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폐와 하악골에 다발성으로 발생한 Histiocytosis X
황진혁(Jin-Hyuk Hwang),이부규(Bu-Kyu Lee) 대한구강악안면외과학회 2005 대한구강악안면외과학회지 Vol.31 No.3
Hitiocytosis X, recently termed Langergans cell histiocytosis, is a rare disease histologically characterized by an abnormal proliferation of histiocytes, and of which the pathophysiology is still ambiguous. The clinical presentation is highly varied. Typically, there is a solitary or multiple bony involvements, and less frequently, lesions are found in other organs such as the lungs, liver, lymph nodes, skin, and mucosae. Interestingly, so far, there has been no report which shows multiple developments in both soft and hard tissues. In this report, we present a case of hitiocytosis X in both mandible and lung. This may provide some information for understanding the pathophysilogy of the histiocytosis X.
백서에서 자가 구강점막세포와 혈소판 농축 혈장의 이식에 의한 점막 근 피판의 조직공학적 제작
이부규(Bu Kyu Lee),황진혁(Jin Hyuk Hwang) 대한구강악안면외과학회 2007 대한구강악안면외과학회지 Vol.33 No.4
Backgrounds: To overcome limited amount of autogenous mucosa for the reconstruction of various mucosal defect including oral mucosal defect, tissue engineered mucosa has been recently introduced. However, introduced conventional technique of tissue engineered mucosa still have serious pitfalls such as long fabrication time, fragility of the reconstructed mucosa, and complexity of the technique. Aim of the study: To examine whether the complex of preconfluent autologous keratinocytes and autologous PRP (Platelet rich plasma) can reconstruct oral mucosa on the muscular flap with easier and faster way compared to conventional mucosal tissue engineering technique. Materials and methods: One day before the operation, oral mucosa (3mm in diameter) were taken and treated for extraction of oral keratinocytes according to the routine manner. The day of operation, oral keratinocytes were prepared in the laboratory and then moved to the operating theater. Autologous PRP was also prepared and then mixed with oral keratinocytes just before grafting on the prepared muscular flap. After keratinocyte-PRP complex was seated, then a sterilized rubber sheet was placed on the graft and the elevated skin flap was replaced and sutured. Biopsies were proceeded at 3,5,7,14 and 21 days. Tissue samples were evaluated clinically, histologically, and immunohistochemically. Results: All of the oral keratinocyte-PRP complexes were successfully grafted on the recipient sites (100%). On 3 days after the operation, 1-2 continuous epithelial layer and many inflammatory cells were observed. On 5 days after the operation, increase of layers of keratinocyte was observed with less inflammatory response. Thickness of the layers was gradually increased from 7 to 21 days after the operation. Cytokeratin confirms epithelium in every specimen. Conclusions: Preconfluent graft of autogenous oral keratinocytes mixed with autogenous PRP have successfully reconstructed myo-mucosal flap. This technique could be a useful alternative for oral mucosal reconstruction in the near future.
연구논문 : 우리나라 비알코올지방간 환자에서 혈중 철분 과잉의 빈도와 HFE 유전자(H63D) 변이의 존재
이동훈 ( Don Hun Lee ),정숙향 ( Sook Hyang Jeong ),이명진 ( Myung Jin Lee ),조영애 ( Young Ae Cho ),김진욱 ( Jin Wook Kim ),박영수 ( Young Soo Park ),황진혁 ( Jin Hyuk Hwang ),김나영 ( Na Young Kim ),이동호 ( Doug Ho Lee ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.2
단일 병원에서 경험한 최근 급성 바이러스간염의 원인 및 임상 양상
강형민 ( Hyung Min Kang ),정숙향 ( Sook Hyang Jeong ),김진욱 ( Jin Wook Kim ),이동훈 ( Don Hun Lee ),최창규 ( Chang Kyu Choi ),박영수 ( Young Soo Park ),황진혁 ( Jin Hyuk Hwang ),김나영 ( Na Young Kim ),이동호 ( Dong Ho Lee ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.4