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肝吸蟲症에 대한 Praziquantel (Embay 8440)의 治療效果에 關한 硏究
林漢鍾,柳光司 고려대학교 의과대학 1979 고려대 의대 잡지 Vol.16 No.3
A total of 162 patients with proven Clonorchis sinensis infection were treated by 8 different dosages with praziquantel at a single dose and 2 or 3 divided doses on a single or two days. A single dose of 40 ㎎/㎏ bwt and 50 ㎎/㎏ bwt of praziquantel were given to 28 and 15 patients respectively and each 15 patients were treated with a single dose of 20 ㎎/㎏ bwt and 30 ㎎/㎏ bwt for 2 days. Follow-up examinations were carried out at about 30 and 60 days after treatment. Two months after therapy, the results were shown 82.6 to 99.1% in the egg reduction rates but only 6.7% (in dosage group of 20 ㎎/㎏×2 days) to 33.3% (in dosage group of 50 ㎎/㎏×1 day) in cure rates. On the other hand, two doses of 25 ㎎/㎏ bwt (50 ㎎/㎏ bwt) and 3 doses of 25 ㎎/㎏ (75 ㎎/㎏ bwt) of praziquantel with the interval of 6 hours on one or two days were given to the other patients. The dosage of 2×25 ㎎/㎏×1 day and 2×25 ㎎/㎏×2 days were given to 15 and 24 patients respectively. The high egg reduction rates of 97.4% and 99.9% were shown in the follow-up examinations, however 46.7% and 75.0% of cure rates were obtained. Considerably high egg reduction rate (99.7%) and cure rate (85.7%) were obtained in 35 patients received 3×25 ㎎/㎏ bwt in a single day. However in 15 patients received 3×25 ㎎/㎏ bwt for two days complete cure was obtained at the follow-up examinations. In case eggs were found at the first or second follow-up examination, patients were treated again with the same dosage of praziquantel and another follow-up period of 60 days was required. Six of 24 patients received 2×25 ㎎/㎏×2 days and 5 of 35 patients received 3×25 ㎎/㎏×1 day treated again with the same dosage of praziquantel and all were completely cured. After a single dose of 40 ㎎/㎏×1 day, only 7 of 28 patients were cured at 30 and 60 days after therapy, and 21 patients received for another time 40 ㎎/㎏ once on a single day and 7 of these 21 patients (33.3%) were cured. The remaining 14 patients showed egg reduction rates of over 90%. Therefore 50.0% of cure rate was obtained after the 2nd medication. Eight of 15 cases received 2×25 ㎎/㎏×1 day were treated again with the same dosage, and only 4 cases were cured. In the final result, 73.3% of cure rate with 99.4% of egg reduction rate was shown at 60 days follow-up examination after the second medication. The assessment of tolerance recorded only a few side effects, such as headache, dizziness and nausea etc. Extended hematological and biochemical tests showed no abnormal findings after thereapy which might be due to the medication. It was evidently shown that the human clonorchiasis could be successfully treated with a few doses of praziquantel without any serious side effects. Therefore praziquantel is the most promising drug for the treatment against Clonorchis sinensis infection.
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강정대(JD Kang),임태웅(TW Lim),유광사(KS Yoo) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.9
This report deals with a case of giant leiomyoma arising in the right mid portion of the cervix uteri in 27 year old unmarried female. The leiomyoma has grown into the right broad ligament, and it has cystic degeneration and hematoma leading to fistula formation into the cervical canal. The pertinent literature has been reviewed. The case is found to be rare in occurrence.
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안관순(GS Ahn),강정대(JD Kang),임태웅(TW Lim),유광사(KS Yoo) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.10
1. 분만 및 수술후 창상봉합부위의 동통 및 국소반응이 다른 어떤 봉합사를 사용했을때 보다도 현저히 감소되었다. 2. 분만 및 수술후 봉합사에 기인한 합병증이 아주적다. 3. 같은 크기의 다른 봉합사에 비하여 훨씬 질기기 때문에 smaller suture & needle에 사용할 수 있고 handling이 용이하고 knot의 아전도가 높다. 4. 전자궁척출술후 vaginal vault 및 parametriumsite의 치유가 우수하다. 5. 결찰시 dexon은 미끄러지지 않기 때문에 first tying이 중요하며 이점이 사용상의 주 의점이다. catgut은 first tying이 약간 Loosening되는 경우라도 2 tying시 미끄러지면 서 Tight tying이 되는 경향이 있다. 6. Dexon은 모든 점에서 catgut등 다른 어떤 봉합사보다 우수하며 marshall- marchetti operation 및 다른 (other suspensory operationdmf 제외한 어떤 종류의 산 부인과적인 수술에도 사용할 수 있는 만족할만한 봉합사이다. 210 cases ard presented in which synthetic polyglycolic acid (Dexon) strtre materials were used in Korea General Hospital from Feb. 1976 to July. In 80 cases, the dexom were fsed for episiotomy repair. In Obstetrical & gynecological abdminal surgery group which consisted 112 cases Dexon were used for closure of abdominal wall in 69 cases, silk, catgut and Dexon were combined in 43 cases for closure of abdominal wall. In 18 cases, Dexon were used in a variety of vaginal surgery. the results obtained were as follows. 1. the most noteworthy finding was the significant redution in the degree of pain and tissue local reaction. 2. There were no complications attributable to the use of Cexon suture materials. 3. Dexon suture materials is extremely strong, easy to handle, and has excellent non-slip prorerties, thus the Cexon not only can be used to relatively smaller sutures and needles but knot security superpass those of any other suture materials. 4. Vaginal vault healing after TAH was excellent without granulation tissue growth and bleeding in 17 Cexon series. 5. Dexon does not run like ctgur and it is important to tighten the knot well from the very beginning. 6. We believe that this suture materials in superior to any other sutures in many respects, and it was found satisfactory results for all types of Obstetrical and Gynecological procedures except Marshall-Machetti operation and other suspensory operation.
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