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활성화된 설치류 RAW 264.7 대식세포에서 당귀 에탄올 추출물의 항염증 효과
장선일,김형진,황기명,배현옥,윤용갑,정헌택,김윤철,Jang Seon-Il,Kim Hyeong-Jin,Hwang Ki-Myeong,Pae Hyeon-Ok,Yun Yong-Gap,Chung Heon-Taek,Kim Yun-Cheol 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
The inhibitory effects of ethanol extract of Radex Angelica uchiyamana, on LPS- or IFN- plus LPS-induced production of NO, and $TNF-{\alpha}$, and expression of iNOS and COX-2 were investigated in the activated RAW 264.7 cells. This extract significantly inhibited the production of NO and $TNF-{\alpha}$, and suppressed the expression of iNOS and COX-2 in a dose-dependent manner. These results show that ethanol extract of Radex Angelica uchiyamana may explain some known biological activities including anti-inflammatory effect, and is of considerable benefit in the treatment for NO and pro-inflammatory cytokine overproduction related immunological diseases.
김정은,황선일,이성봉,신상운,권혜정,이지연,이병훈,모아라,최옥경,Kim, Jeong-Eun,Hwang, Seon-Il,Lee, Seong-Bong,Shin, Sang-Woon,Kwon, Hye-Jung,Lee, Ji-Yeon,Lee, Byoung-Hoon,Mo, A-Ra,Choi, Ok-Kyung 한국식품위생안전성학회 2022 한국식품위생안전성학회지 Vol.37 No.3
In this study, heavy metals (lead, cadmium, and mercury) and shellfish poisoning toxins (diarrhetic shellfish poisoning toxins, amnesic shellfish poisoning toxins) were investigated in a total of 104 shellfishes. According to the analysis of heavy metals, lead (Pb) was detected in the range of 0.0177-0.5709 mg/kg, cadmium (Cd) was detected in the range of 0.0226-1.4602 mg/kg, and mercury (Hg) was detected in the range of 0.0015-0.0327 mg/kg. Levels of Pb, Cd, and Hg were acceptable by Korean standards. Okadaic acid (OA) and dinophysistoxin-1 (DTX-1) were investigated for monitoring of diarrhetic shellfish poisoning toxins and OA and DTX-1 were not detected. As a result of monitoring of amnesic shellfish poisoning toxins, domoic acid was detected in 5 of 104 samples and detection ratio was 4.8%. The detection period was found as follows; 1 case in January, 1 case in February, 1 case in May, 2 cases in September. These showed that continuous monitoring for the management of shellfish poisoning toxins and heavy metals is required. In addition, this study can be used as reference data to strengthen managing heavy metals in fishery products.
아토피 피부염 치료제 개발에 활용할 수 있는 마우스 모델에 대한 고찰
윤용갑,황주민,김형률,장선일,Yun, Young-Gab,Hwang, Joo-Min,Kim, Hyung-Rul,Jang, Seon-Il 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.1
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers. The clinical phenotype that characterizes AD is the product of interactions between susceptible genes, the environmental factors, defective skin barrier function, and immunologic responses. This review summarizes recent progress in our understanding of the immunopathophysiology of AD and the implications for mouse models of AD in drug discovery from medicinal plants.