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황진혁 ( Jin Hyeok Hwang ),정지봉 ( Ji Bong Jeong ),김용태 ( Yong Tae Kim ),윤용범 ( Yong Bum Yoon ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 Trypsinogen의 선방 세포 내에서의 활성화가 cerulein 유발 급성 췌장염의 발병에 있어 가장 주요한 요소로 알려져 있다. 그러나 trypsinogen 활성화에 관여하는 세포내 전달체계에 대해서는 그리 밝혀진 바가 많지 않다, 본 연구는 trypsinogen 활성화에 필요한 세포내 신호전달체계로서 MAPKs(ERK & p38)와 PI3-K의 역할에 대해 알아보고자 했다. 〈방법〉 Wister rats에서 췌장을 얻고 PD98059로
치료 후 담낭내 용종성 종괴 형태의 전이로 나타난 간세포암
황진혁 ( Jin Hyeok Hwang ),윤용범 ( Yong Bum Yoon ),김용태 ( Yong Tae Kim ),강현우 ( Hyoun Woo Kang ),윤원재 ( Won Jae Yoon ),정지봉 ( Ji Bong Jeong ),이효석 ( Hyo Suk Lee ),장진영 ( Jin Young Jang ),김선회 ( Sun Whe Kim ),김우호 대한소화기학회 2003 대한소화기학회지 Vol.41 No.4
Hepatocellular carcinoma (HCC) does not usually cause metastasis because of its lower metastatic potential as well as early detection of the tumor resulting from screening of the high-risk population. However, metastatic HCCs are observed occasionally in the lung, bone, biliary tree, and adrenal gland and rarely in the skin, orbit, and gallbladder. Several cases of metastatic HCC to the gallbladder without direct invasion have been reported in the literature. However, it is extremely rare that only metastatic HCC is detected with no evidence of recurrence of the primary cancer. We experienced a case of metastatic HCC located in the gallbladder of a 64-year-old man as a polypoid mass after twenty-two month disease-free interval. To our knowledge, this is the first report of an isolated metastatic HCC in the gallbladder without any evidence of recurrence of the HCC in the liver. (Korean J Gastroenterol 2003;41:321-324)
황진혁 ( Jin Hyeok Hwang ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6
MicroRNAs (miRNAs) are recently discovered non-coding small RNAs that play a role as regulators of genetic expressions in eukaryotic cells. It comprises about 20 nucleotides, which contains seed sequence to bind 3`-untranslated lesion of specific target mRNA. It regulates self-renewal, proliferation and differentiation via post-transcriptional gene slicing in normal situation. Aberrant expressions of miRNAs are observed in many cancers as well. miRNAs in cancer cells have been investigated extensively to have a role in tumorigenesis, invasion, metastasis and chemoresistance. In cancer cells, miRNAs act both as tumor suppressors or oncogenes by doing down-regulation of oncogenes or up-regulation of tumor suppressors, respectively. This suggests miRNAs can be potential therapeutic and diagnostic targets in cancers. Pancreatic cancer is one of the most lethal tumors. In spite of many efforts, overall 5-year survival rate of pancreatic cancer is still very low (<5%). Recently, several miRNAs as an oncomir (acting like oncogenes or tumor suppressor genes) are discovered in pancreatic cancer. Here, the role of miRNAs in pancreatic cancer will be discussed and its possibility of diagnostic/therapeutic target will be also mentioned. (Korean J Gastroenterol 2012;59:395-400)
위장관 ; 2007년도 3차기관에서 진단된 소화성궤양 환자의 임상상
김진주 ( Jin Joo Kim ),김나영 ( Nayoung Kim ),박현경 ( Hyun Kyung Park ),조현진 ( Hyun Jin Jo ),신철민 ( Cheol Min Shin ),이상협 ( Sang Hyup Lee ),박영수 ( Young Soo Park ),황진혁 ( Jin Hyeok Hwang ),김진욱 ( Jin Wook Kim ),정숙향 대한소화기학회 2012 대한소화기학회지 Vol.59 No.5
Background/Aims: In spite of the improvement of medical treatment for the peptic ulcer disease (PUD), PUD is still one of the common upper gastrointestinal diseases. The purpose of this study was to evaluate the risk factors and general characteristics of Korean patients diagnosed as PUD at a single third referral center. Methods: A total of 310 patients, diagnosed as PUD through endoscopy during one year of 2007 at Seoul National University Bundang Hospital were, retrospectively, evaluated regarding age, gender, Helicobacter pylori (H. pylori) positivity, clinical manifestations, comorbidities and medications. In addition, PUD was analyzed in the aspect of ulcer location, type of visit, gastrointestinal bleeding, and age. Results: The mean age was 61.5 years old (48.1% over 65) and 208 (66.7%) patients were men. The rate of H. pylori infection was 47.8%, and any ulcerogenic medication history such as antiplatelet agents and NSAIDs was found to be 21.0% (65 patients). The rate of idiopathic peptic ulcer without evidence of H. pylori and NSAIDs was found to be 40.6% (126 patients). Among 310 PUD patients, bleeding symptoms such as melena, hematemesis and hematochezia occurred in 110 patients (35.5%). Conclusions: PUD was more prevalent in the elderly patients and frequently associated with bleeding. Substantial proportion of PUD patients had neither H. pylori infection nor history of ulcerogenic medications, suggesting of increasing prevalence of idiopathic PUD. (Korean J Gastroenterol 2012;59:338-346)
최진우 ( Jin Woo Choi ),김나영 ( Na Young Kim ),송호준 ( Ho June Song ),강형민 ( Hyung Min Kang ),유지연 ( Ji Youn Yoo ),이동훈 ( Dong Hun Lee ),최창규 ( Chang Kyu Choi ),박영수 ( Young Soo Park ),황진혁 ( Jin Hyeok Hwang ),김진욱 대한내과학회 2008 대한내과학회지 Vol.74 No.5
Background/Aims: Bleeding is a serious complication of peptic ulcer. Although endoscopic therapy is effective for achieving hemostasis of active bleeding, rebleeding occurs in 10~30% of these patients. Recently, treatment with proton pump inhibitor (PPI) after hemostasis has decreased the rate of rebleeding. In this study, we analyzed risk factors of peptic ulcer rebleeding and we evaluated whether the rebleeding rate could be different depending on the PPI treatment method. Methods: From March 2003 through February 2006, 639 patients visited the emergency room (ER) due to gastrointestinal hemorrhage. Among them, 191 patients were diagnosed to have peptic ulcer by endoscopy, and they were retrospectively analyzed for their clinical, laboratory and endoscopic findings. The PPI treatment method was categorized into the IV bolus group, the 8 mg/hr continuous infusion group and the others group. Results: Emergency endoscopy was performed within 24 hours in 86.9% of the patients with bleeding peptic ulcer. Rebleeding occurred in 9 cases (4.7%) within 7 days after hemostasis. On the basis of univariate analysis, shock on ER arrival (p=0.013) and over 5 units of packed red cells (PRCs) transfusion (p=0.016) were significant risk factors for rebleeding, yet the PPI treatment method did not affect the rate of rebleeding. Conclusions: The rebleeding rate of peptic ulcer in our study was 4.7%, and this was lower than the previous reports, and the rebleeding rate in our report may have been caused by the early hemostatic therapy together with intravenous infusion of PPI. These approaches are necessary as soon as the patients are stabilized, and especially for the group of patients who are at a high risk for rebleeding, such as those who experience shock at the ER and those who need over 5 units of PRC transfusion.(Korean J Med 74:481-490, 2008)