http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
麝香蘇合元이 Alzheimer's disease 모델 백서의 학습과 기억에 미치는 영향
황의완 대한한방신경정신과학회 1999 동의신경정신과학회지 Vol.10 No.1
The effects of Sahyangsohapwon on the enhancement of learning and memory of AD model rats were studied with Morris water maze and radial arm maze. Sample group was electrolytically lesioned on nbM, and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for same duration. The following results were observed. 1. In the learning trials of Morris water maze, all three groups were improved in learning capacity as trials were repeated, but the sham group showed more prominent improvement in learning compared with the control group(p〈0.01). 2. In memory retention test of Morris water maze, the sham group marked more significant improvement statistically in memory retention compared with the control group(p〈0.05). 3. In the learning of radial arm maze, the sham group shows better learning capacity significantly compared with the control group(p〈0.05). With the experimental results above, Sahyangsohapwon can be supposed to have the improving effects on the learning and memory of AD rats induced by electronical injury of nbM.
調胃升淸탕이 Alzheimer's disease 모델 白鼠의 학습과 기억에 미치는 影響
黃義完,박순권,李雄錫,김현택 慶熙大學校韓醫科大學韓醫學硏究所 1998 慶熙韓醫大論文集 Vol.21 No.1
The effects of Jowiseungchungtang on the enhancement of learning and memory of AD model rats were studied with Morris water maze and radial arm maze. Sample group was electrolytically lesioned on nbM, and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for same duration. The following results were observed. 1. As the learning trials of Morris water maze processed repeatedly, sham group achieved 200.21±35.28 seconds in 1st trial, 153.14±62.66 seconds in 2nd, 109.93±42.57 seconds in 3rd, 79.29±50.07 seconds in 4th, and 48.07±29.39 seconds in 5th. The control group achieved 224.85±26.94 in 1st trial, 191.77±67.97 seconds in 2nd, 178.46±65.06 seconds in 3rd, 137.46±76.32 seconds in 4th, and 108.92±90.12 seconds in 5th. The sample group achieved 202.00±33.53 seconds in 1st trial, 196.17±40.65 seconds in 2nd, 172.50±56.30 seconds in 3rd, 88.75±47.70 seconds in 4th, and 84.17±59.73 seconds in 5th. Therefore, these data shows that all three groups were improved in learning capacity as trials were repeated, but the sample group showed more prominent improvement in learning compared with the control group(p<0.05). 2. In memory retention test of Morris water maze that counts the staying time in the target area, sham group stayed for 15.36±5.39 seconds, the control group stayed for 5.54±5.64 seconds, and the sample group stayed for 10.08±5.45 seconds. The analysis of the memory retention data shows that the sample group marked more significant improvement statistically in memory retention compared with the control group(p<0.05). 3. In the learning of radial arm maze, the number and rate of animals that arrive the learning criteria amounted 9 out of 14, 64.29% in sham group, none out of 13.0% in the control group, and 3 out of 12, 25.00% in the sample group. So, the sample group shows better learning capacity significantly compared with the control group(p<0.05). With the experimental results above, Jowiseungchungtang can be supposed to have the improving effects on the learning and memory of AD rats induced by eletronical injury of nbM.
황의완(Wei Wan Whang),김종우(Jong Woo Kim),이조희(Jo Hee Lee),엄효진(Hyo Jin Eom),이승기(Seung Gi Lee) 대한한방신경정신과학회 1996 동의신경정신과학회지 Vol.7 No.1
N/A 1. Out of 21 examples on a clinical base Alzheimer type dementia were 8 examples(38%), 11 vascular types(52%), 1 Alzheimer and vascular mixed type and rest 1 was secondary dementia type(NPH). 2. Between the gendes, there were 5 males and 3 females for Alzheimer types, 6 males and 5 females for the vascular types, 1 male for Alzhrimer and vascular mixed type, and 1 frmale for secondary dementia type(NPH). 3. For the degrees of Alzheimer type dementia there were 2 mild dementia, 4 moderate dementia, and 2 severe dementia. 4. Among the Alzheimer types 2 mild dementia were almost recovered back to normal in approximately 2 months, 2of 4 moderate dementia became significantly better in approximately 2 months and recovered to almost normal state in 3 to 5 months. The rest 2 have been under treatment for 3 months, but showed a little improvement. Out of 2 severe dementia examples, one showed a little improvement even if it has been under treatment over 2 years. The other exampe did not show any improvement, but dementia did not proceed any more. 5. Among the 11 vascular examples, 7 recovered in 2 to 3 months, 1 in 5 months, 2 recovered in a year, and the treatment was stopped arbitrary for the last one. 6 In the case of Alzheimer and vascular mixed type dementia, even the moderate dementia did not show any apparent result in 6 months. 7. For NPHI (Normal Pressure Hydrocephalus), there was an improvement on dementia in 2 months after the treatment, but gait disturbance and urinary incontinence did not show any noticeable difference. As a conclusion, almost all the Alzheimer and vascular type patients recovered, but the treatment periods varied depending on the types of the dementia and the degree of seriousness, especially in the case of the severe Alzheimer patients, the treatment oniy suppression the progression of the dementia. The most important aspect from clinical point of view was even if almost all the patients were almost completely cired, they need to keep being cured for a long period of time. The methol with respect to Four Constitutions is thought of the most desirable.