당뇨황반부종에서 트리암시놀론 유리체강내 단독주입과 후테논낭하주입 병용요법의 효과 비교

황영훈,문상웅,Young Hoon Hwang,Sang Woong Moon,Ph,D 대한안과학회 2007 대한안과학회지 Vol.48 No.4

Purpose: To compare the effect of triamcinolone acetonide injection between intravitreal injection alone group and intravitreal injection in combintaion with posterior subtenon injection group in diabetic macular edema. Methods: Twenty-nine eyes of 29 patients with diabetic macular edema were randomly classified into two groups. Intravitreal injection of triamcinolone acetonide 4 mg was administered to 15 eyes and posterior subtenon injection of triamcinolone acetonide 20 mg in combination with intravitreal injection was administered to 14 eyes. Best corrected visual acuity (BCVA), macular thickness measured by optical coherence tomography were assessed 1, 3, 6, and 12 months after the procedure. Results: Baseline BCVA and macular thickness showed no differences between two groups. BCVA and macular thickness 1, 3, and 6 months after the procedure revealed significant improvement, but no significant differences between two groups were observed. Conclusions: Intravitreal injection of triamcinolone acetonide alone and intravitreal inejction in combination with posterior subtenon injection were equally effective, but had no significant differences.

빛간섭단층촬영을 이용한 망막신경섬유층 검사시 발생한 오류의 양상

황영훈,강자헌,Young-Hoon Hwang,Ja-Heon Kang 대한안과학회 2008 대한안과학회지 Vol.49 No.5

Purpose: To investigate the frequency and characteristics of artifacts which can cause errors in retinal nerve fiber layer analysis using optical coherence tomography (OCT). Methods: The frequency, characteristics and retinal lesions responsible for the artifact were analyzed for 179 patients (338 eyes) by OCT. All images were categorized into two groups according to the presence of artifacts and then, the differences between the two groups were analyzed by t-test and cross-tabulation analysis in terms of age, refractive error, peripapillary atrophic areas, and type of glaucoma. Results: The male to female ratio was 1.37:1, average age was 47.6±15.7 years and average degree of refraction was -1.78±0.23 diopter. Artifacts were noted in 64 eyes (18.9%), and were present in the temporal quadrant in 12 eyes (18.8%), superior quadrant in 51 eyes (79.7%), nasal quadrant in 19 eyes (87.5%), and inferior quadrant in 8 eyes (48.4%). The average angle of the artifact was 138 degrees. Although retinal lesion, age, and glaucoma type were not significantly different between the two groups, peripapillary atrophy and myopia were significantly more common in the group with the artifact. Conclusions: When analyzing retinal nerve fiber layer by OCT, artifacts should be considered, especially in cases of peripapillary atrophy and myopia.

안구내 이물이 발견된 급성수정체녹내장

황영훈,김동수,문상웅,이대영,Young Hoon Hwang,Dong Su Kim,Sang Woong Moon,Dae Young Lee 대한안과학회 2007 대한안과학회지 Vol.48 No.12

Purpose: To report a case of acute lens particle glaucoma with an intraocular foreign body that persisted for a long duration. Case summary: A 47-year-old man visited our clinic due to severe pain in his right eye. His uncorrected visual acuity was hand movement, and intraocular pressure (IOP) measured by a Goldmann applanation tonometer was 76 mmHg in the right eye. Severe corneal edema and floating lens materials in the anterior chamber were revealed by slit-lamp examination. An ultrasonography scan showed that the lens had dislocated into the vitreous cavity and revealed vitreous opacities. To remove lens materials and control IOP, anterior chamber irrigation and trans pars plana vitrectomy with lensectomy were performed under local anesthesia. During the operation, an intraocular foreign body was removed from the anterior chamber. Dislocated lens particles were removed by vitrectomy. After the operation, his best corrected visual acuity was 1.0, and intraocular pressure was 12 mmHg in the right eye. Conclusions: Close observation is needed in cases with lens particle glaucoma, because a long-persisting intraocular foreign body can be accompanied by lens particle glaucoma.

정상안압녹내장 환자의 시신경유두 크기와 망막신경섬유층 두께의 상관관계

황영훈,이주화,Young Hoon Hwang,M,D,Joo Hwa Lee,M,D,Ph,D 대한안과학회 2008 대한안과학회지 Vol.49 No.5

Purpose: To investigate the correlation between optic disc size and retinal nerve fiber layer (RNFL) thickness in healthy subjects and patients with normal tension glaucoma (NTG). Methods: Optical coherence tomography was performed on 50 eyes of 50 healthy subjects and on 50 eyes of 50 NTG patients. Results: The optic disc size showed a significant correlation with the RNFL thickness in healthy subjects and in patients with NTG. Significant correlations were observed between the optic disc size and the ratio of superior-to-total RNFL thickness (r=-0.283, p=0.049) and the ratio of nasal to total RNFL thickness (r=0.403, p=0.004) in healthy subjects. In patients with NTG, significant correlations were observed between the optic disc size and the ratio of superior to total RNFL thickness (r=-0.314, p=0.029) and the ratio of inferior to total RNFL thickness (r=-0.302, p=0.034). Conclusions: RNFL thickness increased significantly with an increase in optic disc size in both healthy subjects and NTG patients. The correlation between optic disc size and the ratios of each quadrant to the total RNFL thickness showed a different pattern between healthy subjects and NTG patients.

1차 및 2차 항결핵제에 의한 DRESS (drug reaction with eosinophilia and systemic symptom) 증후군 1예와 문헌 고찰

황영훈 ( Young-hoon Hwang ),장동연 ( Dong Yeon Jang ),강성윤 ( Sung Yoon Kang ),손경희 ( Kyung-hee Sohn ),강동윤 ( Dong Yoon Kang ),이창훈 ( Chang Hoon Lee ),강혜련 ( Hye-ryun Kang ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.2

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially fatal drug-induced systemic hypersensitivity response characterized by erythematous eruption, fever, leukocytosis with eosinophilia, and internal organ involvement. Antitubercular agents are potential causative agents for DRESS syndrome but difficult to verify as a culprit drug, since antitubercular agents are coadministered as a combination regimen. A 42-year-old female with endobronchial tuberculosis was diagnosed with DRESS syndrome after 4-week treatment of isoniazid, rifampicin, ethambutol, and pyrazinamide with prednisolone 50 mg. All the antitubercular agents were stopped and replaced with levofloxacin, cycloserine, p-aminosalicylic acid, and kanamycin. However, severe exacerbation of DRESS syndrome compelled the patient to discontinue the administration of the second-line antitubercular agents. Two months later, the patient underwent a patch test for all the antitubercular agents which had been used, and the results showed positivity to isoniazid and cycloserine. We report a rare case of DRESS syndrome that reacted to cycloserine as well as isoniazid. Development of coreactivity to other drugs should be differentiated with a flare-up reaction in the management of DRESS syndrome. (Allergy Asthma Respir Dis 2017:5:111-116)

갈릴레이와 세극등 빛간섭단층촬영기로 측정한 전안부계측치의 반복성 및 비교

이원혁,황영훈,김세종,이상목,유정권,김용연,이주화,Won Hyuk Lee,Young Hoon Hwang,Se Jong Kim,Sang Mok Lee,Chungkwon Yoo,Yong Yeon Kim,Joo Hwa Lee 대한안과학회 2011 대한안과학회지 Vol.52 No.1

Purpose: To evaluate the repeatability and comparability of anterior chamber depth (ACD) and central corneal thickness (CCT) measurements obtained by Galilei dual Scheimpflug analyzer (Ziemer, Port, Switzerland) and slit-lamp optical coherence tomography (SL-OCT; Heidelberg Engineering, Dossenheim, Germany). Methods: ACD and CCT were measured by Galilei and SL-OCT in 68 eyes of 68 healthy young subjects. Each measurement was performed 3 times by a single examiner, and the repeatability of 3 consecutive measurements was analyzed. ACD and CCT measurements were compared between the 2 devices. Results: Both Galilei and SL-OCT showed high repeatability (ICCs ≥ 0.994) for ACD and CCT measurements. The mean ACD and CCT measured by Galilei were greater than SL-OCT measurements by 0.11 ± 0.09 mm and 14.01 ± 7.38 μm, respectively. The 95% limit of agreement values for ACD and CCT measurements were 0.36 mm, 27.66 μm, respectively, and were highly correlated (correlation coefficients ≥ 0.89, p < 0.001). Conclusions: Although the repeatability of each device was high, ACD and CCT obtained by Galilei and SL-OCT were significantly different. These differences should be considered when interpreting ACD and CCT measurements obtained by the 2 devices. J Korean Ophthalmol Soc 2011;52(1):53-59

컴퓨터 게임 전후 각막 및 안구의 고위수차 변화

김민서,황영훈,송종석,Min Seo Kim,Young Hoon Hwang,MD,Jong Suk Song,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.11

Purpose: To evaluate changes in corneal and ocular high-order aberration, ocular fatigue, and tear break-up time (TBUT) before and after playing computer games and the correlations among the variables. Methods: Thirty-nine normal healthy subjects played computer games for 1 hour. Ocular fatigue was evaluated with a questionnaire, TBUT was measured with slit-lamp biomicroscopy, and high-order aberrations were measured with a KR-1W aberrometer (Topcon Medical System, Inc., Tokyo, Japan) in each subject before and after playing computer games. The right eye was used for statistical analyses. Results: Subjective ocular fatigue (expressed as the interview score) increased from 4.23 ± 5.35 to 12.05 ± 8.68 after playing games (p < 0.001) and TBUT decreased from 8.03 ± 6.43 sec to 4.90 ± 3.31 sec (p < 0.001). Ocular high-order aberrations in the 4 mm and 6 mm zones were not significantly changed before and after playing games (p = 0.150, p = 0.202, respectively). However, corneal high-order aberrations in the 4 mm and 6 mm zones were significantly increased after playing computer games (p = 0.002, p = 0.002, respectively). Changes in TBUT, interview score, and corneal high-order aberration were not correlated with each other. Conclusions: Playing computer games increased corneal high-order aberrations as well as subjective ocular fatigue and TBUT.

혈액투석이 안압, 망막신경섬유층 두께 및 각막두께에 미치는 영향

강용석,황영훈,김재석,이주화,Yong Seok Kang,Young Hoon Hwang,Jae Suk Kim,Joo Hwa Lee 대한안과학회 2012 대한안과학회지 Vol.53 No.11

Purpose: To compare the intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness and central corneal thickness (CCT) in healthy individuals and patients with chronic renal failure (CRF) undergoing hemodialysis, and to evaluate the changes in each parameter before and after hemodialysis in patients with CRF. Methods: Thirty-six eyes of 36 patients with CRF undergoing hemodialysis were included in the hemodialysis group and 54 eyes of 54 healthy subjects were recruited as the control group. All subjects underwent a complete eye examination, including best-corrected visual acuity (BCVA), slit lamp examination, dilated funduscopic examination, gonioscopy, automated perimetry, IOP measurement, corneal pachymetry, and evaluation of RNFL thickness. In the hemodialysis group, IOP, RNFL thickness, and CCT were measured again within 1 hour of hemodialysis. Results: Age, sex, BCVA, cup-to-disc ratio, IOP, and CCT were not statistically different between the 2 groups. The RNFL of the hemodialysis group was statistically significantly thinner than the control group (p < 0.001). The IOP decreased from 16.52 ± 2.95 mm Hg to 14.88 ± 2.03 mm Hg after hemodialysis (1.63 ± 3.27 mm Hg; p = 0.005). The changes in RNFL thickness and CCT were not statistically significant (p = 0.148, p = 0.352). Conclusions: In CRF patients with hemodialysis, RNFLs were thinner in the control group and hemodialysis induced significant IOP reduction. The results from the present study should be considered for the proper evaluation of ocular disorders in CRF patients with hemodialysis.

아크릴릭 인공수정체안에서 동공영역으로 증식하는 전낭하 상피세포

최계원,황영훈,문상웅,김재호,Gye Won Choi,M,D,Young Hoon Hwang,M,D,Sang Woong Moon,M,D,Jae Ho Kim,M,D,Ph,D 대한안과학회 2007 대한안과학회지 Vol.48 No.1

Purpose: To report upon two cases of anterior capsule opacification (ACO) proliferating into the pupillary region of the anterior surface of a single piece acrylic AcrySof? intraocular lens (IOL) (SA60AT, Alcon Laboratories, Inc., USA). The surgical removal of the ACO was also reported. Methods: An 80-year-old woman and a 75-year-old woman underwent phacoemulsification with implantation of a single piece foldable AcrySof? IOL in the posterior capsular bag. ACO proliferating from the opposite sides of the IOL along the central axis were found three months after surgery. To recover visual acuity in the 80-year-old woman`s eye, ACO was surgically removed with a Sinskey hook and irrigation and aspiration system. Results: The patient`s visual acuity was recovered after surgical removal of the ACO. Histopathologic findings of the removed tissues revealed fibroblastic proliferation of lens epithelial cells. The ACO in 75-year-old woman`s eye was not treated, as it was not associated with a visual disturbance. Conclusions: In eyes containing an AcrySof? IOL, clinically significant ACO proliferation into the pupillary region along the central axis can occur. Surgical removal can be beneficial for recovery of visual acuity.

정상안에서 자세 변화에 따른 안압과 안구계측치의 변화

조효종,황영훈,이주화,Hyo Jong Cho,Young Hoon Hwang,Joo Hwa Lee 대한안과학회 2012 대한안과학회지 Vol.53 No.2

Purpose: To investigate intraocular pressure (IOP) and ocular biometry change according to the posture change in healthy eyes. Methods: Forty eight eyes of 48 healthy young subjects were enrolled. IOP, central anterior chamber depth (cACD), and axial length were measured after keeping each position for 10 minutes (upright, sitting, supine, and prone positions) by using the TonoPen? and A-scan ultrasonography. Results: Mean IOP was 19.68 ± 2.15 mm Hg in prone position, 17.19 ± 1.33 mm Hg in supine position, 16.49 ± 1.76 mm Hg in sitting position, and 15.33 ± 1.34 mm Hg in upright position. Difference among the positions was statistically significant (p < 0.01). Mean cACD was 3.68 ± 0.35 mm in upright position, 3.63 ± 0.32 mm in supine position, 3.59 ± 0.34 mm in sitting position, and 3.47 ± 0.30 mm in prone position. Difference among the positions was statistically significant (p < 0.01) except for the difference between supine and sitting position. Linear regression analysis revealed that cACD was significantly associated with IOP in prone position (R2 = 0.139, p < 0.01). Conclusions: There was a significant change in IOP and cACD according to the posture change. cACD was significantly associated with IOP only in prone position. J Korean Ophthalmol Soc 2012;53(2):306-310