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황준이,지옥표,문형인,Whang, Joon-Ih,Zee, Ok-Pyo,Moon, Hyung-In 한국생약학회 2000 생약학회지 Vol.31 No.3
The root of Actinidia arguta was extracted with methanol and the methanol extract was suspended in $H_2O$ and successively partitioned with n-hexane, $CH_2Cl_2$, EtOAc and n-BuOH. Repeated column chromatographic separation of the EtOAc extract resulted in the isolation of two flavonoids (compounds 2 and 3) and two triterpenes (compounds 1 and 4) and $CH_2Cl_2$, extract to afford three lignans (compounds 5-7). Their structures have been established by spectroscopic, means to be (+)-tormentoside(1), (-)-catechin(2), (-)-epicatechin(3), (+)-uscaphic $acid-28-O-[\beta}-D-glucopyranoside$(4), (+)-pinoresinol(5), (+)-medioresinol(6), and (-)-syringaresinol(7).
황준일,조상희,심현정,이세련,양덕환,김여경,이제중,김형준,정익주,안재숙 대한의학회 2008 Journal of Korean medical science Vol.23 No.4
This phase II study evaluated the efficacy and safety of combination chemotherapy with paclitaxel, cisplatin, and 5-fluorouracil (5-FU) in advanced gastric cancer. Patients with histologically confirmed gastric adenocarcinoma were eligible for the study. Paclitaxel (175 mg/㎡) and cisplatin (75 mg/㎡) were given as a 1-hr intravenous infusion on day 1, followed by 5-FU (750 mg/㎡) as a 24-hr continuous infusion for 5 days. This cycle was repeated every 3 weeks. Forty-five eligible patients (median age, 56 yr) were treated in this way. Of the 41 patients in whom efficacy was evaluable, an objective response rate (ORR) was seen in 51.2% (95% CI, 0.35-0.67), a complete response in two, and a partial response in 19 patients. The median progression free survival was 6.9 months (95% CI, 5.86-7.94 months), and the median overall survival was 12.7 months (95% CI, 9.9-15.5). The main hematological toxicity was neutropenia and greater than grade 3 neutropenia was observed in twelve patients (54%). Febrile neutropenia developed in three patients (6.8%). The major non-hematological toxicities were asthenia and peripheral neuropathy, but most of patients showed grade 1 or 2. In conclusion, combination chemotherapy with paclitaxel, cisplatin, and 5-FU is a promising regimen, and was well tolerated in patients with advanced gastric cancer.
열전모듈을 이용한 냉방기의 최적 운전조건에 관한 실험적 연구
황준,강병하 대한설비공학회 2006 설비공학 논문집 Vol.18 No.1
This article presents the optimal operation of an air conditioner using thermoelectric modules. A prototype of air conditioner using four thermoelectric modules has been designed and built. The system performance with evaporative cooling for hot side of the module are studied in detail for several operating parameters, such as input power to the thermoelectric module, fans and pump. It is found that the optimal input voltage to the thermoelectric module and pump is selected for the best system performance based on the cooling capacity and the COP at a given operating condition. It is also found that both the cooling capacity and COP of a system is increased with an increase in the input power to fans. The cooling performance could be improved when the ambient temperature is increased and the relative humidity is decreased since the evaporative cooling at the hot side has been increased.
황준일,심현정,박영규,조상희,배우균,김대은,김경근,정익주 대한의학회 2011 Journal of Korean medical science Vol.26 No.11
KITENIN (KAI1 C-terminal interacting tetraspanin) promotes invasion and metastasis in mouse colon cancer models. In the present study, we evaluated the effects of KITENIN knockdown by intravenous administration of short hairpin RNAs (shRNAs) in an orthotopic mouse colon cancer model, simulating a primary or adjuvant treatment setting. We established orthotopic models for colon cancer using BALB/c mice and firefly luciferaseexpressing CT-26 (CT26/Fluc) cells. Tumor progression and response to therapy were monitored by bioluminescence imaging (BLI). In the primary therapy model, treatment with KITENIN shRNA substantially delayed tumor growth (P = 0.028) and reduced the incidence of hepatic metastasis (P = 0.046). In the adjuvant therapy model, KITENIN shRNA significantly reduced the extent of tumor recurrence (P = 0.044). Mice treated with KITENIN shRNA showed a better survival tendency than the control mice (P = 0.074). Our results suggest that shRNA targeting KITENIN has the potential to be an effective tool for the treatment of colon cancer in both adjuvant and metastatic setting.
Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
황준일,이지희,박미라,김대은,배우균,심현정,조상희,정익주 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.2
Purpose: Hypoxia-inducible factor-1α (HIF-1α) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1α. Recent reports suggested that HIF-1α also mediated the induction of class III β-tubulin (TUBB3) in hypoxia. TUBB3 confers resistance to taxanes. Inhibition of VEGF may decrease the expression of HIF-1α and TUBB3. This study was undertaken to investigate the roles of vascular endothelial growth factor receptor (VEGFR) in gastric cancer cell behavior and to identify methods to overcome paclitaxel resistance in vitro. Materials and Methods: The protein expression levels of HIF-1α and TUBB3 were measured in human gastric cancer cell lines (AGS) under normoxic and hypoxic conditions. The relationship between TUBB3 and paclitaxel resistance was assessed with small interfering TUBB3 RNA. AGS cells were treated with anti-VEGFR-1, anti-VEGFR-2, placental growth factor (PlGF), bevacizuamb, and paclitaxel. Results: Hypoxia induced paclitaxel resistance was decreased by knockdown of TUBB3. Induction of HIF-1α and TUBB3 in AGS is VEGFR-1 mediated and PlGF dependent. Hypoxia-dependent upregulation of HIF-1α and TUBB3 was reduced in response to paclitaxel treatment. Expressions of HIF-1α and TUBB3 were most decreased when AGS cells were treated with a combination of paclitaxel and anti-VEGFR-1. AGS cell cytotoxicity was most increased in response to paclitaxel, anti-VEGFR-1, and anti-VEGFR-2. Conclusion: We suggest that blockade of VEGFR-1 and VEGFR-2 enhances paclitaxel sensitivity in TUBB3-expressing gastric cancer cells.
황준,Hwang, Joon 한국결정성장학회 2014 韓國結晶成長學會誌 Vol.24 No.6
가공정밀도 요구특성의 지속적인 향상에도 불구하고, 공작기계와 절삭공구를 이용한 절삭가공공정에서의 채터진동은 아직도 개선의 여지가 많이 남아있다. 특히, 더욱 고속화, 고정밀화 되고 있는 가공현장에서 채터진동의 효과적인 감소대책에 대한 다양한 연구가 필요하다. 본 연구에서는 이러한 문제점을 해결하기 위해 고정밀 공구동력계를 이용한 실시간 절삭력 측정과 유한요소해석 방법을 이용해 사용 빈도와 활용이 매우 큰 터닝센터(turning center)에서 폭넓게 적용되고 있는 3종의 절삭공구 툴링에서의 채터진동 특성을 평가하여, 공구형상 및 툴링 특성에 따른 채터진동과의 상관성을 연구하고, 향후 채터진동 저감형 공구개발을 위한 근간 기술자료로 활용코자 한다. Machining performance is often limited by chatter vibration at the tool-workpiece interface. Chatter vibration is a type of machining self-excited vibration which originated from the variation in cutting forces and the flexibility of the machine tool structure. Cutting tooling method is one of major factor to chatter vibration in turning process. Even though lots of cutting tooling methods are developed and used in machining process, precise analysis of cutting tooling effect in view of chatter vibration behavior. This study presents numerical and experimental approaches to verify and effects of various cutting tooling geometry and clamping method on the onset of chatter vibration. Acquired knowledge from this study will apply the optimal geometry design of cutting tooling and adjusting of machining process.