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심영학,황정윤 한국산업경영시스템학회 2013 한국산업경영시스템학회지 Vol.36 No.1
A cell formation approach based on cluster analysis is developed for the configuration of manufacturing cells. Cell formation, which is to group machines and parts into machine cells and the associated part families, is implemented to add the flexibility and efficiency to manufacturing systems. In order to develop an efficient clustering procedure, this paper proposes a cluster analysis-based approach developed by incorporating and modifying two cluster analysis methods, a hierarchical clustering and a non-hierarchical clustering method. The objective of the proposed approach is to minimize intercellular movements and maximize the machine utilization within clusters. The proposed approach is tested on the cell formation problems and is compared with other well-known methodologies available in the literature. The result shows that the proposed approach is efficient enough to yield a good quality solution no matter what the difficulty of data sets is, ill or well-structured.
Propylthiouracil 투여후 발생한 재새불량성 빈혈 2예
김희선,심영학,홍순원,정춘희,김홍승,이미덕 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.2
Aplastic anemia is characterized by a failure of blood cell production resulting in varying degrees of pancytopenia with a markedly hypocellular bone marrow. Most cases of aplastic anemia are acquired, but the disease may also occur as the result of inherited abnormalities. In 50-65% of cases, however, the etiology is unknown. For acquired forms of aplastic anemia, a variety of causative factors, including radiation, viruses, chemicals and drugs, have been implicated. Antithyroid drugs(Carbimazole, Methimazole, Propylthiouracil) are usually listed among agents associated with the development of agranulocytosis, but aplastic anemia rarely follows their use. The first case of aplastic anemia followmg propylthiouracil was reported by Marte~lo et al. in 1967 and the second case was by Aksoy and Erdem in 1968. Recently, we experienced two cases of aplastic anemia following propylthiouracil therapy due to Graves disease, so we report here these cases with literature review (J Kor Soc Endocrinol 13:258-263, 1998).
Herpes Virus 감염과 관련된 Virus 성 혈구 탐식증 1 예
이경원,최미란,심영학,김원천 대한내과학회 1986 대한내과학회지 Vol.30 No.3
A virus associated hemophagocytic syndrome characterized by high fever, severe constitutional symptoms, with hematologic disasters such as coagulation disorder, peripheral pancytopenia, and benign histiocytic hyperplasia with prominent hemophagocytosis in bone marrow and lymph node had been reported and descriptively named Virus Associated Hemophagocytic Syndrome for the distinction with classical Histiocytic Medullary Reticulosis. It had been reported that VAHS is a reactive process to a viral infection in immunoco-mpromised hosts or previously healthy hosts. Treatment should be consisted only supportive care and withdrawal of immunosuppressive therapy. We report a case of hemophagocytic syndrome associated with Herpes simplex virus infection who was previously healthy, 54 years old woman, with the review of the literatures.