

韓國飮食에 대한 女高生의 意識과 嗜好에 關한 調査硏究 : 光州ㆍ全南地域을 中心으로

박미섬,김경애 한국 가정과 교육 학회 1991 한국가정과교육학회지 Vol.3 No.-

The consciousness and food preference of Korean foods by high school girls in Kwangju city and Chonnam area was survery by questionnaire. The resutls were as follows; 1. Although the cooking methods of Korean foods were scientific (63.8%), they have to be improved because of complication and diffeculty. The point of improvement in the urban area was cooing method but that in the rural area was nutrition and hygiene 2. The motives of having interest in korean tradition foods were through home life and school education, mass communication and ets. As the subjects live in more urban area and have high income level, they were affected by school education and mass communication. 3. They are used to eat both traditional and nontraitional foods on the korean festive days and annual functions. There is tendency to decrease the use of traditional foods gradually because of complicated their cooking methods and long cooking time. 4. Most houehold responded that Korean traditional food are must to succession development (52.9%), because of succeed to korean diet culture and suit one's taste. Teh most pride of traitional food are kimchi, rice cake, sweet rice drink, persimmon punch, sweet waxy rice cooked potherbs. 5. The preferenc about the korean foods were high in this order of chopusey, mandu, laver, shikhae, cooked waxy rice. And they were low in salted anchovies salted yellow convina liver cheon, lyster cheon.

動物組織中의 脂質定量에 對하여

朴愛卿 이화화학회 1968 梨花化學會誌 Vol.- No.7

쥐의 뇌, 심장, 허파 등을 試料로 取하여 Thin layer chromatography에 依하여 脂質을 定量한 結果 cholesterol는 특히 뇌신경 조직과 부신에 많이 存在하며 Total cholesterol 含量은 뇌에 17.6㎎/g로 가장 많았고 심장에 3.2㎎/g로 가장 적었다. Free cholesterol 역시 뇌에 가장 많이 있고 심장에 가장 적었다. Glyceride는 Brain에 가장 많았고 大體로 Triglyceride가 많았다. Lipid is accumlated at adipose tissue, Adipose tissue consists of more than 90% triglyceride. Lipid is main energy source in the animal body as you know. In this experiment, we used brain, heart and lug from rat as samples. We tried to investigate the constituents of neutral lipid, and phospholipids. As a resalt, we separated six different material from nuetral lipid and four from the phospholipid. They were monoglyceride, diglyceride, triglyceride, free cholesterol esterified cholesterol fatty acids and phosphatidyl ethanol amine, phosphatidyl choline, phosphatidyl inositol, and one unknown lipid, respectively. Brain had the highest glyceride content and also highest cholesterol content which was about 4 times as high as that in the heart and lug. Phosphatidyl ethanol amine had the highest phospholipid and total cholesterol amount was the highest at the Brain.

일 대학 보건진료소의 결핵 관리에 관한 조사 연구

박경애 東新大學校 1997 論文集 Vol.9 No.-

The proportion of people who contacted T.B. in Korea has drastically decreased as a result of the incessant effort of the Korean government which adopted a policy of "Drive out T.B." as its foremost health policy. However, the proportion still remains relatively high compared with that of developed countries. This study was conducted to find some means for guiding and counseling university students who have T.B. The subjects of this study was consisted of 315 students at C university who were diagnosed as T.B. patients and registered at the C university health clinic front 1991 to 1996. The findings were as follows; 1) Prevalence rates of T.B. according to years were 0.5% in average 2) Incident rates of bacteriologically confirmed T.B. by years were 3.1% in average 3) According to the route of case finding, 91.4% of T.B. patients were identified by period phygical examination. 4) Rates of T.B. patients according to registered agents were 84.5% in average by university health clinic. 5) Seventy-two point six percent of patients were minimal and 20.7% were moderately advanced and 6.7% were far advanced. 6) Eighty-five point seven percent of patients were discharged after complete treatment, 2.0% of them were transfered, 2.3% were changed their diagnosis and 9.1% were under teatment. 7-1) Advantages in utilization of university health clinic were accessibility(61.5%), availability(46.2%), comprehensiveness and affordability(42.3%), care continuity(26.9% ) in order. 7-2) Disadvantages in utilization of university health clinic were difficult in contact doctor(60.0%), too burdensome of staff in clinic(56.0%), fear to be known as T.B. patient to the colleague(44.0%) in order.

日本 紀行歌辭의 계보와 日本觀의 변모양상

박애경 열상고전연구회 2006 열상고전연구 Vol.23 No.-

이 글의 목적은 조선 후기부터 일제 강점기에 사이에 씌여진 세 편의 일본 기행가사를 통해 일본관의 변화를 살피려는 것이다. 이를 위해 18세기 저작인 <일동장유가>, 한말 저작인 <유일록>, 일제 강점기에 나온 「東遊感興錄」을 대상으로 삼았다. 일본 기행가사에 나타난 일본관의 의미를 당대 문화적 환경과 관련하여 살피기 위해 먼저 공식적 여행의 체험을 그린 사행가사가 나오게 된 배경을 가사 장르 자체의 변화와 관련하여 살펴보았다. 또한 사행가사가 유학자이자 관료인 작가의 공적 여행의 기록인 동시에 조선 지식층의 내면의식을 보여주는 통로라는 것을 확인하였다. 3편의 일본 기행가사는 주권 왕조에서 식민지로 급전직하한 국가 운명만큼이나 달라진 대일관을 보여주고 있다. <일동장유가>가 화이관의 지속을 보여준다면, <유일록>은 화이관의 지속과 균열을 보여주는 동시에 일본에 대한 양가적 시선을 드러내고 있다. 일제 강점기 통치정책의 하나로 시행된 내지 시찰의 경험을 담은 「동유감흥록」은 말할 것도 없이, 식민지 담당자의 의도에 포섭된 자의 시선이 두드러지게 나타난다. 이렇듯 일본 기행가사에는 조선 후기 이후 달라진 대일 관계와 양국의 지위, 한학과 유학을 하던 조선의 전통적 지식층들이 시대의 변화를 바라보는 관점이 유장한 호흡 속에 나타나 있다. 따라서 일본 기행가사는 일본관 형성의 기저, 조선 지식층들의 대외 인식의 일단을 살피는 시대적 기록으로서의 가치가 크다고 할 수 있다. The purpose of this study is to inguire the change of an awareness of Japan through 3 works of Ilbon Kihaeng Kasa (Kasa which discribes the experience of a travel in Japan) written in the late of Chosun Dynasty and in the colonial period. For this purpose, this study deals 'Ildongjangyuga(日東壯遊歌)' written in the 18C, 'Yuilrok(游日錄)' written in the late of 19C and 'Dongyugamheungrok(東遊感興錄)‘ written in the colonial period. For analizing the meaning of an awareness of Japan in relation to the cultrural circumstance at that time, this styudy observes the condition for forming Sahaeng Kasa, as the records of the experience of official trip to other contries with a focus on the transformation of Kasa. In addition, this study tries to verificate the fact that Sahaeng Kasa was not only the records of official trip to other contries by the Confucian bureaucrats but also the path to come out their inner consciousness. Each work represents different view of Japan as a consequence of the change of the nation status from a sovereign dynasty to a colony. The meaning of Ilbon Kihaeng Kasa can be summarized as the records of an age which present the origin of a view of Japan as much as the understanding other contries of the intellectuals in Chosun Dynasty.